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公开(公告)号：US20120028965A1
公开(公告)日：2012-02-02
申请号：US12903390
申请日：2010-10-13
IPC分类号： A61K31/551 , A61P35/00 , A61P29/00 , A61P37/06 , A61P3/00 , A61P9/00 , A61P11/06 , A61P37/08 , A61P19/08 , C07D519/00 , A61P25/28
CPC分类号： C07D513/04 , A61K31/55 , A61K31/551 , A61K45/06 , C07D495/04 , C07D519/00 , C07K14/81
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US08017781B2
公开(公告)日：2011-09-13
申请号：US11600311
申请日：2006-11-15
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq , Jingrong Cao
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq , Jingrong Cao
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/02 , C07D471/04 , C07D487/02
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20110190507A1
公开(公告)日：2011-08-04
申请号：US12942287
申请日：2010-11-09
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Sharn Ramaya , Shazia Sadiq
IPC分类号： C07D403/04 , C07D403/14
CPC分类号： C07D409/04 , A61K31/4196 , A61K45/06 , C07D409/14 , C12N9/99
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US07960415B2
公开(公告)日：2011-06-14
申请号：US12140497
申请日：2008-06-17
申请人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Michael Mortimore , John Studley
发明人： Guy Brenchley , Jean-Damien Charrier , Steven Durrant , Ronald Knegtel , Michael Mortimore , John Studley
IPC分类号： A61K31/44 , C07D211/72
CPC分类号： C07D213/75 , C07D213/82 , C07D405/12 , C07D417/12
摘要： The present invention provides a compound of formula I: wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also provides pharmaceutical compositions and methods using such compositions for treating a caspase-mediated diseases and processes for preparing the compounds of the invention.
摘要翻译： 本发明提供式I化合物：其中R 1，R 2，R 3，R 4和R 5如本文所定义。 本发明还提供了使用这种组合物治疗半胱天冬酶介导的疾病的药物组合物和方法以及制备本发明化合物的方法。
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公开(公告)号：US20110021519A1
公开(公告)日：2011-01-27
申请号：US12796174
申请日：2010-06-08
申请人： Jean-Damien Charrier , David Kay , Ronald Knegtel
发明人： Jean-Damien Charrier , David Kay , Ronald Knegtel
IPC分类号： A61K31/5377 , C07D487/12 , A61K31/519 , C07D413/14 , A61P35/00 , A61P37/06 , A61P19/08 , A61P3/00 , A61P25/00 , A61P9/00 , A61P5/00
CPC分类号： C07D487/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US07838517B2
公开(公告)日：2010-11-23
申请号：US12466420
申请日：2009-05-15
IPC分类号： C07D495/04 , C07D513/04 , C07D519/00 , A61K31/4188 , A61K31/4184 , A61K31/55
CPC分类号： C07D513/04 , A61K31/55 , A61K31/551 , A61K45/06 , C07D495/04 , C07D519/00 , C07K14/81
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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![5-CYANO-4- (PYRROLO [2,3] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS](/abs-image/US/2010/07/29/US20100189773A1/abs.jpg.150x150.jpg)
57.发明申请5-CYANO-4- (PYRROLO [2,3] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS 失效用作蛋白激酶抑制剂的5-氰基-4-（吡咯并[2,3]吡啶-3-基） - 吡啶衍生物公开(公告)号：US20100189773A1
公开(公告)日：2010-07-29
申请号：US12448489
申请日：2007-12-21
申请人： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
发明人： Michael Mortimore , Stephen Clinton Young , Simon Robert Lorrie Everitt , Ronald Knegtel , Joanne Louise Pinder , Alistair Peter Rutherford , Steven Durrant , Guy Brenchley , Jean-Damien Charrier , Michael O'Donnell
IPC分类号： A61K9/127 , C07D487/04 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P35/00 , A61P3/10 , A61P7/00 , A61P19/02 , A61P37/00 , A61P35/02 , A61K38/50 , A61K31/565 , A61K38/19 , A61K39/395 , A61K31/7088 , A61K31/661 , A61K33/24 , A61K31/7008 , A61K31/704 , A61K31/7068 , A61K31/69 , A61K38/21 , A61K38/20 , C12N5/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US07622463B2
公开(公告)日：2009-11-24
申请号：US11706070
申请日：2007-02-13
申请人： David Kay , Ronald Knegtel , Jean-Damien Charrier , Heather Twin
发明人： David Kay , Ronald Knegtel , Jean-Damien Charrier , Heather Twin
IPC分类号： C07D401/12 , A61K31/4545
CPC分类号： C07D487/04 , A61K31/551 , A61K45/06 , C07D487/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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59.发明授权Pyrazolylamine substituted quinazoline compounds useful as protein kinase inhibitors 有权用作蛋白激酶抑制剂的吡唑啉胺取代喹唑啉化合物公开(公告)号：US07098330B2
公开(公告)日：2006-08-29
申请号：US09952878
申请日：2001-09-14
申请人： David Bebbington , Hayley Binch , Ronald Knegtel , Julian M. C. Golec , Sanjay Patel , Jean-Damien Charrier , David Kay , Robert J. Davies
发明人： David Bebbington , Hayley Binch , Ronald Knegtel , Julian M. C. Golec , Sanjay Patel , Jean-Damien Charrier , David Kay , Robert J. Davies
IPC分类号： C07D401/14 , C07D403/12 , C07D405/04 , A61K31/517
CPC分类号： C07D401/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： This invention describes novel pyrazole compounds of formula III: wherein Ring D is a 5–7 membered monocyclic ring or 8–10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5–8 membered carbocyclo ring; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译： 本发明描述了式III的新型吡唑化合物：其中环D是选自芳基，杂芳基，杂环基或碳环基的5-7元单环或8-10元双环; R x和R y与它们的插入原子一起形成稠合的，不饱和的或部分不饱和的5-8元碳环; 和R 2和R 2'如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。
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公开(公告)号：US07091343B2
公开(公告)日：2006-08-15
申请号：US10389296
申请日：2003-03-14
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： C07D403/12 , C07D409/14 , C07D417/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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