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    SMART DELAY FOR INTERMITTENT STRESS THERAPY
    52.
    发明申请
    SMART DELAY FOR INTERMITTENT STRESS THERAPY 有权
    智能延迟用于间歇性压力治疗

    公开(公告)号：US20090281591A1

    公开(公告)日：2009-11-12

    申请号：US12436497

    申请日：2009-05-06

    申请人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Robert Shipley

    发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Robert Shipley

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/3682

    摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries. The pacing system receives a set of inputs and calculates parameters for delivering optimized cardiac protection pacing tailored for different stress levels. The system automatically adjusts heart rate to optimize cardiac protection pacing in a closed-loop system. In one embodiment, a method for delivering pacing pulses for cardiac protection is provided. Intrinsic atrioventricular (AV) intervals are sensed. The intrinsic AV interval and a predetermined equation relating the AV interval to an optimal AV delay are used to provide a maximum positive rate of left ventricular pressure change during systole. An AV delay is calculated using a predetermined percentage of the optimal AV delay to deliver ventricular pacing pulses to provide a desired level of stress for cardiac protective pacing therapy (CPPT) to provide a cardiac conditioning therapy to improve autonomic balance.

    摘要翻译： 起搏系统提供心脏保护起搏，以保护心脏免受伤害。 起搏系统接收一组输入，并计算用于提供针对不同应力水平定制的优化心脏保护起搏的参数。 系统自动调节心率以优化闭环系统中的心脏保护起搏。 在一个实施例中，提供了一种用于输送用于心脏保护的起搏脉冲的方法。 感测房室内（AV）间隔。 使用本征AV间隔和将AV间隔与最佳AV延迟相关联的预定方程用于在收缩期间提供左心室压力变化的最大正率。 使用预定百分比的最佳AV延迟来计算AV延迟以递送心室起搏脉冲以提供用于心脏保护起搏治疗（CPPT）的期望水平的应力以提供心脏调节疗法以改善自主神经平衡。

    HIGH-ENERGY ANTI-TACHYCARDIA THERAPY
    53.
    发明申请
    HIGH-ENERGY ANTI-TACHYCARDIA THERAPY 有权
    高能量抗惊厥药治疗

    公开(公告)号：US20090254135A1

    公开(公告)日：2009-10-08

    申请号：US12419074

    申请日：2009-04-06

    申请人： Allan Charles Shuros ,  Shantha Arcot-Krishnamurthy ,  Dan Li

    发明人： Allan Charles Shuros ,  Shantha Arcot-Krishnamurthy ,  Dan Li

    IPC分类号： A61N1/39 ,  A61N1/365

    CPC分类号： A61N1/3621 ,  A61N1/3906

    摘要： Embodiments of the invention are related to medical devices and methods for delivery high-energy anti-tachycardia therapy to a subject, amongst other things. In an embodiment, the invention includes a medical device including a controller module configured to administer a plurality of electrical pulses to a patient in response to a detected tachycardia, the electrical pulses comprising an amplitude of greater than 3 Volts and less than 40 Volts, the controller configured to modulate the amplitude of the electrical pulses. In an embodiment, the invention includes a method of treating a tachyarrhythmia including administering a first series of electrical pulses to a patient with an implantable medical device, the electrical pulses including an amplitude of greater than 8 Volts and less than 40 Volts, the first series of electrical pulses having an interval of less than about 600 ms in between individual pulses. Other embodiments are also included herein.

    摘要翻译： 本发明的实施例涉及用于向对象递送高能抗心动过速疗法的医疗装置和方法。 在一个实施例中，本发明包括医疗装置，其包括控制器模块，其被配置为响应于检测到的心动过速向患者施加多个电脉冲，所述电脉冲包括大于3伏且小于40伏的振幅， 控制器被配置为调制电脉冲的幅度。 在一个实施方案中，本发明包括治疗快速性心律失常的方法，包括用可植入医疗装置向患者施用第一系列电脉冲，所述电脉冲包括大于8伏且小于40伏特的振幅，第一系列 在各个脉冲之间具有小于约600ms的间隔的电脉冲。 本文还包括其它实施例。

    INTERMITTENT PACING THERAPY DELIVERY STATISTICS
    54.
    发明申请
    INTERMITTENT PACING THERAPY DELIVERY STATISTICS 有权
    间歇性治疗传播统计

    公开(公告)号：US20090234416A1

    公开(公告)日：2009-09-17

    申请号：US12401194

    申请日：2009-03-10

    申请人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

    发明人： John R. Zielinski ,  Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Jeffrey E. Stahmann ,  Allan C. Shuros

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61N1/3688

    摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode and stores a statistic related to the stress augmentation mode in a stress augmentation cycle memory area.

    摘要翻译： 本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。 起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。 与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。 当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替，并将与应力增加模式相关的统计量存储在应力增加周期存储区域中。

    Cardiac resynchronization therapy optimization using cardiac activation sequence information
    56.
    发明申请
    Cardiac resynchronization therapy optimization using cardiac activation sequence information 有权
    心脏再同步治疗优化使用心脏激活序列信息

    公开(公告)号：US20080119903A1

    公开(公告)日：2008-05-22

    申请号：US11601216

    申请日：2006-11-17

    申请人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  Jiang Ding ,  Yinghong Yu ,  Yanting Dong

    发明人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  Jiang Ding ,  Yinghong Yu ,  Yanting Dong

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61B5/04011 ,  A61B5/0452 ,  A61N1/365 ,  A61N1/36535 ,  A61N1/36542

    摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.

    摘要翻译： 系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。 调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。 响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。 可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

    Systems and methods for local vasoactive response using temperature modulation
    60.
    发明授权
    Systems and methods for local vasoactive response using temperature modulation 有权
    使用温度调制的局部血管活性反应的系统和方法

    公开(公告)号：US08828068B2

    公开(公告)日：2014-09-09

    申请号：US11779162

    申请日：2007-07-17

    申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Jihong Qu

    发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Jihong Qu

    IPC分类号： A61F7/12 ,  A61F7/00

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0071 ,  A61F2007/0075 ,  A61F2007/126

    摘要： Disclosed herein, among other things, is a device for providing a localized vasomodulation of a vessel. According to an embodiment, the device includes a thermal element configured to conduct thermal energy between the thermal element and a desired region of the vessel wall to elicit the localized vasomodulation of the vessel at the desired region. The device also includes a controller operationally connected to the thermal element. The controller is adapted to control the conduction of thermal energy between the thermal element and the desired region of the vessel wall to control the localized vasomodulation of the vessel at the desired region. In various embodiments, a sensor connected to the device provides feedback to the controller.

    摘要翻译： 这里公开了一种用于提供血管的局部血管调节的装置。 根据实施例，该装置包括热元件，其被配置为在热元件和容器壁的期望区域之间传导热能，以引起容器在期望区域的局部血管调节。 该装置还包括可操作地连接到热元件的控制器。 控制器适于控制热元件与血管壁的所需区域之间的热能传导，以控制血管在所需区域的局部血管调节。 在各种实施例中，连接到设备的传感器向控制器提供反馈。