公开(公告)号：US08738119B2

公开(公告)日：2014-05-27

申请号：US12576453

申请日：2009-10-09

申请人： Yi Zhang ,  Jeffrey E. Stahmann ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Julie A. Thompson ,  John D. Hatlestad ,  Kenneth C. Beck

发明人： Yi Zhang ,  Jeffrey E. Stahmann ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Julie A. Thompson ,  John D. Hatlestad ,  Kenneth C. Beck

IPC分类号： A61B5/02

CPC分类号： A61B5/02055 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/029 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/0816 ,  A61B5/085 ,  A61B5/1118 ,  A61B5/121 ,  A61B5/14542 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/7275 ,  A61B7/04 ,  A61N1/36585 ,  G06F19/00

摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

摘要翻译： 一种装置包括多个传感器和一个处理器。 每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。 处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化 状态根据第一和第二规则发生。

公开(公告)号：US20130079842A1

公开(公告)日：2013-03-28

申请号：US13626399

申请日：2012-09-25

申请人： Eric A. Mokelke ,  Yi Zhang ,  John D. Hatlestad ,  Kenneth C. Beck ,  Viktoria A. Averina ,  Jon Peterson ,  Kent Lee

发明人： Eric A. Mokelke ,  Yi Zhang ,  John D. Hatlestad ,  Kenneth C. Beck ,  Viktoria A. Averina ,  Jon Peterson ,  Kent Lee

IPC分类号： A61N1/36

CPC分类号： A61N1/3611 ,  A61N1/36053

摘要： An apparatus comprises a physiologic sensing circuit and a control circuit. The physiologic sensing circuit is configured to sense an electrical respiration signal representative of respiration of a subject. The control circuit includes a respiration monitor circuit and a therapy circuit. The respiration monitor circuit is configured to extract a respiration parameter from the respiration signal and detect that a value of the respiration parameter is outside of a target value range for the respiration parameter. The therapy circuit is configured to deliver neural stimulation to the carotid sinus of the subject to stimulate respiration and to adjust respiration to maintain the value of the respiration parameter within the target value range.

摘要翻译： 一种装置包括生理感测电路和控制电路。 生理感测电路被配置为感测代表受试者呼吸的电呼吸信号。 控制电路包括呼吸监测电路和治疗电路。 呼吸监视器电路被配置为从呼吸信号中提取呼吸参数，并且检测呼吸参数的值在呼吸参数的目标值范围之外。 治疗电路被配置为将神经刺激递送到受试者的颈动脉窦以刺激呼吸并调节呼吸以将呼吸参数的值保持在目标值范围内。

公开(公告)号：US20100030090A1

公开(公告)日：2010-02-04

申请号：US12508398

申请日：2009-07-23

申请人： YI ZHANG ,  Kenneth C. Beck ,  AARON LEWICKE ,  YUNLONG ZHANG

发明人： YI ZHANG ,  Kenneth C. Beck ,  AARON LEWICKE ,  YUNLONG ZHANG

IPC分类号： A61B5/02

CPC分类号： A61B5/0205 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/03 ,  A61B5/4519

摘要： Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.

摘要翻译： 本发明的各种方法实施例涉及感测指示生理消耗的患者 - 内部压力测量，基于患者内部的压力测量，感测心脏外的心脏反应数据和对应于心脏的心脏反应数据来识别生理消耗的一个或多个稳定状态时段 一个或多个生理活动稳态时段，分别将心外反应数据和心脏响应数据与心脏外反应信息和与一个或多个稳态周期的等效生理消耗强度的等效水平相关联的心脏反应信息进行比较， 以及基于心外反应数据与心外反应信息和对心脏反应信息的心脏反应数据的比较，确定在一个或多个稳态期间发生心肌缺血的可能性。

公开(公告)号：US20090099621A1

公开(公告)日：2009-04-16

申请号：US12249842

申请日：2008-10-10

申请人： Zheng Lin ,  Kenneth C. Beck ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu ,  Jeffrey E. Stahmann

发明人： Zheng Lin ,  Kenneth C. Beck ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu ,  Jeffrey E. Stahmann

IPC分类号： A61N1/36

CPC分类号： A61N1/3611 ,  A61B5/0816 ,  A61N1/3601

摘要： A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.

摘要翻译： 描述了治疗和/或预防的系统和方法，用于治疗以循环过度换气和通气不足为特征的周期性呼吸，其实例包括Cheyne-Stokes呼吸和中枢性睡眠呼吸暂停。 该系统也可用于治疗涉及呼吸驱动障碍的其他病症。

公开(公告)号：US08428711B2

公开(公告)日：2013-04-23

申请号：US12249842

申请日：2008-10-10

申请人： Zheng Lin ,  Kenneth C. Beck ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu ,  Jeffrey E. Stahmann

发明人： Zheng Lin ,  Kenneth C. Beck ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu ,  Jeffrey E. Stahmann

IPC分类号： A61N1/00

CPC分类号： A61N1/3611 ,  A61B5/0816 ,  A61N1/3601

摘要： A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.

摘要翻译： 描述了治疗和/或预防的系统和方法，用于治疗以循环过度换气和通气不足为特征的周期性呼吸，其实例包括Cheyne-Stokes呼吸和中枢性睡眠呼吸暂停。 该系统也可用于治疗涉及呼吸驱动障碍的其他病症。

公开(公告)号：US08065010B2

公开(公告)日：2011-11-22

申请号：US12319642

申请日：2009-01-08

申请人： Marina V. Brockway ,  Donald L. Hopper ,  Gerrard M. Carlson ,  Veerichetty Kadhiresan ,  Kenneth C. Beck

发明人： Marina V. Brockway ,  Donald L. Hopper ,  Gerrard M. Carlson ,  Veerichetty Kadhiresan ,  Kenneth C. Beck

IPC分类号： A61N1/36

CPC分类号： A61B5/087 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521

摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.

摘要翻译： 系统接收指示由多个传感器感测到的心肺疾病的信号，并且基于该信号提供对心肺病状态的监测和自动鉴别诊断。 基于由可植入传感器感测到的一个或多个信号来检测心源性肺水肿。 如果未检测到心源性肺水肿，则基于由可植入或非可行的肺动脉血流检测的呼吸信号测量的强制肺活量（FVC）参数和强制呼气量（FEV）参数，每个都检测到阻塞性肺疾病和限制性肺部疾病， 植入式传感器。 在一个实施例中，可植入医疗装置感测指示心肺病的信号，外部系统通过执行自动检测算法基于这些信号来检测心肺病。

公开(公告)号：US10596381B2

公开(公告)日：2020-03-24

申请号：US13325354

申请日：2011-12-14

申请人： Viktoria A. Averina ,  John D. Hatlestad ,  Abhilash Patangay ,  Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Kenneth C. Beck

发明人： Viktoria A. Averina ,  John D. Hatlestad ,  Abhilash Patangay ,  Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Kenneth C. Beck

IPC分类号： A61B5/11 ,  A61B5/053 ,  A61N1/365 ,  A61B5/0205 ,  A61B5/00 ,  A61B5/08 ,  A61B7/04

摘要： An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

公开(公告)号：US08914113B2

公开(公告)日：2014-12-16

申请号：US13412282

申请日：2012-03-05

申请人： Yi Zhang ,  Shantha Arcot-Krishnamurthy ,  Lili Liu ,  Kenneth C. Beck ,  Kent Lee ,  Jonathan Kwok ,  Zheng Lin

发明人： Yi Zhang ,  Shantha Arcot-Krishnamurthy ,  Lili Liu ,  Kenneth C. Beck ,  Kent Lee ,  Jonathan Kwok ,  Zheng Lin

IPC分类号： A61N1/365 ,  A61N1/36 ,  A61N1/05

CPC分类号： A61N1/3601 ,  A61N1/0558

摘要： An inspiratory muscle stimulation system uses an implantable medical device to deliver stimulation to control diaphragmatic contractions for slower and deeper breathing, thereby conditioning and strengthening inspiratory muscles. In various embodiments, respiratory and/or cardiac performance are monitored for controlling parameters of the stimulation.

摘要翻译： 吸气肌肉刺激系统使用可植入医疗装置来输送刺激以控制膈肌收缩以减慢和深呼吸，从而调节和加强吸气肌肉。 在各种实施例中，监测呼吸和/或心脏性能以控制刺激的参数。

公开(公告)号：US20120259183A1

公开(公告)日：2012-10-11

申请号：US13437318

申请日：2012-04-02

申请人： Pramodsingh Hirasingh Thakur ,  Abhilash Patangay ,  John D. Hatlestad ,  Kenneth C. Beck

发明人： Pramodsingh Hirasingh Thakur ,  Abhilash Patangay ,  John D. Hatlestad ,  Kenneth C. Beck

IPC分类号： A61B5/0205

CPC分类号： A61B5/0205 ,  A61B5/0031 ,  A61B5/02405 ,  A61B5/076 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/4836 ,  A61B5/4848 ,  A61B5/686 ,  A61B5/7246 ,  A61B5/7275 ,  A61B5/742 ,  A61B2560/0462 ,  A61B2562/0219 ,  A61N1/36535 ,  G06F19/34 ,  G16H20/40

摘要： Patient posture information can be received, such as to indicate a change in patient posture by at least a threshold amount. A transient response signal indicative of a change in a physiological parameter can be received at multiple instances near a change in patient posture. Waveform morphology features can be extracted from a transient response signal and used to provide an indication of a cardiac status, such as a heart failure status.

摘要翻译： 可以接收患者姿势信息，例如指示患者姿势的变化至少阈值量。 可以在患者姿势变化附近的多个实例处接收表示生理参数变化的瞬时响应信号。 可以从瞬态响应信号中提取波形形态特征，并用于提供心脏状态的指示，例如心力衰竭状态。

公开(公告)号：US20120157798A1

公开(公告)日：2012-06-21

申请号：US13325354

申请日：2011-12-14

申请人： Viktoria A. Averina ,  John D. Hatlestad ,  Abhilash Patangay ,  Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Kenneth C. Beck

发明人： Viktoria A. Averina ,  John D. Hatlestad ,  Abhilash Patangay ,  Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Kenneth C. Beck

IPC分类号： A61B5/11 ,  A61B5/08 ,  A61B5/053 ,  A61B5/00 ,  A61B5/0205

CPC分类号： A61N1/36542 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/6869 ,  A61B7/04

摘要： An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

摘要翻译： 植入式或其他动态医疗装置包括姿势感测电路，感测时变生理信号的生理感测电路和处理器电路。 处理器电路包括姿势计算电路和测量电路。 姿势计算电路使用姿势信号获得的姿势数据来确定对象的姿势，并且确定被摄体的姿势何时处于稳定状态。 测量电路使用在至少一个时间段内从生理信号中提取的生理数据进行生理测量，当姿势被确定为稳态时，并且将生理测量结果与所确定的稳定性相关联地向用户和过程中的至少一个提供生理测量 状态。