Osmotic devices and methods for diuretic therapy
    1.
    发明授权
    Osmotic devices and methods for diuretic therapy 失效
    渗透装置和利尿剂治疗方法

    公开(公告)号:US08475400B2

    公开(公告)日:2013-07-02

    申请号:US13346485

    申请日:2012-01-09

    Abstract: Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.

    Abstract translation: 本发明的实施方案涉及用于调节肾功能的装置和方法等。 在一个实施方案中,本发明包括调节患者的肾功能的方法,包括在患者体内植入闭塞装置,所述闭塞装置包括半渗透膜,并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩 不渗透膜。 本文提供了其它方面和实施例。

    Temperature based systems and methods for tachycardia discrimination and therapy
    2.
    发明授权
    Temperature based systems and methods for tachycardia discrimination and therapy 有权
    用于心动过速鉴别和治疗的基于温度的系统和方法

    公开(公告)号:US08255052B2

    公开(公告)日:2012-08-28

    申请号:US12411157

    申请日:2009-03-25

    CPC classification number: A61N1/3622 A61N1/3962

    Abstract: Embodiments of the invention are related to an implantable medical system, amongst other things. In an embodiment, the invention includes a processor, an electrical sensor, and a temperature sensor. The processor is configured to monitor myocardial electrical activity with input from the electrical sensor; identify myocardial electrical activity indicative of an arrhythmia, measure temperature of blood in the coronary venous system with input from the temperature sensor; determine if the arrhythmia is hemodynamically stable or hemodynamically unstable based on the temperature of blood in the coronary venous system, and initiate high-voltage shock therapy if the arrhythmia is hemodynamically unstable. Other embodiments are also included herein.

    Abstract translation: 本发明的实施例涉及可植入医疗系统等。 在一个实施例中,本发明包括处理器,电传感器和温度传感器。 处理器被配置为通过来自电传感器的输入来监测心肌电活动; 识别指示心律失常的心肌电活动,用来自温度传感器的输入测量冠状静脉系统中血液的温度; 根据冠状静脉系统中的血液温度,确定心律失常是否为血液动力学稳定或血液动力学不稳定,如果心律失常是血液动力学不稳定的话,开始进行高压休克治疗。 本文还包括其它实施例。

    Method and apparatus to perform transvascular hemodynamic sensing
    4.
    发明申请
    Method and apparatus to perform transvascular hemodynamic sensing 审中-公开
    进行血管内血流动力学检测的方法和装置

    公开(公告)号:US20090088651A1

    公开(公告)日:2009-04-02

    申请号:US11904946

    申请日:2007-09-28

    CPC classification number: A61B5/0215 A61B5/02028 A61B5/418 A61N1/36514

    Abstract: An implantable transvascular pressure sensing device may include at least one deflection sensor configured to output a deflection signal indicative of vascular wall deflections. A implantable transvascular pressure sensing device may further include an implantable sensor support member attached to the deflection sensor, the sensor support member configured to facilitate contact between the deflection sensor and a first vessel wall at a portion of a first vessel proximate a second vessel, wherein the portion of the first vessel wall is adjacent to the second vessel such that wall deflections of the second vessel deflect the portion of the first vessel wall. A method of measuring a parameter of a vessel can include generating a deflection signal from a sensor within a vein, the deflection signal indicative of venous wall deflections of the vein, and determining a parameter value associated with a vessel contacting the vein using the deflection signal.

    Abstract translation: 可植入的经血管压力感测装置可以包括被配置为输出指示血管壁偏转的偏转信号的至少一个偏转传感器。 可植入的经血管压力感测装置还可以包括附接到偏转传感器的可植入传感器支撑构件,所述传感器支撑构件构造成促进偏转传感器与靠近第二容器的第一容器的部分处的第一血管壁之间的接触,其中 第一容器壁的部分与第二容器相邻,使得第二容器的壁偏转使第一容器壁的部分偏转。 测量血管参数的方法可以包括从静脉内的传感器产生偏转信号,所述偏转信号指示静脉的静脉壁偏转,以及使用偏转信号确定与接触静脉的血管相关联的参数值 。

    High-energy anti-tachycardia therapy
    6.
    发明授权
    High-energy anti-tachycardia therapy 有权
    高能抗心动过速治疗

    公开(公告)号:US08412325B2

    公开(公告)日:2013-04-02

    申请号:US12419074

    申请日:2009-04-06

    CPC classification number: A61N1/3621 A61N1/3906

    Abstract: Embodiments of the invention are related to medical devices and methods for delivery high-energy anti-tachycardia therapy to a subject, amongst other things. In an embodiment, the invention includes a medical device including a controller module configured to administer a plurality of electrical pulses to a patient in response to a detected tachycardia, the electrical pulses comprising an amplitude of greater than 3 Volts and less than 40 Volts, the controller configured to modulate the amplitude of the electrical pulses. In an embodiment, the invention includes a method of treating a tachyarrhythmia including administering a first series of electrical pulses to a patient with an implantable medical device, the electrical pulses including an amplitude of greater than 8 Volts and less than 40 Volts, the first series of electrical pulses having an interval of less than about 600 ms in between individual pulses. Other embodiments are also included herein.

    Abstract translation: 本发明的实施例涉及用于向对象递送高能抗心动过速疗法的医疗装置和方法。 在一个实施例中,本发明包括医疗装置,其包括控制器模块,其被配置为响应于检测到的心动过速向患者施加多个电脉冲,所述电脉冲包括大于3伏且小于40伏的振幅, 控制器被配置为调制电脉冲的幅度。 在一个实施方案中,本发明包括治疗快速性心律失常的方法,包括用可植入医疗装置向患者施用第一系列电脉冲,所述电脉冲包括大于8伏且小于40伏特的振幅,第一系列 在各个脉冲之间具有小于约600ms的间隔的电脉冲。 本文还包括其它实施例。

    Rate adaptive cardiac pacing systems and methods
    8.
    发明授权
    Rate adaptive cardiac pacing systems and methods 有权
    评估自适应心脏起搏系统和方法

    公开(公告)号:US08738133B2

    公开(公告)日:2014-05-27

    申请号:US13730362

    申请日:2012-12-28

    CPC classification number: A61N1/36585 G06F19/00 G06F19/3418 G06F19/3481

    Abstract: The invention relates to cardiac rhythm management systems, and more particularly, to rate adaptive cardiac pacing systems and methods. In an embodiment, the invention includes a cardiac rhythm management device. The device can include a pulse generator for generating electrical pulses to be delivered to a heart at a pacing rate, a processor in communication with the pulse generator, and one or more sensors for sensing pulmonary function and cardiac function. The processor can be configured to increase the pacing rate if the pulmonary function is increasing with time and the cardiac function is not decreasing with time, maintain the pacing rate if the pulmonary function is increasing with time and the cardiac function is decreasing with time, and decrease the pacing rate if the respiratory function is decreasing with time.

    Abstract translation: 本发明涉及心律管理系统,更具体地说,涉及适应性心脏起搏系统和方法的速率。 在一个实施例中,本发明包括心律管理装置。 该装置可以包括脉冲发生器,用于产生要以起搏速率递送到心脏的电脉冲,与脉冲发生器通信的处理器以及用于感测肺功能和心脏功能的一个或多个传感器。 如果肺功能随时间增加,心脏功能不随时间减少,则可以配置处理器以增加起搏速率,如果肺功能随时间增加而保持起搏速率,并且心脏功能随时间减少,以及 如果呼吸功能随时间的推移,降低起搏率。

    Osmotic devices and methods for diuretic therapy
    9.
    发明授权
    Osmotic devices and methods for diuretic therapy 有权
    渗透装置和利尿剂治疗方法

    公开(公告)号:US08105261B2

    公开(公告)日:2012-01-31

    申请号:US11772397

    申请日:2007-07-02

    Abstract: Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes an implantable occlusive device including a wall member defining an enclosed volume, the wall member can include a semi-permeable membrane. The device can also include a solution comprising a solvent and a solute disposed within the enclosed volume of the wall member. The semi-permeable membrane can be permeable to the solvent and impermeable to the solute. The enclosed volume can be configured to expand and contract in response to changes in the osmolality of a bodily fluid. The device can include a positioning member configured to maintain the position of the implantable occlusive device relative to a lengthwise axis of a lymphatic vessel. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.

    Abstract translation: 本发明的实施方案涉及用于调节肾功能的装置和方法等。 在一个实施例中,本发明包括可植入闭塞装置,其包括限定封闭容积的壁构件,所述壁构件可包括半透膜。 该装置还可以包括溶液和溶质,该溶质设置在壁构件的封闭体积内。 半透膜对溶剂是可渗透的,并且对溶质是不可渗透的。 封闭体积可以配置为响应于体液渗透压的变化而膨胀和收缩。 该装置可以包括定位构件,其被配置为相对于淋巴管的纵向轴线保持可植入闭塞装置的位置。 在一个实施方案中,本发明包括调节患者的肾功能的方法,包括在患者体内植入闭塞装置,所述闭塞装置包括半渗透膜,并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩 不渗透膜。 本文提供了其它方面和实施例。

    Temperature Based Systems and Methods for Tachycardia Discrimination and Therapy
    10.
    发明申请
    Temperature Based Systems and Methods for Tachycardia Discrimination and Therapy 有权
    基于温度的系统和方法用于心动过速鉴别和治疗

    公开(公告)号:US20090254137A1

    公开(公告)日:2009-10-08

    申请号:US12411157

    申请日:2009-03-25

    CPC classification number: A61N1/3622 A61N1/3962

    Abstract: Embodiments of the invention are related to an implantable medical system, amongst other things. In an embodiment, the invention includes a processor, an electrical sensor, and a temperature sensor. The processor is configured to monitor myocardial electrical activity with input from the electrical sensor; identify myocardial electrical activity indicative of an arrhythmia, measure temperature of blood in the coronary venous system with input from the temperature sensor; determine if the arrhythmia is hemodynamically stable or hemodynamically unstable based on the temperature of blood in the coronary venous system, and initiate high-voltage shock therapy if the arrhythmia is hemodynamically unstable. Other embodiments are also included herein.

    Abstract translation: 本发明的实施例涉及可植入医疗系统等。 在一个实施例中,本发明包括处理器,电传感器和温度传感器。 处理器被配置为通过来自电传感器的输入来监测心肌电活动; 识别指示心律失常的心肌电活动,用来自温度传感器的输入测量冠状静脉系统中血液的温度; 根据冠状静脉系统中的血液温度,确定心律失常是否为血液动力学稳定或血液动力学不稳定,如果心律失常是血液动力学不稳定的话,开始进行高压休克治疗。 本文还包括其它实施例。

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