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86 条记录 (耗时 0.03 秒)

    N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters
    54.
    发明授权
    N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters 失效
    N-烷基1,4-二羟基吡啶二羧酸酯

    公开(公告)号：US5234935A

    公开(公告)日：1993-08-10

    申请号：US680454

    申请日：1991-04-04

    申请人： Otto Behner ,  Hartmut Wollweber ,  Bruno Rosen ,  Siegfried Zaiss ,  Siegfried Goldmann

    发明人： Otto Behner ,  Hartmut Wollweber ,  Bruno Rosen ,  Siegfried Zaiss ,  Siegfried Goldmann

    IPC分类号： A61K31/445 ,  A61K31/44 ,  A61K31/451 ,  A61P9/08 ,  A61P9/10 ,  C07D211/90

    CPC分类号： C07D211/90

    摘要： Improving circulation, with minimal effect on blood pressure, using N-alkylated 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 represents hydrogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, halogen or methyl,R.sup.2 represents hydrogen, halogen, nitro, hydroxyl, trifluoromethyl or methyl,R.sup.3 represents hydrogen or cyano, orR.sup.2 and R.sup.3 together form a fused benzo ring,R.sup.4 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by alkoxy having up to 4 carbon atoms, andR.sup.6 represents straight-chain or branched alkyl having up to 10 carbon atoms or represents cycloalkyl having 3 to 7 carbon atoms.Many of the compounds are new.

    摘要翻译： 使用其中R 1表示氢，硝基，氰基，三氟甲基，三氟甲氧基，卤素或甲基的式（I）的N-烷基化1,4-二氢吡啶，改善循环，对血压影响最小，R 2表示氢， 卤素，硝基，羟基，三氟甲基或甲基，R 3表示氢或氰基，或R 2和R 3一起形成稠合的苯并环，R 4和R 5相同或不同，表示具有至多8个碳原子的直链或支链烷基， 任选被具有至多4个碳原子的烷氧基取代，R6代表具有至多10个碳原子的直链或支链烷基或代表具有3至7个碳原子的环烷基。 许多化合物是新的。

    3-Nitro-5-amide-1,4-dihydropyridines with positive inotropic activity
    58.
    发明授权
    3-Nitro-5-amide-1,4-dihydropyridines with positive inotropic activity 失效
    具有正性肌力活性的3-硝基-5-酰胺-1,4-二氢吡啶

    公开(公告)号：US4540684A

    公开(公告)日：1985-09-10

    申请号：US612093

    申请日：1984-05-18

    申请人： Jurgen Stoltefuss ,  Gerhard Franckowiak ,  Horst Boshagen ,  Siegfried Goldmann ,  Matthias Schramm ,  Gunter Thomas ,  Rainer Gross

    发明人： Jurgen Stoltefuss ,  Gerhard Franckowiak ,  Horst Boshagen ,  Siegfried Goldmann ,  Matthias Schramm ,  Gunter Thomas ,  Rainer Gross

    IPC分类号： A61K31/455 ,  A61P3/08 ,  A61P9/02 ,  A61P9/04 ,  C07D211/90 ,  C07D211/98 ,  A61K31/70 ,  C07D405/12

    CPC分类号： C07D211/90

    摘要： A 1,4-dihydropyridine derivative of the formula ##STR1## in which R and R.sub.1 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 to C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, trifluoromethyl, ##STR2## X is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, trifluoromethyl, amino or nitro, andR.sub.2 and R.sub.3 each independently is hydrogen, a C.sub.1 -C.sub.10 -alkyl, C.sub.2 -C.sub.10 -alkenyl or C.sub.3 -C.sub.10 -alkinyl radical which is optionally substituted by halogen, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, mono- and di-C.sub.1 -C.sub.4 -alkylamino, carbo-C.sub.1 -C.sub.6 -alkoxy and/or nitro, a C.sub.3 to C.sub.6 -membered cycloalkyl radical, a phenyl radical which is optionally substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, amino and/or nitro, or a phenyl-C.sub.1 -C.sub.3 -alkyl radical, or a carbohydrate radical which is optionally bonded via a C.sub.1 -C.sub.8 -alkyl chain to the amide nitrogen atomor a pharmaceutically acceptable acid addition salt thereof, which improves the contractility of the heart, raises the blood pressure, lowers the blood sugar, reduces the swelling of mucous membranes and affects the salt and fluid balances of a patient.

    摘要翻译： 其中R和R 1各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 12 - 烷氧基，C 1 -C 4卤代烷氧基，卤素，硝基，三氟甲基， X是氧或硫，R4和R5各自独立地是氢，C1-C4-烷基，C1-C6-烷氧基，卤素，三氟甲基，氨基或硝基，R2和R3各自独立地是氢，C1-C10 - 烷基，C 2 -C 10 - 烯基或C 3 -C 10 - 炔基，其任选被卤素，羟基，C 1 -C 4 - 烷氧基，氨基，单 - 和二-C 1 -C 4 - 烷基氨基，C 1 -C 6 - 和/或硝基，C3至C6元环烷基，任选被C 1 -C 4 - 烷基，C 1 -C 6 - 烷氧基，卤素，氨基和/或硝基取代的苯基，或苯基-C 1 -C 3 - 烷基或通过C1-C8烷基链任选与酰胺氮原子键合的碳水化合物基团或其药学上可接受的酸加成盐，其改善心脏的收缩力，使血压升高 ure，降低血糖，减少粘膜肿胀，影响患者的盐和液体平衡。

    Bromo-phenyl substituted thiazolyl dihydropyrimidines
    59.
    发明授权
    Bromo-phenyl substituted thiazolyl dihydropyrimidines 有权
    溴 - 苯基取代的噻唑基二氢嘧啶

    公开(公告)号：US08236797B2

    公开(公告)日：2012-08-07

    申请号：US12664392

    申请日：2008-06-18

    申请人： Siegfried Goldmann ,  Jing Li ,  Yi Song Liu

    发明人： Siegfried Goldmann ,  Jing Li ,  Yi Song Liu

    IPC分类号： A61K31/535 ,  C07D413/14

    CPC分类号： C07D417/04 ,  C07D417/14

    摘要： This invention relates to a bromo-phenyl substituted thiazolyl dihydropyrimidine, its preparation method and use as a medicament for treating and preventing hepatitis B infections. The invention also relates to a composition comprising the dihydropyrimidine, one or more antiviral agents and, optionally, an immunomodulator for treating and preventing HBV infections.

    摘要翻译： 本发明涉及溴 - 苯基取代的噻唑基二氢嘧啶，其制备方法和用作治疗和预防乙型肝炎感染的药物。 本发明还涉及包含二氢嘧啶，一种或多种抗病毒剂和任选的用于治疗和预防HBV感染的免疫调节剂的组合物。