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79 条记录 (耗时 0.084 秒)

    Methods of inducing immunosuppression by administering 7C10 and 16C10 CD80-specific antibodies
    53.
    发明授权
    Methods of inducing immunosuppression by administering 7C10 and 16C10 CD80-specific antibodies 失效
    通过施用7C10和16C10 CD80特异性抗体诱导免疫抑制的方法

    公开(公告)号：US07510713B2

    公开(公告)日：2009-03-31

    申请号：US11840597

    申请日：2007-08-17

    申请人： Darrell R. Anderson ,  Nabil Hanna ,  Peter Brams

    发明人： Darrell R. Anderson ,  Nabil Hanna ,  Peter Brams

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2827 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.

    摘要翻译： 本发明涉及对人B7.1抗原（CD80）特异性并且能够抑制B7.1与CD28受体的结合并且不能抑制B7.1结合的抗体的鉴定 到CTLA-4受体。 尽管存在第二活化配体B7.2（CD86），但是这些抗体16C10和7C10中的两个显着抑制了IL-2的产生。 阻断CD28和B7.1（CD80）之间的主要激活信号与这些抗体同时允许CTLA-4和B7.1和/或B7.2的未受损或一致的相互作用代表对阳性共刺激的组合拮抗作用， 对负信号的激动作用。 这些抗体可以用作特异性免疫抑制剂，例如用于治疗自身免疫性疾病和预防器官移植排斥。

    Identification of Unique Binding Interactions Between Certain Antibodies and the Human B7.1 and B7.2 Co-Stimulatory Antigens
    57.
    发明申请
    Identification of Unique Binding Interactions Between Certain Antibodies and the Human B7.1 and B7.2 Co-Stimulatory Antigens 有权
    鉴定某些抗体与人B7.1和B7.2共刺激抗原之间的独特结合相互作用

    公开(公告)号：US20060275291A1

    公开(公告)日：2006-12-07

    申请号：US11464133

    申请日：2006-08-11

    申请人： Darrell Anderson ,  Nabil Hanna ,  Peter Brams

    发明人： Darrell Anderson ,  Nabil Hanna ,  Peter Brams

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2827 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.

    摘要翻译： 本发明涉及对人B7.1抗原（CD80）特异性并且能够抑制B7.1与CD28受体的结合并且不能抑制B7.1结合的抗体的鉴定 到CTLA-4受体。 尽管存在第二活化配体B7.2（CD86），但是这些抗体16C10和7C10中的两个显着抑制了IL-2的产生。 阻断CD28和B7.1（CD80）之间的主要激活信号与这些抗体同时允许CTLA-4和B7.1和/或B7.2的未受损或一致的相互作用代表对阳性共刺激的组合拮抗作用， 对负信号的激动作用。 这些抗体可以用作特异性免疫抑制剂，例如用于治疗自身免疫性疾病和预防器官移植排斥。

    Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof
    59.
    发明授权
    Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof 失效
    中和RSV F蛋白特异性的高亲和力人单克隆抗体及其制备方法及其治疗用途

    公开(公告)号：US06537809B2

    公开(公告)日：2003-03-25

    申请号：US09740002

    申请日：2000-12-20

    申请人： Peter Brams ,  Phillip R. Morrow

    发明人： Peter Brams ,  Phillip R. Morrow

    IPC分类号： C12N506

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/92 ,  C12N2760/18522 ,  C12N2799/028

    摘要： A highly efficient method for generating human antibodies in particular which are specific to be RSV fusion protein which combines in vitro primary of human spleen cells and antigen boosting in SCID mice is taught. This method provides for very high human antibody titers which are predominantly of the IgG isotype which contain antibodies of high specificity and affinity to desired antigens. This method is well suited for generating human monoclonal antibodies for therapeutic and diagnostic applications as well as for rescue of human cells for generation of combinational human antibody gene libraries. Two human monoclonal antibodies, RF-1 and RF-2 which each possess an affinity for RSV F-protein ≦2×10−9 Molar are taught as well as their corresponding amino acid and DNA sequences. These antibodies are to be used therapeutically and prophylactically for treating or preventing RSV infection, as well as for diagnosis of RSV in analytes.

    摘要翻译： 教导了特异性产生特异性的人抗体的高效方法，其特征在于将体外原代人脾细胞和SCID小鼠中的抗原增强相结合的RSV融合蛋白。 该方法提供非常高的人抗体滴度，其主要是IgG同种型，其含有对所需抗原具有高特异性和亲和力的抗体。 该方法非常适用于产生用于治疗和诊断应用的人单克隆抗体以及用于拯救人细胞以产生组合人抗体基因文库。 教导了两种人类单克隆抗体RF-1和RF-2，它们各自具有对RSV F蛋白的亲和力<= 2x10-9摩尔，以及它们相应的氨基酸和DNA序列。 这些抗体应用于治疗和预防性用于治疗或预防RSV感染以及分析物中RSV的诊断。