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84 条记录 (耗时 0.117 秒)

    Human MutT2
    51.
    发明授权
    Human MutT2 失效
    人类MutT2

    公开(公告)号：US06344547B1

    公开(公告)日：2002-02-05

    申请号：US09432253

    申请日：1999-11-02

    申请人： Ying-Fei Wei ,  Ewen F. Kirkness

    发明人： Ying-Fei Wei ,  Ewen F. Kirkness

    IPC分类号： C07H1900

    CPC分类号： C12N9/16 ,  A61K38/00 ,  Y10S530/809

    摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.

    摘要翻译： 公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。 还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。

    Human DNA topoisomerase I &agr;
    52.
    发明授权
    Human DNA topoisomerase I &agr; 有权
    人类DNA拓扑异构酶Iα

    公开(公告)号：US06255077B1

    公开(公告)日：2001-07-03

    申请号：US09325430

    申请日：1999-06-04

    申请人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    发明人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    IPC分类号： C12N1563

    CPC分类号： C12N9/90 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12Y599/01002

    摘要： Disclosed is a human is a hTopI-&agr; polypeptide and DNA (RNA) encoding such hTopI-&agr; polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-&agr; for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的如抗肿瘤剂的作用以检测自身免疫性疾病或逆转录病毒感染并治疗结肠腺癌的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Human DNA topoisomerase I alpha
    55.
    发明申请
    Human DNA topoisomerase I alpha 审中-公开

    公开(公告)号：US20060234342A1

    公开(公告)日：2006-10-19

    申请号：US10602043

    申请日：2003-06-24

    申请人： Ying-Fei Wei ,  Mark Adams ,  Robert Fleischmann

    发明人： Ying-Fei Wei ,  Mark Adams ,  Robert Fleischmann

    IPC分类号： C07K16/18 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C12N5/06

    CPC分类号： C12N9/90 ,  A61K38/00

    摘要： Disclosed is a human is a hTopI-α polypeptide and DNA (RNA) encoding such hTopI-α polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-α for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    Antibodies to chemokine alpha-6
    58.
    发明申请
    Antibodies to chemokine alpha-6 失效
    趋化因子α-6的抗体

    公开(公告)号：US20050208591A1

    公开(公告)日：2005-09-22

    申请号：US11081021

    申请日：2005-03-16

    申请人： Ying-Fei Wei ,  Steven Ruben ,  Craig Rosen

    发明人： Ying-Fei Wei ,  Steven Ruben ,  Craig Rosen

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C07K16/24 ,  C12N5/06 ,  C12N15/12 ,  C12N15/19 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543

    CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K14/522

    摘要： The present invention relates to a novel CKα-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6 protein. CKα-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CKα-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.

    摘要翻译： 本发明涉及作为α趋化因子家族成员的新型CKalpha-6蛋白。 特别地，提供编码人CKalpha-6蛋白的分离的核酸分子。 还提供了CKalpha-6多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和免疫系统相关疾病的治疗方法。

    Human MutT2 antibodies
    59.
    发明授权
    Human MutT2 antibodies 失效
    人类MutT2抗体

    公开(公告)号：US06552174B2

    公开(公告)日：2003-04-22

    申请号：US09974800

    申请日：2001-10-12

    申请人： Ying-Fei Wei ,  Ewen F. Kirkness

    发明人： Ying-Fei Wei ,  Ewen F. Kirkness

    IPC分类号： C07K1640

    CPC分类号： C12N9/16 ,  A61K38/00 ,  Y10S530/809

    摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.

    摘要翻译： 公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。 还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。

    Human deoxycytidine kinase 2
    60.
    发明授权
    Human deoxycytidine kinase 2 失效
    人脱氧胞苷激酶2

    公开(公告)号：US06063376A

    公开(公告)日：2000-05-16

    申请号：US860995

    申请日：1997-10-16

    申请人： Ying-Fei Wei ,  Ewen F. Kirkness

    发明人： Ying-Fei Wei ,  Ewen F. Kirkness

    IPC分类号： A61K38/00 ,  A61P31/18 ,  A61P37/02 ,  C12N9/12 ,  A61K38/45

    CPC分类号： C12N9/1205 ,  A61K38/00

    摘要： A human deoxycytidine kinase 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of malignancies and viral infections. Antagonist against such polypeptides and their use as a therapeutic to treat immunodeficiency disorders are also disclosed. Diagnostic assays for detecting diseases related to mutations in the hdCK2 nucleic acid sequence and the concentration of the polypeptide encoded by such nucleic acid sequence is also disclosed.

    摘要翻译： PCT No.PCT / US95 / 00532 Sec。 371日期：1997年10月16日 102（e）日期1997年10月16日PCT提交1995年1月13日PCT公布。 出版物WO96 / 21724 日期1996年7月18日公开了一种编码这种多肽的人脱氧胞苷激酶2多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽治疗恶性肿瘤和病毒感染的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗性免疫缺陷病症治疗剂的用途。 还公开了用于检测与hdCK2核酸序列中的突变有关的疾病的诊断测定和由该核酸序列编码的多肽的浓度。