Use of isoindolinone derivatives as stabilizers for organic materials
    53.
    发明授权
    Use of isoindolinone derivatives as stabilizers for organic materials 失效
    异吲哚啉酮衍生物作为有机材料的稳定剂的使用

    公开(公告)号:US06210657B1

    公开(公告)日:2001-04-03

    申请号:US09207624

    申请日:1998-12-09

    IPC分类号: A61K742

    摘要: Isoindolinone derivatives of the formula I, in which the variables have the following meanings: R1 is hydrogen, COOR4, COR4, CONR4R5, CN, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, aryl or heteroaryl, substituted or unsubstituted; R1 and R2 together are C7-C10-bicycloalkyl or C7-C10-bicycloalkenyl; R3 is hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl, C1-C12-alkoxy, C1-C20-alkoxycarbonyl, C1-C12-alkylamino, C1-C12-dialkylamino, aryl or heteroaryl, substituted or unsubstituted, substituents which confer solubility in water, selected from the group consisting of carboxylate, sulfonate or ammonium radicals; R4 and R5 independently of one another are hydrogen, C1-C20-alkyl, C2-C10-alkenyl, C3-C10-cycloalkyl, C3-C10-cycloalkenyl; aryl or heteroaryl, substituted or unsubstituted; are used as stabilizers for organic materials.

    摘要翻译: 式I的异吲哚啉酮衍生物,其中变量具有以下含义:R1是氢,COOR4,COR4,CONR4R5,CN,C1-C20-烷基,C2-C10-烯基,C3-C10-环烷基,C3-C10- 环烯基,芳基或杂芳基,取代或未取代的; R1和R2一起是C7-C10-双环烷基或C7-C10-双环烯基; R3是氢,C1-C20-烷基,C2-C10-烯基,C3-C10-环烷基,C3 -C 10 - 环烯基,C 1 -C 12 - 烷氧基,C 1 -C 20 - 烷氧基羰基,C 1 -C 12 - 烷基氨基,C 1 -C 12 - 二烷基氨基,芳基或杂芳基,取代或未取代的赋予水溶性的取代基, 羧酸酯,磺酸酯或铵基; R 4和R 5彼此独立地是氢,C 1 -C 20 - 烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基,C 3 -C 10 - 环烯基; 芳基或杂芳基,取代或未取代的;被用作有机材料的稳定剂。

    Cosmetic and pharmaceutical preparations comprising photostable UV
filters
    54.
    发明授权
    Cosmetic and pharmaceutical preparations comprising photostable UV filters 失效
    包含光稳定型紫外线过滤器的化妆品和药物制剂

    公开(公告)号:US6090374A

    公开(公告)日:2000-07-18

    申请号:US172672

    申请日:1998-10-15

    摘要: The use of substituted .alpha.-methylstyrene derivatives of the formula I, ##STR1## where the variables have the following meanings: R.sup.1 C.sub.4 -C.sub.10 -alkoxy, C.sub.1 -C.sub.12 -alkylamino, C.sub.1 -C.sub.12 -dialkylamino, substituents which confer solubility in water and which are selected from the group consisting of carboxylate, sulfonate or ammonium residues;R.sup.2 hydrogen, C.sub.2 -C.sub.10 -alkyl, C.sub.1 -C.sub.12 -alkoxy;R.sup.3 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN;R.sup.4 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN; where the substituents R.sup.3 and R.sup.4 are identical in each case;R.sup.5 andR.sup.6 independently of one another hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.10 -alkenyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.3 -C.sub.10 -cycloalkenyl, aryl, hetaryl, unsubstituted or substituted;as photostable UV filters in cosmetic and pharmaceutical preparations to protect the human skin or human hair from the sun's rays, alone or together with UV-absorbing compounds known per se for cosmetic and pharmaceutical preparations.

    摘要翻译: 使用式I的取代的α-甲基苯乙烯衍生物,其中变量具有以下含义:R 1 C 4 -C 10 - 烷氧基,C 1 -C 12 - 烷基氨基,C 1 -C 12 - 二烷基氨基,赋予在水中溶解度并且被选择的取代基 由羧酸盐,磺酸盐或铵残基组成的组; R2氢,C2-C10-烷基,C1-C12-烷氧基; R3 COOR5,COR5,CONR5R6,CN; R4 COOR5,COR5,CONR5R6,CN; 其中取代基R 3和R 4在每种情况下相同; R 5和R 6彼此独立地为氢,C 1 -C 12 - 烷基,C 2 -C 10 - 烯基,C 3 -C 10 - 环烷基,C 3 -C 10 - 环烯基,芳基,杂芳基,未取代或取代的; 作为化妆品和药物制剂中的光稳定紫外线过滤器,用于保护人体皮肤或人体毛发免受太阳光线的照射,或者与本身已知的用于化妆品和药物制剂的紫外线吸收化合物一起使用。

    Dermocosmetic Preparations
    60.
    发明申请
    Dermocosmetic Preparations 审中-公开
    皮肤科药物制剂

    公开(公告)号:US20080220031A1

    公开(公告)日:2008-09-11

    申请号:US11996424

    申请日:2006-07-14

    摘要: The present invention relates to dermocosmetic compositions comprising a compound comprising the structural element of the formula I where the radical Z has the following meaning: H, C1-C22alkyl group, C6-C10-aryl group, C1-C22-alkoxy group or a C6-C10-O-aryl group substituted by a C1-C22-alkyl or C-C22-alkoxy group,and the radicals R1 to R6, independently of one another, have the following meaning: H, C1-C22-alkyl group, C6-C10-aryl group, O, OH, C1-C22-alkoxy group or a C6-C10-O-aryl group substituted by a C1-C22-alkyl or C1-C22-alkoxy group,it being possible for R5 and R6 to be bridged in such a way that a five- to eight-membered ring is formed and, in the case of a five-membered ring, this ring may be part of an oligomer as a result of covalent bonds at positions 3 and 4.The invention furthermore relates to the use of said compounds in dermocosmetic formulations and the use of the dermocosmetics according to the invention for reducing skin or hair damage caused by free radicals. The invention furthermore relates to the use of the compounds according to the invention for increasing the stability of dermocosmetic formulations.

    摘要翻译: 本发明涉及皮肤科药物组合物,其包含包含式I结构元素的化合物,其中基团Z具有以下含义:H,C 1 -C 22烷基 C 6 -C 10 - 芳基,C 1 -C 22 - 烷氧基或C 1 -C 12 - 被C 1 -C 22 -C 22 - 烷基取代的芳基或CC 22个 - 烷氧基,基团R 1至R 6彼此独立地具有如下含义:H,C 1 C 22 - - - 烷基,C 6 -C 10 - 芳基,O,OH,C 1 -C 22 - 烷氧基或被C 1 -C 6烷基取代的C 6 -C 10 -C 10 -O-芳基, C 1 -C 22烷基或C 1 -C 22 - 烷氧基,可以是R 5 和R 6以桥接形式形成五至八元环,并且在五元环的情况下, 由于位置3和4的共价键,s环可以是低聚物的一部分。本发明还涉及所述化合物在皮肤科药物制剂中的用途以及根据本发明的皮肤用品用于减少皮肤或毛发损伤的用途 由自由基。 本发明还涉及根据本发明的化合物用于增加皮肤科药物制剂的稳定性的用途。