公开(公告)号：US20220057328A1

公开(公告)日：2022-02-24

申请号：US17516490

申请日：2021-11-01

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  UNIVERSITY HEALTH NETWORK

Inventor： Keith D. Paulsen ,  David W. Roberts ,  Dennis Wirth ,  Brian C. Wilson ,  Mira Sibai

IPC: G01N21/64 ,  G01B11/22 ,  G01N21/47 ,  G01N33/483

Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

公开(公告)号：US10993677B2

公开(公告)日：2021-05-04

申请号：US16806749

申请日：2020-03-02

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Ryan J. Halter ,  Keith D. Paulsen ,  Alexander Hartov

IPC: G06K9/00 ,  A61B5/00 ,  A61B6/00 ,  A61B5/055 ,  G06T7/00 ,  A61B5/024 ,  A61B5/1455 ,  A61B5/0205 ,  A61B5/0536 ,  A61B6/03 ,  A61B5/0245 ,  A61B5/026

Abstract: A method for cardiovascular-dynamics correlated imaging includes receiving a time series of images of at least a portion of a patient, receiving a time series of cardiovascular data for the patient, evaluating correlation between the time series of images and the time series of cardiovascular data, and determining a property of the at least a portion of a patient, based upon the correlation. A system for cardiovascular-dynamics correlated imaging includes a processing device having: a processor, a memory communicatively coupled therewith, and a correlation module including machine-readable instructions stored in the memory that, when executed by the processor, perform the function of correlating a time series of images of at least a portion of a patient with a time series of cardiovascular data of the patient to determine a property of the at least a portion of a patient.

公开(公告)号：US10631936B2

公开(公告)日：2020-04-28

申请号：US15735907

申请日：2016-06-10

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Venkataramanan Krishnaswamy ,  Richard J. Barth, Jr. ,  Keith D. Paulsen

IPC: G06K9/00 ,  A61B34/20 ,  A61B17/34 ,  A61B17/00

Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.

公开(公告)号：US20200069187A1

公开(公告)日：2020-03-05

申请号：US16673165

申请日：2019-11-04

Applicant: The Trustees of Dartmouth College

Inventor： Stephen Chad Kanick ,  Brian William Pogue ,  Keith D. Paulsen ,  Jonathan T. Elliott ,  David M. McClatchy, III ,  Venkataramanan Krishnaswamy

IPC: A61B5/00

Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

公开(公告)号：US10568535B2

公开(公告)日：2020-02-25

申请号：US15367243

申请日：2016-12-02

Applicant: The Trustees of Dartmouth College

Inventor： David W. Roberts ,  Keith D. Paulsen ,  Alexander Hartov ,  Songbai Ji ,  Xiaoyao Fan

IPC: G06T3/00 ,  H04N13/257 ,  H04N13/239 ,  A61B34/10 ,  A61B5/0484 ,  A61B5/00 ,  G06T7/33 ,  A61B90/00 ,  A61B5/0476 ,  A61B5/055

Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.

公开(公告)号：US09786048B2

公开(公告)日：2017-10-10

申请号：US14766660

申请日：2014-02-07

Applicant: The Trustees of Dartmouth College

Inventor： Paul M. Meaney ,  Neil Epstein ,  Keith D. Paulsen

IPC: G06K9/00 ,  G06T7/00 ,  A61K49/00 ,  A61B5/05 ,  A61B5/00 ,  A61K49/18 ,  G06T1/00

CPC classification number: G06T7/0012 ,  A61B5/0507 ,  A61B5/4312 ,  A61K49/00 ,  A61K49/1818 ,  G06T1/0007 ,  G06T2200/28 ,  G06T2207/10096 ,  G06T2207/30068 ,  G06T2210/41

Abstract: A system and method of imaging tissue includes administering a contrast agent having charged gold nanoparticles in suspension into a vessel of the subject, such that the nanoparticles are carried into the tissue; and performing microwave imaging of the tissue after administering the contrast agent. In embodiments, the nanoparticles have a tissue-selective protein tag. In embodiments, images are taken prior to administering the contrast agent, and further images may be taken during an agent—washout period after imaging with contrast agent. The contrast agent is injectable, with the nanoparticles suspended as a colloid in a biocompatible, isotonic, carrier. In particular embodiments, the nanoparticles have median diameter of less than fifty nanometers, or less than five nanometers, and may have a tissue-selective protein tag. A microwave imaging system has injection apparatus with the gold-nanoparticle agent, and is configured to take, and difference, pre and post contrast images as well as washout images.

公开(公告)号：US09456200B2

公开(公告)日：2016-09-27

申请号：US14370713

申请日：2013-01-04

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Songbai Ji ,  Xiaoyao Fan ,  Keith D. Paulsen ,  David W. Roberts ,  Alex Hartov

IPC: G06K9/00 ,  H04N13/02 ,  G01C11/02 ,  G01C25/00 ,  G06T3/00 ,  H04N13/00

CPC classification number: H04N13/246 ,  G01C11/02 ,  G01C25/00 ,  G06T3/0093 ,  G06T2200/04 ,  H04N2013/0074

Abstract: A system for, and method of, extracting a surface profile from a stereo pair of images obtained at an arbitrary setting S of an optical system, includes determining surface profile reconstruction parameters for images obtained with the optical system at a reference setting So of the optical system; determining warping parameters for a digital image processor for warping images obtained with the optical system at the arbitrary setting S into images corresponding to the reference setting So; obtaining the stereo pair of images from at least one camera of the optical system; warping the stereo pair of images into images corresponding to the reference setting So, and using the surface profile reconstruction parameters to determine the surface profile. In a particular embodiment, the surface profile is passed to a computer model of tissue deformation and used to determine an intra-surgery location of a tumor or other anatomic feature of tissue.

Abstract translation: 从在光学系统的任意设置S获得的立体图像对中提取表面轮廓的系统和方法包括：在光学系统的参考设置So处确定用光学系统获得的图像的表面轮廓重建参数 系统; 确定用于使用任意设置S处的光学系统获得的图像的数字图像处理器的翘曲参数变为与参考设置So对应的图像; 从所述光学系统的至少一个相机获得立体声图像对; 将立体声对的图像变形成与参考设置So对应的图像，并且使用表面轮廓重建参数来确定表面轮廓。 在特定实施例中，将表面轮廓传递到组织变形的计算机模型，并用于确定肿瘤的手术内部位置或组织的其他解剖特征。

公开(公告)号：US20140362186A1

公开(公告)日：2014-12-11

申请号：US14370713

申请日：2013-01-04

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Songbai Ji ,  Xiaoyao Fan ,  Keith D. Paulsen ,  David W. Roberts ,  Alex Hartov

IPC: H04N13/02 ,  G06T3/00

CPC classification number: H04N13/246 ,  G01C11/02 ,  G01C25/00 ,  G06T3/0093 ,  G06T2200/04 ,  H04N2013/0074

Abstract: A system for, and method of, extracting a surface profile from a stereo pair of images obtained at an arbitrary setting S of an optical system, includes determining surface profile reconstruction parameters for images obtained with the optical system at a reference setting So of the optical system; determining warping parameters for a digital image processor for warping images obtained with the optical system at the arbitrary setting S into images corresponding to the reference setting So; obtaining the stereo pair of images from at least one camera of the optical system; warping the stereo pair of images into images corresponding to the reference setting So, and using the surface profile reconstruction parameters to determine the surface profile. In a particular embodiment, the surface profile is passed to a computer model of tissue deformation and used to determine an intra-surgery location of a tumor or other anatomic feature of tissue.

Abstract translation: 从在光学系统的任意设置S获得的立体图像对中提取表面轮廓的系统和方法包括：在光学系统的参考设置So处确定用光学系统获得的图像的表面轮廓重建参数 系统; 确定用于使用任意设置S处的光学系统获得的图像的数字图像处理器的翘曲参数变为与参考设置So对应的图像; 从所述光学系统的至少一个相机获得立体声图像对; 将立体声对的图像变形成与参考设置So对应的图像，并且使用表面轮廓重建参数来确定表面轮廓。 在特定实施例中，将表面轮廓传递到组织变形的计算机模型，并用于确定肿瘤的手术内部位置或组织的其他解剖特征。