公开(公告)号：US06974259B2

公开(公告)日：2005-12-13

申请号：US10362337

申请日：2001-08-30

申请人： Keisuke Nomura ,  Masahiro Inoue ,  Koji Shima ,  Yoshifumi Shige ,  Setsuji Suzuki ,  Makoto Okada ,  Seiji Hojo ,  Koichi Aida

发明人： Keisuke Nomura ,  Masahiro Inoue ,  Koji Shima ,  Yoshifumi Shige ,  Setsuji Suzuki ,  Makoto Okada ,  Seiji Hojo ,  Koichi Aida

IPC分类号： B60B35/14 ,  B60B27/00 ,  F16B4/00 ,  F16C19/18 ,  F16C35/063 ,  F16D1/06 ,  F16D1/112 ,  F16D3/20

CPC分类号： F16D1/06 ,  B60B27/00 ,  B60B27/0084 ,  F16C19/186 ,  F16C35/0635 ,  F16C2326/02 ,  F16D2001/103

摘要： A vehicle-use bearing device having a double row rolling bearing fitted around an outer peripheral surface of a hollow shaft portion of a hub wheel, wherein a held portion between an axially intermediate position and a vehicle outer side in the hollow shaft portion of the hub wheel is axially held between the axially intermediate position of an outer ring shaft portion of a constant velocity joint and the vehicle outer side so that a cup-shaped cylindrical portion of an outer ring of the constant velocity joint is free of contact with a caulked portion in the hollow shaft portion of the hub wheel at the shaft end on the vehicle inner side in order to connect the hub wheel with the constant velocity joint without a clearance, whereby an excessive preload which can affect a rolling performance of the double row rolling bearing is not imparted on the bearing.

摘要翻译： 一种车轮用轴承装置，其具有安装在轮毂轮的中空轴部的外周面上的双列滚动轴承，其中，在所述轮毂的中空轴部的轴向中间位置与车辆外侧之间的保持部 轮轴被保持在等速万向节的外环轴部分的轴向中间位置与车辆外侧之间，使得等速万向节的外圈的杯形圆柱形部分与铆接部分不接触 在车轮内侧的轴端的轮毂轮的中空轴部中，为了将轮毂轮与等速万向节无间隙地连接，由此能够影响双列滚动轴承的滚动性能的过大的预载 没有赋予轴承。

公开(公告)号：US5595986A

公开(公告)日：1997-01-21

申请号：US510342

申请日：1995-08-02

申请人： Makoto Okada ,  Masaki Takahashi ,  Kaoru Hosoi ,  Shokichi Nakajima

发明人： Makoto Okada ,  Masaki Takahashi ,  Kaoru Hosoi ,  Shokichi Nakajima

IPC分类号： C07D501/56 ,  A61K9/08 ,  A61K9/19 ,  A61K31/545 ,  A61K31/546 ,  A61K47/18 ,  A61P31/04

CPC分类号： A61K31/545 ,  A61K47/183 ,  A61K9/0019 ,  A61K9/19

摘要： A stably storable and readily water soluble composition for use in preparing injections and containing Cefditoren, namely a cephalosporin of the formula ##STR1## is now provided, which composition comprises a physical mixture of Cefditoren or a non-toxic salt thereof with a proportion of arginine and/or lysine and/or a non-toxic salt thereof. This new composition of Cefditoren can be stored for long periods of time without discoloration and without undesirable reduction in the antibacterial activity, and the composition can be dissolved completely and quickly in water.

摘要翻译： 现在提供一种用于制备注射剂并含有头孢托仑的稳定易溶的易溶于水的组合物，即式“IMAGE”的头孢菌素，该组合物包含头孢托伦或其无毒盐与精氨酸的比例的物理混合物 和/或赖氨酸和/或其无毒盐。 这种新的头孢托仑组合物可以长时间储存​​，不会变色，并且不会降低抗菌活性，组合物可以完全溶解并快速地溶于水。

公开(公告)号：USPP7924P

公开(公告)日：1992-07-28

申请号：US483857

申请日：1990-02-23

申请人： Makoto Okada ,  Satomi Saito

发明人： Makoto Okada ,  Satomi Saito

摘要： A cherry tree rootstock characterized by wide and strong root anchorage, easy vegetative propagation, a thicker shoot and a harder root than the known variety "Colt", a more compact tree shape and darker green leaves than the Colt variety, and a hexaploid (2n=48) chromosome structure as compared to the triploid (2n=24) chromosome structure in the Colt variety.

公开(公告)号：US08524940B2

公开(公告)日：2013-09-03

申请号：US13312150

申请日：2011-12-06

申请人： Teruhiko Ishikawa ,  Seiki Saito ,  Takayuki Kudoh ,  Kotaro Suto ,  Hironori Nishiuchi ,  Makoto Okada ,  Masatoshi Taniguchi

发明人： Teruhiko Ishikawa ,  Seiki Saito ,  Takayuki Kudoh ,  Kotaro Suto ,  Hironori Nishiuchi ,  Makoto Okada ,  Masatoshi Taniguchi

IPC分类号： C07C205/05 ,  C07C69/003 ,  C07C61/22

CPC分类号： C07D317/30 ,  C07C205/50 ,  C07C205/55 ,  C07C2601/16 ,  C07D317/32 ,  C07D493/04

摘要： It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4c): (wherein R1, R2 and R6 are same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously).

摘要翻译： 通过使用式（4c）的二羟基己烯酸酯作为原料酒石酸，甘露糖醇或阿拉伯糖，可大量安全稳定地生产奥司他韦：（其中R1，R2和R6各自相同或不同） 烷基，芳基，取代的芳基，芳烷基，取代的芳烷基或芳族杂环基，R1和R2不同时为甲基）。

公开(公告)号：US20130085127A1

公开(公告)日：2013-04-04

申请号：US13699892

申请日：2011-05-23

申请人： Makoto Okada ,  Koichi Hasumi ,  Takahiro Nishimoto ,  Miwa Yoshida ,  Kouki Ishitani ,  Tomoji Aotsuka ,  Hashime Kanazawa

发明人： Makoto Okada ,  Koichi Hasumi ,  Takahiro Nishimoto ,  Miwa Yoshida ,  Kouki Ishitani ,  Tomoji Aotsuka ,  Hashime Kanazawa

IPC分类号： C07D405/06 ,  C07D401/06 ,  C07D211/46

CPC分类号： C07D405/06 ,  C07D211/46 ,  C07D213/79 ,  C07D333/40 ,  C07D401/06 ,  C07D407/08 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： A heterocyclic compound useful as an antiallergic agent is provided.A compound represented by the following formula (1) or a salt thereof: wherein the ring A is a homocyclic or heterocyclic ring; the ring B is a heterocyclic ring which contains G and nitrogen atom N as constituent atoms thereof, wherein G is CH or N; R1 is a carbonyl group or an alkylene group; R2a and R2b are an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; X is an oxygen atom or a sulfur atom; Z is a hydroxyl group, an alkoxy group, a cycloalkyloxy group, an aryloxy group, an aralkyloxy group, an amino group, or an N-substituted amino group; and n is 0 or 1; with the proviso that when the ring A is a benzene ring or when the ring B is a piperazine ring, R1 is an alkylene group which may have a substituent.

摘要翻译： 提供了可用作抗过敏剂的杂环化合物。 由下式（1）表示的化合物或其盐：其中环A是稠环或杂环; 环B是含有G和氮原子N作为其构成原子的杂环，其中G是CH或N; R1是羰基或亚烷基; R2a和R2b是烷基，环烷基，芳基或杂环基; X是氧原子或硫原子; Z是羟基，烷氧基，环烷氧基，芳氧基，芳烷氧基，氨基或N-取代氨基; 并且n为0或1; 条件是当环A为苯环时，或当环B为哌嗪环时，R 1为可具有取代基的亚烷基。

公开(公告)号：US08293754B2

公开(公告)日：2012-10-23

申请号：US11922233

申请日：2006-06-13

申请人： Kotaro Gotanda ,  Atsushi Shinbo ,  Youichi Nakano ,  Hideo Kobayashi ,  Makoto Okada ,  Akira Asagarasu

发明人： Kotaro Gotanda ,  Atsushi Shinbo ,  Youichi Nakano ,  Hideo Kobayashi ,  Makoto Okada ,  Akira Asagarasu

IPC分类号： C07D495/04 ,  A61K31/519 ,  A61P25/28

CPC分类号： C07D495/04

摘要： This invention provides thienopyrimidine derivatives of the formula, wherein R1 stands for hydrogen atom, an alkyl group or the like; R2 stands for a hydrogen atom, an alkyl or amino group or the like, R3 stands for an alkyl, alkenyl or alkylthio group or the like or a group Y—X—; or R2 and R3 may together form tetramethylene group; X standing for a direct bond or linking group such as CH2, CH(OH), S, O, NH; Y standing for a substituted or unsubstituted aromatic carbocycylic, aromatic heterocylic, cycloalkyl or saturated heterocyclic group or the like; Z stands for S or O, and n is 0 or an integer of 1 to 4, or salts thereof, which exhibit an inhibitory effect on PDE9, and are therefore useful for prevention or treatment of overactive bladder syndrome, pollakiuria, urinary incontinence, dysuria associated with prostatic hyperplasia, urolithiasis, Alzheimer's disease, chronic obstructive pulmonary disease, myocardial infarction, thrombosis, diabetes and the like.

摘要翻译： 本发明提供下式的噻吩并嘧啶衍生物，其中R1代表氢原子，烷基等; R2表示氢原子，烷基或氨基等，R3表示烷基，烯基或烷硫基等或Y-X-基团; 或者R 2和R 3可以一起形成四亚甲基; X代表直接键或连接基团如CH 2，CH（OH），S，O，NH; Y表示取代或未取代的芳族碳环，芳香杂环，环烷基或饱和杂环基等; Z代表S或O，n为0或1〜4的整数，或其盐，对PDE9具有抑制作用，因此可用于预防或治疗膀胱过度活动症，尿频尿失禁，排尿困难 与前列腺增生，尿石症，阿尔茨海默病，慢性阻塞性肺疾病，心肌梗塞，血栓形成，糖尿病等相关。

公开(公告)号：US20120130092A1

公开(公告)日：2012-05-24

申请号：US13312150

申请日：2011-12-06

申请人： Teruhiko Ishikawa ,  Seiki Saito ,  Takayuki Kudoh ,  Kotaro Suto ,  Hironori Nishiuchi ,  Makoto Okada ,  Masatoshi Taniguchi

发明人： Teruhiko Ishikawa ,  Seiki Saito ,  Takayuki Kudoh ,  Kotaro Suto ,  Hironori Nishiuchi ,  Makoto Okada ,  Masatoshi Taniguchi

IPC分类号： C07D493/04 ,  C07C205/50 ,  C07D407/04 ,  C07D317/30 ,  C07D317/32 ,  C07C205/55 ,  C07C201/12

CPC分类号： C07D317/30 ,  C07C205/50 ,  C07C205/55 ,  C07C2601/16 ,  C07D317/32 ,  C07D493/04

摘要： It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4c). (wherein R1, R2 and R6 are same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously)

摘要翻译： 通过使用式（4c）的二羟基己酸酯作为原料酒石酸，甘露糖醇或阿拉伯糖，可以大量安全稳定地生产奥司他韦。 （其中R 1，R 2和R 6相同或不同，各自为烷基，芳基，取代的芳基，芳烷基，取代的芳烷基或芳族杂环基，并且R 1和R 2不同时为甲基）

公开(公告)号：US08101624B2

公开(公告)日：2012-01-24

申请号：US12310025

申请日：2007-07-24

申请人： Akira Asagarasu ,  Shuichiro Sato ,  Makoto Okada

发明人： Akira Asagarasu ,  Shuichiro Sato ,  Makoto Okada

IPC分类号： A61K31/517 ,  C07D401/06 ,  C07D239/88

CPC分类号： C07D239/91 ,  C07D401/06 ,  C07D409/06

摘要： The invention discloses quinazoline derivatives or salts thereof, which possess PDE9-inhibiting activity and are useful as treating agents of dysuria and the like, the derivatives being represented by the formula (I) in the formula, R1 stands for phenyl or aromatic heterocyclic group which are optionally substituted with 1-3 substituents selected from halogen, C1-6 alkyl, C1-6 haloalkyl containing 1-6 halogen atoms and C1-6 alkoxy; and n is an integer of 1-3.

摘要翻译： 本发明公开了具有PDE9抑制活性的喹唑啉衍生物或其盐，可用作排尿困难等的治疗剂，该衍生物由式中的式（I）表示，R 1表示苯基或芳族杂环基， 任选被1-3个选自卤素，C 1-6烷基，含有1-6个卤原子的C 1-6卤代烷基和C 1-6烷氧基取代的取代基取代; n为1-3的整数。

公开(公告)号：US07941794B2

公开(公告)日：2011-05-10

申请号：US11212598

申请日：2005-08-29

申请人： Makoto Ozone ,  Hiroshi Nakajima ,  Tatsuo Hiramatsu ,  Katsunori Hirase ,  Makoto Okada

发明人： Makoto Ozone ,  Hiroshi Nakajima ,  Tatsuo Hiramatsu ,  Katsunori Hirase ,  Makoto Okada

IPC分类号： G06F9/45 ,  G06F15/00

CPC分类号： G06F8/433

摘要： A data flow graph processing method divides a program describing target operations into two or more subprograms and converts each of the two or more subprograms into a data flow graph (DFG) representing dependency in execution between operations carried out in sequence. Also generated is flow data indicating the order of execution of DFGs corresponding to respective subprograms. DFGs are converted into configuration data and the flow data is converted into control data.

摘要翻译： 数据流图处理方法将描述目标操作的程序划分为两个或更多个子程序，并将两个或多个子程序中的每一个子程序转换为表示在顺序执行的操作之间的执行中依赖性的数据流图（DFG）。 还产生指示对应于各个子程序的DFG的执行顺序的流量数据。 DFG被转换成配置数据，流数据被转换成控制数据。

公开(公告)号：US07852893B2

公开(公告)日：2010-12-14

申请号：US12035959

申请日：2008-02-22

申请人： Akira Tanaka ,  Makoto Okada ,  Takayuki Matsuyama

发明人： Akira Tanaka ,  Makoto Okada ,  Takayuki Matsuyama

IPC分类号： H01S5/00

CPC分类号： H01S5/22 ,  G11B7/127 ,  H01S5/0014 ,  H01S5/0021 ,  H01S5/028 ,  H01S5/0282 ,  H01S5/0287 ,  H01S5/1039 ,  H01S5/2009 ,  H01S5/32341

摘要： A semiconductor laser device includes: a substrate of a first conductivity type; a laminated body of a nitride semiconductor provided on the substrate and including at least an active layer and a cladding layer, the cladding layer being of a second conductivity type and having a ridge-shaped waveguide; a first film provided on one end surface of an optical resonator composed of the laminated body, the first film having a reflectance of 40% or more and 60% or less; and a second film provided on the other end surface of the optical resonator and having a higher reflectance than the first film. The optical resonator has a length of 400 μm or less. The one end surface serves as a light emitting surface.

摘要翻译： 半导体激光器件包括：第一导电类型的衬底; 设置在所述基板上并且至少包括有源层和包层的氮化物半导体层叠体，所述包层为第二导电型并具有脊形波导; 设置在由所述层叠体构成的光谐振器的一个端面的第一膜，所述第一膜的反射率为40％以上且60％以下; 以及设置在所述光谐振器的另一端面上并且具有比所述第一膜高的反射率的第二膜。 光谐振器的长度为400μm以下。 一端面用作发光面。