公开(公告)号：US20050209215A1

公开(公告)日：2005-09-22

申请号：US10510008

申请日：2002-04-11

申请人： Shin Ikeda ,  Yasuhiro Takahashi

发明人： Shin Ikeda ,  Yasuhiro Takahashi

IPC分类号： A61K31/55 ,  C07D223/18 ,  C07D223/20 ,  C07D403/06

CPC分类号： C07D403/06 ,  C07D223/20

摘要： A production method of 6-aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepin characterized in that said compound is produced via N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide which is prepared by reducing 2-(11H-dibenz[b,e]azepin-6-ylmethyl)-1H-isoindole-1,3(2H)-dione employing a metal hydride or a metal hydride complex in a water based alcohol, and N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-o-hydroxymethylbenzamide which is useful for the aforesaid production method.

摘要翻译： 6-氨基甲基-6,11-二氢-5H-二苯并[b，e]氮杂的制备方法，其特征在于所述化合物是通过N - [（6,11-二氢-5H-二苯并[b，e]氮杂 -6-基）甲基] - 羟基甲基苯甲酰胺，其是使用金属氢化物还原2-（11H-二苯并[b，e]氮杂-6-基甲基）-1H-异吲哚-1,3（2H） 或水基醇中的金属氢化物络合物和可用于上述制备方法的N - [（6,11-二氢-5H-二苯并[b，e]氮杂-6-基）甲基] - 羟基甲基苯甲酰胺 。

公开(公告)号：US08540864B2

公开(公告)日：2013-09-24

申请号：US12829077

申请日：2010-07-01

申请人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

IPC分类号： G01N27/327

CPC分类号： G01N27/3274 ,  C12Q1/001 ,  C12Q1/006 ,  G01N33/66 ,  G01N33/728

摘要： The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The sensor for measuring a component in blood has a first analysis portion and a second analysis portion. The first analysis portion has a first electrode system (11,12) and a reagent layer (14), and the reagent layer (14) has an oxidoreductase that acts on the component and a mediator. In the first analysis portion, the component in the blood is measured by causing a redox reaction of the component with the oxidoreductase in the presence of the mediator and detecting a redox current caused when a voltage is applied by the first electrode (11,12). The second analysis portion has a working electrode and a counter electrode, and a mediator is provided on the counter electrode but not on the working electrode. In the second analysis portion, a Hct value of the blood is measured by supplying the blood to the electrode system, applying a voltage to cause a current to flow, and detecting a value of the current. Using this Hct value, the amount of the component is corrected.

摘要翻译： 本发明提供了一种测量血液中的成分的方法，通过以高精度和高可靠性测量血液的血细胞比容（Hct）值，能够精确地校正成分的量，并且还提供了该方法中使用的传感器 。 用于测量血液中成分的传感器具有第一分析部分和第二分析部分。 第一分析部分具有第一电极系统（11,12）和试剂层（14），并且试剂层（14）具有作用于组分的氧化还原酶和介体。 在第一分析部分中，通过在介体存在下引起组分与氧化还原酶的氧化还原反应并检测当通过第一电极（11,12）施加电压时引起的氧化还原电流来测量血液中的组分， 。 第二分析部分具有工作电极和对电极，并且在对电极上而不是在工作电极上设置介体。 在第二分析部分中，通过将血液供给到电极系统，施加电压以使电流流动并检测电流的值来测量血液的Hct值。 使用此Hct值，校正组件的数量。

公开(公告)号：US20120152763A1

公开(公告)日：2012-06-21

申请号：US13392630

申请日：2010-08-30

申请人： Yoshifumi Takahara ,  Takahiro Nakaminami ,  Shin Ikeda

发明人： Yoshifumi Takahara ,  Takahiro Nakaminami ,  Shin Ikeda

IPC分类号： C12Q1/26 ,  C12Q1/54 ,  C12Q1/32

CPC分类号： G01N27/3272 ,  C12Q1/006 ,  C12Q1/32 ,  G01N21/8483

摘要： A reagent layer (4) of a sensor (1) contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor 1.

摘要翻译： 传感器（1）的试剂层（4）作为介体含有具有亲水性官能团的醌化合物，菲醌和/或菲醌衍生物。 醌化合物的氧化还原电位低于常规介体，因此干扰物质对该传感器1的检测结果影响较小。

公开(公告)号：US07785271B2

公开(公告)日：2010-08-31

申请号：US10952702

申请日：2004-09-28

申请人： Masaki Fujiwara ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Shin Ikeda

IPC分类号： A61B5/00

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150572 ,  A61B5/150969 ,  A61B2562/0295 ,  C12Q1/005 ,  C12Q1/006 ,  G01N27/3272

摘要： A sensor for blood component analysis, which allows even a trace amount of blood to be led to an analysis portion reliably. The sensor for blood component analysis includes a substrate, a spacer, and a cover. The cover is disposed on the substrate with the spacer intervening between the cover and the substrate, whereby a space that serves as an analysis portion and a channel for leading blood to the analysis portion is formed inside the sensor. Through holes are formed in the substrate and the spacer, respectively, so that a common through hole through which a needle of a lancet can pass is formed when the spacer is disposed on the substrate. The through hole of the spacer communicates with the channel and a top of the through hole of the spacer is covered with the cover, whereby a lancing portion is formed by the common through hole and a portion of the cover covering the top of the through hole of the spacer. In use, the sensor is placed at a position where blood collection is to be performed, the portion of the cover covering the lancing portion is broken through with the needle of the lancet so that the needle is allowed to pass through the common through hole to puncture the position, and blood that has come out is guided by a downwardly protruding burr formed when the cover is broken through so that the blood is led to the channel and flows through the channel to be led to the analysis portion.

摘要翻译： 用于血液成分分析的传感器，其甚至允许将微量的血液可靠地引导到分析部分。 用于血液成分分析的传感器包括基底，间隔物和盖。 盖子设置在基板上，间隔物插入在盖和基板之间，由此在传感器的内部形成用作分析部分的空间和用于使血液引导到分析部分的通道。 在衬底和间隔件中分别形成通孔，使得当间隔件设置在基板上时，形成有刺血针的针穿过的公共通孔。 间隔件的通孔与通道连通，并且间隔件的通孔的顶部被盖覆盖，由此通过公共通孔形成起毛部分，并且覆盖通孔顶部的盖的一部分 的间隔物。 在使用中，将传感器置于要进行血液收集的位置，覆盖穿刺部分的盖部分用刺血针的针断开，使得针被允许穿过公共通孔 穿刺位置，并且当盖被破坏时形成的向下突出的毛刺引导出来的血液，使得血液被引导到通道并流过通道以被引导到分析部分。

公开(公告)号：US20070062822A1

公开(公告)日：2007-03-22

申请号：US10578988

申请日：2004-12-03

申请人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

IPC分类号： G01F1/64 ,  G01N33/487

CPC分类号： G01N27/3274

摘要： The present invention provides a method of electrochemically measuring a hematocrit (Hct) value using a sensor, capable of achieving excellent measurement accuracy and reliability and also provides a sensor used in the method. The method of electrochemically measuring a hematocrit (Hct) value of blood include: providing an electrode system having a working electrode (11) and a counter electrode (12), in which a redox substance is provided on the counter electrode (12) but not on the working electrode (11); supplying blood to the electrode system; applying a voltage to the electrode system in this state to cause an oxidation current or a reduction current to flow between the working electrode (11) and the counter electrode (12); detecting the oxidation current or the reduction current; and determining a Hct value based on a value of the detected current.

摘要翻译： 本发明提供一种使用传感器电化学测量血细胞比容（Hct）值的方法，其能够实现优异的测量精度和可靠性，并且还提供了该方法中使用的传感器。 电化学测量血液血细胞比容（Hct）值的方法包括：提供具有工作电极（11）和对电极（12）的电极系统，其中在对电极（12）上设置氧化还原物质 在工作电极（11）上; 向电极系统供应血液; 在该状态下向电极系统施加电压，使得氧化电流或还原电流在工作电极（11）和对电极（12）之间流动。 检测氧化电流或还原电流; 以及基于检测到的电流的值确定Hct值。

公开(公告)号：US07022218B2

公开(公告)日：2006-04-04

申请号：US10333232

申请日：2002-05-27

申请人： Yuko Taniike ,  Shin Ikeda ,  Toshihiko Yoshioka

发明人： Yuko Taniike ,  Shin Ikeda ,  Toshihiko Yoshioka

IPC分类号： G01N27/327 ,  G01N27/26

CPC分类号： C12Q1/001 ,  C12Q1/006 ,  C12Q1/26 ,  G01N27/3272

摘要： The present invention provides a highly sensitive biosensor capable of yielding good response even when the amount of a sample is extremely small. The biosensor of the present invention includes: a first insulating base plate which has a working electrode comprising a plurality of branches and a first counter electrode comprising a plurality of branches, the branches of the working electrode and the first counter electrode being arranged alternately; a second insulating base plate which has a second counter electrode and which is disposed at a position opposite to the first insulating base plate; a reagent system comprising an oxidoreductase; and a sample supply pathway formed between the first and second insulating base plates, wherein the branches of the working electrode and the first counter electrode that are arranged alternately, the second counter electrode, and the reagent system are exposed in the sample supply pathway.

摘要翻译： 本发明提供了一种高灵敏度的生物传感器，即使当样品量非常小时也能够产生良好的响应。 本发明的生物传感器包括：第一绝缘基板，其具有包括多个分支的工作电极和包括多个分支的第一对电极，所述工作电极和所述第一对置电极的分支交替布置; 第二绝缘基板，其具有第二对置电极，并且设置在与所述第一绝缘基板相对的位置; 包含氧化还原酶的试剂系统; 以及形成在第一绝缘基板和第二绝缘基板之间的样品供给路径，其中交替布置的工作电极和第一对电极的分支，第二对电极和试剂系统暴露在样品供应路径中。

公开(公告)号：US20050224345A1

公开(公告)日：2005-10-13

申请号：US10616305

申请日：2003-07-10

申请人： Yuko Taniike ,  Mariko Miyashita ,  Shin Ikeda ,  Toshihiko Yoshioka ,  Yoshinobu Tokuno

发明人： Yuko Taniike ,  Mariko Miyashita ,  Shin Ikeda ,  Toshihiko Yoshioka ,  Yoshinobu Tokuno

IPC分类号： A61B5/00 ,  G01N27/30 ,  G01N33/487 ,  G01N27/26

CPC分类号： G01N33/4875 ,  A61B5/1486 ,  A61B2562/0295

摘要： In biosensor system 1, biosensor 2 is mounted in measuring apparatus 3 for quantifying or detecting existence of a targeted substrate in a sample solution. Mounting end portion 20 of biosensor 2 to be mounted in measuring apparatus 3 has an extension of one base plate in the length direction, and further extensions of the other base plate in the width direction. Sensor mounting portion 30 of measuring apparatus 3 has a shape matching up with the shape of mounting end portion 20. Thereby wrong insertion of biosensor 2 in measuring apparatus 3 can be prevented. Further, varying shapes of plural biosensors 5 and 6 to have a common part and a non-common part, such biosensors can be handily measured by one measuring apparatus 7.

摘要翻译： 在生物传感器系统1中，将生物传感器2安装在用于定量或检测样品溶液中目标基板的存在的测量装置3中。 安装在测量装置3中的生物传感器2的安装端部20在长度方向上具有一个基板的延伸部，另一个底板在宽度方向上延伸。 测量装置3的传感器安装部30具有与安装端部20的形状相匹配的形状。从而可以防止生物传感器2错误地插入到测量装置3中。 此外，多个生物传感器5和6的不同形状具有公共部分和非共同部分，可以通过一个测量装置7轻松测量这样的生物传感器。

公开(公告)号：US20050123443A1

公开(公告)日：2005-06-09

申请号：US10952702

申请日：2004-09-28

申请人： Masaki Fujiwara ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Shin Ikeda

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157 ,  C12Q1/00 ,  G01N31/22

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150572 ,  A61B5/150969 ,  A61B2562/0295 ,  C12Q1/005 ,  C12Q1/006 ,  G01N27/3272

摘要： A sensor for blood component analysis, which allows even a trace amount of blood to be led to an analysis portion reliably. The sensor for blood component analysis includes a substrate, a spacer, and a cover. The cover is disposed on the substrate with the spacer intervening between the cover and the substrate, whereby a space that serves as an analysis portion and a channel for leading blood to the analysis portion is formed inside the sensor. Through holes are formed in the substrate and the spacer, respectively, so that a common through hole through which a needle of a lancet can pass is formed when the spacer is disposed on the substrate. The through hole of the spacer communicates with the channel and a top of the through hole of the spacer is covered with the cover, whereby a lancing portion is formed by the common through hole and a portion of the cover covering the top of the through hole of the spacer. In use, the sensor is placed at a position where blood collection is to be performed, the portion of the cover covering the lancing portion is broken through with the needle of the lancet so that the needle is allowed to pass through the common through hole to puncture the position, and blood that has come out is guided by a downwardly protruding burr formed when the cover is broken through so that the blood is led to the channel and flows through the channel to be led to the analysis portion.

摘要翻译： 用于血液成分分析的传感器，其甚至允许将微量的血液可靠地引导到分析部分。 用于血液成分分析的传感器包括基底，间隔物和盖。 盖子设置在基板上，间隔物插入在盖和基板之间，由此在传感器的内部形成用作分析部分的空间和用于使血液引导到分析部分的通道。 在衬底和间隔件中分别形成通孔，使得当间隔件设置在基板上时，形成有刺血针的针穿过的公共通孔。 间隔件的通孔与通道连通，并且间隔件的通孔的顶部被盖覆盖，由此通过公共通孔形成起毛部分，并且覆盖通孔顶部的盖的一部分 的间隔物。 在使用中，将传感器置于要进行血液收集的位置，覆盖穿刺部分的盖部分用刺血针的针断开，使得针被允许穿过公共通孔 穿刺位置，并且当盖被破坏时形成的向下突出的毛刺引导出来的血液，使得血液被引导到通道并流过通道以被引导到分析部分。

公开(公告)号：US4729643A

公开(公告)日：1988-03-08

申请号：US821445

申请日：1986-01-22

申请人： Isao Kawaguchi ,  Masakuni Tai ,  Shin Ikeda

发明人： Isao Kawaguchi ,  Masakuni Tai ,  Shin Ikeda

IPC分类号： G02B15/20 ,  G02B15/173 ,  G02B15/16 ,  G02B9/64

CPC分类号： G02B15/173

摘要： A telephoto zoom lens system comprises a first lens group having a positive refractive power, a second lens group having a negative refractive power, and a third lens group having a positive refractive power. In a zooming operation, the first lens group moves arithmetically, the second lens group moves from the objective side toward the image side in the first half of the movement and then from the image side toward the objective side in the latter half of movement, and the third lens group moves so as to maintain the image side focal point thereof in a fixed position in conjunction with the first and second lens groups.

摘要翻译： 远摄变焦透镜系统包括具有正折光力的第一透镜组，具有负折光力的第二透镜组和具有正折光力的第三透镜组。 在变焦操作中，第一透镜组以算术方式移动，第二透镜组在运动的前半部分中从物体侧朝向像侧移动，然后在后半部分中从图像侧朝向物体侧移动， 第三透镜组移动，以便与第一和第二透镜组一起将图像侧焦点保持在固定位置。

公开(公告)号：US08480869B2

公开(公告)日：2013-07-09

申请号：US13279787

申请日：2011-10-24

申请人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

IPC分类号： G01N27/327

CPC分类号： G01N27/3274

摘要： The present invention provides a method of electrochemically measuring a hematocrit (Hct) value using a sensor, capable of achieving excellent measurement accuracy and reliability and also provides a sensor used in the method. The method of electrochemically measuring a hematocrit (Hct) value of blood include: providing an electrode system having a working electrode (11) and a counter electrode (12), in which a redox substance is provided on the counter electrode (12) but not on the working electrode (11); supplying blood to the electrode system; applying a voltage to the electrode system in this state to cause an oxidation current or a reduction current to flow between the working electrode (11) and the counter electrode (12); detecting the oxidation current or the reduction current; and determining a Hct value based on a value of the detected current.

摘要翻译： 本发明提供一种使用传感器电化学测量血细胞比容（Hct）值的方法，其能够实现优异的测量精度和可靠性，并且还提供了该方法中使用的传感器。 电化学测量血液血细胞比容（Hct）值的方法包括：提供具有工作电极（11）和对电极（12）的电极系统，其中在对电极（12）上设置氧化还原物质 在工作电极（11）上; 向电极系统供应血液; 在该状态下向电极系统施加电压，使得氧化电流或还原电流在工作电极（11）和对电极（12）之间流动。 检测氧化电流或还原电流; 以及基于检测到的电流的值确定Hct值。