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51.发明授权公开(公告)号：US08557961B2
公开(公告)日：2013-10-15
申请号：US13078499
申请日：2011-04-01
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to compositions comprising alpha 1-antitrypsin linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of alpha 1-antitrypsin-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的α1-抗胰蛋白酶的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用这些组合物治疗α1- 抗胰蛋白酶相关疾病，病症和病症。
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52.发明申请BINDING FUSION PROTEINS, BINDING FUSION PROTEIN-DRUG CONJUGATES, XTEN-DRUG CONJUGATES AND METHODS OF MAKING AND USING SAME 有权结合融合蛋白，结合融合蛋白 - 药物结合物，XTEN-DRUG结合体及其制备和使用方法公开(公告)号：US20130165389A1
公开(公告)日：2013-06-27
申请号：US13631361
申请日：2012-09-28
申请人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Susan E. Alters , Nathan Geething
发明人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Susan E. Alters , Nathan Geething
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸重组多肽（XTEN）连接的靶向部分，结合融合蛋白 - 药物共轭组合物和XTEN-药物共轭组合物的结合融合蛋白组合物，编码组合物和载体的分离的核酸和含有该重组多肽的宿主细胞 以及使用这些组合物治疗疾病，病症和病症的方法。
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53.发明申请COAGULATION FACTOR VII COMPOSITIONS AND METHODS OF MAKING AND USING SAME 审中-公开凝血因子VII组合物及其制备方法和使用方法公开(公告)号：US20120263701A1
公开(公告)日：2012-10-18
申请号：US13392509
申请日：2010-08-02
申请人： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
发明人： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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54.发明申请公开(公告)号：US20110262953A1
公开(公告)日：2011-10-27
申请号：US12950880
申请日：2010-11-19
申请人： Katherine D. Collier , Edwin Lee , Nicholas Leiva , Thomas B. Morrison , Volker Schellenberger , Olga V. Selifonova , Adam C. Kean
发明人： Katherine D. Collier , Edwin Lee , Nicholas Leiva , Thomas B. Morrison , Volker Schellenberger , Olga V. Selifonova , Adam C. Kean
摘要： An evolvable production strain of B. subtilis exhibiting continuous or high level expression during protein evolution is described. An evolved Bacillus subtilis pstS promoter facilitates screening and production of secreted proteins.
摘要翻译： 描述了在蛋白质进化期间表现出连续或高水平表达的枯草芽孢杆菌的可进化生产菌株。 一种进化的枯草芽孢杆菌pstS启动子有助于分泌蛋白的筛选和产生。
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55.发明授权公开(公告)号：US07858762B2
公开(公告)日：2010-12-28
申请号：US10483842
申请日：2002-07-26
申请人： Katherine D Collier , Edwin Lee , Nicholas Leiva , Thomas B Morrison , Volker Schellenberger , Olga V Selifonova , Adam C Kean
发明人： Katherine D Collier , Edwin Lee , Nicholas Leiva , Thomas B Morrison , Volker Schellenberger , Olga V Selifonova , Adam C Kean
摘要： An evolvable production strain of B. subtilis exhibiting continuous or high level expression during protein evolution is described. An evolved Bacillus subtilis pstS promoter facilitates screening and production of secreted proteins.
摘要翻译： 描述了在蛋白质进化期间表现出连续或高水平表达的枯草芽孢杆菌的可进化生产菌株。 一种进化的枯草芽孢杆菌pstS启动子有助于分泌蛋白的筛选和产生。
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公开(公告)号：US07855279B2
公开(公告)日：2010-12-21
申请号：US11715276
申请日：2007-03-06
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US20090099031A1
公开(公告)日：2009-04-16
申请号：US11715300
申请日：2007-03-06
申请人： Willem P. Stemmer , Volker Schellenberger , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Willem P. Stemmer , Volker Schellenberger , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
CPC分类号： C07K14/415 , A61K38/00
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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58.发明申请公开(公告)号：US20080286808A1
公开(公告)日：2008-11-20
申请号：US11715296
申请日：2007-03-06
申请人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem P. Stemmer , Chia-wei Wang , Michael D. Scholle , Mikhail Popkov , Nathaniel C. Gordon , Andreas Crameri
IPC分类号： G01N33/53 , C12P21/02 , C07K19/00 , C07K1/107 , G01N33/566
CPC分类号： C07K14/415 , A61K38/00 , C07K14/001 , C07K14/475 , C07K2319/21 , C07K2319/43 , C12N15/1044 , C12N2795/14011 , G01N33/68 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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公开(公告)号：US20080146456A1
公开(公告)日：2008-06-19
申请号：US11958592
申请日：2007-12-18
CPC分类号： C40B30/04 , C12N15/1086 , C12Q1/6897 , G01N33/53 , G01N33/54306 , G01N33/581 , G01N33/6845
摘要： The present invention relates to methods for improving a binding characteristic of a molecule, e.g., a peptide, for a binding target, in which the molecule is covalently linked to a detectable moiety, e.g., an enzyme, or an active portion or derivative thereof. The present invention also relates to molecules produced by the methods of the present invention.
摘要翻译： 本发明涉及用于改善结合靶分子例如肽的结合特性的方法，其中分子共价连接到可检测部分，例如酶或其活性部分或衍生物。 本发明还涉及通过本发明的方法制备的分子。
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公开(公告)号：US20080039341A1
公开(公告)日：2008-02-14
申请号：US11715276
申请日：2007-03-06
申请人： Volker Schellenberger , Willem Stemmer , Chia-wei Wang , Michael Scholle , Mikhail Popkov , Nathaniel Gordon , Andreas Crameri
发明人： Volker Schellenberger , Willem Stemmer , Chia-wei Wang , Michael Scholle , Mikhail Popkov , Nathaniel Gordon , Andreas Crameri
CPC分类号： C07K14/56 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/415 , C07K14/47 , C07K14/53 , C07K14/535 , C07K14/61 , C07K2319/31 , C07K2319/35 , C12N15/1044 , G01N33/6845
摘要： The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译： 本发明提供非结构化重组聚合物（URP）和含有一种或多种URP的蛋白质。 本发明还提供微蛋白，毒素和其它相关的蛋白质实体，以及显示这些实体的遗传包。 本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。 主题组合物具有各种实用性，包括一系列药物应用。
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