公开(公告)号：US20110177162A1

公开(公告)日：2011-07-21

申请号：US13003420

申请日：2009-07-10

申请人： Christian Kemmer ,  David Fluri ,  Ulrich Witschi ,  Wilfried Weber ,  Martin Fussenegger

发明人： Christian Kemmer ,  David Fluri ,  Ulrich Witschi ,  Wilfried Weber ,  Martin Fussenegger

IPC分类号： A61K9/50 ,  A61K35/12 ,  A61P15/00

CPC分类号： A61K35/52 ,  A61K9/5042 ,  A61K9/5068

摘要： The invention relates to microcapsules consisting of a polymer degradable by a polypeptide comprising a drug or other compound of interest and a genetically engineered cell expressing said polypeptide in response to a triggering compound, and to methods of directed release of the compound of interest. The preferred polymer is optionally modified cellulose sulfate/poly-diallyl-dimethyl-ammonium chloride. Such microcapsules are non-toxic, do not elicit an immunological response and have an extended half-life time in mammals. The expression system for cellulase is, for example, based on TET and doxycycline, or E.REX and erythromycin. In another example, expression of cellulase is triggered by luteinizing hormone, which can be used for artificial insemination with microcapsules carrying sperm.

摘要翻译： 本发明涉及由可由可包含药物或目的的其它化合物的多肽降解的聚合物和响应于引发化合物表达所述多肽的遗传工程改造的细胞组成的微胶囊以及目的化合物的定向释放方法。 优选的聚合物是任选改性的硫酸纤维素/聚二烯丙基二甲基氯化铵。 这样的微胶囊是无毒的，不引起免疫应答并且在哺乳动物中具有延长的半衰期。 纤维素酶的表达系统例如是基于TET和多西环素，或E.REX和红霉素。 在另一个实例中，纤维素酶的表达由黄体生成激素引发，其可用于携带精子的微胶囊的人工授精。

公开(公告)号：US07909796B2

公开(公告)日：2011-03-22

申请号：US10566659

申请日：2004-07-23

申请人： Wilfried Weber

发明人： Wilfried Weber

IPC分类号： A61M5/20

CPC分类号： A61M5/20 ,  A61M5/2033 ,  A61M5/315 ,  A61M5/326 ,  A61M5/46 ,  A61M2005/206 ,  A61M2005/208 ,  A61M2005/2086 ,  A61M2005/3152 ,  A61M2205/581

摘要： An injection device for a syringe, having a syringe body, a cannula with a needle, a plunger with a plunger rod, and an injection carriage for displacing the syringe body and the plunger, comprises at least one actuating element that acts on the injection carriage to carry out the injection procedure. The actuating element (120, 220, 320) cooperates with components which withdraw the needle (108, 208, 308) from the puncture site once the injection procedure has been completed, using a return stroke (H3) that is applied to the injection carriage. A single, targeted linear movement inserts the needle to a defined depth, injects the medicament and, once the injection has been completed, produces a return stroke which allows the needle to be withdrawn into the housing and thus out from the puncture site.

摘要翻译： 一种用于注射器的注射装置，其具有注射器主体，具有针的套管，具有柱塞杆的柱塞和用于移动注射器主体和柱塞的注射托架，包括作用在注射支架上的至少一个致动元件 执行注射程序。 致动元件（120,220,320）与从注射过程完成后将针头（108,208,308）从穿刺部位撤回的部件使用施加到注射支架的返回冲程（H3） 。 单一的目标线性运动将针插入到限定的深度，注射药物，并且一旦注射完成就产生返回行程，该返回行程允许针被抽出到外壳中，从而从穿刺部位出来。

公开(公告)号：US20100051399A1

公开(公告)日：2010-03-04

申请号：US12515053

申请日：2007-11-07

申请人： Wilfried Weber ,  Jochen Heimsch

发明人： Wilfried Weber ,  Jochen Heimsch

IPC分类号： F16F9/12

CPC分类号： F16F9/12

摘要： A rotational damper comprises a stator and a rotor that is rotatably supported in the stator, the rotor having a first friction element (31, 31 A . . . 31 F), wherein the volume between the stator and the rotor is filled with a viscous fluid. According to the invention, the rotor has a second friction element (32, 32A . . . 32F), which is supported coaxially in relation to the first friction element and rotationally coupled thereto, and which can be axially displaced relative to the first friction element. Due to the two-piece design of the friction element and the ability for axial displacement of the two friction elements, the entire effective surface of the friction element in the viscous fluid, and thus the frictional resistance and the damping characteristics of the rotational damper, can be varied. For this purpose, the second friction element preferably comprises a plurality of segments (5, 5A . . . 5F), which immerse into the first friction element and can be displaced by means of an actuator (4, 4A . . . 4G). These segments bring about the rotational coupling of the two friction elements. In this manner, continuous adjustment of the damping torque can occur across a broad range using simple means, in order to meet the diverse requirements in terms of size and type of rotational damping in various applications, using only one model.

摘要翻译： 旋转阻尼器包括定子和可旋转地支撑在定子中的转子，转子具有第一摩擦元件（31,31A ... 31F），其中定子和转子之间的体积填充有粘性 流体。 根据本发明，转子具有第二摩擦元件（32,32A ... 32F），该第二摩擦元件相对于第一摩擦元件同轴地支撑并且可旋转地联接到其上并且可相对于第一摩擦元件轴向移位 。 由于摩擦元件的两件式设计和两个摩擦元件轴向位移的能力，摩擦元件在粘性流体中的整个有效表面，因此旋转阻尼器的摩擦阻力和阻尼特性， 可以变化。 为此目的，第二摩擦元件优选地包括多个段（5,5A。.5F），其浸入第一摩擦元件中并且可以借助于致动器（4A，4A ...）移动。 这些段导致两个摩擦元件的旋转联接。 以这种方式，使用简单的手段可以在宽范围内发生阻尼扭矩的连续调节，以便仅使用一种模型来满足各种应用中的旋转阻尼的尺寸和类型的不同要求。

公开(公告)号：US20060258990A1

公开(公告)日：2006-11-16

申请号：US10566659

申请日：2004-07-23

申请人： Wilfried Weber

发明人： Wilfried Weber

IPC分类号： A61M5/00

CPC分类号： A61M5/20 ,  A61M5/2033 ,  A61M5/315 ,  A61M5/326 ,  A61M5/46 ,  A61M2005/206 ,  A61M2005/208 ,  A61M2005/2086 ,  A61M2005/3152 ,  A61M2205/581

摘要： An injection device for a syringe, having a syringe body, a cannula with a needle, a plunger with a plunger rod, and an injection carriage for displacing the syringe body and the plunger, comprises at least one actuating element that acts on the injection carriage to carry out the injection procedure. The actuating element (120, 220, 320) cooperates with components which withdraw the needle (108, 208, 308) from the puncture site once the injection procedure has been completed, using a return stroke (H3) that is applied to the injection carriage. A single, targeted linear movement inserts the needle to a defined depth, injects the medicament and, once the injection has been completed, produces a return stroke which allows the needle to be withdrawn into the housing and thus out from the puncture site. The injection device is advantageously equipped with additional components which produce a delay (TV) between the completion of the injection stroke (H2) and the start of the return stroke (H3). The advantage of said delay is that the pressure that has been produced in the subcutaneous tissue by the injection of the medicament can subside before the needle is withdrawn, thus preventing to a great extent the penetration of the medicament into the insertion channel of the needle. A volume adapter (410) can advantageously be used to predetermine the injection stroke (H2) and thus the quantity of a medicament that is administered during the course of the injection stroke (H2).

摘要翻译： 一种用于注射器的注射装置，其具有注射器主体，具有针的套管，具有柱塞杆的柱塞和用于移动注射器主体和柱塞的注射托架，包括作用在注射支架上的至少一个致动元件 执行注射程序。 致动元件（120,220,320）与从注射过程完成后从穿刺部位撤回针头（108,208,308）的部件使用施加到注射器上的返回冲程（H 3） 运输。 单一的目标线性运动将针插入到限定的深度，注射药物，并且一旦注射完成就产生返回行程，该返回行程允许针被抽出到外壳中，从而从穿刺部位出来。 注射装置有利地配备有在完成注射冲程（H 2）和返回冲程（H 3）的开始之间产生延迟（TV）的附加部件。 所述延迟的优点在于，通过注射药物而在皮下组织中产生的压力在针被取出之前可以消退，因此在很大程度上防止药物渗入针的插入通道。 容积适配器（410）可有利地用于预先确定注射冲程（H 2），并因此预测注射冲程过程中施用的药物的量（H 2）。

公开(公告)号：US07077689B2

公开(公告)日：2006-07-18

申请号：US10239709

申请日：2001-03-15

申请人： Dieter Hölzle ,  Hubert Willmann ,  Wilfried Weber

发明人： Dieter Hölzle ,  Hubert Willmann ,  Wilfried Weber

IPC分类号： H01R12/24

CPC分类号： H01R13/629 ,  H01R12/772

摘要： A plug connector for printed circuits comprises a plug (10), which supports the contact section (42) of the printed circuit (40) on one side and a retaining element (261, 262), by means of which the plug (10) may be pre-fixed, restrained in a pre-determined axial catch position in the port. On passing the axial catch position, the contact section (42) reaches the contact position with the contact spot of the port, by means of a vertical movement component, where the contact section is locked in a final position by means of a locking element.

摘要翻译： 用于印刷电路的插头连接器包括一个插头（10），该插头支撑在一侧的印刷电路（40）的接触部分（42）和一个保持元件（261,262），借助于该插头 可以预先固定，限制在端口中预定的轴向捕获位置。 在通过轴向卡止位置时，接触部分（42）通过垂直运动部件到达端口的接触点的接触位置，其中接触部分通过锁定元件锁定在最终位置。

公开(公告)号：US20050032407A1

公开(公告)日：2005-02-10

申请号：US10239709

申请日：2001-03-15

申请人： Dieter Holzle ,  Hubert Willmann ,  Wilfried Weber

发明人： Dieter Holzle ,  Hubert Willmann ,  Wilfried Weber

IPC分类号： H01R12/70 ,  H01R13/629 ,  H01R13/62

CPC分类号： H01R13/629 ,  H01R12/772

摘要： A plug connector for printed circuits comprises a plug (10), which supports the contact section (42) of the printed circuit (40) on one side and a retaining element (261, 262), by means of which the plug (10) may be pre-fixed, restrained in a pre-determined axial catch position in the port. On passing the axial catch position, the contact section (42) reaches the contact position with the contact spot of the port, by means of a vertical movement component, where the contact section is locked in a final position by means of a locking element.

摘要翻译： 用于印刷电路的插头连接器包括一个插头（10），该插头支撑在一侧的印刷电路（40）的接触部分（42）和一个保持元件（261,262），借助于该插头 可以预先固定，限制在端口中预定的轴向捕获位置。 在通过轴向卡止位置时，接触部分（42）通过垂直运动部件到达端口的接触点的接触位置，其中接触部分通过锁定元件锁定在最终位置。

公开(公告)号：US06454743B1

公开(公告)日：2002-09-24

申请号：US09674253

申请日：2000-10-30

申请人： Wilfried Weber

发明人： Wilfried Weber

IPC分类号： A61M3700

CPC分类号： A61M5/2033 ,  A61M5/31511 ,  A61M5/3157 ,  A61M2005/206 ,  A61M2005/2086 ,  A61M2005/3152 ,  A61M2205/581

摘要： An injection device that is used with a syringe, wherein the injection needle of the syringe is initially introduced into the skin and the injection fluid is injected afterwards. The injection device is essentially driven and controlled by a control sleeve (6) which can be displaced and/or rotated in relation to the housing (7) and which can be moved between a closing and functional position (P1) and an open and safety position (P2). In the closing and functional position, the control sleeve prevents access to the syringe and activates a release device for the injection process. In the open and safety position, a syringe (1) can be removed or inserted. A plurality of components carrying out the injection process (a slide (2) in which the syringe (1) is placed and a plunger (4) that impinges upon the syringe piston) are moved or controlled depending on the movement and position of the control sleeve or supported (for example, an ejection device for the syringe or a signaling device informing that injection has been completed). The device enables full-automatic injection that can be reliably carried out by patients themselves with few handling procedures.

摘要翻译： 一种与注射器一起使用的注射装置，其中注射器的注射针头最初被引入皮肤中，并且之后注射注射液体。 注射装置基本上由控制套筒（6）驱动和控制，控制套筒（6）可以相对于壳体（7）移位和/或旋转，并且可以在关闭和功能位置（P1）之间移动并且打开和安全 位置（P2）。 在关闭和功能位置，控制套筒防止进入注射器并激活用于注射过程的释放装置。 在打开和安全的位置，可以取下或插入注射器（1）。 执行注射过程的多个部件（其中放置注射器（1）的滑块（2）和撞击注射器活塞的柱塞（4））根据控制器的移动和位置而移动或控制 套筒或支撑（例如，用于注射器的喷射装置或通知注射已经完成的信号装置）。 该装置能够实现全自动注射，由患者自己可靠地执行，操作程序少。

公开(公告)号：US5482671A

公开(公告)日：1996-01-09

申请号：US311430

申请日：1994-09-23

申请人： Wilfried Weber

发明人： Wilfried Weber

IPC分类号： B22F7/02 ,  B22D17/00 ,  B22F3/20 ,  B22F3/22 ,  B22F5/10 ,  B22F7/06 ,  B28B1/24 ,  B29C45/14 ,  F16B1/00

CPC分类号： B22F3/225 ,  B22F3/22 ,  B22F3/227 ,  B22F5/10 ,  B22F2005/103 ,  B22F2998/00 ,  B22F2999/00 ,  F16B2001/0007

摘要： A method is provided for manufacturing interlocking parts, in which at least one part is manufactured by powder injection molding. To compensate for the amount of contraction of one of the parts manufactured by powder injection molding and, if desired, to produce an additional clearance, a separation layer of plastic material is applied between the interlocking parts. After the injection process to form the separation layer, the separation layer and the binder are removed by a binder-removing and sintering process step. The method is also applicable to powdered metal extrusion for manufacture of double-layered metal parts.

摘要翻译： 提供一种用于制造互锁部件的方法，其中通过粉末注射成型制造至少一个部件。 为了补偿通过粉末注射成型制造的部件之一的收缩量，并且如果需要，为了产生另外的间隙，在互锁部件之间施加塑料材料分离层。 在注射工艺形成分离层之后，通过粘合剂去除和烧结工艺步骤除去分离层和粘合剂。 该方法也适用于制造双层金属部件的粉末金属挤压。

公开(公告)号：US5384939A

公开(公告)日：1995-01-31

申请号：US14386

申请日：1993-02-05

申请人： Wilfried Weber

发明人： Wilfried Weber

IPC分类号： A47G27/04 ,  B60N3/04 ,  A44B21/00

CPC分类号： B60N3/046 ,  Y10T24/2708 ,  Y10T24/2725

摘要： The fixing element for fixing a mat to a floor part in a vehicle consists of a bottom part anchorable to the floor part to which the mat is to be secured and a top part having a clamping device and securable to the mat via the clamping device. The top part and the bottom part each have a disk-shaped flange with a coupling face. The coupling faces of the disk-shaped flanges face each other and have a plurality of identical coupling elements which cooperate by interlocking when the top part engages the bottom part. The coupling elements can be rows of pins having heads. The heads of the pins on the top part engage with those on the bottom part when the top part engages with the bottom part.

摘要翻译： 用于将垫固定到车辆的地板部件上的固定元件包括可固定到垫被固定的地板部分的底部部分和具有夹紧装置的顶部部分，并通过夹紧装置固定到垫子上。 顶部和底部各自具有带耦合面的盘形凸缘。 盘状凸缘的连接面相互面对并具有多个相同的联接元件，当顶部接合底部时，它们通过互锁协作。 联接元件可以是具有头部的销排。 当顶部与底部接合时，顶部的销的头部与底部的销的头部接合。

公开(公告)号：US5328300A

公开(公告)日：1994-07-12

申请号：US108634

申请日：1993-08-25

申请人： Artur Fischer ,  Wilfried Weber

发明人： Artur Fischer ,  Wilfried Weber

IPC分类号： E04B1/41 ,  F16B13/06 ,  F16B13/14 ,  E21D20/02

CPC分类号： F16B13/141

摘要： An anchoring means for anchoring by a bonding mass in a drilled hole in a concrete part or the like has a threaded bolt with a reduced portion and an expansion cone followed by a head part, forming at the same time a stop shoulder. Over the reduced portion and expansion cone is slipped an anchoring sleeve which is provided on its outer surface with a plurality of longitudinal grooves. By the longitudinal grooves and the elasticity of the anchoring sleeve consisting of plastics material, the possibility is obtained of compensating for the enlargement of the drilled hole when a crack forms, thus making it possible for the anchoring means to be used in the zone subject to tensile forces.

摘要翻译： PCT No.PCT / EP93 / 01095 Sec。 371日期：1993年8月25日 102（e）1993年8月25日PCT 1993年5月5日提交PCT。用于通过粘结块锚固在混凝土部件等的钻孔中的锚固装置具有带有减小部分和膨胀锥的螺栓， 通过头部，同时形成止挡肩。 在缩小部分和膨胀锥体上滑动一个锚固套筒，其在其外表面上设置有多个纵向凹槽。 通过纵向凹槽和由塑料材料组成的锚固套筒的弹性，获得了当形成裂缝时补偿钻孔扩大的可能性，从而使锚固装置可用于受 张力。