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    ROTATIONAL DAMPER
    1.
    发明申请
    ROTATIONAL DAMPER 有权
    旋转阻尼器

    公开(公告)号：US20100051399A1

    公开(公告)日：2010-03-04

    申请号：US12515053

    申请日：2007-11-07

    申请人： Wilfried Weber ,  Jochen Heimsch

    发明人： Wilfried Weber ,  Jochen Heimsch

    IPC分类号： F16F9/12

    CPC分类号： F16F9/12

    摘要： A rotational damper comprises a stator and a rotor that is rotatably supported in the stator, the rotor having a first friction element (31, 31 A . . . 31 F), wherein the volume between the stator and the rotor is filled with a viscous fluid. According to the invention, the rotor has a second friction element (32, 32A . . . 32F), which is supported coaxially in relation to the first friction element and rotationally coupled thereto, and which can be axially displaced relative to the first friction element. Due to the two-piece design of the friction element and the ability for axial displacement of the two friction elements, the entire effective surface of the friction element in the viscous fluid, and thus the frictional resistance and the damping characteristics of the rotational damper, can be varied. For this purpose, the second friction element preferably comprises a plurality of segments (5, 5A . . . 5F), which immerse into the first friction element and can be displaced by means of an actuator (4, 4A . . . 4G). These segments bring about the rotational coupling of the two friction elements. In this manner, continuous adjustment of the damping torque can occur across a broad range using simple means, in order to meet the diverse requirements in terms of size and type of rotational damping in various applications, using only one model.

    摘要翻译： 旋转阻尼器包括定子和可旋转地支撑在定子中的转子，转子具有第一摩擦元件（31,31A ... 31F），其中定子和转子之间的体积填充有粘性 流体。 根据本发明，转子具有第二摩擦元件（32,32A ... 32F），该第二摩擦元件相对于第一摩擦元件同轴地支撑并且可旋转地联接到其上并且可相对于第一摩擦元件轴向移位 。 由于摩擦元件的两件式设计和两个摩擦元件轴向位移的能力，摩擦元件在粘性流体中的整个有效表面，因此旋转阻尼器的摩擦阻力和阻尼特性， 可以变化。 为此目的，第二摩擦元件优选地包括多个段（5,5A。.5F），其浸入第一摩擦元件中并且可以借助于致动器（4A，4A ...）移动。 这些段导致两个摩擦元件的旋转联接。 以这种方式，使用简单的手段可以在宽范围内发生阻尼扭矩的连续调节，以便仅使用一种模型来满足各种应用中的旋转阻尼的尺寸和类型的不同要求。

    Rotational damper
    2.
    发明授权
    Rotational damper 有权
    旋转阻尼器

    公开(公告)号：US08286764B2

    公开(公告)日：2012-10-16

    申请号：US12515053

    申请日：2007-11-07

    申请人： Wilfried Weber ,  Jochen Heimsch

    发明人： Wilfried Weber ,  Jochen Heimsch

    IPC分类号： F16D55/02

    CPC分类号： F16F9/12

    摘要： A rotational damper having a stator and a rotor that is rotatably supported in the stator, the rotor having a first friction element (31, 31 A . . . 31 F), wherein the volume between the stator and the rotor is filled with a viscous fluid. According to the invention, the rotor has a second friction element (32, 32A . . . 32F), which is supported coaxially in relation to the first friction element and rotationally coupled thereto, and which can be axially displaced relative to the first friction element. Due to the two-piece design of the friction element and the ability for axial displacement of the two friction elements, the entire effective surface of the friction element in the viscous fluid, and thus the frictional resistance and the damping characteristics of the rotational damper, can be varied. For this purpose, the second friction element preferably has a plurality of segments (5, 5A . . . 5F), which immerse into the first friction element and can be displaced by an actuator (4, 4A . . . 4G). These segments bring about the rotational coupling of the two friction elements. In this manner, continuous adjustment of the damping torque can occur across a broad range using a simple mechanism, in order to meet the diverse requirements in terms of size and type of rotational damping in various applications, using only one model.

    摘要翻译： 一种旋转阻尼器，具有可旋转地支撑在所述定子中的定子和转子，所述转子具有第一摩擦元件（31,31A ... 31F），其中所述定子和所述转子之间的体积填充有粘性 流体。 根据本发明，转子具有第二摩擦元件（32,32A ... 32F），该第二摩擦元件相对于第一摩擦元件同轴地支撑并且可旋转地联接到其上并且可相对于第一摩擦元件轴向移位 。 由于摩擦元件的两件式设计和两个摩擦元件轴向位移的能力，摩擦元件在粘性流体中的整个有效表面，因此旋转阻尼器的摩擦阻力和阻尼特性， 可以变化。 为此目的，第二摩擦元件优选地具有多个段（5,5A。.5F），其浸入第一摩擦元件中并且可被致动器（4A，4A。。4G）移位。 这些段导致两个摩擦元件的旋转联接。 以这种方式，使用简单的机构可以在宽范围内进行阻尼扭矩的连续调节，以便仅使用一个模型来满足各种应用中的旋转阻尼的尺寸和类型的不同要求。

    Composition for treatment of tuberculosis
    3.
    发明授权
    Composition for treatment of tuberculosis 有权
    用于治疗结核病的组合物

    公开(公告)号：US09050295B2

    公开(公告)日：2015-06-09

    申请号：US12808801

    申请日：2008-11-25

    申请人： Martin Fussenegger ,  Wilfried Weber ,  Ronald Schoenmakers

    发明人： Martin Fussenegger ,  Wilfried Weber ,  Ronald Schoenmakers

    IPC分类号： A61K31/17 ,  A61K31/4409 ,  A61K45/06

    CPC分类号： A61K31/17 ,  A61K31/4409 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates to a pharmaceutical composition comprising a compound preventing EthR from binding to the ethA promoter, for example a compound of formula 1 wherein R1 is optionally substituted phenyl or optionally substituted pyridyl; R2 (CH2)n wherein n is 1, 2, 3 or 4; R3 is CH3(CH2)m wherein m is 0, 1, 2 or 3; X1 is O, S, NH, N(CH3) or CH2; and X2 is O, S or NH; in particular 2-phenylethyl butyrate, and a thioamide or thiourea of formula 2 wherein R4 is optionally substituted phenyl, optionally substituted pyridyl, optionally substituted indolyl, —NR7R8; or —NH—N═CH—R9; and substituents R5 to R9 have the meanings indicated in the description, in particular ethionamide. The pharmaceutical composition is useful, e.g., in the treatment of multidrug-resistant tuberculosis.

    摘要翻译： 本发明涉及包含防止EthR与ethA启动子结合的化合物的药物组合物，例如式1的化合物，其中R 1是任选取代的苯基或任选取代的吡啶基; R2（CH2）n，其中n为1,2,3或4; R3是CH3（CH2）m，其中m是0,1,2或3; X 1是O，S，NH，N（CH 3）或CH 2; X2是O，S或NH; 特别是丁酸2-苯基乙酯和式2的硫代酰胺或硫脲，其中R 4是任选取代的苯基，任选取代的吡啶基，任选取代的吲哚基，-NR 7 R 8; 或-NH-N = CH-R 9; 并且取代基R 5至R 9具有在说明书中指出的含义，特别是乙二胺。 药物组合物可用于例如治疗多重耐药性结核病。

    Injection device
    4.
    发明授权
    Injection device 有权
    注射装置

    公开(公告)号：US08603045B2

    公开(公告)日：2013-12-10

    申请号：US12663585

    申请日：2008-06-03

    申请人： Wilfried Weber

    发明人： Wilfried Weber

    IPC分类号： A61M5/315

    CPC分类号： A61M5/2033 ,  A61M5/2066 ,  A61M5/2448 ,  A61M5/326 ,  A61M5/46 ,  A61M2005/2006 ,  A61M2005/206 ,  A61M2005/2086 ,  A61M2005/3152

    摘要： An injection device having parts, the relative movement of which causes the active substance to be injected. For this purpose, a receptacle, into and in which a carpule/syringe can be inserted and mounted, is retained in a housing, the receptacle can be moved by means of a carriage, and a plunger that applies a force to the piston/s of the carpule/syringe is movably retained in the receptacle. A traction rope which is deflected by means of a roll mounted on the carriage is provided for performing the pricking stroke, injection stroke, and retracting stroke. One end of the traction rope is connected to the receptacle while the other end thereof is connected to a tension spring that is retained on the housing. Mechanisms between the housing, the receptacle, the plunger, and the carriage control the reciprocal coupling thereof to the traction rope.

    摘要翻译： 一种具有部分的注射装置，其相对运动导致活性物质被注射。 为此目的，将容器插入并安装在其中并且其中可插入和安装卡普/注射器的容器被保持在壳体中，容器可以通过滑架移动，并且柱塞将活塞施加力 容器/注射器可移动地保持在容器中。 提供通过安装在滑架上的辊偏转的牵引绳，用于执行穿刺行程，注射行程和缩回行程。 牵引绳的一端连接到容器，而其另一端连接到保持在壳体上的张力弹簧。 壳体，插座，柱塞和滑架之间的机构控制其与牵引绳的往复耦合。

    STIMULI-RESPONSIVE HYDROGEL
    6.
    发明申请
    STIMULI-RESPONSIVE HYDROGEL 审中-公开
    刺激性水凝胶

    公开(公告)号：US20110151006A1

    公开(公告)日：2011-06-23

    申请号：US12996492

    申请日：2009-06-05

    申请人： Wilfried Weber ,  Martin Fussenegger ,  Ronald Schoenmakers

    发明人： Wilfried Weber ,  Martin Fussenegger ,  Ronald Schoenmakers

    IPC分类号： A61K9/14 ,  A61K38/18 ,  A61P5/00

    CPC分类号： A61K38/52 ,  A61K38/1866 ,  A61K47/549 ,  A61K47/552 ,  A61K47/58 ,  A61K47/60 ,  A61K47/62 ,  A61K47/6903

    摘要： The present invention relates to a hydrogel comprising a polymer, a first polypeptide and a polypeptide binding partner, wherein the polypeptide binding partner is a second polypeptide, a nucleic acid or a small molecule, and wherein the interaction between the first polypeptide and the polypeptide binding partner stabilizes the hydrogel and is modulated by the addition of a modulating compound. A drug may be physically entrapped in the hydrogel, bound to the polymer forming the hydrogel structure, or bound to the first polypeptide or the polypeptide binding partner, and then be set free on addition of the modulating compound. Such a hydrogel comprising a drug may be injected into a patient, and drug release modulated by orally administering the modulating compound.

    摘要翻译： 本发明涉及包含聚合物，第一多肽和多肽结合配偶体的水凝胶，其中多肽结合配偶体是第二多肽，核酸或小分子，并且其中第一多肽和多肽结合之间的相互作用 配偶体稳定水凝胶，并通过加入调节化合物进行调节。 药物可以被物理地包埋在水凝胶中，与形成水凝胶结构的聚合物结合，或者与第一多肽或多肽结合配偶体结合，然后在加入调节化合物时释放。 包含药物的这种水凝胶可以注射到患者体内，并通过口服施用调节化合物调节药物释放。

    Apparatus on a carding machine for processing textile fibres, for example cotton, synthetic fibres and the like, with a cylinder
    7.
    发明申请
    Apparatus on a carding machine for processing textile fibres, for example cotton, synthetic fibres and the like, with a cylinder 失效

    公开(公告)号：US20060207065A1

    公开(公告)日：2006-09-21

    申请号：US11375005

    申请日：2006-03-15

    申请人： Achim Breuer ,  Wilfried Weber

    发明人： Achim Breuer ,  Wilfried Weber

    IPC分类号： D01G15/00

    CPC分类号： D01G15/32

    摘要： An apparatus on a carding machine for processing textile fibres, with a cylinder, has, in the preliminary carding zone, after carding zone and/or underneath carding zone, covering elements which lie opposite the cylinder clothing. A fixed carding element is associated with at least one cover element. The spacing of the cylinder clothing from the clothing of the fixed carding element is smaller than the spacing from the cover element. In order to reduce nep formation, to allow improved carding work and to give a better carding result, between at least one clothing strip of the fixed carding element and a cover element arranged upstream and/or downstream thereof, there is arranged an air guide element the spacing of which with respect to the cylinder clothing gradually decreases or increases.

    Anchor bolt for anchoring by compound mass, and method of manufacturing the same
    8.
    发明授权
    Anchor bolt for anchoring by compound mass, and method of manufacturing the same 失效
    用于通过复合物质锚固的锚栓及其制造方法

    公开(公告)号：US5634752A

    公开(公告)日：1997-06-03

    申请号：US383018

    申请日：1995-02-02

    申请人： Manfred Haage ,  Guenter Seibold ,  Bernd Plocher ,  Bernd Hein ,  Wilfried Weber

    发明人： Manfred Haage ,  Guenter Seibold ,  Bernd Plocher ,  Bernd Hein ,  Wilfried Weber

    IPC分类号： F16B13/02 ,  B22F5/00 ,  F16B13/14 ,  F16B15/06 ,  F16B39/00 ,  F16B39/02

    CPC分类号： B22F5/00 ,  F16B13/143 ,  Y10S411/93

    摘要： An anchor bolt has locking elements arranged over a part of the outer surface and formed as radially projecting lugs which are spaced circumferentially and axially from one another. Therefore a good mixing of a compound mass and reduction of the driving-in resistance is obtained. Therefore the outer diameter measured over the lugs of the anchor bolt can be matched approximately to the diameter of the drilled hole. Simple and inexpensive manufacture of the anchor bolt can be provided by powdered metal injection molding method using a system of binders with subsequent removal of the binders and sintering.

    摘要翻译： 锚定螺栓具有布置在外表面的一部分上的锁定元件，并且形成为径向突出的凸缘，其彼此周向和轴向间隔开。 因此，可以获得复合物质的良好混合和耐驱动电阻的降低。 因此，在锚定螺栓的凸耳上测量的外径可以大致匹配于钻孔的直径。 可以通过使用粘合剂系统的粉末金属注射成型方法来提供锚定螺栓的简单和便宜的制造，随后除去粘合剂并进行烧结。

    Expansible metal anchor and method of manufacturing it
    9.
    发明授权
    Expansible metal anchor and method of manufacturing it 失效
    可膨胀金属锚及其制造方法

    公开(公告)号：US5569091A

    公开(公告)日：1996-10-29

    申请号：US375649

    申请日：1995-01-20

    申请人： Manfred Haage ,  Guenter Seibold ,  Bernd Plocher ,  Bernd Hein ,  Wilfried Weber

    发明人： Manfred Haage ,  Guenter Seibold ,  Bernd Plocher ,  Bernd Hein ,  Wilfried Weber

    IPC分类号： E04B1/48 ,  F16B1/00 ,  F16B13/06 ,  B23G9/00 ,  F16B13/04

    CPC分类号： F16B13/065 ,  F16B2001/0007

    摘要： The expansible metal anchor (1) for anchoring in a hole drilled in a component includes a shank part (2) and an expander cone (4) having a polygonal cross-section defining several faces (13) at its front end. On each face (13) of the expander cone (4) an expansible segment (5) is arranged spaced from that face by a gap (7) corresponding approximately to the distance (8) by which the expansible segments (5) project radially from the shank part (2). Each expansible segment (5) is joined to the shank part (2) at its end face directed towards the shank part (2) by web members (6, 6') constituting predetermined break points. As the expansible anchor is driven into the hole drilled in the component, the web members (6,6') break off, so that the expansible segments (5) are displaceable on the faces (13) of the expander cone. The expansible anchor (1) is manufactured from powdered metal by an injection-molding process using a system of binders with subsequent removal of the binders and sintering, and a slide member of the mold divided at the corner edges (20) of the faces (13) is used to make the gap (7) between the expansible segments (5) and the faces (13) of the expander cone (4).

    摘要翻译： 用于锚定在组件中钻孔的可膨胀金属锚固件（1）包括柄部（2）和具有在其前端限定多个面（13）的多边形横截面的膨胀锥体（4）。 在膨胀锥体（4）的每个表面（13）上，可膨胀段（5）与该表面间隔开距离（8）的间隙（7），所述间隙（8）相应于可扩展段（5）径向地从 柄部分（2）。 每个可膨胀段（5）在构成预定断点的腹板构件（6,6'）的端面处连接到柄部（2）。 当可膨胀的锚被驱动到在部件中钻出的孔中时，腹板构件（6,6'）断裂，使得可膨胀段（5）可在膨胀锥的表面（13）上移位。 可膨胀锚（1）由粉末金属通过注射成型工艺制造，使用粘合剂系统随后除去粘合剂并烧结，并且模具的滑动构件在面部的角部边缘（20）处分开 13）用于形成可膨胀段（5）和膨胀锥（4）的面（13）之间的间隙（7）。