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59 条记录 (耗时 0.054 秒)

    Muscarinic Receptor Antagonists
    51.
    发明申请
    Muscarinic Receptor Antagonists 审中-公开
    毒蕈碱受体拮抗剂

    公开(公告)号：US20080255188A1

    公开(公告)日：2008-10-16

    申请号：US11995433

    申请日：2006-07-11

    申请人： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Chugh ,  Sandeep Sinha

    发明人： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Chugh ,  Sandeep Sinha

    IPC分类号： A61K31/472 ,  C07D217/26

    CPC分类号： C07D471/08

    摘要： This present invention generally relates to muscarinic receptor antagonists of Formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

    摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

    Oxazolidinone Derivatives as Antimicrobials
    53.
    发明申请
    Oxazolidinone Derivatives as Antimicrobials 失效
    恶唑烷酮衍生物作为抗菌剂

    公开(公告)号：US20080188470A1

    公开(公告)日：2008-08-07

    申请号：US11911576

    申请日：2006-04-12

    申请人： Biswajit Das ,  Sonali Rudra ,  Sangita Sangita ,  Mohammad Salman ,  Ashok Rattan

    发明人： Biswajit Das ,  Sonali Rudra ,  Sangita Sangita ,  Mohammad Salman ,  Ashok Rattan

    IPC分类号： A61K31/5383 ,  C07D498/04 ,  A61P31/04

    CPC分类号： Y02A50/478 ,  Y02P20/55

    摘要： Provided herein are novel substituted phenyl oxazolidinones and to processes for the synthesis thereof. Also provided are pharmaceutical compositions comprising one or more compounds described herein The compounds described can be useful antimicrobial agents, which can be effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci, as well as, anaerobic organisms, such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms, such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

    摘要翻译： 本文提供了新的取代的苯基恶唑烷酮，以及其合成方法。 还提供了包含本文所述的一种或多种化合物的药物组合物。所述化合物可以是有用的抗微生物剂，其可以对许多人和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌 ，以及厌氧生物，如细菌属。 和梭菌属（Clostridia spp。） 物种和酸性快速生物，如结核分枝杆菌，鸟分枝杆菌和分枝杆菌。

    Azabicyclo derivatives as muscarinic receptor antagonists
    55.
    发明申请
    Azabicyclo derivatives as muscarinic receptor antagonists 审中-公开
    偶氮二环衍生物作为毒蕈碱受体拮抗剂

    公开(公告)号：US20070021487A1

    公开(公告)日：2007-01-25

    申请号：US10552503

    申请日：2004-01-06

    申请人： Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

    发明人： Mohammad Salman ,  Naresh Kumar ,  Pakala Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Chugh

    IPC分类号： A61K31/403 ,  C07D209/02

    CPC分类号： C07D209/52 ,  C07D403/06

    摘要： This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0]hexanes, as well as pharmaceutical compositions containing such compounds and methods of treating diseases mediated through muscarinic receptors.

    摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 具体地，本发明涉及氮杂二环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷，以及含有这些化合物的药物组合物和治疗通过毒蕈碱受体介导的疾病的方法。