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    Method and apparatus for induced T-wave alternans assessment
    55.
    发明授权
    Method and apparatus for induced T-wave alternans assessment 有权
    诱导T波交替评估的方法和装置

    公开(公告)号：US08437837B2

    公开(公告)日：2013-05-07

    申请号：US11536946

    申请日：2006-09-29

    申请人： Xiaohong Zhou

    发明人： Xiaohong Zhou

    IPC分类号： A61B5/04 ,  A61N1/00

    CPC分类号： A61B5/0456 ,  A61B5/0452 ,  A61N1/365 ,  G16H40/63

    摘要： An implantable medical device and associated method assesses T-wave alternans. The method includes sensing a cardiac signal from implanted electrodes subsequent to a premature contraction; measuring a T-wave parameter from the sensed cardiac signal for a plurality of cardiac cycles; and determining a T-wave alternans metric corresponding to the measured T-wave parameter.

    摘要翻译： 可植入医疗器械和相关方法评估T波交替。 该方法包括在过早收缩之后感测来自植入电极的心脏信号; 从感测的心脏信号中测量多个心动周期的T波参数; 以及确定对应于所测量的T波参数的T波交替量度。

    Implantable medical device having optical fiber for sensing electrical activity
    56.
    发明授权
    Implantable medical device having optical fiber for sensing electrical activity 有权
    具有用于感测电活动的光纤的可植入医疗装置

    公开(公告)号：US08396539B2

    公开(公告)日：2013-03-12

    申请号：US11676128

    申请日：2007-02-16

    申请人： Vinod Sharma ,  Xiaohong Zhou

    发明人： Vinod Sharma ,  Xiaohong Zhou

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

    摘要： An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

    摘要翻译： 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

    Delivery of a sympatholytic cardiovascular agent to the central nervous system
    57.
    发明授权
    Delivery of a sympatholytic cardiovascular agent to the central nervous system 有权
    交配性心血管药物向中枢神经系统递送

    公开(公告)号：US08348884B2

    公开(公告)日：2013-01-08

    申请号：US12128046

    申请日：2008-05-28

    申请人： Keith R. Hildebrand ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

    发明人： Keith R. Hildebrand ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

    IPC分类号： A61M31/00

    CPC分类号： A61M5/142 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3523 ,  A61M2230/00 ,  A61M2230/04 ,  A61M2230/63 ,  A61N1/3962

    摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).

    摘要翻译： 由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。 药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。 患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。 交感神经心血管药物是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西汀，脱甲基丸，美托咪定和 右美托咪定）。

    Therapy module crosstalk mitigation
    58.
    发明授权
    Therapy module crosstalk mitigation 有权
    治疗模块串扰减轻

    公开(公告)号：US08301263B2

    公开(公告)日：2012-10-30

    申请号：US12363180

    申请日：2009-01-30

    申请人： William T. Donofrio ,  Paul G. Krause ,  Gerald P. Arne ,  John E. Burnes ,  David J. Peichel ,  Xiaohong Zhou

    发明人： William T. Donofrio ,  Paul G. Krause ,  Gerald P. Arne ,  John E. Burnes ,  David J. Peichel ,  Xiaohong Zhou

    IPC分类号： A61N1/00

    CPC分类号： A61N1/37288 ,  A61N1/36114

    摘要： A first implantable medical device (IMD) implanted within a patient may communicate with a second IMD implanted within the patient by encoding information in an electrical stimulation signal. The delivery of the electrical stimulation signal may provide therapeutic benefits to the patient. The second IMD may sense the electrical stimulation signal, which may be presented as an artifact in a sensed cardiac signal, and process the sensed signal to retrieve the encoded information. The second IMD may modify its operation based on the received therapy information. Crosstalk between the first and second IMDs may be reduced using various techniques described herein. For example, the first IMD may generate the electrical stimulation signal to include a spread spectrum energy distribution or a predetermined signal signature. The second IMD may effectively remove a least some of the signal artifact in a sensed cardiac signal based on the predetermined signal signature.

    摘要翻译： 植入在患者体内的第一可植入医疗装置（IMD）可以通过对电刺激信号中的信息进行编码来与植入患者内的第二IMD进行通信。 电刺激信号的传递可以为患者提供治疗益处。 第二IMD可以感测电刺激信号，其可以被呈现为感测到的心脏信号中的伪像，并且处理感测到的信号以检索经编码的信息。 第二IMD可以基于接收到的治疗信息修改其操作。 可以使用本文所述的各种技术来减少第一和第二IMD之间的串扰。 例如，第一IMD可以产生电刺激信号以包括扩频能量分布或预定信号特征。 基于预定的信号签名，第二IMD可以有效地去除感测到的心脏信号中的至少一些信号伪像。

    Method and apparatus for monitoring T-wave alternans
    60.
    发明授权
    Method and apparatus for monitoring T-wave alternans 有权
    用于监测T波交替的方法和装置

    公开(公告)号：US08126539B2

    公开(公告)日：2012-02-28

    申请号：US11871405

    申请日：2007-10-12

    申请人： Xiaohong Zhou ,  Jeffrey M. Gillberg

    发明人： Xiaohong Zhou ,  Jeffrey M. Gillberg

    IPC分类号： A61B5/0402

    CPC分类号： A61B5/0452 ,  A61B5/021 ,  A61N1/3702

    摘要： An implantable medical device and associated method assess T-wave alternans by sensing a cardiac electrogram (EGM) signal and selecting a pair of consecutive T-wave signals from the EGM signal. A first amplitude and a second amplitude from each of the consecutive T-wave signals are determined. The differences between the first amplitudes and the second amplitudes of the consecutive T-wave signal pairs are used to compute a T-wave alternans metric.

    摘要翻译： 可植入医疗装置和相关方法通过感测心电图（EGM）信号和从EGM信号中选择一对连续的T波信号来评估T波交替。 确定来自每个连续T波信号的第一幅度和第二幅度。 使用连续T波信号对的第一幅度和第二幅度之间的差异来计算T波交替量度。