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    Cardiac Activation Sequence Monitoring for Ischemia Detection
    51.
    发明申请
    Cardiac Activation Sequence Monitoring for Ischemia Detection 失效
    缺血检测心脏激活序列监测

    公开(公告)号：US20100298729A1

    公开(公告)日：2010-11-25

    申请号：US12847657

    申请日：2010-07-30

    申请人： Yi Zhang ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Marina Brockway ,  Aaron R. McCabe ,  Yinghong Yu ,  Donald L. Hopper

    发明人： Yi Zhang ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Marina Brockway ,  Aaron R. McCabe ,  Yinghong Yu ,  Donald L. Hopper

    IPC分类号： A61B5/0452

    CPC分类号： A61N1/3702 ,  A61B5/0452 ,  A61B5/7203

    摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.

    摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。 缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。 可以使用后续分离来检测信号矢量的变化。 该变化可以是心​​脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。 该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。 与矢量相关联的信息可以被存储并用于跟踪矢量。

    Cardiac activation sequence monitoring for ischemia detection
    52.
    发明授权
    Cardiac activation sequence monitoring for ischemia detection 有权
    心脏激活序列监测缺血检测

    公开(公告)号：US07797036B2

    公开(公告)日：2010-09-14

    申请号：US11079744

    申请日：2005-03-14

    申请人： Yi Zhang ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Marina Brockway ,  Aaron R. McCabe ,  Yinghong Yu ,  Donald I. Hopper

    发明人： Yi Zhang ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Carlos Alberto Ricci ,  Marina Brockway ,  Aaron R. McCabe ,  Yinghong Yu ,  Donald I. Hopper

    IPC分类号： A61B5/04

    CPC分类号： A61N1/3702 ,  A61B5/0452 ,  A61B5/7203

    摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.

    摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。 缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。 可以使用后续分离来检测信号矢量的变化。 该变化可以是心​​脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。 该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。 与矢量相关联的信息可以被存储并用于跟踪矢量。

    Defibrillation threshold prediction methods and systems
    53.
    发明授权
    Defibrillation threshold prediction methods and systems 有权
    除颤阈值预测方法和系统

    公开(公告)号：US07711425B2

    公开(公告)日：2010-05-04

    申请号：US11208923

    申请日：2005-08-22

    申请人： Xuan Wei ,  Robert J. Sweeney ,  Joseph M. Bocek ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Yi Zhang

    发明人： Xuan Wei ,  Robert J. Sweeney ,  Joseph M. Bocek ,  Scott A. Meyer ,  Jeffrey E. Stahmann ,  Yi Zhang

    IPC分类号： A61N1/08 ,  A61N1/39

    CPC分类号： A61N1/3943

    摘要： A nondefibrillating and nonfibrillation-inducing energy is delivered at a first internal thoracic location. A first resulting electrical signal is detected at a second internal thoracic location in or near a target region of a heart. A first defibrillation threshold is estimated using the nondefibrillating and nonfibrillation-inducing energy, the first resulting electrical signal, and a target electric field strength. The defibrillation threshold represents an energy that when delivered at the first internal thoracic location creates an electric field strength in the target region of the heart that meets or exceeds the target electric field strength.

    摘要翻译： 在第一内部胸部位置输送非去纤颤和非诱导性能量。 在心脏的目标区域中或附近的第二内部胸部位置检测到第一个产生的电信号。 使用非去纤颤和非原纤维诱发能量，首先得到的电信号和目标电场强度来估计第一除颤阈值。 除颤阈值表示当在第一内部胸部位置递送时在心脏的目标区域中产生满足或超过目标电场强度的电场强度的能量。

    DEVICES AND METHODS FOR DISEASE DETECTION, MONITORING AND/OR MANAGEMENT
    54.
    发明申请
    DEVICES AND METHODS FOR DISEASE DETECTION, MONITORING AND/OR MANAGEMENT 审中-公开
    疾病检测，监测和/或管理的设备和方法

    公开(公告)号：US20080294060A1

    公开(公告)日：2008-11-27

    申请号：US11751111

    申请日：2007-05-21

    申请人： Carlos F. Haro ,  Kent Lee ,  Kenneth C. Beck ,  Yi Zhang ,  Jeffrey E. Stahmann

    发明人： Carlos F. Haro ,  Kent Lee ,  Kenneth C. Beck ,  Yi Zhang ,  Jeffrey E. Stahmann

    IPC分类号： A61B5/087

    CPC分类号： A61B5/087 ,  A61B5/03 ,  A61B5/0535 ,  A61B5/0809 ,  A61B5/6846

    摘要： Embodiments of the invention are related to methods and devices for respiratory or cardiac disease detection, monitoring, and/or management. In an embodiment, the invention includes a method of calculating a pulmonary function parameter of a subject. The method can include obtaining a first signal indicative of lung volume change during breathing from a first sensor, obtaining a second signal indicative of distending pressure from a second sensor, and calculating the pulmonary function parameter based on the first signal and the second signal. In an embodiment, the invention includes a method of monitoring pulmonary or cardiac disease status. In an embodiment, the invention includes an implantable medical device. The implantable medical device can include a first sensor configured to produce a first signal indicative of lung volume change during breathing, a second sensor configured to produce a second signal indicative of intrapleural pressure, and a processor configured to calculate lung compliance or pulmonary resistance based on the first signal and the second signal. Other aspects and embodiments are provided herein.

    摘要翻译： 本发明的实施例涉及用于呼吸或心脏疾病检测，监测和/或管理的方法和装置。 在一个实施例中，本发明包括计算受试者的肺功能参数的方法。 该方法可以包括获得指示来自第一传感器的呼吸期间的肺体积变化的第一信号，获得表示来自第二传感器的膨胀压力的第二信号，以及基于第一信号和第二信号计算肺功能参数。 在一个实施方案中，本发明包括监测肺或心脏疾病状态的方法。 在一个实施例中，本发明包括可植入医疗装置。 可植入医疗装置可以包括第一传感器，其被配置为产生指示呼吸期间肺体积变化的第一信号，配置成产生指示胸膜内压力的第二信号的第二传感器，以及被配置为基于以下步骤计算肺顺应性或肺阻力的处理器： 第一信号和第二信号。 本文提供了其它方面和实施例。

    Cardiac activation sequence monitoring and tracking
    57.
    发明授权
    Cardiac activation sequence monitoring and tracking 有权
    心脏激活序列监测和跟踪

    公开(公告)号：US07890159B2

    公开(公告)日：2011-02-15

    申请号：US10955397

    申请日：2004-09-30

    申请人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

    发明人： Yi Zhang ,  Scott A. Meyer ,  Aaron McCabe ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Carlos Alberto Ricci

    IPC分类号： A61B5/0428 ,  A61B5/0452

    CPC分类号： A61B5/04011 ,  A61B5/7203

    摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

    摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断和除颤和/或起搏疗法。 信号处理器接收与多个源相关联的多个复合信号，执行源分离，并且基于源分离产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号矢量。 信号分离的方法包括检测心脏信号矢量相对于基线的特征的变化。 可以选择一个或多个载体和/或激活序列，并且可以存储和跟踪与载体和/或激活序列相关联的信息。

    Detection of Stenosis
    58.
    发明申请
    Detection of Stenosis 审中-公开
    狭窄检测

    公开(公告)号：US20080139951A1

    公开(公告)日：2008-06-12

    申请号：US11608578

    申请日：2006-12-08

    申请人： Abhilash Patangay ,  Marina Brockway ,  Jeffrey E. Stahmann ,  Yi Zhang ,  Gerrard M. Carlson

    发明人： Abhilash Patangay ,  Marina Brockway ,  Jeffrey E. Stahmann ,  Yi Zhang ,  Gerrard M. Carlson

    IPC分类号： A61B5/026 ,  A61F2/82

    CPC分类号： A61B5/411 ,  A61B5/0031 ,  A61B5/02007 ,  A61B5/02158 ,  A61B5/026 ,  A61B5/0402 ,  A61B5/076 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61F2/02 ,  A61F2/91 ,  A61F2250/0002

    摘要： A system for detecting stenosis in a patient. The system includes an implantable sensing unit having a turbulence sensor and a communication device for transmitting a signal from the turbulence sensor. The system also includes a cardiac sensor for generating a signal corresponding to cardiac activity and a processing device configured to receive signals from the sensing unit and from the cardiac sensor. The processing device is configured to determine a time window corresponding to cardiac activity, to determine a turbulence level from the turbulence signal within the time window, and to detect the presence of stenosis from the turbulence level.

    摘要翻译： 一种用于检测患者狭窄的系统。 该系统包括具有湍流传感器的可植入感测单元和用于从湍流传感器发送信号的通信装置。 该系统还包括用于产生对应于心​​脏活动的信号的心脏传感器和被配置为从感测单元和心脏传感器接收信号的处理装置。 处理装置被配置为确定对应于心脏活动的时间窗口，以确定在时间窗口内的湍流信号的湍流水平，并且从湍流水平检测狭窄的存在。

    Arrhythmia discrimination using ECG's sensed from multiple implanted electrodes
    60.
    发明授权
    Arrhythmia discrimination using ECG's sensed from multiple implanted electrodes 有权
    使用从多个植入电极感测的心电图进行心律失常辨别

    公开(公告)号：US08321002B2

    公开(公告)日：2012-11-27

    申请号：US13027608

    申请日：2011-02-15

    申请人： Yi Zhang ,  Carlos A. Ricci ,  Jeffrey E. Stahmann ,  Aaron McCabe ,  Scott Meyer ,  Yinghong Yu

    发明人： Yi Zhang ,  Carlos A. Ricci ,  Jeffrey E. Stahmann ,  Aaron McCabe ,  Scott Meyer ,  Yinghong Yu

    IPC分类号： A61B5/0464

    CPC分类号： A61B5/04011 ,  A61B5/7203

    摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.

    摘要翻译： 心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些能力的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。 本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。 本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。 使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。 使用一个或多个心脏信号载体来区分心律失常。