公开(公告)号：US20050056867A1

公开(公告)日：2005-03-17

申请号：US10665189

申请日：2003-09-16

申请人： Krzysztof Nauka ,  Zhiyong Li ,  Theodore Kamins

发明人： Krzysztof Nauka ,  Zhiyong Li ,  Theodore Kamins

IPC分类号： G01N27/00 ,  G01N27/12 ,  H01G9/20 ,  H01L29/768

CPC分类号： H01G9/2031 ,  G01N27/002 ,  Y02E10/542 ,  Y02P70/521

摘要： Surface photovoltage is used for molecule sensing. The sensing is performed by exposing a surface of a semiconductor to molecules, and sensing a change in surface photovoltage of the semiconductor. Chemical and biological sensors may be based on such sensing.

摘要翻译： 表面光电压用于分子感测。 通过将半导体的表面暴露于分子并感测半导体的表面光电压的变化来进行感测。 化学和生物传感器可以基于这种感测。

公开(公告)号：US06855647B2

公开(公告)日：2005-02-15

申请号：US10405294

申请日：2003-04-02

申请人： Patricia A. Beck ,  Douglas Ohlberg ,  Duncan Stewart ,  Zhiyong Li

发明人： Patricia A. Beck ,  Douglas Ohlberg ,  Duncan Stewart ,  Zhiyong Li

IPC分类号： H01L21/28 ,  G11C13/02 ,  H01L21/285 ,  H01L27/28 ,  H01L29/06 ,  H01L21/26

CPC分类号： H01L27/28 ,  G11C13/02 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method is provided for fabricating molecular electronic devices comprising at least a bottom electrode and a molecular switch film on the bottom electrode. The method includes forming the bottom electrode by a process including: cleaning portions of the substrate where the bottom electrode is to be deposited; pre-sputtering the portions; depositing a conductive layer on at least the portions; and cleaning the top surface of the conductive layer. Advantageously, the conductive electrode properties include: low or controlled oxide formation (or possibly passivated), high melting point, high bulk modulus, and low diffusion. Smooth deposited film surfaces are compatible with Langmuir-Blodgett molecular film deposition. Tailored surfaces are further useful for SAM deposition. The metallic nature gives high conductivity connection to molecules. Barrier layers may be added to the device stack, i.e., Al2O3 over the conductive layer.

公开(公告)号：US20050026427A1

公开(公告)日：2005-02-03

申请号：US10930062

申请日：2004-08-30

申请人： Patricia Beck ,  Douglas Ohlberg ,  Duncan Stewart ,  Zhiyong Li

发明人： Patricia Beck ,  Douglas Ohlberg ,  Duncan Stewart ,  Zhiyong Li

IPC分类号： H01L21/28 ,  G11C13/02 ,  H01L21/285 ,  H01L27/28 ,  H01L29/06 ,  H01L21/00

CPC分类号： H01L27/28 ,  G11C13/02 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method is provided for fabricating molecular electronic devices comprising at least a bottom electrode and a molecular switch film on the bottom electrode. The method includes forming the bottom electrode by a process including: cleaning portions of the substrate where the bottom electrode is to be deposited; pre-sputtering the portions; depositing a conductive layer on at least the portions; and cleaning the top surface of the conductive layer. Advantageously, the conductive electrode properties include: low or controlled oxide formation (or possibly passivated), high melting point, high bulk modulus, and low diffusion. Smooth deposited film surfaces are compatible with Langmuir-Blodgett molecular film deposition. Tailored surfaces are further useful for SAM deposition. The metallic nature gives high conductivity connection to molecules. Barrier layers may be added to the device stack, i.e., Al2O3 over the conductive layer.

摘要翻译： 提供了一种用于制造分子电子器件的方法，该分子电子器件至少包括底部电极和底部电极上的分子开关膜。 该方法包括通过以下工艺形成底部电极，该方法包括：清洗要沉积底部电极的衬底的部分; 预溅射部分; 在至少部分上沉积导电层; 并清洁导电层的顶表面。 有利地，导电电极的性质包括：低或受控的氧化物形成（或可能钝化），高熔点，高体积弹性模量和低扩散。 光滑的沉积膜表面与Langmuir-Blodgett分子膜沉积相容。 定制的表面对于SAM沉积是更有用的。 金属性质使分子具有高导电性。 阻挡层可以被添加到器件堆叠，即在导电层上的Al 2 O 3。

公开(公告)号：US06815706B2

公开(公告)日：2004-11-09

申请号：US10323139

申请日：2002-12-17

申请人： Zhiyong Li ,  Yong Chen ,  Sean Xiao-An Zhang

发明人： Zhiyong Li ,  Yong Chen ,  Sean Xiao-An Zhang

IPC分类号： H01L2906

CPC分类号： H01L51/42 ,  H01L51/005 ,  H01L51/0071 ,  H01L51/0077 ,  H01L51/428 ,  Y02E10/549 ,  Y10S977/954

摘要： An optical sensor is provided, comprising (a) a silicon nanowire of finite length having an electrical contact pad at each end thereof; and (b) a plurality of self-assembled molecules on a surface of the silicon nanowire, the molecules serving to modulate electrical conductivity of the silicon nanowire by either a reversible change in dipole moment of the molecules or by a reversible molecule-assisted electron/energy transfer from the molecules onto the silicon nanowire. Further, a method of making the optical sensor is provided. The concept of molecular self-assembly is applied in attaching functional molecules onto silicon nanowire surfaces, and the requirement of molecule modification (hydroxy group in molecules) is minimal from the point view of synthetic difficulty and compatibility. Self-assembly will produce well-ordered ultra-thin films with strong chemical bonding on a surface that cannot be easily achieved by other conventional methods.

摘要翻译： 提供了一种光学传感器，其包括（a）有限长度的硅纳米线，其每端具有电接触焊盘; 和（b）在硅纳米线的表面上的多个自组装分子，所述分子用于通过分子的偶极矩的可逆变化或通过可逆分子辅助电子/分子调制硅纳米线的导电性， 能量从分子转移到硅纳米线上。 此外，提供了制造光学传感器的方法。 分子自组装的概念应用于将功能分子附着在硅纳米线表面上，从合成难度和相容性的观点来看，分子修饰（分子中的羟基）的要求是最小的。 自组装将产生在表面上具有强化学键合的良好有序的超薄膜，其不能通过其它常规方法实现。

公开(公告)号：US09664560B2

公开(公告)日：2017-05-30

申请号：US14381009

申请日：2012-03-06

申请人： R. Stanley Williams ,  Zhiyong Li

发明人： R. Stanley Williams ,  Zhiyong Li

IPC分类号： G01J3/02 ,  G01J3/44 ,  G01N21/65

CPC分类号： G01J3/0205 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/658 ,  G01N2201/06113 ,  G01N2201/068

摘要： A double-grating surface-enhanced Raman spectrometer. The spectrometer includes a substrate; a plurality of nanofingers carried by the substrate, the nanofingers arranged to define a first optical grating; a light source oriented to project a beam of light toward the first optical grating; a second optical grating oriented to receive a beam of light scattered from the first optical grating; and a detector oriented to receive a beam of light scattered from the second optical grating.

公开(公告)号：US20160251405A1

公开(公告)日：2016-09-01

申请号：US15137606

申请日：2016-04-25

申请人： Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

发明人： Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

IPC分类号： C07K14/475

CPC分类号： A61K38/19 ,  A23L33/17 ,  A23V2002/00 ,  A61K38/22 ,  A61K39/00 ,  C07K14/475 ,  C07K14/52

摘要： The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present invention further provides a method for preparing a mouse with fat-specific overexpression of Metrnl.

摘要翻译： 本发明提供Metrnl蛋白在制备降血脂，降血糖药或膳食补充剂中的应用。 本发明还提供了制备具有Metrn1脂肪特异性过表达的小鼠的方法。

公开(公告)号：US09377409B2

公开(公告)日：2016-06-28

申请号：US13194556

申请日：2011-07-29

申请人： Min Hu ,  Zhiyong Li ,  Fung Suong Ou ,  Ansoon Kim

发明人： Min Hu ,  Zhiyong Li ,  Fung Suong Ou ,  Ansoon Kim

IPC分类号： G01J3/44 ,  G01N21/65 ,  G01J3/02 ,  B82Y20/00

CPC分类号： G01N21/658 ,  B82Y20/00 ,  G01J3/0256 ,  G01J3/4412 ,  G01N2201/06113 ,  Y10S977/954 ,  Y10T29/49

摘要： In a method of fabricating an apparatus for use in a sensing application, a plurality of nano-fingers are formed on a substrate and a Raman-active material nano-particle is formed on respective tips of the nano-fingers. In addition, the Raman-active material nano-particles on the tips of adjacent ones of the nano-fingers are caused to come into contact with the Raman-active material nano-particle on the tip of at least another one of the plurality of nano-fingers to form respective clusters and the clusters of Raman-active material nano-particles are transferred to a component layer from the plurality of nano-fingers while maintaining a spatial relationship between the contacting Raman-active material nano-particles.

摘要翻译： 在制造用于感测应用的装置的方法中，在衬底上形成多个纳米指，并且在纳米手指的各个尖端上形成拉曼活性材料纳米颗粒。 另外，使相邻的纳米指尖的拉曼活性物质纳米粒子与多个纳米尺寸中的至少另一个的前端的拉曼活性物质纳米粒子接触 - 形成相应的簇，并且拉曼活性材料纳米颗粒簇从多个纳米指转移到组分层，同时保持接触拉曼活性材料纳米颗粒之间的空间关系。

公开(公告)号：US08848183B2

公开(公告)日：2014-09-30

申请号：US13188941

申请日：2011-07-22

申请人： Wei Yi ,  Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Zhiyong Li

发明人： Wei Yi ,  Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Zhiyong Li

IPC分类号： G01N21/65 ,  B82Y20/00 ,  B82Y40/00 ,  B82Y15/00

CPC分类号： G01N21/658 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y40/00 ,  Y10T29/49826 ,  Y10T428/24893

摘要： An apparatus includes a substrate and a plurality of nano-fingers attached at respective first ends to the substrate and freely movable along their lengths, in which a first set of the plurality of nano-fingers comprises a first physical characteristic, wherein a second set of the plurality of nano-fingers comprises a second physical characteristic, and wherein the first physical characteristic differs from the second physical characteristic.

摘要翻译： 一种装置包括：衬底和多个纳米指，其各自的第一端附接到衬底并且可沿其长度自由移动，其中多个纳米指的第一组包括第一物理特性，其中第二组 所述多个纳米指包含第二物理特性，并且其中所述第一物理特性与所述第二物理特性不同。

公开(公告)号：US20140198314A1

公开(公告)日：2014-07-17

申请号：US14239336

申请日：2011-10-18

申请人： Zhiyong Li ,  Ansoon Kim

发明人： Zhiyong Li ,  Ansoon Kim

IPC分类号： G01J3/44

CPC分类号： G01J3/4412 ,  G01N21/253 ,  G01N21/658

摘要： A molecular sensing device includes a substrate; a well i) formed in a material that is positioned on a surface of the substrate or ii) formed in a surface of the substrate; a signal amplifying structure positioned in the wed; and an immersion fluid deposited into the well and surrounding the signal amplifying structure.

摘要翻译： 分子感测装置包括基板; 形成在位于基板的表面上的材料中，或ii）形成在基板的表面中的材料; 定位在所述信号放大结构中的信号放大结构; 以及沉积到井中并围绕信号放大结构的浸没流体。

公开(公告)号：US08687186B2

公开(公告)日：2014-04-01

申请号：US13383387

申请日：2009-07-30

申请人： Shih-Yuan Wang ,  Jingjing Li ,  Huei Pei Kuo ,  David A. Fattal ,  Nobuhiko Kobayashi ,  Zhiyong Li

发明人： Shih-Yuan Wang ,  Jingjing Li ,  Huei Pei Kuo ,  David A. Fattal ,  Nobuhiko Kobayashi ,  Zhiyong Li

IPC分类号： G01J3/44

CPC分类号： G01N21/658 ,  B82Y15/00 ,  G01J3/44

摘要： Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate having a surface and a plurality of tapered nanowires disposed on the surface. Each nanowire has a tapered end directed away from the surface. The system also includes a plurality of nanoparticles disposed near the tapered end of each nanowire. When each nanowire is illuminated with light of a pump wavelength, Raman excitation light is emitted from the tapered end of the nanowire to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles.

摘要翻译： 本发明的实施方案涉及用于进行表面增强拉曼光谱的基于纳米线的系统。 在一个实施例中，系统包括具有设置在表面上的表面和多个锥形纳米线的基板。 每个纳米线具有远离表面的锥形端。 该系统还包括设置在每个纳米线的锥形端附近的多个纳米颗粒。 当每个纳米线被泵浦波长的光照射时，拉曼激发光从纳米线的锥形端发射以与纳米颗粒相互作用，并从位于紧邻纳米颗粒的分子产生增强的拉曼散射光。