公开(公告)号：US09377409B2

公开(公告)日：2016-06-28

申请号：US13194556

申请日：2011-07-29

Applicant: Min Hu ,  Zhiyong Li ,  Fung Suong Ou ,  Ansoon Kim

Inventor： Min Hu ,  Zhiyong Li ,  Fung Suong Ou ,  Ansoon Kim

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/02 ,  B82Y20/00

CPC classification number: G01N21/658 ,  B82Y20/00 ,  G01J3/0256 ,  G01J3/4412 ,  G01N2201/06113 ,  Y10S977/954 ,  Y10T29/49

Abstract: In a method of fabricating an apparatus for use in a sensing application, a plurality of nano-fingers are formed on a substrate and a Raman-active material nano-particle is formed on respective tips of the nano-fingers. In addition, the Raman-active material nano-particles on the tips of adjacent ones of the nano-fingers are caused to come into contact with the Raman-active material nano-particle on the tip of at least another one of the plurality of nano-fingers to form respective clusters and the clusters of Raman-active material nano-particles are transferred to a component layer from the plurality of nano-fingers while maintaining a spatial relationship between the contacting Raman-active material nano-particles.

Abstract translation: 在制造用于感测应用的装置的方法中，在衬底上形成多个纳米指，并且在纳米手指的各个尖端上形成拉曼活性材料纳米颗粒。 另外，使相邻的纳米指尖的拉曼活性物质纳米粒子与多个纳米尺寸中的至少另一个的前端的拉曼活性物质纳米粒子接触 - 形成相应的簇，并且拉曼活性材料纳米颗粒簇从多个纳米指转移到组分层，同时保持接触拉曼活性材料纳米颗粒之间的空间关系。

公开(公告)号：US20140198314A1

公开(公告)日：2014-07-17

申请号：US14239336

申请日：2011-10-18

Applicant: Zhiyong Li ,  Ansoon Kim

Inventor： Zhiyong Li ,  Ansoon Kim

IPC: G01J3/44

CPC classification number: G01J3/4412 ,  G01N21/253 ,  G01N21/658

Abstract: A molecular sensing device includes a substrate; a well i) formed in a material that is positioned on a surface of the substrate or ii) formed in a surface of the substrate; a signal amplifying structure positioned in the wed; and an immersion fluid deposited into the well and surrounding the signal amplifying structure.

Abstract translation: 分子感测装置包括基板; 形成在位于基板的表面上的材料中，或ii）形成在基板的表面中的材料; 定位在所述信号放大结构中的信号放大结构; 以及沉积到井中并围绕信号放大结构的浸没流体。

公开(公告)号：US09709538B2

公开(公告)日：2017-07-18

申请号：US14239330

申请日：2011-09-30

Applicant: Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

Inventor： Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

IPC: G01N31/22 ,  G01N21/64 ,  G01N21/65 ,  B01L3/00 ,  B82Y15/00

CPC classification number: G01N31/22 ,  B01L3/5085 ,  B01L3/50853 ,  B01L2200/141 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0819 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  G01N2201/0227 ,  G01N2201/023 ,  Y10T436/25

Abstract: Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining an externally accessible chamber and a seal to enclose at least a portion of the chamber. The example device also includes a substrate includes nanoparticles positioned within the chamber. The nanoparticles to react to the substance when exposed thereto. The example device also includes a non-analytic solution within the chamber to protect the nanoparticles from premature exposure.

公开(公告)号：US09678013B2

公开(公告)日：2017-06-13

申请号：US14394295

申请日：2012-04-20

Applicant: Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

Inventor： Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

IPC: G01N21/01 ,  G01N21/65 ,  G01N35/00 ,  B01L3/00 ,  G01N21/64

CPC classification number: G01N21/658 ,  B01L3/5088 ,  B01L2300/0627 ,  B01L2300/0819 ,  B01L2300/161 ,  G01N21/648 ,  G01N35/00009 ,  G01N2035/00019

Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures.

公开(公告)号：US09592001B2

公开(公告)日：2017-03-14

申请号：US14406601

申请日：2012-07-29

Applicant: Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

Inventor： Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

IPC: G01J3/44 ,  A61B5/1459 ,  G01N21/65 ,  A61B5/00

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/6862 ,  G01N21/658

Abstract: An implantable nanosensor includes a stent to be implanted inside a fluid conduit. The stent has a well in a surface of the stent. The implantable nanosensor further includes a nanoscale-patterned sensing substrate disposed in the well. The nanoscale-patterned sensing substrate is to produce an optical scattering response signal indicative of a presence of an analyte in a fluid carried by the fluid conduit when interrogated by an optical stimulus signal.

Abstract translation: 可植入纳米传感器包括待植入流体导管内的支架。 支架在支架表面有一个井。 可植入纳米传感器还包括设置在井中的纳米级图案感测基片。 纳米级图案化感测衬底将产生光学散射响应信号，该信号指示由光学刺激信号询问时由流体导管携带的流体中分析物的存在。

公开(公告)号：US20150241355A1

公开(公告)日：2015-08-27

申请号：US14406653

申请日：2012-07-31

Applicant: Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Steven Barcelo ,  Ansoon Kim ,  Mineo Yamakawa ,  Zhang-Lin Zhou ,  Huei Pei Kuo

Inventor： Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Steven Barcelo ,  Ansoon Kim ,  Mineo Yamakawa ,  Zhang-Lin Zhou ,  Huei Pei Kuo

IPC: G01N21/65 ,  A61F2/02 ,  A61F2/82 ,  G02B5/10

CPC classification number: G01N21/658 ,  A61F2/02 ,  A61F2/82 ,  G01N2201/068 ,  G02B5/10 ,  Y10T29/49826

Abstract: According to an example, an apparatus for performing spectroscopy includes a parabolic reflector and a plurality of surface-enhanced Raman spectroscopy (SERS) elements spaced from the parabolic reflector and positioned substantially at a focal point of the parabolic reflector. The parabolic reflector is to reflect Raman scattered light emitted from molecules in a near field generated by the plurality of SERS elements to substantially increase the flux of the Raman scattered light emitted out of the apparatus.

Abstract translation: 根据一个实例，用于执行光谱学的装置包括抛物面反射器和与抛物面反射器间隔开并且基本上位于抛物面反射器的焦点的多个表面增强拉曼光谱（SERS）元件。 抛物面反射器是反射由多个SERS元件产生的近场中的分子发射的拉曼散射光，以大大增加从该装置发出的拉曼散射光的通量。

公开(公告)号：US09442071B2

公开(公告)日：2016-09-13

申请号：US14394287

申请日：2012-04-24

Applicant: Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

Inventor： Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

IPC: G01J3/44 ,  G01B11/16 ,  G01N21/00 ,  G01N33/566 ,  G01N30/96 ,  G01N21/65 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01N2201/06113 ,  Y10S977/954

Abstract: An apparatus for performing a sensing application includes a reservoir to contain a solution, a dispenser to dispense the solution from the reservoir, and a substrate having a plurality of nano-fingers positioned to receive the dispensed solution, in which the plurality of nano-fingers are flexible, such that the plurality of nano-fingers are configurable with respect to each other. The apparatus also includes an illumination source to illuminate the received solution, an analyte introduced around the plurality of nano-fingers, and the plurality of nano-fingers, in which light is to be emitted from the analyte in response to being illuminated. The apparatus further includes a detector to detect the light emitted from the analyte.

Abstract translation: 用于执行感测应用的装置包括容纳溶液的储存器，用于从储存器分配溶液的分配器以及具有多个纳米手指的基板，该多个纳米手指定位成接收分配的溶液，其中多个纳米手指 是柔性的，使得多个纳米手指可相对于彼此配置。 所述装置还包括照亮所接收的溶液的照明源，围绕所述多个纳米手指引入的分析物和所述多个纳米手指，其中光将响应于被照亮从分析物发射。 该装置还包括检测器，用于检测从分析物发射的光。

公开(公告)号：US08993339B2

公开(公告)日：2015-03-31

申请号：US14006721

申请日：2011-03-23

Applicant: Ansoon Kim ,  Zhiyong Li ,  R Stanley Williams

Inventor： Ansoon Kim ,  Zhiyong Li ,  R Stanley Williams

IPC: G01N21/00 ,  G01N21/65 ,  G01N21/552 ,  G01N21/64

CPC classification number: G01N21/00 ,  G01N21/554 ,  G01N21/648 ,  G01N21/658

Abstract: A hybrid nanostructure for molecular analysis is disclosed. The structure includes a plurality of nanofingers wherein each nanofinger is coated with a metal coating, is attached at one end to a substrate, and is freely bendable along its length such that the second ends of each nanofinger are capable of movement toward each other to form a cavity. The structure further includes a nanoparticle trapped in the cavity. An array of hybrid nanostructures and a method for fabricating the hybrid nanostructures are also disclosed.

Abstract translation: 公开了用于分子分析的杂化纳米结构。 该结构包括多个纳米针，其中每个纳米针涂覆有金属涂层，其一端连接到基底，并且可沿其长度自由弯曲，使得每个纳米针的第二端能够朝向彼此移动以形成 一个空腔。 该结构还包括捕获在空腔中的纳米颗粒。 还公开了一系列混合纳米结构和制备混合纳米结构的方法。

公开(公告)号：US09638625B2

公开(公告)日：2017-05-02

申请号：US14345277

申请日：2011-10-27

Applicant: Ansoon Kim ,  Zhiyong Li ,  Wei Wu

Inventor： Ansoon Kim ,  Zhiyong Li ,  Wei Wu

IPC: G01J3/44 ,  G01N21/05 ,  G01N21/65 ,  G01N21/552 ,  G01N33/49 ,  G01N1/40 ,  B82Y20/00

CPC classification number: G01N21/05 ,  B82Y20/00 ,  G01N21/554 ,  G01N21/658 ,  G01N33/491 ,  G01N2001/4088 ,  G01N2021/651

Abstract: An apparatus for filtering species in a fluid includes a body having a first side and a second side, a first set of nano-fingers positioned on the body near the first side, a second set of nano-fingers positioned on the body closer to the second side than the first set of nano-fingers, wherein the nano-fingers in the second set of nano-fingers are arranged on the body at a relatively more densely than the nano-fingers in the first set of nano-fingers, and a cover positioned over the first set of nano-fingers and the second set of nano-fingers to form a channel with the body within which the first and second sets of nano-fingers are positioned.

公开(公告)号：US09588048B2

公开(公告)日：2017-03-07

申请号：US14118801

申请日：2011-05-20

Applicant: Ansoon Kim ,  Zhiyong Li

Inventor： Ansoon Kim ,  Zhiyong Li

IPC: G01N21/65 ,  G01J3/44 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44

Abstract: A surface enhanced Raman spectroscopy (SERS) sensor, system and method employ nanorods and independent nanoparticles that interact. The sensor includes at least two spaced apart nanorods attached at first ends to a substrate and an independent nanoparticle. Second ends of the nanorods are movable into close proximity to one another and include a Raman active surface. The nanoparticle has a functionalized surface that includes a Raman signal generator. An interaction between the nanoparticle and the nanorod second ends in close proximity is detectable. The system includes the SERS sensor, an illumination source and a Raman signal detector. The method includes illuminating the interaction of the nanoparticle and the nanorods with an analyte, and detecting an effect on a Raman signal caused by the analyte.

Abstract translation: 表面增强拉曼光谱（SERS）传感器，系统和方法采用纳米棒和独立纳米粒子相互作用。 传感器包括至少两个间隔开的纳米棒，其在第一端附着到基底和独立的纳米颗粒。 纳米棒的第二端可以彼此靠近移动并且包括拉曼活性表面。 纳米颗粒具有包括拉曼信号发生器的官能化表面。 纳米颗粒和纳米棒第二末端之间的相互作用是可以接近的。 该系统包括SERS传感器，照明源和拉曼信号检测器。 该方法包括用分析物照射纳米颗粒和纳米棒的相互作用，并检测由分析物引起的对拉曼信号的影响。