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154 条记录 (耗时 0.046 秒)

    Compositions and Methods for RNA Hybridization Applications
    51.
    发明申请
    Compositions and Methods for RNA Hybridization Applications 有权
    RNA杂交应用的组成和方法

    公开(公告)号：US20110306047A1

    公开(公告)日：2011-12-15

    申请号：US13203137

    申请日：2009-12-02

    申请人： Steen Hauge Matthiesen

    发明人： Steen Hauge Matthiesen

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： C12Q1/6841 ,  C12Q1/6832 ,  C12Q2527/125 ,  C12Q2527/137

    摘要： The invention provides methods and compositions for hybridizing at least one molecule to an RNA target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in RNA hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to enable hybridization to RNA.

    摘要翻译： 本发明提供了用于将至少一个分子与RNA靶标杂交的方法和组合物。 例如，本发明可以在RNA杂交应用中消除使用或减少对甲酰胺的依赖性。 用于本发明的组合物包括水性组合物，其包含至少一种核酸序列和至少一种极性非质子溶剂，其量有效使得能够与RNA杂交。

    Automated slide stainer with slide housing
    53.
    发明授权
    Automated slide stainer with slide housing 失效
    带滑动壳体的自动滑片染色机

    公开(公告)号：US07718435B1

    公开(公告)日：2010-05-18

    申请号：US09702298

    申请日：2000-10-31

    申请人： Steven A. Bogen ,  Herbert H. Loeffler

    发明人： Steven A. Bogen ,  Herbert H. Loeffler

    IPC分类号： G01N35/10 ,  G01N35/04

    CPC分类号： F04B23/025 ,  B01L3/0293 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/3032 ,  B05B11/3067 ,  B67D7/0216 ,  F04B43/08 ,  F04B53/107 ,  F16K15/144 ,  G01N1/312 ,  G01N35/1002 ,  G01N35/1016 ,  G01N2035/0443 ,  Y10T436/111666 ,  Y10T436/112499 ,  Y10T436/114998

    摘要： This invention describes a cartridge pump and dispensing assembly for applications where cartridges containing liquid reagents are interchanged often. The cartridge pump has a reagent reservoir which directly empties into a metering chamber. A valve is at each end of the metering chamber. The two valves are aligned in the same direction so as to allow unidirectional liquid flow. The metering chamber is made of a compressible material, such as flexible tubing, so that when an external compression is applied to the chamber, the liquid contained therein is forcibly expelled. As the compression is removed, the metering chamber resumes its former shape and draws liquid into the chamber from the reagent reservoir. A dispensing assembly with electromechanical actuators for compression of the metering chamber and a sensor for sensing the amount of liquid contained within the reagent reservoir are also shown.

    摘要翻译： 本发明描述了一种盒式泵和分配组件，用于其中经常与含有液体试剂的盒相互交换的应用。 墨盒泵具有直接排入计量室的试剂容器。 阀门位于计量室的每一端。 两个阀在相同的方向对准，以允许单向液体流动。 计量室由诸如柔性管的可压缩材料制成，使得当向腔室施加外部压缩时，其中容纳的液体被强制排出。 当压缩被去除时，计量室恢复其前一形状并将液体从试剂储存器抽入腔室。 还示出了具有用于压缩计量室的机电致动器和用于感测包含在试剂储存器中的液体量的传感器的分配组件。

    SYSTEMS AND METHODS FOR THE AUTOMATED PRE-TREATMENT AND PROCESSING OF BIOLOGICAL SAMPLES
    54.
    发明申请
    SYSTEMS AND METHODS FOR THE AUTOMATED PRE-TREATMENT AND PROCESSING OF BIOLOGICAL SAMPLES 审中-公开
    自动预处理和生物样品处理的系统和方法

    公开(公告)号：US20100017030A1

    公开(公告)日：2010-01-21

    申请号：US12494542

    申请日：2009-06-30

    申请人： Gordon Alan Feingold ,  James B. Gilmartin ,  Mark Richard Holbrook ,  John A. Favuzzi ,  Marc E. Key

    发明人： Gordon Alan Feingold ,  James B. Gilmartin ,  Mark Richard Holbrook ,  John A. Favuzzi ,  Marc E. Key

    IPC分类号： G06F19/00

    CPC分类号： G01N1/312 ,  G01N35/0092 ,  G01N35/0099 ,  G16H10/40 ,  G16H40/63 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/111666 ,  Y10T436/112499 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

    摘要： Systems and methods in accordance with embodiments of the present invention allow for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.

    摘要翻译： 根据本发明的实施例的系统和方法允许对存在于装置内的载玻片上的生物样品的染色装置进行自动控制和调度。 在一些实施例中，可以对与染色设备耦合的机器人的动作进行优先级排列，所述机器人根据各自的协议在各个幻灯片上执行一些染色任务。 在一些实施例中，调度可导致增加或最大化幻灯片的吞吐量。 在一些实施例中，机器人调度确保各个滑块基本上在其各自协议规定的公差内被处理。 在一些实施例中，机器人调度器可以响应自发的用户动作并且自适应地调度或重新调度机器人动作。

    MHC peptide complexes and uses thereof in infectious diseases
    60.
    发明授权
    MHC peptide complexes and uses thereof in infectious diseases 有权

    公开(公告)号：US10336808B2

    公开(公告)日：2019-07-02

    申请号：US13482472

    申请日：2012-05-29

    申请人： Jøgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    发明人： Jøgen Schøller ,  Henrik Pedersen ,  Liselotte Brix

    IPC分类号： C07K14/74 ,  A61K47/64 ,  G01N33/569 ,  A61K49/18 ,  G01N33/574 ,  A61K47/61 ,  A61K38/00

    摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.