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    Methods and Systems for Slide Processing
    4.
    发明申请
    Methods and Systems for Slide Processing 审中-公开
    幻灯片处理方法与系统

    公开(公告)号：US20160370264A1

    公开(公告)日：2016-12-22

    申请号：US15112310

    申请日：2015-01-17

    申请人： William Eugene CAMPBELL

    发明人： William Eugene CAMPBELL

    IPC分类号： G01N1/31

    CPC分类号： G01N1/312 ,  B01L9/52 ,  G01N1/2813 ,  G01N1/30 ,  G01N1/31 ,  G01N2001/317 ,  G02B21/34 ,  H04L12/02 ,  H04W4/80

    摘要： Various examples of systems and methods are provided for slide processing. In one example, among others, a system for processing microscope slides includes a slide positioner that can adjust a position of a slide and a slide treatment system that can dispense a micro stream of a fluid at a location on the slide when the slide is positioned beneath a jet nozzle of the slide treatment system. The system can include a slide sled that can align a smearing slide with a surface of the slide including a fluid sample is disposed, and support the smearing slide at a predefined angle with respect to the surface of the slide. In another example, a method includes obtaining a slide including a sample disposed on a surface, positioning the slide below to a jet nozzle, and dispensing a micro stream of a fluid onto the sample using the jet nozzle.

    摘要翻译： 提供了用于滑动处理的各种系统和方法的示例。 在一个示例中，其中包括用于处理显微镜幻灯片的系统，其包括滑块定位器，该滑块定位器可以调整滑块的位置和滑动处理系统，当滑块被定位时，可以在幻灯片上的位置处分配流体的微流 在滑动治疗系统的喷嘴下方。 系统可以包括滑动滑板，其可以使拖尾滑块与滑动件的表面对准，其中包括设置流体样本，并且相对于滑块的表面以预定的角度支撑拖尾滑动件。 在另一示例中，一种方法包括获得包括设置在表面上的样品的载玻片，将载玻片定位到喷嘴上，并使用喷嘴将流体的微流分配到样品上。

    System and method for anatomical pathology sample handling, storage, and analysis
    5.
    发明授权
    System and method for anatomical pathology sample handling, storage, and analysis 有权
    用于解剖病理学样本处理，储存和分析的系统和方法

    公开(公告)号：US09250253B2

    公开(公告)日：2016-02-02

    申请号：US13034958

    申请日：2011-02-25

    申请人： Rodney S. Markin

    发明人： Rodney S. Markin

    IPC分类号： G01N1/30 ,  B01L99/00 ,  B01L3/00 ,  C12M1/00 ,  G01N21/00 ,  A61B5/00 ,  G01N35/00 ,  B01L3/02 ,  G01N1/31 ,  G01N35/10

    CPC分类号： G01N1/312 ,  B01L3/0227 ,  B01L3/505 ,  B01L2200/141 ,  B01L2300/021 ,  B01L2300/0812 ,  B01L2300/123 ,  G01N1/30 ,  G01N1/31 ,  G01N33/4833 ,  G01N35/00009 ,  G01N35/00029 ,  G01N2001/317 ,  G01N2001/362 ,  G01N2035/1086 ,  Y10T436/25

    摘要： A carrier strip having a plurality of areas for retaining anatomical pathology specimens may have a backing, a cover coupled to the backing along side regions located along opposite longitudinal edges of the carrier strip and along lateral intermediate regions positioned between each of the plurality of areas for retaining anatomical pathology specimens. The carrier strip may be configured to individually retain each of the anatomical pathology specimens in one of the plurality of areas for retaining anatomical pathology specimens between the backing and the cover. Diagnostic studies of anatomical pathology specimens may be facilitated by distributing a digital copy of an image of the specimen may be to a pathologist. A diagnosis may be received from the pathologist based on the digital image of the specimen.

    摘要翻译： 具有用于保持解剖病理样本的多个区域的载体带可以具有背衬，沿着沿着载体条的相对纵向边缘定位的侧部区域以及位于多个区域中的每一个之间的侧向中间区域联接到背衬的盖， 保留解剖病理标本。 载体条可以被构造成将每个解剖病理样本保持在多个区域中的一个区域中，用于将解剖病理样本保留在背衬和盖之间。 解剖病理标本的诊断研究可以通过将样本的图像的数字副本分发给病理学家来实现。 可以根据样本的数字图像从病理学家接收诊断。

    AUTOMATIC DEVICE FOR CARRYING OUT DETECTION REACTIONS, AND METHOD FOR DOSING REAGENTS ONTO MICROSCOPE SLIDES
    8.
    发明申请
    AUTOMATIC DEVICE FOR CARRYING OUT DETECTION REACTIONS, AND METHOD FOR DOSING REAGENTS ONTO MICROSCOPE SLIDES 审中-公开
    用于携带检测反应的自动装置，以及用于将试剂加入微量滑动剂的方法

    公开(公告)号：US20110143393A1

    公开(公告)日：2011-06-16

    申请号：US12937808

    申请日：2009-04-14

    申请人： Hartmut Merz ,  Kay Van Der Wolk

    发明人： Hartmut Merz ,  Kay Van Der Wolk

    IPC分类号： G01N1/28 ,  C12M1/00

    CPC分类号： G01N1/312 ,  G01N35/1002 ,  G01N35/109 ,  G01N2001/317

    摘要： The invention relates to an automatic device to meter reagents onto a multitude of slides comprising holding devices for a multitude of slides which contain each a multitude of separated slots which are adapted to absorb cell or tissue samples; a dosing head unit with a multitude of reservoirs which are adapted to absorb liquid reagents and which have a metering valve at the end/side facing the slots to dose and apply the reagents into the slots; a positioning device to position the reservoirs of the dosing head unit above the respective slots of the slides.

    摘要翻译： 本发明涉及一种将试剂计量​​到多个载玻片上的自动装置，其包括用于多个载玻片的保持装置，每个载玻片含有适于吸收细胞或组织样本的多个分离的槽; 具有多个储存器的计量头单元，其适于吸收液体试剂，并且在面向狭缝的端部/侧具有计量阀，以将试剂施加到槽中; 定位装置，用于将计量头单元的储存器定位在载玻片的相应槽上方。

    Method and apparatus for computer controlled cell based diagnosis
    9.
    发明授权
    Method and apparatus for computer controlled cell based diagnosis 有权
    用于基于计算机控制的基于细胞的诊断的方法和装置

    公开(公告)号：US07346200B1

    公开(公告)日：2008-03-18

    申请号：US10130559

    申请日：1999-11-18

    申请人： Petros Tsipouras ,  Triantafyllos P. Tafas

    发明人： Petros Tsipouras ,  Triantafyllos P. Tafas

    IPC分类号： G06K9/00

    CPC分类号： G01N1/312 ,  G01N15/1475 ,  G01N2001/282 ,  G01N2001/317 ,  G01N2015/1006 ,  G01N2015/1472 ,  G01N2015/1477 ,  G01N2015/1488 ,  G01N2800/36 ,  G06K9/00127

    摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

    摘要翻译： 提供了一种用于检测和诊断组织样本中的稀有细胞类型的计算机控制方法，所述方法包括处理组织样本，使得其产生指示在罕见细胞的位置存在的第一信号，检测第一信号， 处理检测到第一信号的位置以产生指示诊断有用的细胞特征的第二信号并检测第二信号。 在染色之前或之后，第一信号可以是形态学或寻找细胞中存在的颜色。 第二信号可以通过原位PCR或PCR原位杂交产生。 在一个优选实施方案中，稀有细胞类型是母体血液组织样品中的胎儿细胞，所述样品由未培养的母体血液的涂片组成。 在另一个实施方案中，该方法用于诊断或基因型血液或组织活检样本中的癌细胞。