公开(公告)号：US20190350858A1

公开(公告)日：2019-11-21

申请号：US15982593

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/606 ,  A61K31/708 ,  A61K31/734 ,  A61K31/43 ,  A61K31/165

Abstract: The invention relates to an oral tablet for delivery of active ingredients to the gastrointestinal tract comprising a population of particles and an active ingredient to be delivered to the gastrointestinal tract, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in induced saliva generation upon mastication of the tablet, wherein the tablet is designed to be masticated and designed to deliver the active ingredient to the gastrointestinal tract as part of the saliva generated upon mastication of the tablet.

公开(公告)号：US20190350857A1

公开(公告)日：2019-11-21

申请号：US15982510

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/522

Abstract: The invention relates to an oral tablet for taste masking of active ingredients, the tablet comprising a population of particles and an active ingredient with off-note taste, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting at least partly in induced taste masking of the active ingredient upon mastication of the tablet.

公开(公告)号：US10426726B2

公开(公告)日：2019-10-01

申请号：US15302441

申请日：2015-04-08

Applicant: FERTIN PHARMA A/S

Inventor： Jesper Neergaard

IPC: A61K9/68 ,  A61K31/465 ,  A61K47/32 ,  A23G4/08 ,  A23G4/12 ,  A24B13/00 ,  A23G4/06

Abstract: The invention relates to a medical chewing gum comprising gum base polymers and an active pharmaceutical ingredient, the gum base polymers comprising polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight, wherein the gum base polymers include 20-95% by weight of polyvinyl acetate and -80% by weight of vinyl laurate-vinyl acetate copolymer, and wherein the chewing gum contains no polyterpene resins and no resins based on gum rosin, wood rosin or tall oil resin.

公开(公告)号：US20190255035A1

公开(公告)日：2019-08-22

申请号：US16065986

申请日：2018-06-25

Applicant: Fertin Pharma A/S

Inventor： Heidi Ziegler Bruun

IPC: A61K31/465 ,  A61K9/00 ,  A61K47/22 ,  A61K47/38

Abstract: A pouch designed for administration of an active ingredient in the oral cavity is disclosed, the pouch containing a matrix composition including a combination of nicotine and a water-soluble composition.

公开(公告)号：US20190174812A1

公开(公告)日：2019-06-13

申请号：US16213678

申请日：2018-12-07

Applicant: Fertin Pharma A/S

Inventor： Bruno Provstgaard Nielsen ,  Kent Albin Nielsen

IPC: A24B15/16 ,  A24B15/24

Abstract: The invention relates to a solid oral nicotine formulation for fast onset nicotine craving relief comprising nicotine and a pH regulating agent, wherein the formulation is designed to release the content of nicotine within a period of 90 seconds in contact with oral saliva and the formulation is designed to release the content of pH regulating agent within a period of 60 seconds in contact with oral saliva.

公开(公告)号：US20190134207A1

公开(公告)日：2019-05-09

申请号：US16095145

申请日：2016-04-21

Applicant: Fertin Pharma A/S

Inventor： Jesper Thorsen ,  Bjarne Vestbö ,  Birgitte Kringelum Breindal ,  Jesper Neergaard

IPC: A61K47/58 ,  A61K31/465 ,  A61K9/16 ,  A61K9/00 ,  A61K9/68

Abstract: The present invention relates to a nicotine delivery product comprising, or even consisting essentially of, a population of nicotine-loaded cation exchange resin particles, said population comprises at least 50% (w/w) particles having a size in the range of 90-300 micron which provides an improved nicotine stability to oral dosage forms comprising the nicotine delivery product. The invention furthermore relates to methods of producing the nicotine delivery product and the oral dosage forms and to the use of the nicotine delivery product.

公开(公告)号：US20190060228A1

公开(公告)日：2019-02-28

申请号：US15735723

申请日：2016-06-23

Applicant: Fertin Pharma A/S

Inventor： Heidi Ziegler BRUUN

IPC: A61K9/68 ,  A61K47/30 ,  A61K47/26 ,  A61K47/24 ,  A61P1/00 ,  A61K33/16 ,  A61K47/02

CPC classification number: A61K9/0058 ,  A61K33/16 ,  A61K47/02 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30 ,  A61P1/00

Abstract: The invention relates to a chewing gum composition for use in the alleviation of xerostomia induced by radiotherapy treatment, where the chewing gum composition comprises gum base and substantially no flavour ingredients. Moreover, the invention also relates to a dosage regimen for administering the chewing gum composition for use in alleviation of xerostomia induced by radiotherapy treatment. So in one embodiment of the invention the chewing gum composition is administered to a human subject before and/or during and/or after radiotherapy treatment.

公开(公告)号：US08828361B2

公开(公告)日：2014-09-09

申请号：US13948917

申请日：2013-07-23

Applicant: Carsten Andersen

Inventor： Carsten Andersen

IPC: A61K9/68 ,  A61K31/465

CPC classification number: A61K9/0058 ,  A23G4/068 ,  A23V2002/00 ,  A61K31/465 ,  A61K45/06 ,  A23V2200/30

Abstract: The invention relates to a tobacco alkaloid releasing chewing gum comprising tobacco alkaloid, gum base, and chewing gum ingredients, said gum base comprising elastomer and resin-compounds constituting an amount in the range of about 2 to 20% by weight of said chewing gum.

Abstract translation: 本发明涉及一种含烟草生物碱释放口香糖，其包含烟草生物碱，胶基和口香糖成分，所述胶基包含弹性体和树脂化合物，其量占所述口香糖约2至20重量％。

公开(公告)号：US08728444B2

公开(公告)日：2014-05-20

申请号：US13701482

申请日：2010-05-31

Applicant: Carsten Andersen

Inventor： Carsten Andersen

IPC: A61K31/787

CPC classification number: A61K31/787 ,  A61K9/0058 ,  A61K9/08 ,  A61K31/465

Abstract: A method of producing a nicotine delivery product includes preparing a first mixture including nicotine, a cation exchange resin and water by mixing the constituent components of the first mixture. The method optionally includes removing up to 85 wt. % of the water contained in the first mixture to form a second mixture. A mixture selected from the first and second mixtures is combined with further components to produce a nicotine delivery product.

Abstract translation: 制备尼古丁递送产物的方法包括通过混合第一混合物的组成成分制备包括尼古丁，阳离子交换树脂和水的第一混合物。 该方法任选地包括去除高达85wt。 包含在第一混合物中的水的百分比形成第二混合物。 将选自第一和第二混合物的混合物与其它组分组合以产生尼古丁递送产物。

公开(公告)号：US08623332B2

公开(公告)日：2014-01-07

申请号：US13360102

申请日：2012-01-27

Applicant: Bruno Provstgaard Nielsen ,  Jesper Neergaard

Inventor： Bruno Provstgaard Nielsen ,  Jesper Neergaard

IPC: A61K9/68

CPC classification number: A61K31/465 ,  A23G4/066 ,  A23G4/12 ,  A61K9/0058 ,  A61K31/787

Abstract: The present invention relates to a chewing gum having a high Surface Area to Volume ratio (SAV ratio), wherein said chewing gum comprises a water insoluble gum base matrix, a water soluble bulk portion and nicotine, wherein the gum base matrix, nicotine and the bulk portion are mixed and extruded to form a final extruded chewing gum product having a SAV ratio above 0.7, and wherein sustained release of nicotine is facilitated by adding 0.1-10% of C8-C10 triglycerides by weight of the chewing gum.

Abstract translation: 本发明涉及具有高表面积/体积比（SAV比）的口香糖，其中所述口香糖包括水不溶性胶基基质，水溶性本体部分和尼古丁，其中胶基基质，尼古丁和 将本体部分混合并挤出以形成具有高于0.7的SAV比率的最终挤出的口香糖产品，并且其中通过加入0.1-10％的口香糖重量的C8-C10甘油三酯来促进尼古丁的持续释放。