公开(公告)号：US20090011423A1

公开(公告)日：2009-01-08

申请号：US12183610

申请日：2008-07-31

申请人： Toshiyuki Saito ,  Yoji Mikami ,  Masahiro Kinugasa ,  Kazuya Mori ,  Michiyo Sugimoto ,  Koji Uchida

发明人： Toshiyuki Saito ,  Yoji Mikami ,  Masahiro Kinugasa ,  Kazuya Mori ,  Michiyo Sugimoto ,  Koji Uchida

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： To provide a novel method for determining the risk of lymph node metastasis of breast cancer uses as an index the difference in the expression levels of marker genes between metastatic breast cancer tissue (or cell) and non-metastatic breast cancer tissue (or cell). The method involves (1) measuring the expression level of a gene having a base sequence in human metastatic breast cancer tissue (or cell), (2) measuring the expression level of the same gene in human non-metastatic breast cancer tissue (or cell), and (3) comparing the expression level of (1) with the expression level of (2) and determine the risk of lymph node metastasis of breast cancer based on the difference between the expression levels.

摘要翻译： 提供一种确定乳腺癌淋巴结转移风险的新方法作为转移性乳腺癌组织（或细胞）与非转移性乳腺癌组织（或细胞）之间标记基因表达水平差异的指标。 该方法包括（1）测量人转移性乳腺癌组织（或细胞）中具有碱基序列的基因的表达水平，（2）测量人非转移性乳腺癌组织（或细胞）中相同基因的表达水平 ）和（3）比较（1）的表达水平与（2）的表达水平，并根据表达水平之间的差异确定乳腺癌淋巴结转移的风险。

公开(公告)号：US07091490B2

公开(公告)日：2006-08-15

申请号：US10684413

申请日：2003-10-15

申请人： Keiji Sumiya ,  Hiroyuki Ishibashi ,  Hideo Murayama ,  Naoko Inadama ,  Takaji Yamashita ,  Tomohide Omura

发明人： Keiji Sumiya ,  Hiroyuki Ishibashi ,  Hideo Murayama ,  Naoko Inadama ,  Takaji Yamashita ,  Tomohide Omura

IPC分类号： G01T1/20

CPC分类号： G01T1/2928 ,  G01T1/2018

摘要： A depth of interaction detector with uniform pulse-height comprises a multi-layer scintillator obtained by coupling at least two scintillator cells on a plane and then stacking the planar coupled scintillator cells, in layers, up to at least two stages and a light-receiving element connected to the bottom face of each scintillator cell of this multi-layer scintillator, wherein the detector is provided with a means for discriminating the position of a scintillator cell, which receives radiant rays and emits light rays and a means for making, uniform, the quantity of the light emitted from each scintillator cell and received by the light-receiving element. The detector can provide precise detection information even when radiation is absorbed by and emitted from a scintillator layer positioned above the scintillator layer optically coupled to the light-receiving element, permits the production of a depth of interaction detector having a three-dimensional depth of interaction-detecting function and can provide the same total output signal, which is independent of the position or a specific scintillator cell practically emitting light if the radiation energy is identical.

摘要翻译： 具有均匀脉冲高度的相互作用检测器的深度包括通过在平面上耦合至少两个闪烁体单元然后层叠平面耦合的闪烁体单元达到至少两个阶段而获得的多层闪烁体，以及光接收 连接到该多层闪烁体的每个闪烁体单元的底面的元件，其中检测器设置有用于识别接收辐射线并发射光线的闪烁体单元的位置的装置，以及用于使均匀的， 从每个闪烁体单元发射并由光接收元件接收的光的量。 即使当辐射被位于与光接收元件光耦合的闪烁体层上方的闪烁器层吸收和发射时，检测器也可以提供精确的检测信息，允许产生具有三维相互作用深度的相互作用检测器的深度 - 检测功能并且可以提供与位置无关的相同的总输出信号，或者如果辐射能量相同则实际发射光的特定闪烁体单元。

公开(公告)号：US4321474A

公开(公告)日：1982-03-23

申请号：US105925

申请日：1979-12-21

申请人： Eiichi Tanaka ,  Takehiro Tomitani ,  Katsumi Takami ,  Kenji Ishimatsu

发明人： Eiichi Tanaka ,  Takehiro Tomitani ,  Katsumi Takami ,  Kenji Ishimatsu

IPC分类号： H04B10/11 ,  H04B10/00 ,  H04B10/114 ,  H04B10/524 ,  H04B10/80 ,  G02B27/00

CPC分类号： H04B10/801

摘要： An apparatus for optically transmitting signals from a rotatable body to a stationary side or vice versa in a non-contact manner, includes a plurality of light emitting elements excited by a PCM signal from a signal source and a plurality of light receiving elements disposed in opposition with the light emitting elements for receiving light therefrom. A plurality of sets each including plural light receiving or emitting elements are provided at the stationary side in association with the respective light emitting or receiving elements disposed at the rotatable body side. Alternatively, a plurality of sets each including plural light emitting elements are provided at the rotatable body side in association with the respective light receiving elements disposed at the stationary side. The elements in such plural sets are selected in accordance with the rotation of the rotatable body.

摘要翻译： 一种用于以非接触方式将信号从可旋转体光学传输到静止侧或反之亦然的装置包括由来自信号源的PCM信号激励的多个发光元件和以对置方式设置的多个光接收元件 其中用于从其接收光的发光元件。 与设置在可旋转体侧的各个发光或接收元件相关联地，在固定侧设置有多个包含多个光接收或发光元件的组。 或者，与设置在固定侧的各个光接收元件相关联地，在可旋转体侧设置多个包括多个发光元件的组。 这些多组中的元件根据可旋转体的旋转来选择。

公开(公告)号：US20160136458A1

公开(公告)日：2016-05-19

申请号：US14944672

申请日：2015-11-18

申请人： Kabushiki Kaisha Toshiba ,  National Institute of Radiological Sciences

发明人： Yasunori TAGUCHI ,  Yukinobu SAKATA ,  Ryusuke HIRAI ,  Kyoka SUGIURA ,  Tomoyuki TAKEGUCHI ,  Shinichiro MORI ,  Fumi MARUYAMA

IPC分类号： A61N5/10 ,  G06T7/00 ,  G06T11/00 ,  G06T5/00

CPC分类号： A61N5/1049 ,  A61B6/022 ,  A61B6/032 ,  A61B6/12 ,  A61B6/486 ,  A61B6/5223 ,  A61B6/5235 ,  A61B6/5252 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1061 ,  A61N2005/1062 ,  G06T7/11 ,  G06T7/174 ,  G06T7/194 ,  G06T11/008 ,  G06T2207/10016 ,  G06T2207/10116 ,  G06T2207/10124 ,  G06T2207/30008

摘要： According to one embodiment, a medical image processing apparatus, includes: a first acquisition unit; a second acquisition unit; and a part-removed image generation unit, wherein the first acquisition unit is adapted to acquire a first radiograph that is a virtual radiograph generated to have a specified part or a predetermined part, among parts included in volume data indicative of a three-dimensional structure of an inside of a body of a patient, being emphasized, the second acquisition unit is adapted to acquire a second radiograph of the inside of the body of the patient, and the part-removed image generation unit is adapted to generate a part-removed image by removing the specified or predetermined part or parts other than the specified or predetermined part from the second radiograph with reference to the first radiograph.

摘要翻译： 根据一个实施例，医疗图像处理装置包括：第一获取单元; 第二采集单元; 以及部分去除图像生成单元，其中，所述第一获取单元适于获取作为生成为具有指定部分或预定部分的虚拟X射线照片的第一X射线照片，所述第一X射线照片是包括在指示三维结构 被强调的是，第二采集单元适于获取患者身体的内部的第二射线照片，并且部分去除图像生成单元适于产生部分去除的部分 通过参考第一放射照片从第二射线照相中移除指定或预定的部分或除了指定或预定部分之外的部分的图像。

公开(公告)号：US09226717B2

公开(公告)日：2016-01-05

申请号：US14495543

申请日：2014-09-24

申请人： NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES

发明人： Hideaki Tashima ,  Taiga Yamaya

IPC分类号： G01T1/20 ,  A61B6/03 ,  A61B6/00 ,  A61B6/04

CPC分类号： A61B6/037 ,  A61B6/0478 ,  A61B6/501

摘要： A helmet-type PET device includes a helmet portion (hemispherical detector) and an added portion (jaw portion detector, an ear portion detector, or a neck portion detector). The helmet portion includes a PET detector so as to cover a parietal region of an examination target. The added portion is positioned to dispose a PET detector at a part other than the parietal region of the examination target. PET measurement is performed using both an output from the PET detector at the helmet portion and an output from the PET detector at the added portion.

摘要翻译： 头盔式PET装置包括头盔部分（半球形检测器）和附加部分（颚部检测器，耳部检测器或颈部检测器）。 头盔部分包括PET检测器，以覆盖检查对象的顶叶区域。 所添加的部分定位成在检查对象的顶叶区域之外的部分处设置PET检测器。 使用头盔部分的PET检测器的输出和来自PET检测器的添加部分的输出进行PET测量。

公开(公告)号：US08945576B2

公开(公告)日：2015-02-03

申请号：US13520968

申请日：2011-01-11

申请人： Haruhisa Inoue ,  Hiroki Takeuchi ,  Ryosuke Takahashi ,  Makoto Higuchi ,  Bin Ji ,  Tetsuya Suhara

发明人： Haruhisa Inoue ,  Hiroki Takeuchi ,  Ryosuke Takahashi ,  Makoto Higuchi ,  Bin Ji ,  Tetsuya Suhara

IPC分类号： A61K39/00 ,  A61K38/00 ,  A61K38/16 ,  C07K14/47

CPC分类号： C07K14/4711 ,  A61K39/0005 ,  A61K39/0007 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K2319/02 ,  C12N2799/021

摘要： This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phosphorylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.

摘要翻译： 本发明涉及用于预防或治疗tau蛋白病的疫苗，其包含作为活性成分的载体，其包含编码与分泌信号序列连接的突变型tau蛋白的核酸，其中所述疫苗能够诱导针对（任选地 与直接施用突变型tau蛋白的情况相比，以更持续的方式在受试者中磷酸化tau蛋白。

公开(公告)号：US20140299784A1

公开(公告)日：2014-10-09

申请号：US14346856

申请日：2013-01-12

申请人： National Institute of Radiological Sciences

发明人： Shingo Kobayashi ,  Yukio Uchihori ,  Yoshiyuki Shirakawa

IPC分类号： G01N23/00 ,  G01T7/00

CPC分类号： G01N23/00 ,  G01T1/1648 ,  G01T7/00

摘要： A radioactive substance detection device that detects a radioactive substance being present in a specified direction. A radiation detection element having a thickness that stops and detects a characteristic X-ray arriving from a radioactive substance being present in the specified direction that radiates both gamma rays and the characteristic X-rays, and allows the gamma ray arriving from the radioactive substance to pass through. A screening body having a thickness that screens out characteristic X-rays of radiation which arrives from directions other than the specified direction and allows gamma rays of radiation which arrives from directions other than the specified direction to pass through.

摘要翻译： 一种放射性物质检测装置，其检测沿指定方向存在的放射性物质。 一种放射线检测元件，其具有停止并检测从放射性物质到达的特定X射线的特征X射线，该特定X射线以指定方向存在，辐射伽马射线和特征X射线，并且允许从放射性物质到达的γ射线 通过。 一种屏蔽体，其具有屏蔽从指定方向以外的方向到达的特定X射线的X射线的厚度，并允许从指定方向以外的方向到达的伽马射线通过。

公开(公告)号：US20140186261A1

公开(公告)日：2014-07-03

申请号：US14140218

申请日：2013-12-24

申请人： NIHON MEDI-PHYSICS CO., LTD. ,  NATIONAL CANCER CENTER ,  NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES

发明人： Yukie YOSHII ,  Takako Furukawa ,  Tsuneo Saga ,  Hiroki Matsumoto ,  Mitsuyoshi Yoshimoto

IPC分类号： A61K31/52 ,  A61K31/513 ,  A61K51/04

CPC分类号： A61K31/52 ,  A61K31/513 ,  A61K31/519 ,  A61K31/555 ,  A61K45/06 ,  A61K51/0474 ,  A61K51/0482 ,  A61K2300/00

摘要： An anti-tumor agent comprising combination of a radioactive diacetyl-bis(N4-methylthiosemicarbazone) copper complex and a metabolic inhibitor.

摘要翻译： 一种抗肿瘤剂，其包含放射性二乙酰基 - 双（N 4 - 甲基硫代缩氨基脲）铜络合物和代谢抑制剂的组合。

公开(公告)号：US20140166890A1

公开(公告)日：2014-06-19

申请号：US14124008

申请日：2012-02-02

申请人： Hisayoshi Shimizu ,  Fumio Murakawa ,  Zenichiro Shidara ,  Hidehito Nakamura ,  Yoshiyuki Shirakawa

发明人： Hisayoshi Shimizu ,  Fumio Murakawa ,  Zenichiro Shidara ,  Hidehito Nakamura ,  Yoshiyuki Shirakawa

IPC分类号： G01T1/203

CPC分类号： G01T1/2033 ,  C08G63/187 ,  C08G63/189 ,  C09K11/06 ,  C09K2211/1011

摘要： A resin for scintillators having high radiation sensitivity, which is obtained without using a wavelength conversion agent.The resin for the scintillator of a radiation detector contains a polyester having a unit represented by the following formula (1). (In the above formula (1), Ar is a naphthalenediyl group or an anthracenediyl group all of which may be substituted by an alkyl group having 1 to 6 carbon atoms or a halogen atom. X is an aliphatic hydrocarbon group having 2 to 20 carbon atoms, an alicyclic hydrocarbon group having 2 to 20 carbon atoms or an aromatic hydrocarbon group having 5 to 20 carbon atoms all of which may be substituted by an alkyl group having 1 to 6 carbon atoms or a halogen atom.)

摘要翻译： 用于不使用波长转换剂而获得的具有高辐射灵敏度的闪烁体的树脂。 用于辐射检测器的闪烁体的树脂含有具有由下式（1）表示的单元的聚酯。 （式（1）中，Ar为萘基或蒽基，全部可以被碳原子数1〜6的烷基或卤素原子取代，X为碳原子数为2〜20的脂肪族烃基 原子，碳原子数2〜20的脂环式烃基或碳原子数5〜20的芳香族烃基，全部可以被碳原子数1〜6的烷基或卤原子取代。）

公开(公告)号：US20140046180A1

公开(公告)日：2014-02-13

申请号：US14113334

申请日：2011-05-30

申请人： Taiga Yamaya ,  Hideaki Tashima ,  Mitsuo Watanabe ,  Eiichi Tanaka

发明人： Taiga Yamaya ,  Hideaki Tashima ,  Mitsuo Watanabe ,  Eiichi Tanaka

IPC分类号： A61B6/03 ,  A61N5/10

CPC分类号： A61B6/037 ,  A61B6/4258 ,  A61B6/4275 ,  A61B6/4447 ,  A61N5/1077 ,  A61N2005/1052 ,  G01T1/2985

摘要： An inclined PET device is provided in which the cut plane of a detector ring upon which a plurality of PET detectors are disposed is inclined so that it does not intersect perpendicularly with the long axis of a bed that carries a subject to be examined and in which an open space that passes through the bed in a direction perpendicular to the long axis thereof is formed, in order to enable access to the subject to be examined. The PET detectors are disposed and stacked in a direction parallel to the long axis of the bed. Thereby, the number of PET detectors is reduced and device cost is reduced, while the detector ring as well as the device can be miniaturized. At the same time, the open space that passes through the bed in a direction perpendicular to the long axis can be preserved.

摘要翻译： 提供一种倾斜的PET装置，其中设置有多个PET检测器的检测器环的切割平面倾斜，使得其不与携带受检对象的床的长轴垂直相交，并且其中 形成了沿垂直于其长轴的方向穿过床的开放空间，以便能够进入被检查对象。 PET检测器沿与床的长轴平行的方向设置和堆叠。 由此，能够使检测环和设备小型化，减少PET检测器的数量，降低设备成本。 同时，可以保持沿与长轴垂直的方向穿过床的开放空间。