摘要:
This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phosphorylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
摘要:
This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phosphorylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
摘要:
It is intended to provide an agent for regulating axon extension during neuranagenesis by regulating ephrin-Eph receptor signaling mechanisms and to provide a mouse having abnormal ephrin-Eph receptor signaling mechanisms. The present invention relates to a regulator of axon extension, comprising an agent for promoting or suppressing the function of α-chimerin, and to a miffy (mfy) mouse derived from a B6 strain, which displays autosomal recessive inheritance of an abnormal walking trait exhibiting a hopping gait with left-right synchronized movement of limbs and has mutation in an α-chimerin gene.
摘要:
An object of the present invention is to provide a substrate of Parkin, a system for elucidating the cause of Parkinson's disease using the substrate and a method of screening for a remedy for Parkinson's disease. An animal cell having a DNA encoding a human Pael receptor or a DNA having a variant of the DNA incorporated therein; a non-human mammal having a DNA carrying the aforementioned DNA incorporated therein; a probe comprising the whole or a part of DNA encoding the human Pael receptor; and an antibody specifically recognizing Pael receptor.
摘要:
Provided are a prophylactic and therapeutic agent for amyotrophic lateral sclerosis containing an HMG-CoA reductase inhibitor and a method of screening for a prophylactic and therapeutic drug for amyotrophic lateral sclerosis using an induced pluripotent stem cell derived from a patient with amyotrophic lateral sclerosis.
摘要:
It is intended to provide an agent for regulating axon extension during neuranagenesis by regulating ephrin-Eph receptor signaling mechanisms and to provide a mouse having abnormal ephrin-Eph receptor signaling mechanisms. The present invention relates to a regulator of axon extension, comprising an agent for promoting or suppressing the function of α-chimerin, and to a miffy (mfy) mouse derived from a B6 strain, which displays autosomal recessive inheritance of an abnormal walking trait exhibiting a hopping gait with left-right synchronized movement of limbs and has mutation in an α-chimerin gene.
摘要:
The present invention provides a prophylactic or therapeutic agent for amyotrophic lateral sclerosis, containing a 1,3-diphenylurea derivative or multikinase inhibitor.
摘要:
The present invention provides a method for detecting onset of, or the risk of development of, a protein misfolding disease, and a method for predicting the age of onset of a protein misfolding disease using nerve cells derived from iPS cells. The present invention also provides a kit to be used in these methods.
摘要:
A low-bed type seismic isolator for a display case, which includes: at least two lines of arcuate X-rails (3) fixed to a lower plate (1) on a foundation and having lower central portions and higher end portions; at least two lines of arcuate Y-rails (4) fixed to a lower surface of an upper plate (2) above the X-rails (3) and having higher central portions and lower end portions in a direction perpendicularly to the X-rails; connection blocks (5) having lower portions clamping the X-rails, upper portions clamping the Y-rails, and a disk spring provided at the central portions thereof; absorbers (8) disposed on the ends of the X-rails and Y-rails and recesses which fixedly accommodates support legs (7) fixed to the lower surface of the upper plate and protruded downwardly from a seismic isolation object. The seismic isolator does not substantially change the height of a seismic isolation object, and can be applied, for instance, to a display case of a museum, so as to provide the effective seismic isolation as well as to facilitate an inspection to a displayed exhibit The additional provision of casters makes it possible to readily move the seismic isolator to any arbitrary place.
摘要:
In a magnetic recording/playback apparatus for recording and playing back a digital video signal on a helical track of a magnetic tape using two or more rotary heads, the playback image at the time of high-speed playback is improved by setting the tape travel speed at the time of high-speed playback at an even multiple of a normal playback speed. Further a tracking phase is offset by one half the track pitch with respect to the tracking during normal speed playback. Alternatively, essential information of the information having been high-efficiency coded is recorded in the central part, and near the ends of the tracks, while high-precision information is recorded in intermediate parts intermediate between the central part and the parts near the ends. Still alternatively, the video data of one of the consecutive fields is recorded in the central part of the tracks and the video data of the other of the consecutive fields is recorded near the ends of the tracks.