公开(公告)号：US5884630A

公开(公告)日：1999-03-23

申请号：US773520

申请日：1996-12-23

申请人： Hiroshi Fujishima

发明人： Hiroshi Fujishima

IPC分类号： A61B3/10 ,  A61B5/11 ,  A61B19/00

CPC分类号： A61B5/1103 ,  A61B3/10 ,  A61B3/101 ,  A61B5/6821

摘要： Dry eyes are more objectively and exactly diagnosed on the basis a rate of decrease in corneal surface temperature due to the heat vaporization in tear evaporation as determined by measuring corneal surface temperatures in time course from one blinking to next blinking of eyes of patients by an infrared radiation thermometry.

摘要翻译： 根据通过测量角膜表面温度在时间过程中通过红外线测量患者眼睛的眨眼到下一次眼睛的角度来确定由于泪液蒸发中的热蒸发而导致的角膜表面温度降低的速率，干眼睛被更客观地和准确地诊断 放射测温。

公开(公告)号：US5807711A

公开(公告)日：1998-09-15

申请号：US525505

申请日：1995-09-22

申请人： Hiroshi Hara ,  Hiromitsu Yoshimura ,  Yumiko Matsuki ,  Saeko Shindo ,  Kazunori Hanada

发明人： Hiroshi Hara ,  Hiromitsu Yoshimura ,  Yumiko Matsuki ,  Saeko Shindo ,  Kazunori Hanada

IPC分类号： C07K14/475 ,  C12N15/19 ,  C07K1/32 ,  C12N5/10 ,  C12N15/18

CPC分类号： C07K14/4753

摘要： A novel parenchymal hepatocyte growth factor originating in a human or animal liver, having an estimated molecular weight according to nonreductive SDS-PAGE of about 63,000 to about 69,000, an estimated molecular weight according to reductive SDS-PAGE of about 32,000 to about 36,000 and an estimated molecular weight according to gel filtration of about 60 to about 70 Kd; and having an activity of effecting the growth of parenchymal hepatocyte has been obtained from the hemihepatectomized tissue. Furthermore, a gene coding for the above substance has been obtained from the mRNA of the above tissue and it has thus become possible to mass-produce the above substance.

摘要翻译： PCT No.PCT / JP94 / 00455 Sec。 371日期1995年9月22日 102（e）1995年9月22日PCT 1994年3月22日PCT公布。 公开号WO94 / 21678 日期1994年9月29日一种来源于人或动物肝脏的新型实质肝细胞生长因子，根据非还原性SDS-PAGE估计的分子量为约63,000至约69,000，根据还原性SDS-PAGE估计的分子量为约32,000 约36,000，并且根据凝胶过滤估计的约60至约70Kd的分子量; 并且具有影响实质肝细胞生长的活性已从半肝切除组织获得。 此外，从上述组织的mRNA获得编码上述物质的基因，因此可以大量生产上述物质。

公开(公告)号：US5545666A

公开(公告)日：1996-08-13

申请号：US290745

申请日：1995-04-19

申请人： Fumie Sato ,  Takehiro Amano ,  Kazuya Kameo ,  Tohru Tanami ,  Masaru Mutoh ,  Naoya Ono ,  Jun Goto

发明人： Fumie Sato ,  Takehiro Amano ,  Kazuya Kameo ,  Tohru Tanami ,  Masaru Mutoh ,  Naoya Ono ,  Jun Goto

IPC分类号： C07C405/00 ,  C01C405/00 ,  A61K31/557

CPC分类号： C07C405/0016

摘要： A prostaglandin derivative represented by formula ##STR1## wherein R.sup.1 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, and R.sup.2 represents a cyclohexyl group or a cyclopentylmethyl group. This compound has physiological activities such as platelet aggregation-inhibiting action, renal blood vessel and coronary blood vessel-dilating actions and the like, and is useful for treatment of renal failure and diseases of circulatory organs.

摘要翻译： PCT No.PCT / JP93 / 01493 Sec。 371日期1995年04月19日 102（e）1995年4月19日PCT PCT 1993年10月18日PCT公布。 公开号WO94 / 08959 日本1994年4月28日由式表示的前列腺素衍生物，其中R1表示氢原子或C1-C6烷基，R2表示环己基或环戊基甲基。 该化合物具有血小板聚集抑制作用，肾血管和冠状血管扩张作用等的生理活性，可用于治疗肾衰竭和循环器官疾病。

公开(公告)号：US5017383A

公开(公告)日：1991-05-21

申请号：US395594

申请日：1989-08-18

申请人： Yasuo Ozawa ,  Ikuo Koyama ,  Kimihide Shimano

发明人： Yasuo Ozawa ,  Ikuo Koyama ,  Kimihide Shimano

IPC分类号： A61K9/50

CPC分类号： A61K9/5089

摘要： A method of producing a fine coated pharmaceutical preparation, which includes cooling fine liquid droplets composed of a liquid medium, a drug dissolved or suspended in the liquid medium, and as required, a binder to a temperature of not higher than the freezing point of the liquid medium to form frozen particles of the drug and as required the binder, adjusting the particle sizes of the fine frozen particles, mixing the fine frozen particles with a fine powder of a coating material having a particle diameter smaller than the particles at a temperature higher than the freezing point of the liquid medium to cause the fine powder of the coating material to adhere to the surfaces of the particles, and then removing the liquid medium from the resulting coated particles.

公开(公告)号：US4963654A

公开(公告)日：1990-10-16

申请号：US309161

申请日：1989-02-13

申请人： Nobuhiko Katunuma

发明人： Nobuhiko Katunuma

IPC分类号： C07K14/81

CPC分类号： C07K14/811

摘要： A peptide having an amino acid sequence of the following formula ##STR1## is provided as an inhibitor of trypsin and trypsin-like serine proteases.

摘要翻译： 具有下式Ile-Ala-Ala-Cys-Asn-Leu-Pro-Ile-Val-Gln-Gly-Pro-Cys-Arg-Ala-Phe-Ala-Glu-Leu-Leu的氨基酸序列的肽 -Ala-Phe-Asp-Ala-Ala-Gln-Gly-Lys-Cys-Ile-Gln-Phe-Ile-Tyr-Gly-Gly-Cys-Lys-Gly-Asn-Asn-Asn-Lys-Phe-Tyr -Ser-Glu-Pro-Lys-Cys-Lys-Trp-Tyr-Cys-Gly-Val-Pro-Gly-Asp-Gly-Tyr作为胰蛋白酶和胰蛋白酶样丝氨酸蛋白酶的抑制剂。

公开(公告)号：US4948899A

公开(公告)日：1990-08-14

申请号：US397850

申请日：1989-08-24

申请人： Toshihisa Ogawa ,  Tomomi Ota ,  Shuichi Sato ,  Takemi Sunaga ,  Yoshiaki Watanabe ,  Katsuo Hatayama

发明人： Toshihisa Ogawa ,  Tomomi Ota ,  Shuichi Sato ,  Takemi Sunaga ,  Yoshiaki Watanabe ,  Katsuo Hatayama

IPC分类号： C07D211/90 ,  A61K31/445 ,  A61K31/451 ,  A61P9/12

CPC分类号： C07D211/90

摘要： A 1,4-dihydropyridine derivative represented by the formula ##STR1## wherein R.sup.1 is a hydrogen atom, an alkoxy group having 1 to 4 carbon atoms, a mercapto group, an alkylcarbonylthio group in which the alkyl group has 1 to 4 carbon atoms or a benzoylthio group, R.sup.2 is a mercapto group, an alkylcarbonylthio group in which the alkyl group has 1 to 4 carbon atoms, a benzoylthio group or a 2-cyanoethylthio group, A and B are the same or different and are each an alkylene group having 1 to 4 carbon atoms, and X is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group is disclosed. These compounds increase the therapeutic effect of drug-resistant cancers.

公开(公告)号：US4937332A

公开(公告)日：1990-06-26

申请号：US286171

申请日：1988-12-19

申请人： Chihiro Yokoo ,  Akira Onodera ,  Hiroshi Fukushima ,  Yoshiaki Watanabe ,  Kaoru Sota

发明人： Chihiro Yokoo ,  Akira Onodera ,  Hiroshi Fukushima ,  Yoshiaki Watanabe ,  Kaoru Sota

IPC分类号： A61K31/545 ,  C07D501/36 ,  C07D501/59

CPC分类号： C07D501/59 ,  Y02P20/55

摘要： A cephalosporin derivative represented by the general formula ##STR1## wherein R.sup.1 is a hydrogen atom or a protecting group of the amino group, R.sup.2 is a hydrogen atom or a protecting group of the hydroxyl group, R.sup.3 is a hydrogen atom or a protecting group of the carboxyl group, and R.sup.4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and the non-toxic salts thereof are useful as antibacterial agents.

公开(公告)号：US4906647A

公开(公告)日：1990-03-06

申请号：US103297

申请日：1987-10-01

申请人： Shozo Kouchiwa ,  Masami Nemoto ,  Tetsuo Yamaguchi ,  Atsuro Nakazato

发明人： Shozo Kouchiwa ,  Masami Nemoto ,  Tetsuo Yamaguchi ,  Atsuro Nakazato

IPC分类号： A61K31/455 ,  A61K9/20 ,  A61K31/44 ,  A61K47/00 ,  A61K47/02

CPC分类号： A61K47/02 ,  A61K31/44 ,  A61K9/2009 ,  Y10S514/97

摘要： Stabilized solid pharmaceutical preparations in which one or more of sodium carbonate, sodium hydrogen carbonate, calcium carbonate and calcium hydrogen phosphate are incorporated in a solid composition containing a 1,4-dihydropyridine derivative as an active ingredient. The present compositions are used as an oral therapeutic agent for the circulatory system, especially as a coronary vasodilator.

公开(公告)号：US4892740A

公开(公告)日：1990-01-09

申请号：US147860

申请日：1988-01-25

申请人： Yasuji Takasima ,  Ikuo Koyama ,  Kimihide Shimano ,  Kaoru Maezuru

发明人： Yasuji Takasima ,  Ikuo Koyama ,  Kimihide Shimano ,  Kaoru Maezuru

IPC分类号： A61K9/16 ,  A61K9/22 ,  A61K9/50 ,  A61K9/28

CPC分类号： A61K9/1635 ,  A61K9/5026 ,  A61K9/5089

摘要： An orally administrable pharmaceutical preparation of improved flavoring characteristics composed of a core material containing a drug and a coated layer applied to its surface, said coated layer being composed of a particulate polymeric substance having an average particle diameter of not more than 60 microns and being soluble in gastric juice; and a process for producing said orally administrable pharmaceutical preparation, which comprises causing minute liquid droplets of a volatile liquid containing a drug and optionally a gastric juice-soluble polymeric substance to fall onto a powder bed composed of a gastric juice-soluble particulate polymeric substance having an average particle diameter of not more than 60 microns to coat the surface of the liquid droplets with the gastric juice-soluble particulate polymeric substance, and drying the coated particles.

公开(公告)号：US4883876A

公开(公告)日：1989-11-28

申请号：US239687

申请日：1988-09-02

申请人： Shin-ichi Nakatsuka ,  Masatoshi Hayashi ,  Sadakazu Yokomori ,  Yoshimoto Nakashima ,  Katsuo Hatayama ,  Hiroaki Araki

发明人： Shin-ichi Nakatsuka ,  Masatoshi Hayashi ,  Sadakazu Yokomori ,  Yoshimoto Nakashima ,  Katsuo Hatayama ,  Hiroaki Araki

IPC分类号： C07D461/00

CPC分类号： C07D461/00

摘要： Vincaminic acid derivatives represented by the formula ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkoxyalkyl group having 2 to 6 carbon atoms, R.sup.2 is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a halogenated alkyl group having 1 to 5 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkoxycarbonylallyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, a phenyl group, a phenyl group substituted by alkoxy groups each having 1 or 2 carbon atoms or a thienyl group, A is a hydroxy group, B is a hydrogen atom, or A and B together form a valence bond, and the acid addition salts thereof are disclosed. These compound are useful as thereapeutic effect on cerebovascular injuries.