公开(公告)号：US4958339A

公开(公告)日：1990-09-18

申请号：US293048

申请日：1989-01-03

申请人： Ikuo Koyama ,  Hajime Ohata

发明人： Ikuo Koyama ,  Hajime Ohata

IPC分类号： G11B7/0033 ,  G11B7/013 ,  G11B7/09 ,  G11B19/28 ,  G11B27/30

CPC分类号： G11B7/0033 ,  G11B19/28 ,  G11B27/3027 ,  G11B7/013 ,  G11B7/0938

摘要： An optical card for storing data includes a base member and a plurality of parallel linear tracks on the base member for storing the data. Address data is recorded alternately on an opposite end of each successive track for storing an identifying code corresponding to the respective track.

摘要翻译： 用于存储数据的光卡包括基座构件和用于存储数据的基座构件上的多个平行线性轨道。 地址数据被交替记录在每个连续轨道的相对端上，用于存储对应于相应轨道的识别码。

公开(公告)号：US5707646A

公开(公告)日：1998-01-13

申请号：US295672

申请日：1994-09-09

申请人： Toshio Yajima ,  Kuniaki Ishii ,  Nobuo Umeki ,  Shigeru Itai ,  Hidefumi Hayashi ,  Kimihide Shimano ,  Ikuo Koyama

发明人： Toshio Yajima ,  Kuniaki Ishii ,  Nobuo Umeki ,  Shigeru Itai ,  Hidefumi Hayashi ,  Kimihide Shimano ,  Ikuo Koyama

IPC分类号： A61K9/14 ,  A61K20060101 ,  A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61K31/70 ,  A61K31/7048 ,  A61K47/02 ,  A61K47/04 ,  A61K47/10 ,  A61K47/30 ,  A61K47/32 ,  A61K47/44

CPC分类号： A61K9/1617 ,  A61K9/0095 ,  A61K9/1635 ,  Y10S514/974

摘要： A composition for oral preparations, having a complex formed by dispersing or dissolving an unpleasantly tasting basic drug and a functional polymer compound in a substance having a low melting point, 10 to 70% by weight, based on the composition, of sugar alcohol and 0.1 to 7% by weight, based on the composition, of basic oxide. The composition for oral preparation is excellent in masking unpleasantly tasting basic drugs and has excellent performance in biological use.

摘要翻译： PCT No.PCT / JP93 / 00291 Sec。 371日期1994年9月9日 102（e）1994年9月9日PCT 1993年3月10日PCT公布。 公开号WO93 / 17667 日本1993年9月16日一种口服制剂的组合物，其具有通过将不愉快的品尝碱性药物和功能性高分子化合物分散或溶解在基于组合物的10〜70重量％的低熔点物质中形成的复合物， 的糖醇和0.1〜7重量％，基于组成，碱性氧化物。 用于口服制剂的组合物在掩蔽令人不愉快的基本药物中具有优异的性能，并且在生物学应用中具有优异的性能。

公开(公告)号：US5017383A

公开(公告)日：1991-05-21

申请号：US395594

申请日：1989-08-18

申请人： Yasuo Ozawa ,  Ikuo Koyama ,  Kimihide Shimano

发明人： Yasuo Ozawa ,  Ikuo Koyama ,  Kimihide Shimano

IPC分类号： A61K9/50

CPC分类号： A61K9/5089

摘要： A method of producing a fine coated pharmaceutical preparation, which includes cooling fine liquid droplets composed of a liquid medium, a drug dissolved or suspended in the liquid medium, and as required, a binder to a temperature of not higher than the freezing point of the liquid medium to form frozen particles of the drug and as required the binder, adjusting the particle sizes of the fine frozen particles, mixing the fine frozen particles with a fine powder of a coating material having a particle diameter smaller than the particles at a temperature higher than the freezing point of the liquid medium to cause the fine powder of the coating material to adhere to the surfaces of the particles, and then removing the liquid medium from the resulting coated particles.

公开(公告)号：US4892740A

公开(公告)日：1990-01-09

申请号：US147860

申请日：1988-01-25

申请人： Yasuji Takasima ,  Ikuo Koyama ,  Kimihide Shimano ,  Kaoru Maezuru

发明人： Yasuji Takasima ,  Ikuo Koyama ,  Kimihide Shimano ,  Kaoru Maezuru

IPC分类号： A61K9/16 ,  A61K9/22 ,  A61K9/50 ,  A61K9/28

CPC分类号： A61K9/1635 ,  A61K9/5026 ,  A61K9/5089

摘要： An orally administrable pharmaceutical preparation of improved flavoring characteristics composed of a core material containing a drug and a coated layer applied to its surface, said coated layer being composed of a particulate polymeric substance having an average particle diameter of not more than 60 microns and being soluble in gastric juice; and a process for producing said orally administrable pharmaceutical preparation, which comprises causing minute liquid droplets of a volatile liquid containing a drug and optionally a gastric juice-soluble polymeric substance to fall onto a powder bed composed of a gastric juice-soluble particulate polymeric substance having an average particle diameter of not more than 60 microns to coat the surface of the liquid droplets with the gastric juice-soluble particulate polymeric substance, and drying the coated particles.

公开(公告)号：US5227171A

公开(公告)日：1993-07-13

申请号：US623422

申请日：1990-12-13

申请人： Ikuo Koyama ,  Kimihide Shimano ,  Eri Makabe ,  Yasuo Ozawa

发明人： Ikuo Koyama ,  Kimihide Shimano ,  Eri Makabe ,  Yasuo Ozawa

IPC分类号： A61K9/16 ,  A61K9/32 ,  A61K9/50

CPC分类号： A61K9/1658 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/5026

摘要： The present invention relates to a process for producing a flavored pharmaceutical preparation for oral administraiton and more particularly to a process for producing a flavored pharmaceutical preparation for oral administration, characterized by spraying, in a moistened and heated air, a suspension of a drug or drug-containing particles dispersed in a cold water solution of polyvinyl acetal diethylaminoacetate, and drying the resulting fine particles. Therefore, the present invention has made it possible to provide a process for producing, at a high yield, a flavored pharmaceutical preparation for oral administration wherein the taste of a drug contained therein is well masked and whose bioavailability is as good as that of a powder of the drug itself.

公开(公告)号：US4853249A

公开(公告)日：1989-08-01

申请号：US928370

申请日：1986-11-10

申请人： Yasuji Takashima ,  Ikuo Koyama ,  Tooru Maki ,  Katsu Nakamori

发明人： Yasuji Takashima ,  Ikuo Koyama ,  Tooru Maki ,  Katsu Nakamori

IPC分类号： A61K9/22 ,  A61K9/50 ,  A61K9/54

CPC分类号： A61K9/5078

摘要： A method of preparing a sustained-release pharmaceutical preparation, which comprises applying a solution of a binder in water or an alcohol and a fine powder of a hydrophobic solid material which does not easily dissolve within the stomach and intestines to the surface of solid particles containing a drug while the solid particles are being tumbled, thereby to coat the solid particles with the binder and the hydrophobic solid material.

摘要翻译： 一种制备持续释放药物制剂的方法，其包括将粘合剂在水或醇中的溶液和不易溶于胃和肠内的疏水性固体材料的细粉末涂覆到含有 药物，同时固体颗粒被翻转，从而用粘合剂和疏水性固体材料涂覆固体颗粒。

公开(公告)号：US5565213A

公开(公告)日：1996-10-15

申请号：US318750

申请日：1994-10-21

申请人： Katsu Nakamori ,  Tsuguchika Yoshida ,  Ikuo Koyama ,  Toshiaki Nakajima ,  Mikiko Odawara

发明人： Katsu Nakamori ,  Tsuguchika Yoshida ,  Ikuo Koyama ,  Toshiaki Nakajima ,  Mikiko Odawara

IPC分类号： A61K9/127 ,  A61K47/18 ,  A61K47/20 ,  B01J13/00 ,  B01J13/02

CPC分类号： A61K9/1272 ,  A61K9/127 ,  B01J13/0021 ,  Y10T428/2984

摘要： A liposome aqueous suspension containing taurine and benzalkonium chloride is disclosed. The liposome aqueous suspension undergoes no precipitation, agglomeration or change in particle size even when preserved at 40.degree. C. for 6 months and is inhibited from lyso-phospholipid formation.

摘要翻译： PCT No.PCT / JP92 / 00512 Sec。 371日期：1994年10月21日 102（e）日期1994年10月21日PCT提交1992年4月21日PCT公布。 公开号WO93 / 20934 日期：1993年10月28日公开了含有牛磺酸和苯扎氯铵的脂质体水性悬浮液。 即使在40℃下保存6个月，脂质体水悬浮液也不会发生沉淀，附聚或粒径变化，并被抑制溶解磷脂形成。