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    STABILISATION OF POLYPEPTIDES
    51.
    发明申请
    STABILISATION OF POLYPEPTIDES 审中-公开
    聚氨酯的稳定性

    公开(公告)号：US20140294757A1

    公开(公告)日：2014-10-02

    申请号：US14349481

    申请日：2012-10-05

    申请人： Stabilitech Ltd.

    发明人： Jeffrey Drew ,  David Thomas Woodward ,  Stephen Ward

    IPC分类号： A61K39/39 ,  A61K47/26 ,  A61K47/20 ,  A61K47/18 ,  A61K47/22

    CPC分类号： A61K39/39 ,  A61K9/19 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K2800/84 ,  C12N9/96

    摘要： A method for preserving a polypeptide comprising: (a) providing an aqueous solution of (i) the polypeptide, (ii) one or more sugars, and (iii) a compound of formula (I) or a physiologically acceptable salt or ester thereof and/or a compound of formula (II) or a physiologically acceptable salt or ester thereof; and (b) drying the solution to form a composition incorporating the polypeptide.

    摘要翻译： 一种保存多肽的方法，包括：（a）提供（i）多肽，（ii）一种或多种糖，和（iii）式（I）化合物或其生理学上可接受的盐或酯的水溶液，和 /或式（II）化合物或其生理学上可接受的盐或酯; 和（b）干燥该溶液以形成掺入多肽的组合物。

    METHOD OF PREPARING CARRIER LIQUIDS
    52.
    发明申请
    METHOD OF PREPARING CARRIER LIQUIDS 有权
    制备载体液体的方法

    公开(公告)号：US20140212466A1

    公开(公告)日：2014-07-31

    申请号：US14241965

    申请日：2012-08-20

    申请人： Alison Jayne Foster ,  James Long ,  Steven Paul Rannard ,  Dong Wang

    发明人： Alison Jayne Foster ,  James Long ,  Steven Paul Rannard ,  Dong Wang

    IPC分类号： B01F3/20 ,  A23L1/236 ,  A23L1/22 ,  A61K9/10 ,  A01N25/04

    CPC分类号： B01F3/2064 ,  A01N25/04 ,  A01N31/12 ,  A01N47/38 ,  A01N53/00 ,  A23L27/30 ,  A23L27/82 ,  A61K8/04 ,  A61K9/10 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K2800/10 ,  A61K2800/412 ,  A61K2800/413 ,  A61K2800/84 ,  A61Q19/00 ,  B82Y40/00 ,  A01N2300/00

    摘要： The invention provides a method for the preparation of a carrier liquid which comprises the steps of: (I) preparing a single phase solution comprising: (a) a solvent or a mixture of miscible solvents, (b) a liquid carrier material, which is soluble in solvent (a), and (c) a dopant material which is also soluble in solvent (a); (II) cooling (preferably freezing) the single phase solution produced in step (I) to a temperature at which at least both the solvent (a) and carrier material (b) become solid; and (III) removing solid solvent (a) from the cooled (frozen) single phase solution in vapour form, such that the remaining cooled (frozen) carrier material (b) and dopant material (c) are returned to ambient temperature thus providing a product of liquid carrier material (b) having dopant material (c) dispersed therein.

    摘要翻译： 本发明提供了一种制备载体液体的方法，其包括以下步骤：（I）制备单相溶液，其包含：（a）溶剂或可混溶溶剂的混合物，（b）液体载体材料， 溶于溶剂（a），和（c）也可溶于溶剂（a）的掺杂剂材料; （II）将步骤（I）中制备的单相溶液冷却（优选冷冻）至至少溶剂（a）和载体材料（b）两者变为固体的温度; 和（III）从蒸气形式的冷却（冷冻）单相溶液中除去固体溶剂（a），使得剩余的冷冻（冷冻）载体材料（b）和掺杂剂材料（c）返回到环境温度，从而提供 具有分散在其中的掺杂剂材料（c）的液体载体材料（b）的产物。

    Highly bioavailable coenzyme Q-10 cyclodextrin complex
    53.
    发明授权
    Highly bioavailable coenzyme Q-10 cyclodextrin complex 有权
    高生物可利用的辅酶Q-10环糊精复合物

    公开(公告)号：US07030102B1

    公开(公告)日：2006-04-18

    申请号：US10748096

    申请日：2003-12-30

    申请人： Doddabele L. Madhavi ,  Daniel I. Kagan

    发明人： Doddabele L. Madhavi ,  Daniel I. Kagan

    IPC分类号： A61K31/715

    CPC分类号： A61K31/122 ,  A61K8/0225 ,  A61K8/347 ,  A61K8/738 ,  A61K31/724 ,  A61K47/6951 ,  A61K2800/84 ,  A61Q11/00 ,  B82Y5/00 ,  C08B37/0015 ,  C08L5/16 ,  A61K2300/00

    摘要： The present invention is based on the unexpected discovery that CoQ-10 can be made commercially in a highly bioavailable form suitable for topical, sublingual formulations, or for oral ingestion. One such bioavailable form is a water dispersible freeze-dried CoQ-10/γ-cyclodextrin complex. Complexation in general with γ- or α-cyclodextrin improved the cellular uptake of CoQ-10 as compared to water dispersible liposomal or micellar forms of CoQ-10. Thus, the present invention includes a highly bioavailable CoQ-10/cyclodextrin complex for use in the nutritional supplement, oral care, and pharmaceutical industry.

    摘要翻译： 本发明基于意想不到的发现，CoQ-10可以以适于局部，舌下制剂或口服摄取的高度生物可利用形式在商业上制备。 一种这样的生物可利用形式是水分散性冷冻干燥的CoQ-10 /γ-环糊精复合物。 与水分散性脂质体或胶束形式的CoQ-10相比，通常与γ-或α-环糊精的络合改善了CoQ-10的细胞摄取。 因此，本发明包括用于营养补充剂，口腔护理和制药工业中的高度生物可利用的CoQ-10 /环糊精复合物。

    Dry compositions for preparing submicron emulsions
    55.
    发明授权
    Dry compositions for preparing submicron emulsions 失效
    用于制备亚微米乳液的干组合物

    公开(公告)号：US5472706A

    公开(公告)日：1995-12-05

    申请号：US16913

    申请日：1993-02-12

    申请人： Doron Friedman ,  Yanir Aldouby

    发明人： Doron Friedman ,  Yanir Aldouby

    IPC分类号： A61K8/06 ,  A61K8/44 ,  A61K9/107 ,  A61K9/19 ,  A61K47/18 ,  A61Q19/00 ,  A61K9/127

    CPC分类号： B82Y5/00 ,  A61K47/183 ,  A61K8/06 ,  A61K8/062 ,  A61K8/44 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/19 ,  A61Q19/00 ,  A61K2800/21 ,  A61K2800/84 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/943

    摘要： The present invention relates to dry, stable compositions which can be reconstituted to form pharmaceutical or cosmetic emulsions, and to methods for making such compositions. An emulsion is formed from about 0.2 to 25 weight percent of a first component of an oil, about 0.1 to 5 weight percent of a second component of an emulsifier, about 0.25 to 25 weight percent of a cryoprotectant of an amino compound, such as one or more amino acids, peptides or protein hydrolysates, and an aqueous component, wherein the amino compound is present in an amount that is equal to or greater than that of the first component. Optionally, a co-emulsifier, a suspension agent, a preservative, an antioxidant and a drug can be added to these emulsions. Thereafter, the emulsion is lyophilized to form dry compositions that have from about 40 to about 90 weight percent of the amino compound; from about 0.1 to about 20 weight percent of the emulsifier; and from about 0.2 to about 40 weight percent of the oily component. By combining the dry composition with an appropriate quantity of an aqueous liquid, the composition is reformed as an oil-in-water emulsion.

    摘要翻译： 本发明涉及可重构以形成药物或化妆品乳剂的干燥，稳定的组合物，以及制备这种组合物的方法。 乳液由约0.2至25重量％的第一组分油，约0.1至5重量％的第二组分的乳化剂，约0.25至25重量％的氨基化合物的冷冻保护剂，例如一种 或更多的氨基酸，肽或蛋白质水解物，和水性组分，其中氨基化合物的存在量等于或大于第一组分的量。 任选地，可以向这些乳液中加入共乳化剂，悬浮剂，防腐剂，抗氧化剂和药物。 此后，将乳液冻干以形成具有约40至约90重量％氨基化合物的干燥组合物; 约0.1至约20重量％的乳化剂; 和约0.2至约40重量％的油性组分。 通过将干组合物与适量的水性液体混合，将组合物重整为水包油乳液。

    New process for preparing pharmaceutical, cosmetic or diagnostic formulations
    57.
    发明授权
    New process for preparing pharmaceutical, cosmetic or diagnostic formulations 失效
    制备药物，化妆品或诊断制剂的新方法

    公开(公告)号：US4178695A

    公开(公告)日：1979-12-18

    申请号：US875542

    申请日：1978-02-06

    申请人： Angelo Erbeia

    发明人： Angelo Erbeia

    IPC分类号： A61K49/00 ,  A01N1/02 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61K9/14 ,  A61K9/19 ,  A61K9/20 ,  A61Q19/00 ,  A61Q90/00 ,  B01D9/04 ,  B01D43/00 ,  F26B5/06 ,  F26B7/00

    CPC分类号： F26B5/06 ,  A61K8/0283 ,  A61K8/365 ,  A61K8/368 ,  A61K8/8176 ,  A61K9/19 ,  A61K9/2095 ,  A61Q19/00 ,  A61K2800/222 ,  A61K2800/412 ,  A61K2800/524 ,  A61K2800/56 ,  A61K2800/652 ,  A61K2800/84

    摘要： The process produces pharmaceutical, cosmetic or diagnostic formulations by the freeze drying of one or more substances in solution or in suspension in a solvent or a mixture of solvents. The solution or suspension is locally and progressively cooled in a controlled manner while agitating so as to produce microcrystals of solvent which are put in suspension in the remainder of the liquid until there is obtained a high-viscosity microcrystalline complex system comprising essentially isolated microcrystals of solvent in intimate mixture with interstitial liquid phases having a high concentration of the initially present substances. The microcrystalline complex system is hardened by cooling and lyophilized. This process permits the obtainment of lyophilized formulations having a higher dissolving or dispersing rate and lyophilized compositions of normally incompatible substances.

    摘要翻译： 该方法通过将溶液中的一种或多种物质或溶剂或溶剂混合物中的悬浮液冷冻干燥来产生药物，化妆品或诊断制剂。 溶液或悬浮液以受控的方式局部和逐渐冷却，同时搅拌，以产生溶剂的微晶，将其悬浮在剩余液体中，直到获得包含基本上分离的溶剂微晶的高粘度微晶复合体系 与具有高浓度的初始存在物质的间质液相紧密混合。 微晶复合体系通过冷却和冻干来硬化。 该方法允许获得具有较高溶解度或分散速率的冻干制剂以及通常不相容物质的冻干组合物。

    Refillable Package For A Frozen Personal Care Product
    59.
    发明申请
    Refillable Package For A Frozen Personal Care Product 审中-公开

    公开(公告)号：US20190166973A1

    公开(公告)日：2019-06-06

    申请号：US15833294

    申请日：2017-12-06

    申请人： ELC Management LLC

    发明人： Francis Corbellini ,  Herve F. Bouix

    IPC分类号： A45D33/26 ,  A45D34/04

    CPC分类号： A45D33/26 ,  A45D34/04 ,  A45D40/00 ,  A45D2200/05 ,  A61K2800/84 ,  A61Q19/00

    摘要： A refillable unit dose package for frozen cosmetic or personal care products that can provide a chilling effect during application. The main components of the package are a reservoir and an applicator. The applicator comprises a handle and an applicator head depending from the handle. In use, a product in the reservoir is frozen, which causes the product to bond to the applicator head. The handle is used to lift the frozen product out of the reservoir, and draw the frozen product over the skin. As it melts from the heat of the skin, the product can be spread on the skin. The reservoir is refillable by a consumer.