利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

287 条记录 (耗时 0.043 秒)

    Assay for JC virus antibodies
    53.
    发明授权
    Assay for JC virus antibodies 有权
    测定JC病毒抗体

    公开(公告)号：US09316641B2

    公开(公告)日：2016-04-19

    申请号：US13521311

    申请日：2011-01-11

    申请人： Leonid Gorelik ,  Kenneth J. Simon ,  Meena Subramanyam ,  Mia Marie Rushe

    发明人： Leonid Gorelik ,  Kenneth J. Simon ,  Meena Subramanyam ,  Mia Marie Rushe

    IPC分类号： C12Q1/70 ,  G01N33/569

    CPC分类号： G01N33/56983 ,  G01N2333/025 ,  G01N2469/20 ,  G01N2800/50

    摘要： The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.

    摘要翻译： 本公开涉及用于分析样品存在JC病毒抗体的方法和试剂。 公开了一种方法，其包括从受试者（例如血浆，血清，血液，尿液或脑脊髓液）获得生物样品，在适合于结合JCV的条件下使样品与高度纯化的病毒样颗粒（HPVLP）接触 样品中的抗体与HPVLP的检测，并检测JCV抗体在样品中与HPVLP结合的水平。 在一个实施方案中，确定受试样品中抗JCV抗体的水平提供了在受试者中鉴定PML风险的方法。

    IN SITU DETECTION OF EARLY STAGES AND LATE STAGES HPV INFECTION
    56.
    发明申请
    IN SITU DETECTION OF EARLY STAGES AND LATE STAGES HPV INFECTION 有权
    在初步检测早期阶段和晚期HPV感染

    公开(公告)号：US20150147748A1

    公开(公告)日：2015-05-28

    申请号：US14335511

    申请日：2014-07-18

    申请人： Shuling Cheng

    发明人： Shuling Cheng

    IPC分类号： G01N33/569

    CPC分类号： G01N33/56983 ,  C07K16/084 ,  C12Q1/708 ,  G01N33/571 ,  G01N2333/025 ,  G01N2469/10

    摘要： Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by various HPV genotypes, early and/or late stage HPV-associated or HPV-specific cancers. The anti-HPV antibodies are used in performing immunological assays on clinical samples. Various immunological assays and kits for detecting HPV infection, cervical cancer, other HPV related cancers, early stage precancerous lesions as well as late stage cancer progression are also provided.

    摘要翻译： 本发明的实施方案提供用于检测HPV感染和HPV相关癌症诊断的方法，单克隆抗体，多克隆抗体，测定和试剂盒，包括各种HPV基因型，早期和/或晚期HPV相关或HPV特异性癌症的感染。 抗HPV抗体用于对临床样品进行免疫测定。 还提供了用于检测HPV感染，子宫颈癌，其他HPV相关癌症，早期癌前病变以及晚期癌症进展的各种免疫学测定和试剂盒。

    Detection, screening, and diagnosis of HPV-associated cancers
    57.
    发明授权
    Detection, screening, and diagnosis of HPV-associated cancers 有权
    HPV相关癌症的检测，筛选和诊断

    公开(公告)号：US08968995B2

    公开(公告)日：2015-03-03

    申请号：US12590747

    申请日：2009-11-12

    申请人： Shuling Cheng

    发明人： Shuling Cheng

    IPC分类号： C12Q1/70 ,  G01N33/53 ,  G01N33/574 ,  G01N33/569

    CPC分类号： G01N33/57484 ,  C12Q1/708 ,  G01N33/56983 ,  G01N2333/025 ,  C12Q2563/131

    摘要： Embodiments of the invention provide methods, polyclonal antibodies, monoclonal antibodies, assays, and kits for detecting HPV infection, including infection by various HPV genotypes, early and/or late HPV-associated or HPV-specific proteins or antibodies. Mononoclonal antibodies are used to detect oncogenic high risk and low risk HPV types in a single assay, which is not limited to assay type or format. Useful tools for specific detection of various HPV associated cancers are provided. HPV associated cancer biomarkers are identified and can be used in a screening method for early stage precancerous lesions as well as late stage cancer progression.

    摘要翻译： 本发明的实施方案提供用于检测HPV感染的方法，多克隆抗体，单克隆抗体，测定和试剂盒，包括各种HPV基因型，早期和/或晚期HPV相关或HPV特异性蛋白或抗体的感染。 单克隆抗体用于在单个测定中检测致癌性高风险和低风险HPV类型，其不限于测定类型或形式。 提供了用于特定检测各种HPV相关癌症的有用工具。 HPV相关癌症生物标志物被鉴定并且可以用于早期癌前病变的筛选方法以及晚期癌症进展。

    Monoclonal antibodies against HPV proteins
    58.
    发明授权
    Monoclonal antibodies against HPV proteins 有权
    针对HPV蛋白的单克隆抗体

    公开(公告)号：US08865162B2

    公开(公告)日：2014-10-21

    申请号：US12456053

    申请日：2009-06-10

    申请人： Shuling Cheng

    发明人： Shuling Cheng

    IPC分类号： A61K39/395 ,  G01N33/569 ,  G01N33/571 ,  C12Q1/70 ,  C07K16/08

    CPC分类号： G01N33/56983 ,  C07K16/084 ,  C12Q1/708 ,  G01N33/571 ,  G01N2333/025 ,  G01N2469/10

    摘要： Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by various HPV genotypes, early and/or late stage HPV-associated or HPV-specific cancers. Various monoclonal antibodies recognizing specific epitope for specific HPV protein or HPV type, common epitope for various HPV proteins or HPV types are obtained. These obtained monoclonal antibodies are useful tools in early clinical detection of HPV infection and general detection of HPV related diseases, specific detection of invasive cervical cancer, detection of other HPV related cancers, early stage precancerous lesions as well as late stage cancer progression.

    摘要翻译： 本发明的实施方案提供用于检测HPV感染和HPV相关癌症诊断的方法，单克隆抗体，多克隆抗体，测定和试剂盒，包括各种HPV基因型，早期和/或晚期HPV相关或HPV特异性癌症的感染。 获得识别特定HPV蛋白或HPV型特异性表位的各种单克隆抗体，各种HPV蛋白或HPV类型的常见表位。 这些获得的单克隆抗体是早期临床检测HPV感染和HPV相关疾病的一般检测，侵袭性宫颈癌的特异性检测，其他HPV相关癌症的检测，早期癌前期病变以及晚期癌症进展的有用工具。