公开(公告)号：US06867311B2

公开(公告)日：2005-03-15

申请号：US10414541

申请日：2003-04-14

申请人： Aslam A. Malik ,  Todd E. Clement ,  Hasan Palandoken ,  James Robinson, III ,  Joy A. Stringer

发明人： Aslam A. Malik ,  Todd E. Clement ,  Hasan Palandoken ,  James Robinson, III ,  Joy A. Stringer

IPC分类号： C07C213/00 ,  C07C215/08 ,  C07D263/20 ,  C07D301/27 ,  C07D303/36 ,  C07D301/24

CPC分类号： C07C271/22 ,  C07B2200/09 ,  C07C213/00 ,  C07D263/20 ,  C07D303/36 ,  C07C215/08

摘要： The present invention provides compounds and methods that can be used to convert the intermediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.

摘要翻译： 本发明提供可用于将中间卤代甲基酮（HMK）如氯甲基酮转化成相应的S，S-和R，S-非对映异构体的化合物和方法。 更具体地说，本发明提供：（1）还原方法; （2）反演方法; 和（3）涉及烯烃环氧化的方法。 使用本发明的各种方法，可以高产率和高纯度可靠地制备R，S-环氧化物和中间体化合物。

公开(公告)号：US20010018532A1

公开(公告)日：2001-08-30

申请号：US09852652

申请日：2001-05-11

申请人： KANEKA CORPORATION

发明人： Kazumi Okuro ,  Kenji Inoue

IPC分类号： C07D301/24

CPC分类号： C07D303/36

摘要： A process for producing (2R,3S)-3-amino-4-phenylbutane-1,2-epoxide compounds which comprises treating a (2S,3S)-3-amino-1-halo-2-hydroxy-4-phenylbutane compound a (2S,3S)-3-amino-4-phenylbutane-1,2-epoxide with a carboxylic acid quaternary ammonium salt or a carboxylic acid metal salt a quaternary ammonium salt and a quaternary ammonium salt, to give a (2S,3S)-1-acyloxy-3-amino-2-hydroxy-4-phenylbutane compound, further treating the same with a sulfonic acid halide in the presence of an organic base to give a (2S,3S)-1-acyloxy-3-amino-2-sulfonyloxy-4-phenylbutane compound furthermore treating said compound with an inorganic base. An intermediate for the production of an HIV protease inhibitor can be produced from L-phenylalanine.

摘要翻译： 一种制备（2R，3S）-3-氨基-4-苯基丁烷-1,2-环氧化物化合物的方法，包括（2S，3S）-3-氨基-1-卤代-2-羟基-4-苯基丁烷化合物 （2S，3S）-3-氨基-4-苯基丁烷-1,2-环氧化物与羧酸季铵盐或羧酸金属盐季铵盐和季铵盐反应，得到（2S，3S ）-1-酰氧基-3-氨基-2-羟基-4-苯基丁烷化合物，在有机碱的存在下，用磺酸卤化物进一步处理，得到（2S，3S）-1-酰氧基-3- 氨基-2-磺酰氧基-4-苯基丁烷化合物，此外用无机碱处理所述化合物。 用于生产HIV蛋白酶抑制剂的中间体可以由L-苯丙氨酸制备。

公开(公告)号：US5847169A

公开(公告)日：1998-12-08

申请号：US843079

申请日：1997-04-25

申请人： Laurence J. Nummy ,  Denis P. Byrne

发明人： Laurence J. Nummy ,  Denis P. Byrne

IPC分类号： C07D301/00 ,  B01J31/02 ,  C07C215/28 ,  C07D301/02 ,  C07D301/24 ,  C07D303/36 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12

CPC分类号： C07D405/12 ,  C07C215/28 ,  C07D301/02 ,  C07D301/24 ,  C07D303/36 ,  C07D407/12 ,  C07D409/12

摘要： A process for preparing oxiranemethane derivatives which are useful as intermediates for preparing aspartyl protease inhibitors comprising the steps of activating an aminodiol, acylating the aminodiol and reacting the acylated aminodiol with a base to form an epoxy compound.

摘要翻译： 制备环氧乙烷甲烷衍生物的方法，其可用作制备天冬氨酰蛋白酶抑制剂的中间体，包括活化氨基二醇，酰化氨基二醇并使酰化的氨基二醇与碱反应形成环氧化合物的步骤。

公开(公告)号：US5717116A

公开(公告)日：1998-02-10

申请号：US624084

申请日：1996-03-29

申请人： Kenji Saito ,  Norio Kometani ,  Azusa Fujiwara ,  Yukio Yoneyoshi ,  Gohfu Suzukamo

发明人： Kenji Saito ,  Norio Kometani ,  Azusa Fujiwara ,  Yukio Yoneyoshi ,  Gohfu Suzukamo

IPC分类号： C07D301/26 ,  C07D303/02 ,  C12P7/62 ,  C12P41/00 ,  C07D301/24

CPC分类号： C07D303/02 ,  C07D301/26 ,  C12P41/004 ,  C12P7/62

摘要： The present invention provides a process for producing (R)-styrene oxides represented by the formula (1): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and X are as defined in the specification, which comprises treating a mixture of (R)- and (S)-phenylhalogenomethylcarbinols with a lipase in the presence of a carboxylate to preferentially convert the (S)-phenylhalogenomethylcarbinols, and treating a mixture of the formed carbinol alkylates (3) and (R)-phenylhalogenomethylcarbinols with a base to cyclize the (R)-phenylhalogenomethylcarbinols, and also provides an industrially excellent process for producing (R)-styrene oxides (1) which comprises using a mixture enriched with (R)-phenylhalogenomethylcarbinols as the mixture of (R)- and (S)-phenylhalogenomethylcarbinols (2).

摘要翻译： 本发明提供一种由式（1）表示的（R） - 苯乙烯氧化物的制备方法：其中R 1，R 2，R 3和X如说明书中所定义，其包括将 R） - 和（S） - 苯基卤代甲基甲醇与羧酸酯存在下的脂肪酶以优先转化（S） - 苯基卤代甲基甲醇，并将形成的烷基醇烷基化物（3）和（R） - 苯基卤代甲基甲醇的混合物与碱反应 （R） - 苯基卤代甲基甲醇环化，并且还提供了工业上优异的（R） - 苯乙烯氧化物（1）的制备方法，其包括使用（R） - 苯基卤代甲基甲醇作为（R） - 和（S） - 苯基卤甲基甲醇（2）。

公开(公告)号：US5451689A

公开(公告)日：1995-09-19

申请号：US170191

申请日：1993-12-30

申请人： Katsuya Matsumoto ,  Takashi Ebata ,  Koshi Koseki ,  Koji Okano ,  Hiroshi Kawakami ,  Hajime Matsushita

发明人： Katsuya Matsumoto ,  Takashi Ebata ,  Koshi Koseki ,  Koji Okano ,  Hiroshi Kawakami ,  Hajime Matsushita

IPC分类号： C07D301/02 ,  C07D301/03 ,  C07D301/24 ,  C07D303/04 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07H3/10 ,  C07D407/14 ,  C07D407/02

CPC分类号： C07D301/14 ,  C07D301/02 ,  C07D301/24 ,  C07D303/04 ,  C07D493/04 ,  C07D493/08 ,  C07H3/10

摘要： There is provided a method of preparing an epoxide (1a) or (1b) shown below: ##STR1## where R.sup.1, R.sup.2, R.sup.3, and R.sup.4 represent a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an alkoxy group, an aryloxy group, an acyl group, an alkyloxycarbonyl group, an aryloxycarbonyl group, allalkyl group, a silyl group, and a silyloxy group; the groups may be bonded with each other to form rings in the case where these groups can be bivalent; these groups may be the same or different, may have substituting groups, or may be branched; and each form (isomer) has a structure in which one side of the plane constituted by double bonds, R.sup.1, R.sup.2, R.sup.3 and R.sup.4, is more seterically hindered in comparison with the other side;characterized in that:an olefin represented by the formula (2) below, is reacted with iodine in the presence of compound generating acyloxy ion, ##STR2## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same as defined above; and then the reaction mixture is treated in the presence of a base, thereby forming an oxirane ring stereoselectively on the more sterically hindered side of the olefin.

摘要翻译： PCT No.PCT / JP93 / 00648 Sec。 371日期：1993年12月30日 102（e）日期1993年12月30日PCT提交1993年5月18日PCT公布。 公开号WO93 / 23387 （1a）或（1b）的制备方法：其中R 1，R 2，R 3和R 4表示氢原子， 原子，烷基，烯基，芳基，烷氧基，芳氧基，酰基，烷氧基羰基，芳氧基羰基，全烷基，甲硅烷基和甲硅烷氧基; 在这些基团可以是二价的情况下，基团可以彼此键合形成环; 这些基团可以相同或不同，可以具有取代基团，或者可以是支链基团; 并且每种形式（异构体）具有其中由双键R1，R2，R3和R4构成的平面的一侧与另一侧相比更受阻碍的结构; 其特征在于：下述式（2）表示的烯烃与碘反应，生成酰氧基的化合物存在下，与上述相同; 然后在碱的存在下处理反应混合物，从而立体选择性地在烯烃的空间位阻侧上形成环氧乙烷环。

公开(公告)号：US4902810A

公开(公告)日：1990-02-20

申请号：US72189

申请日：1987-07-06

申请人： Masanori Ikeda ,  Morikazu Miura ,  Atsushi Aoshima

发明人： Masanori Ikeda ,  Morikazu Miura ,  Atsushi Aoshima

IPC分类号： C07D301/24 ,  C07D303/08 ,  C07D303/48

CPC分类号： C07D301/14 ,  C07D303/48

摘要： A process for producing hexafluoropropylene oxide from hexafluoropropylene is described. The process comprises epoxidizing hexafluoropropylene in a two-phase system of an aqueous phase and an organic phase by the use of a hypochlorite as an oxidizing agent, the hypochlorite being dissolved or dispersed in the aqueous phase, in the presence of at least one catalyst selected from the group consisting of (a) quaternary ammonium salts, (b) quaternary phosphonium salts, (c) quaternary arsonium salts, and (d) lipophilic complexing agents for cations contained in the hypochlorite, and also, in the presence or absence of an inorganic base.

摘要翻译： 对六氟丙烯制造六氟环氧丙烷的方法进行了说明。 该方法包括使用次氯酸盐作为氧化剂在次相水相和有机相的两相体系中环氧化六氟丙烯，次氯酸盐在选择的至少一种催化剂存在下溶解或分散在水相中 由（a）季铵盐，（b）季鏻盐，（c）季ium盐和（d）次氯酸盐中所含的阳离子的亲脂性络合剂组成，以及（d）存在或不存在 无机碱。

公开(公告)号：US20230122812A1

公开(公告)日：2023-04-20

申请号：US17905799

申请日：2021-03-09

申请人： Kureha Corporation

发明人： Shigeru SUZUKI ,  Nobuyuki KUSANO ,  Hisataka KOBAYASHI

IPC分类号： C07D303/48 ,  C07D301/24

摘要： A method by which an intermediate product of an azole derivative can be produced at a lower cost and in a higher yield than those of known production methods is realized. A method of producing a compound of General Formula (III) includes: producing the compound of General Formula (III) by allowing a cyanide compound to act on a ketone derivative of General Formula (II); and washing the compound of General Formula (III) produced in the producing the compound of General Formula (III) with an alkaline aqueous solution.

公开(公告)号：US09062016B2

公开(公告)日：2015-06-23

申请号：US14374352

申请日：2013-04-12

申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： Takashi Aoki ,  Hiroshi Horikoshi

IPC分类号： C07D301/24 ,  C07D301/02 ,  C07D301/26 ,  C07D303/34

摘要： An object of the present invention is to provide a method for producing a sulfur-containing epoxy compound producing no scum-like insoluble matter. According to the present invention, a sulfur-containing halohydrin compound is dripped into and reacted with a mixed solvent containing an organic solvent and a basic compound to provide the method for producing the sulfur-containing epoxy compound. According to aspects of the present invention, the organic solvent is at least one type of compound selected from toluene and benzene, the basic compound is at least one type of compound selected from sodium hydroxide, potassium hydroxide and calcium hydroxide, and the reaction temperature is between −5° C. and 30° C.

公开(公告)号：US09006465B2

公开(公告)日：2015-04-14

申请号：US13959198

申请日：2013-08-05

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Hideyoshi Yanagisawa

IPC分类号： C07D301/27 ,  C07D301/24 ,  C07D303/12 ,  C07D303/02 ,  C07F7/18 ,  C07D407/12 ,  C07C39/23 ,  C07F7/08

CPC分类号： C07F7/1876 ,  C07C39/23 ,  C07C2603/18 ,  C07D303/27 ,  C07D407/12 ,  C07F7/0838

摘要： An epoxy group-containing a fluorene compound has a methallyl group at the end thereof and is represented by the following general formula (1): wherein R represents a hydrogen atom or a methyl group. The compound gives a compound excellent in regioselectivity at the time of hydrosilylation with a Si—H containing organosilicon compound, with a less formed amount of an internally added β adduct, as compared with the conventionally known fluorene compound having an allyl group, so that heat resistance of the resulting organosilicon compound is expected to be improved whereby it is a useful compound.

摘要翻译： 含有环氧基的芴化合物的末端具有甲代烯丙基，并且由以下通式（1）表示：其中R表示氢原子或甲基。 该化合物在与含Si-H的有机硅化合物的氢化硅烷化时具有优异的区域选择性的化合物，内部添加的少量形成量。 与常规已知的具有烯丙基的芴化合物相比，预期所得有机硅化合物的耐热性得到改善，从而是有用的化合物。

公开(公告)号：US08969631B2

公开(公告)日：2015-03-03

申请号：US13806911

申请日：2011-06-08

申请人： Won Seob Song ,  Sung Yul Woo ,  Boo Weon Song ,  Seong Han Park ,  Myoung Suk Kwon

发明人： Won Seob Song ,  Sung Yul Woo ,  Boo Weon Song ,  Seong Han Park ,  Myoung Suk Kwon

IPC分类号： C07C31/34 ,  C07D301/28 ,  C07C29/62 ,  C07C29/80 ,  C07D303/08 ,  C07D301/24

CPC分类号： C07D301/28 ,  C07C29/62 ,  C07C29/80 ,  C07D303/08 ,  C07C31/36

摘要： A method of preparing a chlorohydrin composition and a method of preparing epichlorohydrin by using a chlorohydrin composition prepared by using the method are provided. The method of preparing a chlorohydrin composition in which a polyhydroxy aliphatic hydrocarbon is reacted with a chlorination agent in the presence of a catalyst includes performing at least one combination of a series of unit operations comprising a first reaction step, a water removal step, and a second reaction step in this stated order, wherein the method further includes mixing a chlorohydrin concentrate obtained by purifying the reaction mixture discharged from the final reaction step from among the plurality of reaction steps and a water-rich layer discharged from the water-removal step. The method of preparing epichlorohydrin includes contacting the chlorohydrin composition prepared by using the method of preparing a chlorohydrin composition with an alkaline agent.

摘要翻译： 提供了一种制备氯代醇组合物的方法和通过使用通过使用该方法制备的氯代醇组合物制备表氯醇的方法。 制备其中多羟基脂族烃与氯化剂在催化剂存在下反应的氯代醇组合物的方法包括进行一系列单元操作的至少一种组合，该组合操作包括第一反应步骤，脱水步骤和 第二反应步骤，其中所述方法还包括混合通过纯化从多个反应步骤中排出的最终反应步骤的反应混合物获得的氯代醇浓缩物和从除水步骤排出的富含水层。 制备表氯醇的方法包括使通过使用氯醇组合物与碱性试剂的制备方法制备的氯代醇组合物接触。