公开(公告)号：US20210038740A1

公开(公告)日：2021-02-11

申请号：US17075738

申请日：2020-10-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Valery KRIZHANOVSKY ,  Yossi OVADYA

IPC: A61K47/68 ,  A61P35/00 ,  A61K45/06 ,  C07K16/18 ,  C12N15/113

Abstract: A method of targeting a pharmaceutical agent to a senescent cell is disclosed. The method comprises administering the pharmaceutical agent to the subject, wherein said pharmaceutical agent is attached to an affinity moiety, said affinity moiety being capable of binding specifically to a polypeptide selected from the group consisting of HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 and a polypeptide set forth in Table 1. The targeting may be for therapeutics or diagnostics.

公开(公告)号：US20210030856A1

公开(公告)日：2021-02-04

申请号：US17041974

申请日：2019-03-26

Applicant: Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts ,  Yeda Research and Development Co., LTD.

Inventor： Rachel Lea Eisenbach ,  Esther Tzehoval ,  Gal Cafri ,  Adi Sharbi Yunger ,  Mareike Grees

IPC: A61K39/00 ,  C07K14/74 ,  A61P35/00

Abstract: The present invention pertains to a novel cell based tumor vaccine platform. The invention provides a method for modifying antigen presenting cells (APCs) to present both MHC class I and/or MHC class II peptides in context of improved peptide presentation protein complexes in order to increase activation of a patient's immune response. In this invention, an MHC II mRNA dendritic cell based vaccine platform was developed to activate CD4+T cells in patients and to enhance the anti-tumor response. The invariant chain (Ii) was modified and the semi-peptide CLIP was replaced with an MHCII binding peptide sequences of tumor associated antigens. These chimeric MHC II constructs are presented by APCs and induce proliferation of tumor specific CD4+T cells. The invention provides the constructs, proteins, nucleic acids, recombinant cells, as well as medical applications of these products.

公开(公告)号：US20210015889A1

公开(公告)日：2021-01-21

申请号：US17035829

申请日：2020-09-29

Applicant: Yeda Research and Development Co. Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Ilana KOLODKIN-GAL ,  Alona KEREN-PAZ ,  Eitan KEREM ,  Gideon ZAMIR ,  Dror KOLODKIN-GAL ,  Malena COHEN-CYMBERKNOH

IPC: A61K38/14 ,  A61K31/43 ,  A61K38/00

Abstract: Methods of disrupting a biofilm and/or preventing formation of a biofilm are provided. Accordingly there is provided a method of reducing or preventing formation of a biofilm and/or disrupting a biofilm comprising contacting a biofilm-producing microorganism with a carbonic anhydrase inhibitor; a urease inhibitor; a Ca2+ ATPase inhibitor; a tlp activator; and/or a myo-inositol catabolism pathway activator. Also provided are articles of manufacture and methods of treating a medical condition in which disrupting a biofilm and/or preventing formation of same is beneficial and methods of predicting or increasing sensitivity to an anti-microbial agent.

公开(公告)号：US10828318B2

公开(公告)日：2020-11-10

申请号：US16068172

申请日：2017-01-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Idit Shachar ,  Hadas Lewinsky ,  Lihi Radomir ,  Anna Wiener

IPC: A61K31/713 ,  C07K16/28 ,  A61P37/06 ,  A61P35/02 ,  A61P29/00 ,  A61K38/17 ,  A61K39/00

Abstract: A method of treating a malignant disease involving T cell exhaustion in a subject, with the proviso that said malignant disease is not a B cell malignancy, is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84, thereby treating the malignant disease involving the T cell exhaustion. Also disclosed is a method of treating an autoimmune or inflammatory disease in a subject, the method comprising administering to a subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84. A method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of SLAMF1, with the proviso that said agent is not an agent capable of decreasing an activity or expression of CD84, is also disclosed.

公开(公告)号：US20200341093A1

公开(公告)日：2020-10-29

申请号：US16891437

申请日：2020-06-03

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Aharon BLANK ,  Itai KATZ ,  Akiva FEINTUCH

IPC: G01R33/56 ,  A61K49/20 ,  G01R33/28 ,  G01R33/62 ,  A61B5/055 ,  A61M5/00

Abstract: A method tor the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

公开(公告)号：US20200332033A1

公开(公告)日：2020-10-22

申请号：US16919138

申请日：2020-07-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob KLEIN ,  Weifeng LIN ,  Ronit GOLDBERG

IPC: C08F130/02 ,  A61K9/127 ,  C07F9/10 ,  A61K9/08 ,  A61P19/02 ,  A61K9/00

Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.

公开(公告)号：US10806119B2

公开(公告)日：2020-10-20

申请号：US16123248

申请日：2018-09-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph Aharoni ,  Prashant Sonawane ,  Maxim Itkin

IPC: C12N15/82 ,  A01H6/82 ,  A01H5/10 ,  C12N9/10

Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.

公开(公告)号：US20200261577A1

公开(公告)日：2020-08-20

申请号：US16830461

申请日：2020-03-26

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Dalit TALMI-FRANK ,  Inna SOLOMONOV ,  Ido AMIT

IPC: A61K39/395 ,  A61K45/06 ,  A61K31/351 ,  A61K31/196 ,  C07K16/40 ,  A61K31/215

Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.

公开(公告)号：US20200260068A1

公开(公告)日：2020-08-13

申请号：US16758471

申请日：2018-10-25

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Shimon ULLMAN ,  Daniel HARARI ,  Liav ASSIF ,  lgal KOIFMAN

IPC: H04N13/388 ,  G02B27/01 ,  G06T19/00 ,  G06K9/00

Abstract: A multi-layer viewing system includes a stationary imager and a beam projector to project physical layer markings onto a region of an object. A headset includes an augmented reality display that is sufficiently transparent to enable a user who is wearing the headset to directly view the object through the display, and to display annotation that is superimposed on the object. A processor is configured to receive a selected location relative to the target for display of the annotation, determine an orientation of the augmented reality display by identifying images of markings in acquired images or markings on the object, calculate a display location for displaying the annotation on the augmented reality display such that the annotation is perceivable by the user as displayed at the selected position, and display the annotation at the calculated display location

公开(公告)号：US20200256857A1

公开(公告)日：2020-08-13

申请号：US16783524

申请日：2020-02-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MARGULIES ,  Leila MOTIEI ,  Naama LAHAV

IPC: G01N33/533 ,  C07D249/04 ,  G01N33/58 ,  G01N33/68

Abstract: This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.