公开(公告)号：US12030888B2

公开(公告)日：2024-07-09

申请号：US17561680

申请日：2021-12-23

申请人： Massachusetts Institute of Technology

发明人： Mohammad Movassaghi ,  Bradley L. Pentelute ,  Carly Schissel ,  Kyan Anthony D'Angelo

IPC分类号： C07D519/00 ,  C07D209/86 ,  C07D487/04 ,  C07D487/14 ,  C07D487/22 ,  C07D498/22

CPC分类号： C07D487/04 ,  C07D209/86 ,  C07D487/14 ,  C07D487/22 ,  C07D498/22 ,  C07D519/00 ,  C07B2200/05 ,  C07B2200/07

摘要： The present disclosure provides compounds of Formula I, methods of preparing the compounds, compositions, kits, and methods of using the compounds for treating or preventing microbial infections.

公开(公告)号：US12030839B2

公开(公告)日：2024-07-09

申请号：US17106345

申请日：2020-11-30

申请人： Massachusetts Institute of Technology

发明人： Mircea Dinca ,  Constanze Nicole Neumann

IPC分类号： C07C29/44 ,  B01J23/46 ,  B01J31/16 ,  C07C31/12 ,  C07C31/125 ,  C07F15/00 ,  C07F15/04 ,  C07F15/06 ,  C07C29/16

CPC分类号： C07C29/44 ,  B01J23/46 ,  B01J31/1691 ,  C07C31/12 ,  C07C31/125 ,  C07F15/0046 ,  C07F15/04 ,  C07F15/06 ,  B01J2231/46 ,  B01J2531/0208 ,  B01J2531/821 ,  B01J2531/845 ,  B01J2531/847 ,  C07C29/16

摘要： Compositions and methods of use related to metal organic frameworks (MOFs) and/or nanoparticles are generally described. In some embodiments, methods and compositions for the catalytic upgrading of alcohols using MOFs and/or nanoparticles associated with MOFs are generally described. In some embodiments, a catalytic MOF composition is provided, wherein the MOF composition comprises a MOF compound and a plurality of metal catalytic compounds. In some embodiments, an alcohol may be exposed to the MOF composition and/or a plurality of nanoparticles associated with the MOF composition such that the alcohol is converted to a higher order alcohol. Advantageously, in some embodiments, the alcohol conversion occurs at a relatively high turnover frequency and/or with a relatively high selectivity as compared to traditional methods for converting alcohols.

公开(公告)号：US12030085B2

公开(公告)日：2024-07-09

申请号：US16488223

申请日：2018-02-28

申请人： Yale University

发明人： Peter Rakich ,  Prashanta Kharel ,  William Renninger ,  Ryan Orson Behunin

IPC分类号： B06B1/04 ,  G02F1/11 ,  G10K15/00 ,  H01S3/08 ,  H03F3/00

CPC分类号： B06B1/04 ,  G10K15/00 ,  H01S3/08059 ,  H03F3/00 ,  G02F1/11

摘要： Techniques are provided to optomechanically couple light to a crystal structure, thereby producing stable, coherent bulk acoustic modes within the structure. In some embodiments, a resonator may comprise a plano-convex crystal structure to which pump light may be applied. The pump light may transfer energy to acoustic phonon modes of the crystal structure so as to create acoustic phonon modes with a coherence length greater than a length of the crystal structure. High frequency and high quality factor resonators may thereby be produced and operated.

公开(公告)号：US12030081B2

公开(公告)日：2024-07-09

申请号：US17767125

申请日：2020-10-06

申请人： The University of Chicago

发明人： Jiwoong Park ,  Yu Zhong ,  Baorui Cheng

IPC分类号： B05D1/20 ,  B05D1/18

CPC分类号： B05D1/185 ,  B05D1/20

摘要： Disclosed herein are inventive methods of making thin films, inventive thin films, and inventive articles and systems comprising thin films. Certain embodiments are related to methods of making thin films in which reagents are arranged within a first phase and a second phase such that at least one reagent reacts to form a thin film proximate to the interface between the first phase and the second phase. Thin films (including two-dimensional materials) disclosed herein can have one or more of a variety of beneficial properties including large lateral dimension(s), lateral continuity, high mechanical strength, consistent spatial composition, and/or consistent thickness. In accordance with certain embodiments, thin films disclosed herein can be combined to form a variety of inventive multi-layer articles, including multi-layer articles comprising a combination of thin films having different compositions that interact with each other via van der Waals forces.

公开(公告)号：US12029714B2

公开(公告)日：2024-07-09

申请号：US18095354

申请日：2023-01-10

申请人： Seth Feuerstein

发明人： Seth Feuerstein

IPC分类号： A61M21/02 ,  A61B5/16 ,  A61K31/202 ,  A61K31/437 ,  A61K31/4985 ,  A61K36/35 ,  A61K45/06 ,  A61M21/00

CPC分类号： A61K31/202 ,  A61B5/165 ,  A61K31/437 ,  A61K31/4985 ,  A61K36/35 ,  A61K45/06 ,  A61M21/00 ,  A61M21/02 ,  A61K31/437 ,  A61K2300/00 ,  A61K31/4985 ,  A61K2300/00

摘要： Pharmaceutical combinations and methods for using such combinations to treat depression are disclosed. In various embodiments the pharmaceutical combinations include combinations of omega-3 fatty acids, pharmacological sleep agents, and nonpharmacological sleep therapies, and may include other ingredients such as antidepressants. The present invention relates pharmaceutical combinations and methods for their use to treat depression.

公开(公告)号：USD1033236S1

公开(公告)日：2024-07-02

申请号：US29712918

申请日：2019-11-12

申请人： Consider Provisions, LLC

设计人： Jesse Laflamme ,  James T. McGee ,  Steffen F. Koury ,  Yen Wei Lee ,  Darryl F. Khalil ,  Paul K. Metaxatos

摘要： FIG. 1 is a top, front, and right side perspective view of an egg carton according to our new design;
FIG. 2 is a bottom, front, and right side perspective view thereof;
FIG. 3 is top plan view thereof;
FIG. 4 is a bottom plan view thereof;
FIG. 5 is a right side elevation view thereof;
FIG. 6 is a front elevation view thereof;
FIG. 7 is a rear elevation view thereof; and,
FIG. 8 is a left side elevation view thereof.
The dash-dash broken lines represent portions of the egg carton that form no part of the claimed design. The dot-dash broken lines represent boundaries of the claim and form no part of the claimed design.

公开(公告)号：US12024325B2

公开(公告)日：2024-07-02

申请号：US17192939

申请日：2021-03-05

申请人： Coravin, Inc.

发明人： Sarah Deslandes ,  Michael Rider

IPC分类号： B65B31/02 ,  F17C1/00

CPC分类号： B65B31/025 ,  F17C1/00 ,  F17C2201/0109 ,  F17C2201/058 ,  F17C2205/0308 ,  F17C2221/013 ,  F17C2270/0736

摘要： A gas source for pressuring sparkling and other beverage containers, e.g., to re-pressurize the container to keep a carbonation level of beverage during storage.

公开(公告)号：US12018314B2

公开(公告)日：2024-06-25

申请号：US15738871

申请日：2016-07-04

申请人： Arima Genomics, Inc.

发明人： Siddarth Selvaraj ,  Nathaniel Heintzman ,  Christian Edgar Laing

IPC分类号： C12Q1/6806 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B20/40 ,  G16B40/00

CPC分类号： C12Q1/6806 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B20/40 ,  G16B40/00 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present disclosure relates to methods to deconvolute a mixture sample of genetic material from different origins or sources. The disclosed methods can be used in various applications, including, the non-invasive determination of a fetal genome, a fetal -ome (e.g. exome). or other targeted fetal locus from cell-free nucleic acids in maternal plasma or other body fluids; the determination of cancer-associated mutations from cell-free nucleic acids in a body fluid sample that contains a mixture of nucleic acids from normal cells and tumor cells; and quantification of donor cell contamination using a body fluid from a transplantation recipient to monitor and/or predict the outcome of a transplantation procedure.

公开(公告)号：US12018087B2

公开(公告)日：2024-06-25

申请号：US18468580

申请日：2023-09-15

申请人： Dyne Therapeutics, Inc.

发明人： Romesh R. Subramanian ,  Mohammed T. Qatanani ,  Timothy Weeden ,  Cody A. Desjardins

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P21/00 ,  C12N15/113

CPC分类号： C07K16/2881 ,  A61K47/6807 ,  A61K47/6849 ,  A61K47/6889 ,  A61P21/00 ,  C12N15/113 ,  C07K2317/55 ,  C07K2317/92

摘要： Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DUX4. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.

公开(公告)号：US12017585B2

公开(公告)日：2024-06-25

申请号：US17622173

申请日：2020-07-08

申请人： Sony Semiconductor Solutions Corporation

发明人： Yutaro Yamashita

IPC分类号： B60R1/00 ,  G06Q40/08 ,  H04N23/55 ,  H04N23/56 ,  H04N23/67 ,  H04N25/61

CPC分类号： B60R1/00 ,  G06Q40/08 ,  H04N23/55 ,  H04N23/56 ,  H04N23/67 ,  H04N25/61

摘要： The imaging unit 500 captures an image using a lens having an effective image circle smaller than the imaging surface of an image sensor. A vignetting amount calculation unit 2212 of a detection unit 221 individually calculates, for four corners, a region size of a vignetting region generated in the captured image acquired by the imaging unit 500, for example. A determination unit 2214 detects a change in the region size calculated at the time of focus abnormality detection processing with respect to the region size calculated at the reference time, and determines that a focus abnormality is detected when the change in the region size exceeds a threshold at any of the four corners. This enables accurate detection of focus abnormality.