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    SOLUTION-PHASE AFFINITY SELECTION OF INHIBITORS FROM COMBINATORIAL PEPTIDE LIBRARIES
    1.
    发明申请
    SOLUTION-PHASE AFFINITY SELECTION OF INHIBITORS FROM COMBINATORIAL PEPTIDE LIBRARIES 审中-公开

    公开(公告)号：US20200308231A9

    公开(公告)日：2020-10-01

    申请号：US16206944

    申请日：2018-11-30

    申请人： Massachusetts Institute of Technology

    发明人： Bradley L. Pentelute ,  Faycal Touti

    IPC分类号： C07K7/64 ,  C07K7/08 ,  C07K1/22

    摘要： The present invention provides novel peptides (e.g., peptides, macrocyclic peptides, mini-proteins) that modulate protein-protein interactions or salts thereof, and methods of making and using the inventive peptides. In some embodiments, the peptides are high affinity inhibitors (e.g., KD of at most 100 nM, at most 10 nM, at most 1 nM) of a protein-protein interaction. In certain embodiments, these peptides interfere with p53-MDM2 binding interactions (e.g., by binding to MDM2 (GenBank® Gene ID: 4193)). In some embodiments, the peptides interfere with the dimerization of the C-terminal domain of the human immunodeficiency virus (HIV) capsid protein (C-CA), comprising residues 146-231 of the HIV capsid protein (e.g., by binding to the C-terminal domain of the HIV capsid protein (C-CA), thereby inhibiting the dimeric interface of HIV capsid protein, thereby inhibiting viral assembly). These inventive peptides were rapidly generated and identified using novel methods described herein comprising combinatorial peptide synthesis and/or solution affinity selection.

    METHODS AND SYSTEMS FOR SOLID PHASE PEPTIDE SYNTHESIS
    6.
    发明申请
    METHODS AND SYSTEMS FOR SOLID PHASE PEPTIDE SYNTHESIS 有权

    公开(公告)号：US20210047365A1

    公开(公告)日：2021-02-18

    申请号：US16874824

    申请日：2020-05-15

    申请人： Massachusetts Institute of Technology

    发明人： Dale Arlington Thomas ,  Alexander James Mijalis ,  Bradley L. Pentelute ,  Mark David Simon ,  Surin Mong

    IPC分类号： C07K1/04 ,  C07K14/60 ,  C07K7/06 ,  C07K14/47 ,  C07K14/61 ,  C07K14/62 ,  G01N21/33 ,  G01N33/487

    摘要： Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.