公开(公告)号：US20200291071A1

公开(公告)日：2020-09-17

申请号：US16731084

申请日：2019-12-31

Applicant: Academia Sinica

Inventor： Tsung-Lin LI ,  Chun-Man HUANG ,  Kuan-Hung LIN

IPC: C07K9/00 ,  A61P31/04

Abstract: Disclosed herein are novel compounds and uses thereof. The present compounds are useful in suppressing the growth of various bacteria, including gram-positive and gram-negative bacteria. Accordingly, these compounds may be used to manufacture a medicament or pharmaceutic composition for treating disease and/or disorders associated with bacterial infection, especially antibiotic-resistant bacterial infection. Al so disclosed herein are methods for treating infectious diseases by use of the present compounds, medicament or pharmaceutical composition.

公开(公告)号：US10605755B2

公开(公告)日：2020-03-31

申请号：US15359623

申请日：2016-11-23

Applicant: Academia Sinica

Inventor： Yi-Sheng Wang

IPC: G01N27/02 ,  H01J37/00 ,  G01N1/00 ,  G01N15/00

Abstract: The present invention relates to a device for detecting charged particles (e.g., ions). The device includes components arranged to neutralize or strip the charges of ions generated from a sample material, in which the charge stripping events produce signals that can be detected subsequently by a detector. A method for detecting charged particles generated from a sample material using the device is also provided.

公开(公告)号：US10603346B2

公开(公告)日：2020-03-31

申请号：US15552103

申请日：2016-03-03

Applicant: Academia Sinica

Inventor： Pei-wen Hsiao ,  Chin-hsien Tsai ,  Shih-chuan Hsieh

IPC: A61K36/00 ,  A61K36/28

Abstract: A method for preparing a standardized Wedelia chinensis extract and an extract prepared by the method. Also provided is a method for qualifying the standardized extract by characterizing its most abundant compounds and its biological activity in vitro. Additionally, a method is provided for treating an androgen-stimulated disorder with the qualified Wedelia chinensis extract.

公开(公告)号：US20200061205A1

公开(公告)日：2020-02-27

申请号：US16111250

申请日：2018-08-24

Applicant: ACADEMIA SINICA ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： STEVEN R. ROFFLER ,  TIAN-LU CHENG ,  CHIEN-HAN KAO ,  BING-MAE CHEN ,  YU-CHENG SU ,  HSIN-YI TUNG ,  KUO-HSIANG CHUANG

IPC: A61K47/68 ,  A61P35/00 ,  C07K16/32 ,  A61K39/395 ,  C07K16/28 ,  C07K16/26 ,  A61K47/14 ,  A61K47/69

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

公开(公告)号：US10562976B2

公开(公告)日：2020-02-18

申请号：US16166220

申请日：2018-10-22

Applicant: Academia Sinica

Inventor： An-Suei Yang ,  Wei-Ying Kuo ,  Hung-Ju Hsu ,  Hong-Sen Chen ,  Yu-Chi Chou ,  Yueh-Liang Tsou ,  Hung-Pin Peng ,  Jhih-Wei Jian ,  Chung-Ming Yu ,  Yi-Kai Chiu ,  Ing-Chein Chen ,  Chao-Ping Tung ,  Michael Hsiao ,  Hwei-Jiung Wang

IPC: A61K39/00 ,  A61K39/38 ,  A61K39/395 ,  C07K16/30 ,  A61K47/68 ,  A61P35/00 ,  C07K16/32

Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.

公开(公告)号：US20200038497A1

公开(公告)日：2020-02-06

申请号：US16338501

申请日：2017-10-03

Applicant: NATIONAL TAIWAN UNIVERSITY ,  Academia Sinica

Inventor： Jin-Town Wang ,  Shih-Hsiung Wu ,  Chung-Yi Wu

IPC: A61K39/108 ,  C08B37/00 ,  A61P31/04

Abstract: The disclosure provides various immunogens comprising a repeat unit of saccharide of Klebsiella pneumoniae CPS, which has a formula selected from the group consisting of Formulae (I) to (VI) as described herein. Also provided are vaccines including one or more immunogens selected from Formula (I) to (VI) and methods of eliciting an immune response against a Klebsiella pneumoniae and preventing infection of Klebsiella pneumoniae by using an immunogen of the invention.

公开(公告)号：US10548861B2

公开(公告)日：2020-02-04

申请号：US15745639

申请日：2016-08-17

Applicant: Academia Sinica ,  Memorial Sloan Kettering Cancer Center

Inventor： Malcolm Moore ,  Jae-Hung Shieh ,  Tsann-Long Su ,  Te-Chang Lee

IPC: A61K31/167 ,  A61K31/17 ,  A61K45/06 ,  A61P35/02

Abstract: Method of using ureidomustine (BO-1055), a water-soluble NDA cross-linking agent, in the treatment of a cancer, selected from the group consisting of various types of human leukemia [such as acute myeloid leukemia (ALL) and acute B Lymphoblastic leukemia (B-ALL)], lymphomas, small lung cell carcinoma (SCLC), sarcomas, and others.

公开(公告)号：US20200031875A1

公开(公告)日：2020-01-30

申请号：US16597850

申请日：2019-10-10

Applicant: ACADEMIA SINICA

Inventor： HAN-CHUNG WU ,  CHUNG-TAO TANG

IPC: C07K14/005 ,  A61K39/12 ,  C07K16/10 ,  G01N33/569 ,  A61K39/39 ,  C12N7/00

Abstract: Isolated mutant dengue virus E protein variants are disclosed. The variant comprises an amino acid sequence that is at least 80% identical to SEQ ID NO: 1 and has one or more amino acid residue substitutions at position corresponding to Asn8 (N8), Arg9 (R9), Val12 (V 12) and/or Glu13 (E13). The variant may comprise an amino acid sequence that is at least 90% identical to the SEQ ID NO: 1 and lack an infection-enhancing antibody-binding motif comprising the amino acid sequence of SEQ ID NO: 28 at domain I. An isolated nucleic acid sequence encoding the variant, a plasmid expressing the variant, a plasmid expressing a virus-like particle comprising the variant, a DNA vaccine, and a method of detecting the presence of a dengue virus in a biological sample are also disclosed.

公开(公告)号：US20190389898A1

公开(公告)日：2019-12-26

申请号：US16481042

申请日：2018-01-26

Applicant: Academia Sinica

Inventor： Chih-Cheng CHEN ,  Jim-Min FANG ,  Cheng-Han LEE ,  Jen-Yao CHANG

IPC: C07H19/16 ,  A61P29/00 ,  A61K38/04 ,  A61K47/55 ,  A61K31/7076

Abstract: Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, the compound is 5′-glycylcarbonyl-N6-(4-hydroxybenzyl)adenosine (I-a1). In another embodiment of the invention, the compound is 5′-deoxy-5′-(N′-glycylureido)-N6-(4-hydroxybenzyl)adenosine (I-d1). Also disclosed are methods of making and using the same.

公开(公告)号：US10415033B2

公开(公告)日：2019-09-17

申请号：US16202106

申请日：2018-11-28

Applicant: Academia Sinica

Inventor： An-Suei Yang ,  Jhih-Wei Jian ,  Hong-Sen Chen ,  Yi-Kai Chiu ,  Hung-Pin Peng ,  Chao-Ping Tung ,  Chung-Ming Yu ,  Wei-Ying Kuo ,  Hung-Ju Hsu

IPC: C12N15/10 ,  C40B40/02 ,  C07K16/00 ,  C07K16/32 ,  C07K16/30 ,  C07K16/22 ,  C07K16/28

Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.