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公开(公告)号：US09745350B2
公开(公告)日：2017-08-29
申请号：US14431336
申请日：2013-10-03
Applicant: AFFIBODY AB
Inventor： Magdalena Malm , John Löfblom , Stefan Ståhl
IPC: A61K51/08 , G01N33/574 , C07K14/00 , C07K14/71
CPC classification number: C07K14/00 , A61K51/088 , C07K14/71 , G01N33/57492 , G01N2333/71
Abstract: The present disclosure relates to polypeptides which bind to human epidermal growth factor receptor 3 (HER3) and to use of such polypeptides in imaging and therapy. The disclosure provides an HER3 binding polypeptide comprising a HER3 binding motif, which motif consists of the amino acid sequence EKYX4AYX7EIW X11LPNLTX17X18QX20 AAFIGX26 LX28D (SEQ ID NO:110).
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公开(公告)号：US20170008936A1
公开(公告)日：2017-01-12
申请号：US15238184
申请日：2016-08-16
Applicant: Affibody AB
Inventor： Lars Abrahmsén , Nina Herne , Christofer Lendel , Joachim Feldwisch
Abstract: Populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ (SEQ ID NO: 1) or AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q (SEQ ID NO: 2), wherein each X individually corresponds to an amino acid residue which is varied in the population are disclosed. Also populations of polynucleotides, wherein each member encodes a member of a polypeptide population are disclosed. Furthermore, combinations of such polypeptide populations and such polynucleotide populations are disclosed, wherein each member of polypeptide population is physically or spatially associated with the polynucleotide encoding that member via means for genotype-phenotype coupling.
Abstract translation: 基于共同支架的多肽变体群体，群体中的每个多肽包含支架氨基酸序列EXXXAXXEIX XLPNLTXXQX XAFIXKLXDD PSQSSELLSE AKKLNDSQ（SEQ ID NO：1）或AKYAKEXXXAXX EIXXLPNLTX XQXXAFIXKL XDDPSQSSEL LSEAKKLNDS Q（SEQ ID NO：2），其中每个 X分别对应于在群体中变化的氨基酸残基。 还公开了多核苷酸的种群，其中每个成员编码多肽群体的成员。 此外，公开了这种多肽群体和这种多核苷酸群体的组合，其中多肽群体的每个成员通过用于基因型 - 表型偶联的方式与编码该成员的多核苷酸物理或空间相关联。
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Patent Agency Ranking
公开(公告)号：US20160199521A1
公开(公告)日：2016-07-14
申请号：US15083424
申请日：2016-03-29
Applicant: General Electric Company , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
IPC: A61K51/08
CPC classification number: A61K51/088 , C07K14/71
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
Abstract translation: 包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。
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公开(公告)号：US20160031967A1
公开(公告)日：2016-02-04
申请号：US14776319
申请日：2014-03-17
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Malin Lindborg , Lars Abrahmsen , John Löfblom , Torbjörn Gräslund , Johan Seijsing
IPC: C07K14/745
CPC classification number: C07K14/745 , A61K38/00 , C07K14/31 , C07K14/435 , C07K14/70535 , C07K14/70539 , C07K2319/74
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2X3X4AX6X7 EIRWLPNL X16X17X18QRX21 AFIX25X26LX28X29 (SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
Abstract translation: 本公开涉及对新生儿Fc受体具有结合亲和力的一类工程化多肽（在下文中称为FcRn），并提供包含序列EX2X3X4AX6X7EIRWLPNL X16X17X18QRX21AFIX25X26LX28X29（SEQ ID NO：1075）的FcRn结合多肽。 本公开还涉及这种FcRn结合多肽作为用于改变药代动力学和药效学性质的试剂以及作为治疗剂的用途。
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公开(公告)号：US20150291668A1
公开(公告)日：2015-10-15
申请号：US14437623
申请日：2013-10-25
Applicant: AFFIBODY AB
Inventor： Per Jonasson , Pär Eklund
IPC: C07K14/315
CPC classification number: C07K14/315 , C07K14/00 , C07K14/195 , G01N33/68 , G01N33/6827
Abstract: The disclosure provides an ABD binding polypeptide comprising an ABD binding motif BM, which motif consists of an amino acid sequence selected from EX2X3X4AX6X7EIX10X11LPNLX16X17X18QX20X21AFIX25X26LX28D (SEQ ID NO:166) and amino acid sequences with at least 89% identity thereto.
Abstract translation: 本公开提供了包含ABD结合基序BM的ABD结合多肽，该基序由选自EX2X3X4AX6X7EIX10X11LPNLX16X17X18QX20X21AFIX25X26LX28D（SEQ ID NO：166）的氨基酸序列和与其具有至少89％同一性的氨基酸序列组成。
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公开(公告)号：US20150225464A1
公开(公告)日：2015-08-13
申请号：US14427102
申请日：2013-09-25
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Joachim Feldwisch , Kyong-Hoon Ahn
IPC: C07K14/195 , A61K47/48
CPC classification number: C07K14/195 , A61K47/64 , C07K14/315 , C07K2319/00 , C07K2319/31
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. In particular, the present invention relates to albumin binding polypeptides which have a high resistance to enzymatic cleavage. The disclosure provides an albumin binding polypeptide comprising an albumin binding motif, which motif consists of the amino acid sequence GVSDFYKKLI XaKAKTVEGVE ALKXbXcI (SEQ ID NO:29).
Abstract translation: 本公开涉及对白蛋白具有结合亲和力的一类工程改造的多肽。 特别地，本发明涉及对酶裂解具有高抗性的白蛋白结合多肽。 本公开提供了包含白蛋白结合基序的白蛋白结合多肽，该基序由氨基酸序列GVSDFYKKLI XaKAKTVEGVE ALKXbXcI（SEQ ID NO：29）组成。
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公开(公告)号：US20150098991A1
公开(公告)日：2015-04-09
申请号：US14385618
申请日：2013-03-15
Applicant: AFFIBODY AB
Inventor： David Bejker , Caroline Ekblad
IPC: C07K14/315 , C07K14/31 , C07K14/195 , C07K14/00 , A61K9/00
CPC classification number: C07K14/315 , A61K9/0053 , A61K38/00 , A61K47/50 , A61K47/643 , C07K14/00 , C07K14/195 , C07K14/31 , C07K2319/31
Abstract: The present invention is within the field of administration of biopharmaceuticals. More specifically, the invention provides for oral administration of a compound comprising a moiety which confers a desired therapeutic activity; and a polypeptide moiety which binds to albumin.
Abstract translation: 本发明在生物药物的管理领域内。 更具体地，本发明提供了口服给予包含赋予所需治疗活性的部分的化合物; 和与白蛋白结合的多肽部分。
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