公开(公告)号：US20230200721A1

公开(公告)日：2023-06-29

申请号：US17927853

申请日：2021-05-31

Applicant: Agency for Science, Technology and Research ,  National University Hospital (Singapore) Pte Ltd

Inventor： Yao Du ,  Mahesh Choolani ,  Jun Hui Ho ,  Renzhe Bi ,  Poongkulali Rajarahm ,  Malini Olivo

IPC: A61B5/00 ,  A61B5/107 ,  A61B5/11

CPC classification number: A61B5/4362 ,  A61B5/1072 ,  A61B5/0077 ,  A61B5/11

Abstract: A system for monitoring foetal growth. The system may include a plurality of devices. Each device of the plurality of devices may be configured to determine measurements of a baby bump over a time period, and may be further configured to store the measurements. The system may also include a server configured to receive the measurements from each of the plurality of devices. The server may be configured to compare the measurements from different devices of the plurality of devices. The system may be further configured to send an alert upon detecting an abnormality based on the measurements from the different devices of the plurality of devices.

公开(公告)号：US20230183791A1

公开(公告)日：2023-06-15

申请号：US16495744

申请日：2018-03-23

Applicant: National University of Singapore ,  Agency for Science, Technology and Research

Inventor： Jonathan Scolnick ,  Eugene Yeo ,  Shawn Hoon

IPC: C12Q1/6851 ,  G01N33/53

CPC classification number: C12Q1/6851 ,  G01N33/5308 ,  C12Q2600/16 ,  C12Q1/6804

Abstract: The present invention provides methods, antibodies and kits for detecting and/or quantifying expression of both non-nucleic acid molecules, such as proteins, and nucleic acid molecules in a single sample or single cell. The antibody is covalently conjugated to an oligonucleotide, such as a single-stranded DNA molecule, which comprises an identification tag and a blocking group, such as a ddNTP or an inverted dTTP, which prevents extension of the oligonucleotide by a polymerase. The method comprises the steps of reverse transcribing the conjugated oligonucleotide and the target nucleic acid simultaneously, amplifying both transcription production, and detecting the amplicons thereof. The method is also useful for detecting and/or quantifying the number of cells in a sample expressing a given non -nucleic acid molecule (e.g. protein).

公开(公告)号：US20230175968A1

公开(公告)日：2023-06-08

申请号：US17922349

申请日：2021-04-30

Applicant: Agency for Science, Technology and Research

Inventor： Malini Olivo ,  Jayakumar Perumal ,  Mohesh Moothanchery ,  Gurpreet Singh

IPC: G01N21/65

CPC classification number: G01N21/65 ,  G01N2201/0221 ,  G01N2201/06113 ,  G01N2021/0106

Abstract: A portable device which detects a Raman signal from an analyte of interest contained in or suspected to contain in a sample. The portable device includes a laser source in optical communication with a dichroic mirror, an objective lens optically positioned to consolidate the laser from the laser source to the sample, (i) a pair of rotatable filters in optical communication with the dichroic mirror and an optical transmission module or (ii) a first band-pass filter in optical communication with the dichroic mirror and an optical transmission module, and a detector optically positioned to receive and detect a Raman signal produced from the laser incident on the analyte of interest. The dichroic mirror directs the laser from the laser source to the sample through the objective lens and transmits any Raman signal from the sample toward the detector. The detector is absent of a spectrometer and detects the Raman signal.

公开(公告)号：US20230166981A1

公开(公告)日：2023-06-01

申请号：US17920738

申请日：2021-04-16

Applicant: National University of Singapore ,  Agency for Science, Technology and Research

Inventor： Moaz WAQAR ,  John WANG ,  Stephen John PENNYCOOK ,  Haijun WU ,  Kui YAO ,  Huajun LIU

IPC: C01G33/00 ,  H10N30/00 ,  H10N30/853 ,  H10N30/076

CPC classification number: C01G33/006 ,  H10N30/10516 ,  H10N30/8542 ,  H10N30/076 ,  C01P2006/40 ,  C01P2002/78 ,  C01P2002/60 ,  C01P2002/77 ,  C01P2004/04

Abstract: The present invention relates, in general terms, to piezoelectric thin films with an empirical formula (K1xNax)yNbO3, wherein 0≤x≤1 and 0.64≤y≤0.95. In particular, the piezoelectric thin film comprises at least two adjacent NbO2 planes in an antiphase boundary, the at least two adjacent NbO2 planes displaced from each other by about half a lattice length in either the (100), (010) or (100) crystallographic plane. The present invention also relates to methods of fabricating the piezoelectric thin films.

公开(公告)号：US20230122378A1

公开(公告)日：2023-04-20

申请号：US17494708

申请日：2021-10-05

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： James L. Hedrick ,  Yi Yan Yang ,  Agnes Mari Kuroki ,  Jiayu Eunice Leong ,  Wei Ping Eddy Tan

IPC: A61K31/795 ,  C08G64/02 ,  A61P31/14

Abstract: A water-soluble polymer having an aliphatic polycarbonate backbone, a first carbonate monomer with at least one hydrophilic functionality, and a second carbonate monomer with at least one hydrophobic functionality is able to completely and quickly eliminate a virus from a human and/or animal cell. The at least one hydrophilic functionality is a sulfate, a sulfonate, a carboxylate, and/or a phosphate and the at least one hydrophobic functionality is an alkyl. The hydrophilic/hydrophobic functionalities of the polymer may be tuned to enhance the antiviral properties of the polymer and/or to decrease any cytotoxicity associated with the application of the polymer to a human and/or animal cell. The antiviral polymer is biocompatible and biodegradable.

公开(公告)号：US11630110B2

公开(公告)日：2023-04-18

申请号：US16632646

申请日：2018-08-20

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Soon Heng Tan

IPC: G01N33/68

Abstract: The present invention discloses methods for identifying a protein interaction between one or more first proteins and one or more further proteins comprising the steps of: exposing one or more samples comprising the proteins to at least one preselected condition for at least one preselected duration; isolating and separating at least one soluble fraction from an insoluble fraction of said one or more samples; and analyzing the at least one soluble fraction or the insoluble fraction to identify said protein interaction between one or more first proteins and one or more further proteins. Use of the method of the invention are also disclosed.

公开(公告)号：US20230079226A1

公开(公告)日：2023-03-16

申请号：US17797950

申请日：2021-02-10

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jiaxu WANG ,  Yue WAN

IPC: C12Q1/6806 ,  C12Q1/6869

Abstract: The invention relates to a method of determining a structure of ribonucleic acid (RNA) molecules, the method comprising: contacting the RNA molecules with a modifying agent to obtain modified RNA molecules; reverse transcribing the modified RNA molecules; sequencing the product obtained from the preceding step to generate sequencing reads; and analysing the sequencing reads to determine the structure of the RNA molecules. In a preferred embodiment, the RNA molecules consist of RNA molecules of a single cell, and the modifying agent is 2-methylnicotinic acid imidazolide-azide (NAI-N3). There is also provided a method of classifying cells into one or more cell populations, the method comprising: determining the structure of RNA molecules in each cell; and classifying the cells into one or more cell populations based on similarity in the structure of their RNA molecules.

公开(公告)号：US20230051661A1

公开(公告)日：2023-02-16

申请号：US17788270

申请日：2020-12-28

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Liwei Chen ,  Wei Leong Chew

IPC: A61K38/53 ,  A61K38/50 ,  A61K38/45 ,  C07K14/47 ,  C12N9/00 ,  C12N9/78 ,  C12N15/62

Abstract: The present invention refers to a fusion protein or a protein complex comprising a DNA binding protein (DnaBP), a nucleobase modifying protein (NMP), and a Base Excision Repair associated protein (BERAP. Also, described herein are a method of replacing a cytosine with a guanine on a DNA strand in a cell and a method of treating a subject having or suspected of having a disease or disorder.

公开(公告)号：US20230006254A1

公开(公告)日：2023-01-05

申请号：US17780489

申请日：2020-11-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Dan Thien NGUYEN ,  Zhi Wei SEH

IPC: H01M10/0568 ,  H01M10/0569 ,  H01M4/46 ,  H01M10/054 ,  H01M50/109

Abstract: The present disclosure relates to an electrolyte comprising at least one magnesium salt having a polyatomic anion, an aluminium halide salt and a solvent comprising at least one ether group. The electrolyte described herein does not comprise magnesium chloride. The electrolyte described herein may be used in magnesium ion electrochemical cells.

公开(公告)号：US20220406998A1

公开(公告)日：2022-12-22

申请号：US17777942

申请日：2019-11-22

Applicant: Agency for Science, Technology and Research

Inventor： Wen Dong Song ,  Hock Koon Lee ,  Weijie Wang ,  Yao Zhu

IPC: H01L45/00 ,  G06N3/063

Abstract: Various embodiments may provide an electronic synapse device. The electronic synapse device may include a body including a doped chalcogenide layer including a chalcogenide material and a dopant. The electronic synapse device may also include a drain electrode in contact with the body. The electronic synapse device may further include a source electrode in contact with the body. The electronic synapse device may additionally include a gate electrode including an electrode contact layer in contact with the doped chalcogenide layer. The electrode contact layer may be any one selected from a group consisting of an electrically conductive layer including an electrically conductive material and a dopant layer including the dopant.