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公开(公告)号:US11254743B2
公开(公告)日:2022-02-22
申请号:US16869315
申请日:2020-05-07
Applicant: ALECTOR LLC
Inventor: Patricia Culp , Helen Lam , Arnon Rosenthal , Seung-Joo Lee , Nels P. Nielson , Robert Pejchal
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
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公开(公告)号:US11174313B2
公开(公告)日:2021-11-16
申请号:US15735946
申请日:2016-06-11
Applicant: ALECTOR LLC
Inventor: Arnon Rosenthal , Kate Monroe , Francesca Avogadri-Connors
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
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公开(公告)号:US11136390B2
公开(公告)日:2021-10-05
申请号:US15735947
申请日:2016-06-11
Applicant: ALECTOR LLC
Inventor: Kate Monroe , Helen Lam , Francesca Avogadri-Connors , Seung-Joo Lee , William Monteith , Herve Rhinn , Arnon Rosenthal
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
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公开(公告)号:US20210284710A1
公开(公告)日:2021-09-16
申请号:US17088149
申请日:2020-11-03
Applicant: Alector LLC
Inventor: Spencer Liang , Samuel Nalle , Jeonghoon Sun , Hua Long , Rashmi Bankoti
Abstract: The present disclosure is generally directed to Siglec-9 ECDs and Siglec-9 ECD fusion molecules, and methods of treatment using Siglec-9 ECDs and Siglec-9 ECD fusion molecules.
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公开(公告)号:US20210017275A1
公开(公告)日:2021-01-21
申请号:US16614302
申请日:2018-05-15
Applicant: Alector LLC
Inventor: Kate MONROE , Helen LAM , Patricia CULP , Arnon ROSENTHAL
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
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公开(公告)号:US20200317776A1
公开(公告)日:2020-10-08
申请号:US16835140
申请日:2020-03-30
Applicant: Alector LLC
Inventor: Tina SCHWABE , Eric BROWN , Philip KONG , Ilaria TASSI , Seung-Joo LEE , Arnon ROSENTHAL , Robert PEJCHAL , Nels P. NIELSON
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
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公开(公告)号:US20200223928A1
公开(公告)日:2020-07-16
申请号:US16741658
申请日:2020-01-13
Applicant: Alector LLC
Inventor: Arnon ROSENTHAL , Tina SCHWABE , Michael KURNELLAS
IPC: C07K16/28 , A61K31/7088
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
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公开(公告)号:US20190330335A1
公开(公告)日:2019-10-31
申请号:US15766363
申请日:2016-10-06
Applicant: ALECTOR LLC
Inventor: Tina SCHWABE , Francesca AVOGADRI-CONNORS , Helen LAM , Ilaria TASSI , Seung-Joo LEE , Arnon ROSENTHAL
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
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公开(公告)号:US10308718B2
公开(公告)日:2019-06-04
申请号:US15867609
申请日:2018-01-10
Applicant: ALECTOR LLC
Inventor: Arnon Rosenthal , Tina Schwabe , Michael Kurnellas , Robert Pejchal , Anthony B. Cooper
IPC: C07K16/28 , A61K31/7088
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.
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公开(公告)号:US20190040131A1
公开(公告)日:2019-02-07
申请号:US16054840
申请日:2018-08-03
Applicant: ALECTOR LLC
Inventor: Patricia Culp , Helen Lam , Arnon Rosenthal , Seung-Joo Lee , Nels P. Nielson , Robert Pejchal
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
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