公开(公告)号：US07855682B2

公开(公告)日：2010-12-21

申请号：US11587139

申请日：2006-07-05

Applicant: Dale Martin Gould ,  Robert David Cooper

Inventor： Dale Martin Gould ,  Robert David Cooper

IPC: G01S1/24

CPC classification number: G04G7/02 ,  G01S5/021 ,  G01S5/06

Abstract: A transmitter of a platform is arranged to generate a transmission pulse, which is transmitted to a receiver of another platform and is also arranged to couple its transmission pulse to a digital receiver associated with its platform via an attenuator and a coupler. Another platform performs a similar task. Each digital receiver determines the time separation between its transmission pulse and a received pulse from the other platform. The determined time separation information is shared with the other platform, and each digital receiver then determines a time offset between the time at its platform and the other platform.

Abstract translation: 平台的发射器被布置成产生传输到另一平台的接收机的传输脉冲，并且还被布置成经由衰减器和耦合器将其传输脉冲耦合到与其平台相关联的数字接收机。 另一个平台执行类似的任务。 每个数字接收机确定其传输脉冲与来自另一平台的接收脉冲之间的时间间隔。 确定的时间分离信息与另一个平台共享，然后每个数字接收机确定其平台的时间与另一个平台之间的时间偏移。

公开(公告)号：US20100036319A1

公开(公告)日：2010-02-11

申请号：US12525348

申请日：2008-01-28

Applicant: David Drake ,  Douglas Ivan Jennings ,  Stuart David Cooper ,  Timothy Donald Barrow-Williams ,  Joseph Peter Corrigan ,  Rosalind Trudy Lee ,  David Whitaker

Inventor： David Drake ,  Douglas Ivan Jennings ,  Stuart David Cooper ,  Timothy Donald Barrow-Williams ,  Joseph Peter Corrigan ,  Rosalind Trudy Lee ,  David Whitaker

IPC: A61M5/20 ,  B23P11/00

CPC classification number: A61J1/2096 ,  A61J1/1406 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2065 ,  A61J2200/10 ,  Y10T29/49826

Abstract: An auto injector including: a housing; an outlet portion with a needle (110) moveable relative to the housing; a container (104) within the housing for containing medicament; and an actuatable deployment mechanism configured to deploy the outlet portion by moving the outlet portion relative to the housing and to eject medicament contained in the container through the outlet portion. The auto injector is configured to store a volume of fluid and includes a filling mechanism configured to expel the volume of fluid from the outlet portion and subsequently to draw medicament through the outlet portion and into the container. An adaptor (112) fits to the auto injector so as to cover the needle and includes a puncture member configured to puncture a vial, the puncture member providing fluid communication to the needle. The auto injector and adaptor are provided as part of an auto injector pack together with a vial containing a substance which in combination with the liquid forms the medicament and a casing configured to house the vial, the auto injector and the adaptor

Abstract translation: 一种自动注射器，包括：壳体; 出口部分，其具有可相对于所述壳体移动的针头（110）; 用于容纳药物的壳体内的容器（104） 以及致动的展开机构，其构造成通过相对于所述壳体移动所述出口部分并且通过所述出口部分排出容纳在所述容器中的药剂而展开所述出口部分。 自动注射器构造成存储一定体积的流体，并且包括填充机构，该填充机构构造成从出口部分排出流体体积，随后通过出口部分抽吸药物并进入容器。 适配器（112）装配到自动注射器以覆盖针并且包括构造成刺穿小瓶的穿刺构件，所述穿刺构件提供与针的流体连通。 自动注射器和适配器作为自动注射器包的一部分与包含与液体组合的物质形成药物的小瓶一起提供，以及被配置为容纳小瓶，自动注射器和适配器

公开(公告)号：US07560420B2

公开(公告)日：2009-07-14

申请号：US11019256

申请日：2004-12-23

Applicant: Bernard Kinker ,  Matthias Fischer ,  Martin Bollinger ,  Robert Cybert ,  Ernst Bielmeier ,  David Cooper ,  Angelika Fischer ,  Melanie Croessmann

Inventor： Bernard Kinker ,  Matthias Fischer ,  Martin Bollinger ,  Robert Cybert ,  Ernst Bielmeier ,  David Cooper ,  Angelika Fischer ,  Melanie Croessmann

IPC: C10M145/14

CPC classification number: C10M149/02 ,  C10M161/00 ,  C10M2205/04 ,  C10M2209/084 ,  C10M2209/086 ,  C10M2217/023 ,  C10M2217/024 ,  C10M2217/028 ,  C10N2220/021 ,  C10N2230/041 ,  C10N2240/102

Abstract: The present invention is directed to a lubricating oil composition, a diesel engine comprising a lubricating oil composition, and a method of lubricating a diesel engine provided with an exhaust gas recirculation system, comprising lubricating said engine with a lubricating oil composition comprising an oil of lubricating viscosity, and a polymeric N-dispersant booster.

Abstract translation: 本发明涉及润滑油组合物，包含润滑油组合物的柴油发动机，以及润滑具有废气再循环系统的柴油发动机的方法，包括用润滑油组合物润滑所述发动机，所述润滑油组合物包含润滑油 粘度和聚合物N-分散剂助剂。

公开(公告)号：US20080243619A1

公开(公告)日：2008-10-02

申请号：US12079575

申请日：2008-03-27

Applicant: Duane R. Sharman ,  Ian Cheung ,  David Cooper

Inventor： Duane R. Sharman ,  Ian Cheung ,  David Cooper

IPC: G06Q30/00 ,  H04Q7/20

CPC classification number: G06Q30/02 ,  G06Q30/0201 ,  G06Q30/0255 ,  G06Q30/0256 ,  G06Q30/0267 ,  G06Q30/0269 ,  G06Q30/0277 ,  H04W4/14

Abstract: Methods and apparatus are disclosed for combining advertising messages with short message service (SMS) messages in a wireless communications system. A signaling message processing and routing node transmits and receives short message service (SMS) data packets via a communications network. The routing node includes an SMS message processing module that determines whether an SMS message should be modified to include advertisements. SMS messages, whether modified or left unmodified, are forwarded to a destination mobile communications device. The SMS message processing module applies rules to match selected advertisements with the SMS message. The determination of whether to modify the SMS message to include a selected advertisement is based on a variety of considerations including: the content and format of the SMS message; the content and format of the advertisements; the communications and display characteristics of the destination mobile communications device; and the limitations of the channel used to communicate the message to the destination mobile communications device.

Abstract translation: 公开了用于在无线通信系统中组合广告消息与短消息服务（SMS）消息的方法和装置。 信令消息处理和路由节点通过通信网络发送和接收短消息服务（SMS）数据分组。 路由节点包括SMS消息处理模块，该模块确定是否应该修改SMS消息以包括广告。 SMS消息，无论是修改还是未修改，都将转发到目标移动通信设备。 SMS消息处理模块应用规则以将所选择的广告与SMS消息相匹配。 是否修改SMS消息以包括所选择的广告的确定是基于各种考虑因素，包括：SMS消息的内容和格式; 广告的内容和格式; 目的地移动通信设备的通信和显示特性; 以及用于将消息传送到目标移动通信设备的信道的限制。

公开(公告)号：US20070185002A1

公开(公告)日：2007-08-09

申请号：US11349815

申请日：2006-02-07

Applicant: Ricky Demmer ,  Dean Peterman ,  Julia Tripp ,  David Cooper ,  Karen Wright

Inventor： Ricky Demmer ,  Dean Peterman ,  Julia Tripp ,  David Cooper ,  Karen Wright

IPC: C11D17/00

CPC classification number: A61L2/22 ,  A62D3/30 ,  A62D2101/02

Abstract: Compositions and methods for decontaminating surfaces are disclosed. More specifically, compositions and methods for decontamination using a composition capable of generating a long lasting foam. Compositions may include a surfactant and gelatin and have a pH of less than about 6. Such compositions may further include affinity shifting chemicals. Methods may include decontaminating a contaminated surface with a composition or a foam that may include a surfactant and gelatin and have a pH of less than about 6.

Abstract translation: 公开了用于去污表面的组合物和方法。 更具体地，使用能够产生持久的泡沫的组合物去污的组合物和方法。 组合物可以包括表面活性剂和明胶，并且具有小于约6的pH。这样的组合物还可以包括亲和转移化学品。 方法可以包括用可包含表面活性剂和明胶并具有小于约6的pH的组合物或泡沫来净化污染的表面。

公开(公告)号：US20070093473A1

公开(公告)日：2007-04-26

申请号：US10571220

申请日：2004-09-09

Applicant: David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Andrew Gribble ,  Andrew Lightfoot ,  Andrew Payne ,  Alexander Smith

Inventor： David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Andrew Gribble ,  Andrew Lightfoot ,  Andrew Payne ,  Alexander Smith

IPC: A61K31/55 ,  C07D403/02 ,  C07D409/02

CPC classification number: C04B35/632 ,  C07D401/12 ,  C07D409/12

Abstract: The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR3R4, —SO2NR3R4, —(CH2)pNR3R4, —(CH2)pNR3COR4, optionally substituted aryl ring, optionally substituted heteroaryl ring, a fused bicyclic heteroaromatic ring system or optionally substituted heterocyclyl ring; Ar1 represents optionally substituted heteroaryl ring; Ar2 represents optionally substituted aryl ring or optionally substituted heteroaryl ring; Z represents —(CH2)qX— wherein the —(CH2)q— group is attached to Ar2, or —X(CH2)q— wherein X is attached to Ar2, and wherein any of the —CH2— groups may be optionally substituted by one or more C1-6alkyl groups; X represents oxygen, —CH(OR5)—, —NR5— or —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups; R3 and R4 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; R5 represents hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 0, 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that when Ar1 is a pyridyl group, and Z is —CH2X— where X is attached to the Ar1 group, X is selected from —CH(OR5)—, —NR5— and —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups. The compounds of formula (I) are useful in therapy, in particular as antipsychotic agents.

公开(公告)号：US20060175520A1

公开(公告)日：2006-08-10

申请号：US11048546

申请日：2005-02-01

Applicant: David Cooper

Inventor： David Cooper

IPC: A47B97/04

CPC classification number: B60N3/005 ,  A47B31/06 ,  A47B97/08 ,  B42F9/001

Abstract: The present invention discloses a portable, collapsible clipboard which may be mounted to a vehicle steering wheel by means of an elastic strap or removed and carried by means of a provided shoulder strap. The clipboard is comprised of two writing portions that are hingedly connected so that the clipboard can be folded in half or expanded to provide a larger writing surface. A latch is provided to keep the clipboard securely folded.

Abstract translation: 本发明公开了一种便携式，可折叠的剪贴板，其可以通过弹性带安装到车辆方向盘，或者通过提供的肩带移除和携带。 剪贴板由铰接连接的两个书写部分组成，使得剪贴板可折叠成一半或扩展以提供较大的书写表面。 提供闩锁以保持剪贴板牢固地折叠。

公开(公告)号：US20060121486A1

公开(公告)日：2006-06-08

申请号：US10539953

申请日：2003-12-11

Applicant: David Cooper ,  Michael Krawczak ,  Jurgen Hedderich

Inventor： David Cooper ,  Michael Krawczak ,  Jurgen Hedderich

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: The invention relates to a method for identifying mutations and/or polymorphisms that are major determinants of a selected phenotype and is based on the identification of haplotypes and the partitioning thereof into groups that are major determinants for said phenotype.

Abstract translation: 本发明涉及用于鉴定作为所选表型的主要决定因素的突变和/或多态性的方法，其基于单倍体的鉴定及其作为所述表型的主要决定因素的分组。

公开(公告)号：US20050130150A1

公开(公告)日：2005-06-16

申请号：US10495234

申请日：2002-11-12

Applicant: David Cooper ,  Ann Marie Procter ,  John Gregory ,  David Millar

Inventor： David Cooper ,  Ann Marie Procter ,  John Gregory ,  David Millar

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6883 ,  G01N37/00 ,  C12P19/34

CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

Abstract: The present invention relates to naturally-occuring growth hormone mutations; to a method for detecting them and their use in screening patients for growth hormone irregularities or for producing variant proteins suitable for treating such irregularities. In one aspect there is disclosed a detection method for detecting a variation in GH1 effective to act as an indicator of GH dysfunction in an individual, which detection method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence of the human GH1 gene from the individual; and (b) comparing the sequence obtained from the test sample with the standard sequence known to be that of the human GH1 gene, wherein a difference between the test sample sequence and the standard sequence indicates the presence of a variation (hereinafter “variant of GH1”) effective to act as an indicator of GH1 dysfunction characterised in that the test sample is obtained from an individual, either or both: exhibiting intra-uterine growth retardation (IUGR), defined as sufficient foetal height velocity diagnosed by standard methods known in the art; and/or small for gestational age (SGA), defined as insufficient (small) foetal body size (weight and/or length) for gestional age diagnosed by standard methods known in the art.

Abstract translation: 本发明涉及天然存在的生长激素突变; 检测它们的方法及其在筛选患者生长激素不规则或用于产生适于治疗这种不规则的变体蛋白质的用途。 一方面，公开了一种检测方法，用于检测有效地作为个体的GH功能障碍的指标的GH1的变异，所述检测方法包括以下步骤：（a）获得包含人的核苷酸序列的测试样品 个体GH1基因; 和（b）将从测试样品获得的序列与已知为人类GH1基因的标准序列进行比较，其中测试样品序列与标准序列之间的差异表明存在变异（以下称为GH1的变体 “）有效地作为GH1功能障碍的指标，其特征在于，测试样品是从个体获得的，其中一种或两种：呈现子宫内生长迟缓（IUGR），定义为通过标准方法诊断的足够的胎儿高度速度 艺术; 和/或小于胎龄（SGA），定义为通过本领域已知的标准方法诊断的胎龄不足（小）胎儿体型（体重和/或长度）。

公开(公告)号：US5688492A

公开(公告)日：1997-11-18

申请号：US672232

申请日：1996-07-22

Applicant: Edward Galley ,  Michael David Cooper

Inventor： Edward Galley ,  Michael David Cooper

IPC: A61K8/19 ,  A61K8/29 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18 ,  A61K7/22 ,  A61K31/28

CPC classification number: A61K8/19 ,  A61K8/29 ,  A61Q11/00

Abstract: An oral hygiene composition comprises an effective amount of an antimicrobial agent in the form of a particulate non-ion-exchanging support material combined with a metal source providing antimicrobial metal ions in use. Preferably the antimicrobial agent is particulate titanium dioxide coated with silver chloride.

Abstract translation: 口腔卫生组合物包含与使用中提供抗微生物金属离子的金属源组合的有效量的微粒非离子交换载体材料形式的抗微生物剂。 优选地，抗微生物剂是用氯化银涂覆的颗粒状二氧化钛。