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61.发明授权Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal 有权用于从哺乳动物的胃肠道中选择性除去钾离子的方法和组合物公开(公告)号：US08617609B2
公开(公告)日：2013-12-31
申请号：US12088625
申请日：2006-10-02
申请人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
发明人： Michael J. Cope , Paul Mansky , Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Kalpesh Biyani , Mingjun Liu , Tony Kwok-Kong Mong , Yan Chen
CPC分类号： A61K31/795 , A61K9/0053 , A61K9/14 , A61K9/1694 , A61K9/5026 , A61K31/74 , A61K31/75 , A61K31/785 , A61K33/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。
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公开(公告)号：US08282960B2
公开(公告)日：2012-10-09
申请号：US10813872
申请日：2004-03-30
申请人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
CPC分类号： A61K9/5031 , A61K9/5026 , A61K9/5047
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
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公开(公告)号：US08282913B2
公开(公告)日：2012-10-09
申请号：US12055746
申请日：2008-03-26
IPC分类号： A61K31/74
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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64.发明申请CROSSLINKED CATION EXCHANGE POLYMERS, COMPOSITIONS AND USE IN TREATING HYPERKALEMIA 审中-公开交联剂交联聚合物，组合物和用于治疗高血压公开(公告)号：US20110236340A1
公开(公告)日：2011-09-29
申请号：US13060207
申请日：2009-08-22
申请人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Ramakrishnan Chidambaram , Jonathan Mills , Werner Strüver
发明人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Ramakrishnan Chidambaram , Jonathan Mills , Werner Strüver
CPC分类号： A61K31/78 , A61K9/14 , A61K31/7004 , A61K47/26 , B01J39/20 , C08F212/36 , C08F220/22
摘要： The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译： 本发明涉及包含氟基团和酸基团的交联阳离子交换聚合物，这些聚合物的药物组合物，线性多元醇的组合物和这种聚合物的盐。 还描述了具有有益物理性质的交联阳离子交换聚合物，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态和/或溶胀比的组合。 这些聚合物和组合物可用于结合胃肠道中的钾。
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公开(公告)号：US20110206631A1
公开(公告)日：2011-08-25
申请号：US13015134
申请日：2011-01-27
IPC分类号： A61K31/795 , A61P7/00
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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公开(公告)号：US07776319B2
公开(公告)日：2010-08-17
申请号：US11095760
申请日：2005-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
IPC分类号： A61K31/74 , A61K31/765 , A61K31/785 , A61K9/14 , A61P3/12 , A61P9/12 , A61P13/12
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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67.发明授权公开(公告)号：US07754199B2
公开(公告)日：2010-07-13
申请号：US11734152
申请日：2007-04-11
申请人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
发明人： Han Ting Chang , Dominique Charmot , Eric Connor , Florence Roger
CPC分类号： C08G73/02 , C08G73/0206
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供包含交联的胺聚合物的聚合物和药物组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗肾脏疾病和高磷酸血症。
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68.发明申请公开(公告)号：US20100111892A1
公开(公告)日：2010-05-06
申请号：US12545812
申请日：2009-08-22
申请人： Han-Ting Chang , Dominique Charmot , Mingjun Liu , Werner Strüver
发明人： Han-Ting Chang , Dominique Charmot , Mingjun Liu , Werner Strüver
CPC分类号： C08F220/22
摘要： The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group and being a polymerization product of at least three monomers. Pharmaceutical compositions of these polymers are useful to bind potassium in the gastrointestinal tract.
摘要翻译： 本发明涉及包含氟基和酸基的交联阳离子交换聚合物，并且是至少三种单体的聚合产物。 这些聚合物的药物组合物可用于结合胃肠道中的钾。
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69.发明申请TREATING HYPERKALEMIA WITH CROSSLINKED CATION EXCHANGE POLYMERS OF IMPROVED PHYSICAL PROPERTIES 审中-公开用改进的物理特性的交联剂交换聚合物处理高分子量公开(公告)号：US20100104527A1
公开(公告)日：2010-04-29
申请号：US12545809
申请日：2009-08-22
申请人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Werner Strüver
发明人： Paul Mansky , Detlef Albrecht , Michael Burdick , Han-Ting Chang , Dominique Charmot , Eric Connor , Sherin Halfon , I-Zu Huang , Mingjun Liu , Werner Strüver
摘要： The present invention is directed to methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio.
摘要翻译： 本发明涉及通过施用具有有益物理性质的交联阳离子交换聚合物的药物组合物来除去钾或治疗高钾血症的方法，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态， 和/或溶胀比。
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70.发明授权Pharmaceutical compositions comprising cross-linked small molecule amine polymers 失效包含交联的小分子胺聚合物的药物组合物公开(公告)号：US07608674B2
公开(公告)日：2009-10-27
申请号：US10980991
申请日：2004-11-03
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译： 描述了阴离子结合聚合物。 阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。 在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。 在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。 还描述了药物组合物，使用方法和试剂盒。
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