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公开(公告)号：US20240316100A1
公开(公告)日：2024-09-26
申请号：US18270261
申请日：2021-12-29
Applicant: INTELLIA THERAPEUTICS, INC.
Inventor： Christopher RUDULIER
IPC: A61K35/17 , A61K39/00 , A61P37/06 , C12N5/0783 , C12N5/10
CPC classification number: A61K35/17 , A61K39/4611 , A61K39/4621 , A61K39/4631 , A61K39/46433 , A61K39/46434 , A61K39/464466 , A61P37/06 , C12N5/0636 , C12N5/10 , C12N2510/00
Abstract: The present disclosure relates to T cells engineered to comprise a modification, e.g., knockdown, of an endogenous nucleic acid sequence encoding an IFNG, a modification, e.g., knockdown, of an endogenous nucleic acid sequence encoding a TNFA, and insertion of sequence(s) encoding a regulatory T cell promoting molecule and compositions and uses thereof.
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公开(公告)号：US12037583B2
公开(公告)日：2024-07-16
申请号：US15780751
申请日：2016-12-02
Applicant: Novartis AG , Intellia Therapeutics, Inc.
Inventor： Ming-Wei Chen , Melissa Deck , Glenn Dranoff , Craig Stephen Mickanin , Reynald Lescarbeau , Celeste Richardson , Morag Helen Stewart , Yi Yang
IPC: C12N15/113 , A61K9/00 , A61K31/7088 , A61K35/17 , A61K38/17 , A61K38/46 , A61K45/06 , C12N15/09 , C12N15/10
CPC classification number: C12N15/113 , A61K9/0009 , A61K31/7088 , A61K35/17 , A61K38/177 , A61K38/1774 , A61K38/465 , A61K45/06 , C12N15/09 , C12N15/102 , C12N15/1135 , C12N15/1138 , C12N2310/10 , C12N2310/20 , C12N2310/315 , C12N2310/321 , C12N2320/32 , C12N2320/35 , C12N2510/00 , Y02A50/30
Abstract: The present invention is directed to genome editing systems, reagents and methods for immunooncology.
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公开(公告)号：US20230383253A1
公开(公告)日：2023-11-30
申请号：US18366064
申请日：2023-08-07
Applicant: Intellia Therapeutics, Inc.
Inventor： Danielle Ryan Cook
IPC: C12N5/0783 , C07K14/725 , C12N9/22
CPC classification number: C12N5/0636 , C07K14/7051 , C12N9/22 , C12N2510/00 , C12N2310/20
Abstract: Compositions and methods for editing, e.g., altering a DNA sequence, within a LAG3 gene are provided. Compositions and methods for immunotherapy are provided.
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公开(公告)号：US20230383252A1
公开(公告)日：2023-11-30
申请号：US18366051
申请日：2023-08-07
Applicant: Intellia Therapeutics, Inc.
Inventor： Danielle Ryan Cook
IPC: C12N5/0783 , C07K14/725 , C12N9/22 , A61P37/02
CPC classification number: C12N5/0636 , C07K14/7051 , C12N9/22 , A61P37/02 , C12N2510/00 , C12N2310/20
Abstract: Compositions and methods for editing, e.g., altering a DNA sequence, within a 2B4 gene are provided. Compositions and methods for immunotherapy are provided.
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65.发明公开公开(公告)号：US20230374456A1
公开(公告)日：2023-11-23
申请号：US18366117
申请日：2023-08-07
Applicant: Intellia Therapeutics, Inc.
Inventor： Danielle Ryan Cook
IPC: C12N5/0783 , C07K14/705 , C07K14/725 , C12N9/22
CPC classification number: C12N5/0636 , C07K14/70503 , C07K14/7051 , C12N9/22 , C12N2510/00 , C12N2310/20
Abstract: Compositions and methods for editing, e.g., altering a DNA sequence, within a TIM3 gene are provided. Compositions and methods for immunotherapy are provided.
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Patent Agency Ranking
公开(公告)号：US11795460B2
公开(公告)日：2023-10-24
申请号：US18064086
申请日：2022-12-09
Applicant: Intellia Therapeutics, Inc.
Inventor： Arti Mahendra Prakash Kanjolia , Shobu Odate , Jessica Lynn Seitzer , Reynald Michael Lescarbeau , Walter Strapps
CPC classification number: C12N15/113 , A61P25/28 , C12N9/22 , C12N15/102 , A61K48/00 , A61K48/0091 , C12N15/111 , C12N2310/20 , C12N2310/321 , C12N2800/80
Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.
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公开(公告)号：US20230287400A1
公开(公告)日：2023-09-14
申请号：US17900960
申请日：2022-09-01
Applicant: Intellia Therapeutics, Inc.
Inventor： Amy Madison Rhoden Smith , David V. Morrissey , Walter Strapps
CPC classification number: C12N15/11 , C12N9/22 , C12N2310/20 , C12N2310/315 , C12N2310/344 , C12N2310/346 , C12N2320/51
Abstract: This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods.
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公开(公告)号：US20230212575A1
公开(公告)日：2023-07-06
申请号：US18063817
申请日：2022-12-09
Applicant: Intellia Therapeutics, Inc.
Inventor： Shobu Odate , Walter Strapps , Reynald Michael Lescarbeau
CPC classification number: C12N15/113 , A61K9/14 , A61K47/28 , A61K47/24 , C12N15/86 , A61K9/5146 , C12N2310/20
Abstract: Compositions and methods for introducing double-stranded breaks within the SERPINA1 gene are provided. Compositions and methods for reducing and eliminating mutant forms of α1-antitrypsin (AAT), such as seen in subjects having α1-antitrypsin deficiency (AATD), are provided.
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公开(公告)号：US20230183753A1
公开(公告)日：2023-06-15
申请号：US18050333
申请日：2022-10-27
Applicant: Intellia Therapeutics, Inc.
Inventor： Pooja Kyatsandra Narendra , Sean Michael Burns , Paula Gutierrez Martinez , Arti Mahendra Prakash Kanjolia , Anthony Monti , Aaron Prodeus , Mohamed Simo Arredouani , Özgün Kiliç , Reed Walker LaRiviere , Palak Sushil Sharma , Eleni Stampouloglou , Qingzhan Zhang
CPC classification number: C12N15/907 , C12N5/0636 , C12N15/87 , C12N15/11 , C12N9/22 , A61K38/1774 , A61K35/17 , A61P35/00 , C12N2510/00 , C12N2310/20 , C12N2800/80
Abstract: Compositions and methods for multiplex delivery and gene editing in vitro are provided.
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公开(公告)号：US11673911B2
公开(公告)日：2023-06-13
申请号：US16791076
申请日：2020-02-14
Applicant: Intellia Therapeutics, Inc.
Inventor： Christian Dombrowski
CPC classification number: C07H21/02 , C12N15/11 , C12N15/63 , C07K14/475 , C07K14/521 , C12N9/22
Abstract: This disclosure relates to the field of poly-adenylated (poly-A) tails. In some embodiments, a DNA encodes a poly-A tail located 3′ to nucleotides encoding a protein of interest, wherein the poly-A tail comprises one or more non-adenine nucleotide.
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