公开(公告)号：US20060013876A1

公开(公告)日：2006-01-19

申请号：US10518909

申请日：2003-06-25

Applicant: Braj Lohray ,  Sandip Tiwari ,  Raveendra Pai ,  Krishna Murthy ,  Pavak Mehta

Inventor： Braj Lohray ,  Sandip Tiwari ,  Raveendra Pai ,  Krishna Murthy ,  Pavak Mehta

IPC: A61K9/24

CPC classification number: A61K9/0065

Abstract: Present invention relates to a novel pharmaceutical composition containing an active ingredient(s) which is retained in the stomach or upper part of gastrointestinal tract for controlled delivery of medicament for improved local treatment, and/or better absorption from upper parts of gastrointestinal tract for effective therapeutic results. Present invention also provides a method for preparation of the said dosage form preferably in the form of a bilayer tablet, in which one layer constitutes for spatial control and the other being for temporal control.

Abstract translation: 本发明涉及含有活性成分的新型药物组合物，其保留在胃或胃肠道上部，用于控制递送用于改善局部治疗的药物和/或从胃肠道上部更好地吸收以有效地 治疗结果。 本发明还提供了优选以双层片剂形式制备所述剂型的方法，其中一层构成用于空间控制，另一层构成用于时间控制。

公开(公告)号：US06896917B2

公开(公告)日：2005-05-24

申请号：US09811780

申请日：2001-03-19

Applicant: Appu Rao Gopala Rao Appu Rao ,  Hole Narasipura Nanjundaiah Chandrasekhara ,  Karadka Govindaraju ,  Johny Joseph ,  Kolara Subramanyam Krishna Murthy ,  Vishweshwariah Prakash ,  Mysore Cheeluvaraya Shamanthaka Sastry

Inventor： Appu Rao Gopala Rao Appu Rao ,  Hole Narasipura Nanjundaiah Chandrasekhara ,  Karadka Govindaraju ,  Johny Joseph ,  Kolara Subramanyam Krishna Murthy ,  Vishweshwariah Prakash ,  Mysore Cheeluvaraya Shamanthaka Sastry

IPC: A23J3/16 ,  A23J3/34 ,  A23L11/30 ,  A23L1/20

CPC classification number: C12Y304/22002 ,  A23J3/16 ,  A23J3/346 ,  A23L11/33

Abstract: A process for preparation of protein hydrolysate from soy flour. The process comprises the steps of hydrolyzing an aqueous slurry of defatted soy flour containing 6-30% solid content w/v using proteolytic enzyme of plant origin at a pH of 5-9 and at a temperature of 53±5° C. under stirring for 30 minutes to 6 hours; inactivating the enzyme by a known manner, neutralizing the pH value of the slurry, separating the solids by a known manner, and drying the clarified liquor so obtained to get the hydrolysate.

Abstract translation: 从大豆粉制备蛋白质水解产物的方法。 该方法包括以下步骤：使用植物来源的蛋白水解酶在5-9℃和53±5℃的温度搅拌下水解含有6-30％固体含量w / v的脱脂大豆粉的水浆液 30分钟至6小时; 以已知的方式灭活酶，中和浆液的pH值，用已知的方式分离固体，并干燥所得到的澄清液以得到水解产物。

公开(公告)号：US4946845A

公开(公告)日：1990-08-07

申请号：US248525

申请日：1988-11-25

Applicant: D. V. Krishna Murthy ,  Michael C. Venuti ,  John M. Young

Inventor： D. V. Krishna Murthy ,  Michael C. Venuti ,  John M. Young

IPC: C12N9/99 ,  A61K20060101 ,  A61K31/215 ,  A61K31/22 ,  A61K31/235 ,  A61K31/265 ,  A61K31/33 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/4418 ,  A61P17/00 ,  A61P29/00 ,  A61P43/00 ,  C07C20060101 ,  C07C50/32 ,  C07C69/013 ,  C07C69/16 ,  C07C69/28 ,  C07C69/635 ,  C07D209/30 ,  C07D213/70 ,  C07D213/71 ,  C07D215/36 ,  C07D233/84 ,  C07D239/38 ,  C07D521/00

CPC classification number: A61K31/22 ,  C07C50/32 ,  C07C69/017 ,  C07C69/16 ,  C07C69/28 ,  C07C69/63 ,  C07C69/635

Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy or optionally substituted phenoxy,R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2;at least one of X or Y is C(O)W and the other X or Y is different and is hydrogen, C(O)W or R.sup.4 whereinW is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl; andR.sup.4 is lower alkyl or optionally substituted phenyl-lower-alkyl.

Abstract translation: 哺乳动物的银屑病通过局部施用下式的萘来减轻：其中：R1和R2相同，为低级烷氧基或任选取代的苯氧基，R3为低级烷基，低级烷氧基或卤素，m为0 ，1或2或R3是任选取代的苯基，任选取代的苯基低级烷基，任选取代的苯基低级烷氧基，氨基，低级烷基氨基，低级二烷基氨基，氰基或S（O）n R其中R是低级烷基; 任选取代的苯基; 任选取代的苯基低级烷基; 或含有一个或两个选自氮，氧和硫的杂原子的三至九个环原子的任选取代的杂环芳基及其药学上可接受的酸加成盐; m为1，n为0,1或2; X或Y中的至少一个为C（O）W，另一个X或Y为不同的且为氢，C（O）W或R 4，其中W为1至7个碳原子的烷基，任选取代的苯基或任选取代的苄基 ; 并且R 4是低级烷基或任选取代的苯基 - 低级 - 烷基。

公开(公告)号：US4833155A

公开(公告)日：1989-05-23

申请号：US936551

申请日：1986-11-25

Applicant: Joseph M. Muchowski ,  Robert Greenhouse ,  John Young ,  D. V. Krishna Murthy

Inventor： Joseph M. Muchowski ,  Robert Greenhouse ,  John Young ,  D. V. Krishna Murthy

IPC: A61K31/40 ,  A61P9/00 ,  A61P25/04 ,  A61P29/00 ,  C07D207/32 ,  C07D207/333 ,  C07D207/335 ,  C07D207/34 ,  C07D207/36

CPC classification number: C07D207/333 ,  C07D207/34 ,  C07D207/36

Abstract: 3-[.omega.-(3,5-Di-t-butyl-4-hydroxyphenyl)alkanoyl]-pyrroles and their de-oxy analogs, for example, 3-(3,5-di-t-butyl-4-hydroxybenzyl)pyrrole, 2-chloro-4-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole, 3-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole and 3-[2-(3,5-di-t-butyl-4-hydroxyphenyl)-1-oxoethyl]pyrrole, have high pharmacological potency as anti-inflammatory, analgesic and antipyretic agents.