公开(公告)号：US20230058593A1

公开(公告)日：2023-02-23

申请号：US18048874

申请日：2022-10-24

Applicant: Repligen Corporation

Inventor： Derek Carroll ,  Bao Le

IPC: F16L25/14 ,  F16L21/03

Abstract: The present disclosure is related to bioprocessing devices, systems, and methods, and particularly to sanitary connections for bioprocessing. The devices, systems, and methods described herein can relate to the sanitary connection of flow fittings, such as reducers, with considerations for ease of assembly and sealing. In some embodiments, the system may include a flow reducer, a ferrule and a gasket. The flow reducer may include a gasket channel, an overmold channel within the gasket channel, and one or more cavities within the overmold channel. The gasket may be overmolded within the gasket channel and extending within the one or more cavities.

公开(公告)号：US11548929B2

公开(公告)日：2023-01-10

申请号：US16965833

申请日：2019-01-28

Applicant: Repligen Corporation

Inventor： Erik Fiedler ,  Ulrich Haupts

IPC: A61K38/00 ,  C07K14/735 ,  C07K1/14

Abstract: The present invention relates to Fc binding proteins comprising one or more domains with Cysteine in the C-terminal helical region. The invention further relates to affinity matrices comprising the Fc binding proteins of the invention. The invention also relates to a use of these Fc binding proteins or affinity matrices for affinity purification of immunoglobulins and to methods of affinity purification using the Fc binding proteins of the invention.

公开(公告)号：US11530752B2

公开(公告)日：2022-12-20

申请号：US17869031

申请日：2022-07-20

Applicant: Repligen Corporation

Inventor： Michael C. Gagne ,  Dean C. Richards ,  Steven V. Cates

IPC: F16K7/04 ,  F16L57/00 ,  F16L57/02 ,  F16K27/02

Abstract: Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.

公开(公告)号：US11519539B2

公开(公告)日：2022-12-06

申请号：US16666970

申请日：2019-10-29

Applicant: Repligen Corporation

Inventor： Derek Carroll ,  Bao Le

IPC: F16L25/14 ,  F16L21/03

Abstract: The present disclosure is related to bioprocessing devices, systems, and methods, and particularly to sanitary connections for bioprocessing. The devices, systems, and methods described herein can relate to the sanitary connection of flow fittings, such as reducers, with considerations for ease of assembly and sealing. In some embodiments, the system may include a flow reducer, a ferrule and a gasket. The flow reducer may include a gasket channel, an overmold channel within the gasket channel, and one or more cavities within the overmold channel. The gasket may be overmolded within the gasket channel and extending within the one or more cavities.

公开(公告)号：US11433326B2

公开(公告)日：2022-09-06

申请号：US17014465

申请日：2020-09-08

Applicant: REPLIGEN CORPORATION

Inventor： Rudolf Pavlik

IPC: B01D29/90 ,  B01D35/26 ,  B01D29/11 ,  B01D37/04 ,  B01D63/00 ,  B01D63/02 ,  C12M1/36 ,  C12M1/00

Abstract: A fluid filtration assembly includes a filter housing having first and second ends and a connector for fluid communication with a fluid storage vessel. A filter element is disposable within the filter housing, and first and second pumps are coupled at the first and second ends of the filter housing. A controller may coordinate the operation of the first and second pumps to induce alternating tangential flow of fluid between the filter housing and the first and second pumps. At least one of the first and second pumps is a diaphragm pump or a plunger pump. The fluid storage vessel can be a bioreactor.

公开(公告)号：US11426697B2

公开(公告)日：2022-08-30

申请号：US17014485

申请日：2020-09-08

Applicant: REPLIGEN CORPORATION

Inventor： Rudolf Pavlik

IPC: B01D63/02 ,  B01D69/08 ,  B01D37/04 ,  B01D35/26 ,  B01D29/11 ,  B01D29/90 ,  F04B43/00 ,  F04B43/06 ,  F04B53/20 ,  C12M1/00 ,  C12M1/12 ,  F04B43/067

Abstract: A fluid filtration assembly includes a filter housing having a first end for fluid connection with a fluid storage vessel. A filter cartridge is disposable within the filter housing, and a plunger pump is coupled at a second end of the filter housing. The plunger pump includes a housing having a rigid portion and a flexible portion. The flexible portion has a plunger-engaging portion for coupling to the plunger of an actuator. The flexible portion selectively movable with respect to the rigid portion via the actuator. The filter cartridge can be a hollow fiber filter. The plunger pump can be configured to induce alternating tangential flow in at least a portion of the assembly. The fluid filtration assembly can be provided as a disposable single-use arrangement.

公开(公告)号：US20220268628A1

公开(公告)日：2022-08-25

申请号：US17672959

申请日：2022-02-16

Applicant: Repligen Corporation

Inventor： Rene Daniel Jean-Marie Gantier ,  Mark C. Salerno

IPC: G01J3/42 ,  G01N21/31

Abstract: The present disclosure relates to spectroscopy with light emitting components including, e.g., UV and/or visible wavelength light, for various applications, including, e.g., chromatography, and more particularly, for a sampling device that facilitates spectroscopic measurements with a variable pathlength and methods for such a device. In an aspect, a device for measuring light absorbance of a sample may include a fluid conduit comprising a first portion, a midportion substantially perpendicular to the first portion, and a second portion substantially perpendicular to the midportion. A first probe may be within the midportion and substantially parallel with the midportion. The first probe may comprise a distal end. A light source may be operably coupled to the first probe. A detector may be aligned with the distal end of the first probe substantially perpendicular to the first probe at a pathlength from the distal end of the first probe.

公开(公告)号：US20220106554A1

公开(公告)日：2022-04-07

申请号：US17426238

申请日：2020-01-30

Applicant: Repligen Corporation

Inventor： Craig Robinson ,  Prity Bengani-Lutz

IPC: C12M1/00 ,  B01D69/02 ,  B01D63/08 ,  B01D39/16 ,  B01D71/50 ,  B01D71/64 ,  B01D71/48 ,  B01D71/34 ,  B32B7/12 ,  B32B27/08 ,  F16L13/11

Abstract: Track-etched membranes for filtration are provided. Filtration methods utilizing such membranes and cell culture methods are also provided.

公开(公告)号：US11225637B2

公开(公告)日：2022-01-18

申请号：US16140146

申请日：2018-09-24

Applicant: Repligen Corporation

Inventor： Jerry Shevitz

IPC: C12M1/00 ,  B01D61/14 ,  B01D61/58 ,  B01D63/02 ,  C12M1/26

Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.

公开(公告)号：US20220008803A1

公开(公告)日：2022-01-13

申请号：US17482802

申请日：2021-09-23

Applicant: Repligen Corporation

Inventor： Travis R. Ward ,  Steven R. Pearl ,  Adam Malone ,  Tim Erlandson

IPC: A63B71/00 ,  A63B21/00 ,  A63B24/00 ,  A63B23/12 ,  A63B21/005 ,  A63B21/16 ,  A63B23/035

Abstract: Disclosed herein are robust disposable alternating tangential flow (ATF) housing and diaphragm pump units and associated methods of manufacturing, testing, wetting, and using the same.