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公开(公告)号：US20200031947A1
公开(公告)日：2020-01-30
申请号：US16488040
申请日：2018-02-21
Applicant: Rinat Neuroscience Corp.
Inventor： Samantha Lisa BUCKTROUT , Bevin Marie Brady SMITH , Edward Derrick PASCUA , Javier Fernando CHAPARRO RIGGERS
Abstract: The present invention provides antibodies that bind Glucocorticoid Induced Tumor necrosis factor Receptor family related protein (GITR) and methods of using same. The anti-GITR antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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公开(公告)号：US20190321482A1
公开(公告)日：2019-10-24
申请号：US16231242
申请日：2018-12-21
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Santiago Esteban Farias , Meritxell Galindo Casas , Pavel Strop
IPC: A61K47/68
Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.
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公开(公告)号：US20190002559A1
公开(公告)日：2019-01-03
申请号：US16125032
申请日：2018-09-07
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US10100114B2
公开(公告)日：2018-10-16
申请号：US15160742
申请日：2016-05-20
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US09708398B2
公开(公告)日：2017-07-18
申请号：US14940710
申请日：2015-11-13
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Jaume Pons , Arnon Rosenthal
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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Patent Agency Ranking
公开(公告)号：US09498530B2
公开(公告)日：2016-11-22
申请号：US13946532
申请日：2013-07-19
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Arnon Rosenthal , David Louis Shelton , Patricia Ann Walicke
IPC: C07K16/22 , A61K39/395 , A61K39/00
CPC classification number: C07K16/22 , A61K39/3955 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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公开(公告)号：US09399074B2
公开(公告)日：2016-07-26
申请号：US14460871
申请日：2014-08-15
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui Liu , Wei-Hsien Ho , Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Louis Shelton , Thomas-Toan Tran
CPC classification number: C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
Abstract translation: 本发明提供特异性结合滋养层细胞表面抗原-2（Trop-2）的抗体。 本发明进一步提供了包含此类抗体的抗体缀合物，编码抗体的核酸，以及获得此类抗体的方法。 本发明还涉及这些抗体和Trop-2抗体缀合物用于治疗与Trop-2表达（例如癌症）如结肠，食管，胃，头颈部，肺， 卵巢癌或胰腺癌。
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公开(公告)号：US20160152698A1
公开(公告)日：2016-06-02
申请号：US14940710
申请日：2015-11-13
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Jaume PONS , Arnon ROSENTHAL
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
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69.发明申请ANTIBODIES DIRECTED AGAINST AMYLOID-BETA PEPTIDE AND METHODS USING SAME 审中-公开针对AMYLOID-BETA肽的抗体和使用其的方法公开(公告)号：US20160096884A1
公开(公告)日：2016-04-07
申请号：US14966175
申请日：2015-12-11
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Arnon ROSENTHAL , Jaume PONS , Wei-Hsien HO
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/28 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
Abstract: Antibodies directed to the C-terminal side of β-amyloid peptide and methods of using these antibodies for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described.
Abstract translation: 针对β-淀粉样蛋白肽的C-末端的抗体以及使用这些抗体诊断和治疗阿尔茨海默病和A＆bgr的方法; 描述了肽相关疾病。
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70.发明授权Human growth hormone receptor antagonist antibodies and methods of use thereof 有权人生长激素受体拮抗剂抗体及其使用方法公开(公告)号：US09249224B2
公开(公告)日：2016-02-02
申请号：US14367483
申请日：2012-12-10
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Sara Iva Siebel , Edward Derrick Pascua , Chia-Yang Lin , Javier Fernando Chaparro Riggers
IPC: C07K16/28 , A61K39/395 , A61K39/00
CPC classification number: C07K16/2869 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation.
Abstract translation: 本发明提供了与生长激素受体（GHR）结合的拮抗性抗体。 本发明还涉及使用这些抗体降低IGF-1水平和/或用于治疗和/或预防与过量IGF-1相关的疾病的治疗方法，包括治疗肢端肥大症，巨人症，癌症，糖尿病性肾病，关节炎 ，和肺部炎症。
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