公开(公告)号：US07235546B2

公开(公告)日：2007-06-26

申请号：US11592542

申请日：2006-11-03

Applicant: Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

Inventor： Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

IPC: A61K31/551 ,  C07D401/04

CPC classification number: A61K31/496 ,  A61K31/52 ,  A61K31/54 ,  A61K31/56 ,  C07D215/54 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

公开(公告)号：US07192955B2

公开(公告)日：2007-03-20

申请号：US11415785

申请日：2006-05-02

Applicant: Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K.C.

Inventor： Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K.C.

IPC: A61K31/551 ,  C07D401/04

CPC classification number: C07D401/12 ,  C07D215/42 ,  C07D215/54 ,  C07D405/12 ,  C07D409/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

公开(公告)号：US07173036B2

公开(公告)日：2007-02-06

申请号：US10778884

申请日：2004-02-13

Applicant: Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

Inventor： Jagadish Sircar ,  Sunil Kumar K C ,  Wenbin Ying

IPC: A61K31/496 ,  C07D401/04 ,  A61K31/551 ,  A61K31/4704 ,  A61K31/4709

CPC classification number: A61K31/496 ,  A61K31/52 ,  A61K31/54 ,  A61K31/56 ,  C07D215/54 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

公开(公告)号：US07157469B2

公开(公告)日：2007-01-02

申请号：US11416004

申请日：2006-05-02

Applicant: Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

Inventor： Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

IPC: A61K31/4709 ,  C07D401/02

CPC classification number: C07D401/12 ,  C07D215/42 ,  C07D215/54 ,  C07D405/12 ,  C07D409/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

公开(公告)号：US07141364B1

公开(公告)日：2006-11-28

申请号：US09821782

申请日：2001-03-29

Applicant: Sunil Kumar Verma ,  Lalji Singh

Inventor： Sunil Kumar Verma ,  Lalji Singh

IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC classification number: C12Q1/6876

Abstract: The invention provides novel universal primers that can amplify the fragment of cytochrome b gene of any animal species in polymerase chain reaction (PCR) and reveal the identity of the biological material of any unknown animal origin and a method for identification of the specific animal from a given biological sample.

Abstract translation: 本发明提供了可以在聚合酶链式反应（PCR）中扩增任何动物物种的细胞色素b基因片段的新型通用引物，并揭示了任何未知动物来源的生物学物质的特性，以及用于鉴定特定动物的方法 给定生物样品。

公开(公告)号：US07084141B2

公开(公告)日：2006-08-01

申请号：US11268375

申请日：2005-11-07

Applicant: Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

Inventor： Federico C. A. Gaeta ,  Andrew Baird ,  Jerry Anchin ,  Wenbin Ying ,  Robert Florkiewicz ,  Jagadish Sircar ,  Sunil Kumar K. C.

IPC: A61K31/496

CPC classification number: C07D401/12 ,  C07D215/42 ,  C07D215/54 ,  C07D405/12 ,  C07D409/12

Abstract: Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Abstract translation: 提供了MIF的抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中n，R 1，R 2，R 3， >，R 4，X，Y和Z如本文所定义。 还提供了含有与药学上可接受的载体组合的MIF抑制剂的组合物，以及使用该组合物的方法。

公开(公告)号：US20060107213A1

公开(公告)日：2006-05-18

申请号：US11206652

申请日：2005-08-17

Applicant: Sunil Kumar ,  Subramanya Uppala ,  Dipanshu Sharma ,  Chandra Kholia ,  Fernando Corona

Inventor： Sunil Kumar ,  Subramanya Uppala ,  Dipanshu Sharma ,  Chandra Kholia ,  Fernando Corona

IPC: G06F3/00 ,  G06K9/20

CPC classification number: G06F3/0346 ,  G06F2203/0381

Abstract: Motion is used as an input to a program running on a mobile device. The mobile device may require input also from alphanumeric or text input device. The motion can be used for items such as selection from a list, or navigation on the map. The motion can be sensed on image processing the output of the camera, or can be directly determine using an accelerometer. Existing programs can be explicitly modified, in which case the program accepts the motion directly. Alternatively, the modification can be implicit—where the motion is converted to a signal that the program can accept, without modification.

Abstract translation: 运动用作在移动设备上运行的程序的输入。 移动设备也可能需要来自字母数字或文本输入设备的输入。 该动作可用于诸如列表中的选择或地图上的导航等项目。 可以在图像处理摄像机的输出上检测运动，或者可以使用加速度计直接确定运动。 现有程序可以被明确地修改，在这种情况下，程序直接接受动作。 或者，修改可以是隐式的，其中运动被转换为程序可以接受的信号，而无需修改。

公开(公告)号：US20060064499A1

公开(公告)日：2006-03-23

申请号：US11264293

申请日：2005-10-31

Applicant: Dipanshu Sharma ,  Sunil Kumar ,  Chandra Kholia

Inventor： Dipanshu Sharma ,  Sunil Kumar ,  Chandra Kholia

IPC: G06F15/16

CPC classification number: H04L69/329 ,  G06F16/9577 ,  H04L67/02 ,  H04L69/08 ,  H04M3/4938

Abstract: A method for retrieving content from one or more remote information sources is disclosed herein. The inventive method contemplates transmitting a user request over a communication link to a voice browser operative in accordance with a voice-based protocol. In response, a browsing request identifying a remote information source corresponding to the user request is generated. Content formatted in accordance with a predefined protocol is then retrieved from the remote information source in accordance with the browsing request. The retrieved content is converted into a file of information formatted in compliance with the voice-based protocol. A response is provided to the user request on the basis of the file of converted information.

公开(公告)号：US20050021826A1

公开(公告)日：2005-01-27

申请号：US10830413

申请日：2004-04-21

Applicant: Sunil Kumar

Inventor： Sunil Kumar

IPC: H04L29/08 ,  G06F15/16

CPC classification number: H04L67/14 ,  H04L69/329

Abstract: A multimode system that allows communicating to different modes of servers, simultaneously. A special interface is used.

Abstract translation: 同时允许与不同模式的服务器通信的多模系统。 使用特殊的界面。

公开(公告)号：US06676976B2

公开(公告)日：2004-01-13

申请号：US10104765

申请日：2002-03-21

Applicant: Sunil Kumar Chattopadhyay ,  Guru Das Bagchi ,  Prem Dutt Dwivedi ,  Sachin Srivastava

Inventor： Sunil Kumar Chattopadhyay ,  Guru Das Bagchi ,  Prem Dutt Dwivedi ,  Sachin Srivastava

IPC: A61K3578

CPC classification number: C07D487/04

Abstract: The present invention relates to an improved process for the production of vasicine of formula (1) from the Adhatoda vasica, said process comprising the steps of: extracting the dried and pulverized leaves with an alcoholic extract at an ambient temperature, concentrating the alcoholic extract to obtain a concentrated extract, treating and stirring extract with an aqueous organic acid for 2-24 hours, extracting the acid solution of with an organic solvent, separating the organic layer and aqueous acidic layer, basifying the aqueous acidic solution with a base, extracting the basified solution with an organic solvent, separating the organic layer, drying and filtering, evaporating the organic layer to obtain an amorphous residue, and treating the amorphous residue with an organic solvent or mixture of organic solvents to obtain vasicine.

Abstract translation: 本发明涉及一种用于从Adhatoda vasica生产式（1）的维生素的改进方法，所述方法包括以下步骤：在室温下用醇提取物萃取干燥和粉碎的叶子，将醇提取物浓缩 获得浓缩提取物，用有机酸水溶液处理和搅拌提取物2-24小时，用有机溶剂萃取酸溶液，分离有机层和酸性水层，用碱将酸性水溶液碱化，提取 碱性溶液与有机溶剂分离，分离有机层，干燥和过滤，蒸发有机层，得到无定形残渣，用有机溶剂或有机溶剂混合物处理无定形残余物，得到vasicine。