公开(公告)号：US11273449B2

公开(公告)日：2022-03-15

申请号：US16393737

申请日：2019-04-24

Applicant: TECAN TRADING AG

Inventor： Marina Knoppke

IPC: B01L9/00

Abstract: A storage box for plastic pipette tips that has a frame part with two longitudinal walls and two transverse walls that enclose an interior space laterally. The storage box has a support plate arranged on the upper side of the frame part with a large number of bearing openings that plastic pipette tips can be inserted. The storage box also includes a pipette tip contact piece on the underside of the frame part for contacting a plastic pipette tip inserted into one of the bearing openings.

公开(公告)号：US11249099B2

公开(公告)日：2022-02-15

申请号：US16359265

申请日：2019-03-20

Applicant: TECAN TRADING AG

Inventor： Anja Wolter ,  Michael Keller

IPC: G01N35/10 ,  G01N35/00

Abstract: A liquid class including control parameters for controlling a laboratory automation device when handling a liquid of a liquid type assigned to the liquid class with a pipette tip of a pipette tip type assigned to the liquid class, and a method for optimizing the liquid class. The method can include initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class. The method can further include optimizing the liquid class iteratively with the genetic algorithm by applying liquid classes from the set of liquid classes to the laboratory automation device, which performs at least one aspiration and dispensing measurement for each applied liquid class, as well as additional method acts.

公开(公告)号：US20220034420A1

公开(公告)日：2022-02-03

申请号：US17276731

申请日：2019-09-20

Applicant: TECAN TRADING AG

Inventor： Philipp OTT

IPC: F16K31/06 ,  B01L3/02 ,  G01F11/12 ,  G01F13/00

Abstract: A method for controlling a magnetic valve and particularly a method for dispensing and/or aspirating a volume of liquid as well as a corresponding dispenser/pipetting apparatus is disclosed. The method for controlling a magnetic valve has measuring a capacitance at the magnetic valve and determining a position of a plunger based on the measured capacitance. The method for dispensing or aspirating a volume of liquid has controlling a flow of a system fluid by a magnetic valve located between a pressure source and a dispenser/pipetting tip, dispensing or aspirating a volume of liquid through an exterior opening of the tip dependent on the flow of the system fluid, wherein controlling the flow and determining a flow time in dependence of the volume of liquid to be dispensed or aspirated, and controlling the magnetic valve is held open for the duration of the flow time.

公开(公告)号：US20220026455A1

公开(公告)日：2022-01-27

申请号：US17296480

申请日：2019-12-10

Applicant: TECAN TRADING AG

Inventor： Michael KELLER

IPC: G01N35/10

Abstract: A method for classifying liquid handling procedures comprises includes receiving measurement data encoding a measurement curve of measurements over time during at least a part of a liquid handling procedure; inputting the measurement data into a neural network; and calculating at least one quality value for the liquid handling procedure with the neural network.

公开(公告)号：US20220023854A1

公开(公告)日：2022-01-27

申请号：US17295624

申请日：2019-12-20

Applicant: Adrian SAGER ,  Philipp OTT ,  Patrick KINNEY ,  Hagen REINHARDT ,  Michael KELLER ,  Sujata IYER ,  TECAN TRADING AG

Inventor： Adrian SAGER ,  Philipp OTT ,  Patrick KINNEY ,  Hagen REINHARDT ,  Michael KELLER ,  Sujata IYER

IPC: B01L3/02 ,  G01N35/10

Abstract: A pipette tip extension attachable to a pipette tip having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip, and at the distal end a dispense aperture. The pipette tip extension further has an inner cavity, a distance element connected to the inner side of the exterior wall, and a constriction element.

公开(公告)号：US11173485B2

公开(公告)日：2021-11-16

申请号：US16373128

申请日：2019-04-02

Applicant: TECAN TRADING AG

Inventor： Basil Nuesch ,  Nicolas Cors

IPC: B01L3/02 ,  B25J15/04 ,  B25J15/02 ,  G01N35/10 ,  B01L9/00 ,  B25J15/06 ,  B25J15/00

Abstract: A pipetting system having at least one pipette tip receptacle with a pipette tip arranged therein that extends along a vertical axis and at least one gripper having a mechanical coupling, the gripper is coupled to the at least one pipette tip receptacle with the coupling and at least one grip element. The at least one grip element has at least one substantially vertical portion and at least one substantially horizontal portion and the coupling has a body having a through channel that extends along the vertical axis over the entire length of the coupling and the pipette tip extends along the through channel of the coupling.

公开(公告)号：US11148138B2

公开(公告)日：2021-10-19

申请号：US15756176

申请日：2015-09-02

Applicant: TECAN TRADING AG ,  Thomas Perroud ,  Dan Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

Inventor： Thomas Perroud ,  Dan Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

IPC: B01L3/00

Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

公开(公告)号：US11131632B2

公开(公告)日：2021-09-28

申请号：US16325647

申请日：2017-08-17

Applicant: TECAN TRADING AG

Inventor： Manfred Lansing ,  Johannes Posch ,  Tobias Sawetzki

IPC: G01N21/76 ,  G01N21/15 ,  G01N21/25

Abstract: A measuring device for the measurement of light signals emitted from samples in wells of a microplate, in particular to a luminescence measuring device for measuring luminescence signals. The luminescence measuring device has a first injector with an injector needle having an outlet end for dispensing a reagent into a well, and a luminescence optical device having an optical axis extending substantially perpendicularly to the microplate and a measuring region surrounding the optical axis. The injector needle extends to below the luminescence optical device and opens with its outlet end into the measuring region. The luminescence measuring device has further a spray deflector arranged between the outlet end of the injector and the luminescence optical device.

公开(公告)号：US20210260541A1

公开(公告)日：2021-08-26

申请号：US17261325

申请日：2019-07-24

Applicant: TECAN TRADING AG

Inventor： Dominic ERB ,  Philipp RIEDEL ,  Christian STREBEL ,  Gero FEHR ,  Klaus LUN ,  Christoph KARTHAUS

IPC: B01F11/00 ,  B01F15/00

Abstract: A mixing apparatus containing a drive unit having a drive and a shaft that is pivotable about a pivot axis and is operatively connected to the drive. A pivotable receptacle is arranged on the shaft, where the pivot axis is oriented essentially horizontally, and the pivotable receptacle has a base plate and at least one retainer spaced therefrom, and the pivotable receptacle is configured in such a way that holders for containers can be inserted between the base plate and the at least one retainer in the direction of the pivot axis.

公开(公告)号：US20210187493A1

公开(公告)日：2021-06-24

申请号：US17122470

申请日：2020-12-15

Applicant: TECAN TRADING AG

Inventor： Michael KELLER ,  Thomas Geiges

IPC: B01L3/02

Abstract: Pipetting device for pipetting a liquid driven by a gaseous working medium, the pipetting device having at least one pipette connector adapted to attach a pipette at a connection opening at least one pressurizing and/or suctioning pressure source, a gas flow connection between said connection opening and at least one pressure source, a flow restriction defining at least a section of said gas flow connection, a first sensor configured to measure a quantity indicative of the temperature of the flow restriction. The invention is further directed to a gas flow connection element for a pipetting device and to a method of pipetting a liquid volume.