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公开(公告)号：US20230175016A1
公开(公告)日：2023-06-08
申请号：US18011592
申请日：2021-06-30
申请人： Syncona Investment Management Limited , The University of Bristol , Purespring Therapeutics Limited
发明人： Alan William Griffith , Lukas Stanczuk , Valeryia Kuzmuk , Chris Hollowood , Dominic Schmidt , Moin Ahson Saleem-Uddin , Gavin Iain Welsh
CPC分类号： C12N15/86 , A61P13/12 , C12N2750/14143 , C12N2830/008 , C12N2830/48
摘要： The present invention provides a viral vector comprising a nucleotide sequence encoding a complement protein, wherein the nucleotide sequence is operably linked to a podocyte-specific promoter and/or the viral vector is capable of specifically transducing podocytes.
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62.发明申请公开(公告)号：US20220370482A1
公开(公告)日：2022-11-24
申请号：US17774051
申请日：2020-11-05
IPC分类号： A61K31/663 , A61K31/662 , A61P13/12
摘要： A compound for use in the treatment of nephrotic syndrome in a subject in need thereof, wherein the compound is an inhibitor of binding between a target protein and keratin 8.
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公开(公告)号：US20220178931A1
公开(公告)日：2022-06-09
申请号：US17437014
申请日：2020-03-06
发明人： Derek Neil Woolfson , William Michael Dawson , Guto Glyn Rhys , David Arne Scott , Jordan Michael Fletcher , Christopher Robin Wells Wood , James Christopher Norman , Cassie Jemma Clarke
IPC分类号： G01N33/574 , G01N21/64
摘要： A method of diagnosing, staging or monitoring cancer, the method comprising the steps of: (a) providing a sensor array comprising at least two sensors, wherein each sensor comprises a protein barrel that comprises five or more alpha helices arranged as an alpha-helical barrel, and a reporter dye, wherein the protein barrel defines a lumen, the reporter dye is bound to the lumen reversibly; and wherein the protein barrel is different in structure in the at least two sensors; (b) contacting the sensor array with a sample obtained from a patient; and then (c) comparing the sensor array to a predetermined standard.
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公开(公告)号：US20220125580A1
公开(公告)日：2022-04-28
申请号：US17434724
申请日：2020-02-28
摘要： The invention relates to a method of manufacturing a heart valve, comprising: a step of injection moulding a first part (110) of the heart valve from a first block-copolymer, wherein the injection moulding is performed at a temperature below an order-disorder transition temperature of the block copolymer, such that a phase structure is present in the molten block-copolymer; a step of injection moulding a second part (114) of the heart valve from a second block-copolymer that is different to the first block-copolymer, by over-moulding over the first part (110) to form an over-moulded structure, wherein the injection moulding is performed at a temperature below order-disorder transition temperatures for the first and second block copolymers, such that a phase structure is present in the molten second block-copolymer and remains present in the first block-copolymer; and a step of cooling the over-moulded structure, without heating it above the order-disorder transition temperatures between the step of injection moulding the second part (114) and the step of cooling, so as to preserve an arrangement of the phase structures created during the steps of injection moulding and produce anisotropic physical properties in the second part (114). The invention also relates to the thus manufactured heart valve.
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公开(公告)号：US11092580B2
公开(公告)日：2021-08-17
申请号：US16805590
申请日：2020-02-28
摘要： A diagnostic apparatus for analysing a sample to diagnose disease, the apparatus comprising: a separating element for separating gas derived from the sample into component parts; a sensor arrangement coupled to the separating element such that a component part of the gas is directed towards the sensor arrangement, the sensor arrangement being configured to detect compounds which may be indicative of disease; and a processing element coupled to an output of the sensor arrangement, the processing element being configured to process a signal output by the sensor arrangement to provide a diagnosis.
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公开(公告)号：US10859610B2
公开(公告)日：2020-12-08
申请号：US16096792
申请日：2017-04-27
发明人： Bernard Stark , Guang Yang , Chunhong Zhang , Plamen Proynov , Salah Adami
IPC分类号： G01R19/165 , G05F3/24 , H03K17/22 , G01R15/04 , G05F3/10
摘要： A voltage detector comprising: a first voltage reference generator for generating a first voltage reference signal; a second voltage reference generator for generating a second voltage reference signal, wherein the second voltage reference signal is higher than the first voltage reference signal; a trigger, powered by an input signal to the voltage detector, and having an input for receiving either the first or second voltage reference signal and an output for generating a detection signal; and a switch for selectively, connecting the input of the trigger to the first or second voltage reference signal, wherein the switch is operative to connect the input of the trigger to the first voltage reference signal when the detection signal output by the voltage detector is low and is operative to connect the input of the trigger to the second voltage reference signal when the detection signal output by the voltage detector is high, and a voltage detector system for monitoring an input signal and outputting a detection signal when a voltage of the input signal meets a first threshold, the voltage detector system comprising: a first voltage detector having an input for receiving the input signal and an output for outputting a detection signal, wherein the first voltage detector is configured to output the detection signal when the voltage of the input signal meets a first rising input voltage threshold; a second voltage detector having an input for receiving the input signal and an output for outputting a detection signal, wherein the second voltage detector is configured to output the detection signal when the voltage of the input signal meets a second rising input voltage threshold which is higher than the first threshold, wherein the output of the second voltage detector controls a connection between the input signal and the input of the first voltage detector such that when the voltage the input signal meets the second rising input voltage threshold the connection between the input and the input of the first voltage detector is inhibited or disconnected.
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公开(公告)号：US20190382424A1
公开(公告)日：2019-12-19
申请号：US16334668
申请日：2017-09-18
IPC分类号： C07F9/50
摘要： A versatile, highly efficient process for the preparation of acylphosphines such as mono- and bisacylphosphines via reaction of phosphines (PH3 and higher homologues) or silylated phosphines with acylhalides in the presence of at least one lewis acid. Further a novel acyl phosphines obtainable by the process.
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公开(公告)号：US10361587B2
公开(公告)日：2019-07-23
申请号：US15326009
申请日：2015-06-30
发明人： ChengHuan Zhong , Anthony Croxford , Paul Wilcox
摘要： This application relates to a wireless sensor (10) suitable for non-destructive testing of a test object. The sensor comprises a transducer (12) and an electrically conductive transducer coil (16) configured to define an enclosure and being electrically coupled to the transducer to enable the transducer to be inductively operated by a remote device. The enclosure defined by the transducer coil has an internal width dimension that is wider than a corresponding width dimension of the transducer.
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公开(公告)号：US10312733B2
公开(公告)日：2019-06-04
申请号：US15326009
申请日：2015-06-30
发明人： ChengHuan Zhong , Anthony Croxford , Paul Wilcox
摘要： This application relates to a wireless sensor (10) suitable for non-destructive testing of a test object. The sensor comprises a transducer (12) and an electrically conductive transducer coil (16) configured to define an enclosure and being electrically coupled to the transducer to enable the transducer to be inductively operated by a remote device. The enclosure defined by the transducer coil has an internal width dimension that is wider than a corresponding width dimension of the transducer.
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公开(公告)号：US20190074152A1
公开(公告)日：2019-03-07
申请号：US16083583
申请日：2017-03-10
CPC分类号： H01H59/0009 , B81B3/0005 , B81B2201/018 , B81B2203/0118 , B81B2203/019 , H01H2001/0052 , H01H2001/0057 , H01H2001/0078 , H01H2201/026 , H01H2209/002 , H01H2209/016 , H01H2227/002
摘要： A electromechanical relay device (100) comprising a source electrode (102), a beam (104) mounted on the source electrode at a first end and electrically coupled to the source electrode; a first drain electrode (112) located adjacent a second end of the beam, wherein a first contact (110) on the beam is arranged to be separated from a second contact (112) on the first drain electrode when the relay device is in a first condition; a first gate electrode (106 arranged to cause the beam to deflect, to electrically couple the first contact and the second contact such that the device is in a second condition; and wherein the first and second contacts are each coated with a layer of nanocrystalline graphite.
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