公开(公告)号：US20210236427A1

公开(公告)日：2021-08-05

申请号：US17052022

申请日：2019-05-06

Applicant: University of Manitoba

Inventor： Chengbo Yang ,  Song Liu ,  Martin Nyachoti

IPC: A61K9/16 ,  A61K31/05 ,  A23K20/163 ,  A23K20/158

Abstract: Antibiotics have long been used at sub-therapeutic levels to control incidences of post-weaning diarrhea and to improve growth performance in pigs. However, the current trend world-wide is to eliminate the use of in-feed antibiotics due to increased public concerns over the spread of antibiotic resistance in bacterial pathogens, which poses a threat to public health. Alternatives to in-feed antibiotics are needed. Thymol essential oil exhibits strong in vitro antibacterial activity; however; direct inclusion of essential oils to pig feeds has limited efficacy due to their high volatility, low stability during feed processing, interactions with other feed components and poor availability in lower gut. To solve these problems, we developed lipid matrix beads using thymol and a fatty acid with incorporation of 2% polysaccharides via a melt-granulation technique. Laurie acid was identified as a suitable carrier for thymol. In vitro release of thymol from lipid matrix granules was determined using simulated salivary fluid (SSF), simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), respectively. The lipid matrix granules with 2% polysaccharides exhibited a slow release rate (%) of essential oil and fatty acid in SSF (21.2±2.3; 36±1.1), SGF (73.7±6.9; 54.8±1.7) and SIF (99.1±1.2; 99.1±0.6), respectively. However, the lipid matrix granules without polysaccharides had quick release (%) of essential oil and fatty acid from the SSF (79.9±11.8; 84.9±9.4), SGF (92.5±3.5; 75.8±5.9) and SIF (93.3±9.4; 93.3±4.6), respectively.

公开(公告)号：US11059790B2

公开(公告)日：2021-07-13

申请号：US15768824

申请日：2016-10-14

Applicant: UNIVERSITY OF MANITOBA

Inventor： Zachary J. Wolff ,  Sadegh Ghanbar ,  Dominic Tessier ,  Chenxi Ning ,  Jonathan van Leeuwen ,  Marcelo Dubiel ,  Gurmeet Singh Bindra ,  Song Liu

IPC: C07D233/76 ,  C07D211/46 ,  C09D5/14 ,  C08K5/3435 ,  C08K5/3445 ,  C07D211/58 ,  C07D233/74 ,  A01N43/40 ,  A01N43/50 ,  C07D233/78 ,  C08K5/19 ,  C08K5/00

Abstract: The present disclosure relates to a compound that has biocidal activity or is a precursor of a compound with biocidal activity. The compound comprises an N-halamine precursor, at least one quaternary ammonium and at least one coating-incorporation group (CIG). In some embodiments of the present disclosure, the compound may be incorporated into a coating formulation. The coating formulation comprises the compound and at least one further component. In some embodiments of the present disclosure, the CIG reacts with the further component of the coating formulation to incorporate the compound into the coating formulation. In some embodiments, the coating formulation comprises a polymer. In some embodiments, the CIG of the compound reacts with the further component to incorporate the compound into the polymer of the coating formulation. The coating formulation may be used to coat a substrate. The coated substrate may demonstrate biocidal activity or the potential for increased biocidal activity.

公开(公告)号：US10975260B2

公开(公告)日：2021-04-13

申请号：US15775816

申请日：2016-11-10

Applicant: University of Manitoba

Inventor： Song Liu ,  Rajbir Kaur ,  Zachary J. Wolff ,  Gurmeet Singh Bindra

IPC: C09D201/02 ,  C09D201/04 ,  C09D5/14 ,  C09D133/24 ,  C09D7/63 ,  C08K5/3415 ,  C08K5/34

Abstract: A modified surface with at least one cationic center and at least one compound. The surface can be modified by various methods. The result of these methods is that the cationic center and the compound are connected to the modified surface. The cationic center and the compound are connected to the modified surface so that both of the cationic center and the compound are available upon the modified surface to react with other chemicals or microorganisms that come into contact with or near to the modified surface. The availability of the cationic center and the compound cause the modified surface to have a functionality that it would not otherwise have. The number of molecules of the cationic center relative to the number of molecules of the at least one compound may influence the functionality of the modified surface.

公开(公告)号：US20210052601A1

公开(公告)日：2021-02-25

申请号：US17041592

申请日：2019-05-24

Applicant: UNIVERSITY OF MANITOBA

Inventor： David E. Herbert ,  Issiah B. Lozada ,  Bin Huang ,  Yaorong Zheng ,  Zihan Qiu

IPC: A61K31/555

Abstract: Described herein is the development of synthetic routes to produce a wide variety of substituted phenanthridines, specifically, multidentate phenanthridine-containing ligand frameworks capable of anchoring to Pt via more than one binding site and with the phenanthridinyl moiety co-planar to the coordination plane of Pt. The multidentate chelation is designed to attenuate the reactivity of the platinum complex in vivo, and ultimately help mitigate side effects. In addition, the geometry of phenanthridine binding to the metal centre is altered compared to in phenanthriplatin, thanks to the constraints of the ligand geometry. By enforcing coplanar binding with the metal's square planar coordination plane, these compounds exhibit altered modes of activity, and should hence enhance/change the spectrum of activity of our prodrug candidates compared with phenanthriplatin.

公开(公告)号：US10927856B2

公开(公告)日：2021-02-23

申请号：US15815181

申请日：2017-11-16

Applicant: University of Manitoba

Inventor： Ahmed A. Imam ,  Nariman Sepehri

IPC: F15B7/00 ,  F15B7/10 ,  F15B21/14

Abstract: Pump-controlled hydraulic circuits are more efficient than valve-controlled circuits, as they eliminate the energy losses due to flow throttling in valves and require less cooling effort. Presently existing pump-controlled solutions for single rod cylinders encounter an undesirable performance during certain operating conditions. Novel circuit designs employ use of different charge pressures on a pair of pilot-operated charging-control valves or different piston areas and/or spring constants on a shuttle-type charging control valve to shift a critical loading region in a load-force/actuator-velocity plane to a lower load force range, thereby reducing the undesired oscillations experienced in the response of the typical critical loading region. One or more specialized valves are controlled by fluid pressures to provide throttling in the circuit only within the critical loading region, thereby reducing the oscillatory amplitude while avoiding throttling-based energy losses outside the critical region over the majority of the circuit's operational overall operating area.

公开(公告)号：US20200280579A1

公开(公告)日：2020-09-03

申请号：US16646815

申请日：2018-09-13

Applicant: University of Manitoba

Inventor： Jesus David Terrazas Gonzalez ,  Witold Kinsner

IPC: H04L29/06 ,  G06N3/08 ,  G06N3/04

Abstract: A system for analyzing internet traffic passing through an exposed computer device includes a preprocessing module for filtering the traffic so as to substantially isolate from the traffic features carrying data representative of a cyberattack, a perception module for extracting the data from the isolated features, a detection module for processing the extracted data to detect characteristics indicative of the cyberattack, and a mitigation module for generating responsive action if a cyberattack is detected.

公开(公告)号：US10693393B2

公开(公告)日：2020-06-23

申请号：US15987564

申请日：2018-05-23

Applicant: University of Manitoba

Inventor： Cyrus Shafai ,  Yu Zhou

IPC: H02N1/06 ,  H02N1/00 ,  B81B3/00

Abstract: A new tri-electrode topology reduces the control voltage requirement for electrostatic actuators. Conventional parallel plate actuators are dual-electrode systems, formed by the MEMS structure and the drive electrode. By placing a perforated intermediate electrode between these elements, a tri-electrode configuration is formed. This topology enables a low voltage on the intermediate electrode to modulate the electrostatic force of the higher voltage drive electrode, whose voltage remains fixed. Results presented show that in comparison to conventional parallel plate electrostatic actuators, the intermediate electrode's modulating voltage can be as low as 20% of normal, while still providing the full actuation stroke.

公开(公告)号：US10582713B2

公开(公告)日：2020-03-10

申请号：US15514702

申请日：2015-09-25

Applicant: UNIVERSITY OF MANITOBA

Inventor： Fuji Jian ,  Digvir Jayas ,  Paul Fields

IPC: G01N25/00 ,  A23B9/04 ,  A01M1/22 ,  G01N1/44 ,  A01M1/02 ,  G01N25/72 ,  G01N33/02 ,  G01N33/24

Abstract: A rapid method to detect and/or remove mobile insects inside granular material is presented. The core of this method is to heat grain samples to the desired temperatures (about 55 C) using microwave or radio frequency energy to force insects to move out of the granular material.

公开(公告)号：US20190298739A1

公开(公告)日：2019-10-03

申请号：US16367964

申请日：2019-03-28

Applicant: University of Manitoba

Inventor： Rizwan A. Manji

IPC: A61K31/573 ,  C07K16/28 ,  A61P9/00

Abstract: A method of treating calcific aortic valve disease (CAVD), such as aortic valve sclerosis or stenosis, comprises administering an immunosuppressive drug or therapy to CAVD patient to slow or prevent progression of CAVD. Individuals who do not have cardiovascular disease may benefit particularly from the method described. The presence of antibody or Infiltration of immune cells into aortic valve tissue may be slowed or prevented using the method described. Uses and kits for addressing CAVD are also provided. Immunosuppressive drugs or therapies comprise but are not limited to steroids, glucocorticoids methotrexate, mycophenolate mofetil, Rituximab, anti-CD 20 monoclonal antibodies, anti-macrophage monoclonal antibodies, azathioprine, cyclosporine, leflunomide, cyclophosphamide, chlorambucil, nitrogen mustard, hydroxychloroquine, sulfasalazine, tacrolimus, or rapamycin.

公开(公告)号：US20190247090A1

公开(公告)日：2019-08-15

申请号：US16272460

申请日：2019-02-11

Applicant: University of Manitoba

Inventor： Sean Armstrong

IPC: A61B17/34 ,  A61M25/01 ,  A61M25/09

CPC classification number: A61B17/3474 ,  A61M5/158 ,  A61M25/0102 ,  A61M25/09041 ,  A61M2025/09175

Abstract: A Veress needle assembly for a peritoneal dialysis catheter guide wire has (i) a hollow needle with a pointed end, (ii) an inner tube received within the hollow needle so as to be slidable relative to the hollow needle in the longitudinal direction between a first position in which the first end of the inner tube protrudes longitudinally beyond the pointed end of the hollow needle and a second position in which the first end of the inner tube is retracted so that the pointed end is unobstructed by the inner tube, and (iii) a biasing mechanism to bias the inner tube towards the first position. The inner tube includes a fluid passage having an outlet opening at the first end of the inner tube that is oriented to allow the peritoneal dialysis catheter guide wire to readily the outlet opening when inserted through the fluid passage of the inner tube.