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132 条记录 (耗时 0.073 秒)

    Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases
    62.
    发明授权
    Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases 有权
    寡核糖核苷酸及其用于治疗纤维化病症和其它疾病的方法

    公开(公告)号：US08198258B2

    公开(公告)日：2012-06-12

    申请号：US13092501

    申请日：2011-04-22

    申请人： Orna Mor ,  Elena Feinstein

    发明人： Orna Mor ,  Elena Feinstein

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C07H21/04 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/76 ,  C12N9/1044 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/322 ,  C12Y203/02013 ,  C12N2310/3527 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide (siRNA), which down-regulates the expression of a human TGaseII gene at the post-transcriptional level. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from a fibrotic disease such as pulmonary, kidney and liver fibrosis or ocular, scarring comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The invention also relates to treatment of fibrotic and other diseases by use of antibodies to TGaseII polypeptide.

    摘要翻译： 本发明涉及在转录后水平下调人TGaseII基因表达的双链化合物，优选寡核糖核苷酸（siRNA）。 本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。 本发明还考虑了治疗患有纤维化疾病如肺，肾和肝纤维化或眼睛，瘢痕形成的患者的方法，其包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。 本发明还涉及通过使用TGaseII多肽的抗体来治疗纤维化和其它疾病。

    Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA
    64.
    发明授权
    Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA 有权
    通过siRNA抑制p53，预防和治疗急性肾功能衰竭等肾脏疾病

    公开(公告)号：US07910566B2

    公开(公告)日：2011-03-22

    申请号：US12006722

    申请日：2008-01-04

    申请人： Elena Feinstein

    发明人： Elena Feinstein

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： A61K31/70

    摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from acute renal failure or other kidney diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient.

    摘要翻译： 本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。 本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。 本发明还考虑了治疗患有急性肾衰竭或其它肾脏疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。

    Use of the ENDO-180 gene and polypeptide for diagnosis and treatment
    65.
    发明申请
    Use of the ENDO-180 gene and polypeptide for diagnosis and treatment 审中-公开
    使用ENDO-180基因和多肽进行诊断和治疗

    公开(公告)号：US20090202566A1

    公开(公告)日：2009-08-13

    申请号：US12317231

    申请日：2008-12-19

    申请人： Orna Mor ,  Elena Feinstein ,  Alexander Faerman

    发明人： Orna Mor ,  Elena Feinstein ,  Alexander Faerman

    IPC分类号： A61K39/395 ,  C12N5/00 ,  A61K31/7052 ,  A61P35/00 ,  A61P19/02 ,  A61P3/00 ,  A61P13/12 ,  A61P9/00

    CPC分类号： G01N33/5032 ,  G01N33/6872 ,  G01N2333/4724 ,  G01N2333/78

    摘要： This application is directed to a process of identifying a compound capable of modulating activity of a human ENDO180 receptor that comprises the steps of measuring the binding of the ENDO180 receptor to an interactor with which the ENDO180 receptor interacts specifically in vivo, in the absence or presence of a compound, and determining whether the binding of the ENDO180 receptor to the interactor is affected by the compound. This application is also directed to use of a compound identified by that process in the preparation of a medicament for therapy of disease, in particular fibrosis. This application also relates to the use of ENDO180 modulators in treatment of disease.

    摘要翻译： 本申请涉及鉴定能够调节人ENDO180受体活性的化合物的方法，该方法包括以下步骤：在不存在或存在下测量ENDO180受体与ENDO180受体在体内特异性相互作用的相互作用因子的结合 的化合物，并确定ENDO180受体与相互作用体的结合是否受化合物的影响。 本申请还涉及通过该方法鉴定的化合物在制备用于治疗疾病，特别是纤维化的药物中的用途。 本申请还涉及使用ENDO180调节剂治疗疾病。

    OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF ALOPECIA, ACUTE RENAL FAILURE AND OTHER DISEASES
    69.
    发明申请
    OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF ALOPECIA, ACUTE RENAL FAILURE AND OTHER DISEASES 审中-公开
    用于治疗阿片样物质，急性肾衰竭和其他疾病的低分子化合物及其使用方法

    公开(公告)号：US20150141487A1

    公开(公告)日：2015-05-21

    申请号：US14321484

    申请日：2014-07-01

    申请人： Elena Feinstein ,  Daniel Zurr ,  Shai Ehrlich

    发明人： Elena Feinstein ,  Daniel Zurr ,  Shai Ehrlich

    IPC分类号： C12N15/113

    CPC分类号： C12N15/1135 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30

    摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.

    摘要翻译： 本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。 本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。 本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。 秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

    OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF ALOPECIA, ACUTE RENAL FAILURE AND OTHER DISEASES
    70.
    发明申请
    OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF ALOPECIA, ACUTE RENAL FAILURE AND OTHER DISEASES 审中-公开
    用于治疗阿片样物质，急性肾衰竭和其他疾病的低分子化合物及其使用方法

    公开(公告)号：US20120184597A1

    公开(公告)日：2012-07-19

    申请号：US13351923

    申请日：2012-01-17

    申请人： Elena Feinstein ,  Daniel Zurr ,  Shai Ehrlich

    发明人： Elena Feinstein ,  Daniel Zurr ,  Shai Ehrlich

    IPC分类号： A61K31/713 ,  A61P1/00 ,  C07H21/02 ,  A61P25/16 ,  A61P35/00 ,  C12N5/071 ,  A61P17/14 ,  A61P25/00

    CPC分类号： C12N15/1135 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30

    摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.

    摘要翻译： 本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。 本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。 本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。 秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。