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113 条记录 (耗时 0.048 秒)

    Polypeptide
    61.
    发明申请
    Polypeptide 审中-公开
    多肽

    公开(公告)号：US20070141693A1

    公开(公告)日：2007-06-21

    申请号：US11483220

    申请日：2006-07-07

    申请人： Casper Berg ,  Patrick Maria Derkx ,  Carol Fioresi ,  Gijsbert Gerritse ,  Anja Kellet-Smith ,  Karsten Kragh ,  Wei Liu ,  Andrew Shaw ,  Bo Sorensen ,  Charlotte Thoudahl

    发明人： Casper Berg ,  Patrick Maria Derkx ,  Carol Fioresi ,  Gijsbert Gerritse ,  Anja Kellet-Smith ,  Karsten Kragh ,  Wei Liu ,  Andrew Shaw ,  Bo Sorensen ,  Charlotte Thoudahl

    IPC分类号： C12N9/32 ,  C12N1/21

    CPC分类号： A21D8/042 ,  A23L33/18 ,  C12N9/2411 ,  C12N9/2414 ,  C12N9/2417 ,  C12N9/2425 ,  C12N9/2428

    摘要： The invention provides for a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity which may be selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and 334; (b) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 145, 146, 157, 178, 179, 223, 229, 272, 303, 307 and 334; (c) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; and (d) a polypeptide comprising an amino acid mutation at each of positions 3, 33, 34, 70, 121, 134, 141, 146, 157, 178, 179, 223, 229, 272, 303, 307, 309 and 334; with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1, uses of such a polypeptide as a food or feed additive, and nucleic acids encoding such.

    摘要翻译： 本发明提供可衍生自具有淀粉酶活性的亲本多肽的PS4变体多肽，其可以选自： 146，157，161，178，179，223，229，272，303，307，309和334; （b）包含位置33,34,121,134,141,145,146,157,178,179,223,229,272,303,307和334的氨基酸突变的多肽; （c）包含位置33,34,121,134,141,146,157,178,179,223,229,272,303,307,309和334的氨基酸突变的多肽; 和（d）包含位置3,33,34,70,121,134,141,146,157,178,179,223,229,272,303,307,309和334中的每一个上的氨基酸突变的多肽 ; 参考如SEQ ID NO：1所示的假单胞菌属酵母内切酶序列的位置编号，这种多肽作为食品或饲料添加剂的使用，以及编码其的核酸。

    Modified target enzymes having catalytic triads and uses thereof
    63.
    发明授权
    Modified target enzymes having catalytic triads and uses thereof 有权
    具有催化三联体的改性靶酶及其用途

    公开(公告)号：US07157264B2

    公开(公告)日：2007-01-02

    申请号：US10068374

    申请日：2002-02-06

    申请人： Andrew Shaw

    发明人： Andrew Shaw

    IPC分类号： C12N9/42 ,  C12N1/20 ,  C12N15/00

    CPC分类号： C12N9/2437 ,  A61K38/47 ,  C11D3/386 ,  C11D3/38645 ,  C12N9/14 ,  C12Y302/01004

    摘要： Modified target molecules are disclosed comprising genetically modified molecules, preferably enzymes, that include a catalytic triad which alters the performance of the polypeptide. Optionally, such a catalytic triad in the modified target molecule comprises three members equivalent to amino acid residues Serine 227, Histidine 200, or Glutamate 139, respectively, in the Bacillus cellulase 103 sequence. Using the embodiments disclosed by the present invention, altered performance profiles, such as enzyme activity or stability, under alkaline conditions can be achieved. Methods of making and using modified target molecules are also disclosed.

    摘要翻译： 公开了修饰的靶分子，其包含遗传修饰的分子，优选酶，其包括改变多肽性能的催化三联体。 任选地，修饰的靶分子中的这种催化三单元组分别包含在纤维素酶103序列中分别等同于氨基酸残基丝氨酸227，组氨酸200或谷氨酸盐139的三个成员。 使用本发明公开的实施方案，可以在碱性条件下实现改变的性能特征，例如酶活性或稳定性。 还公开了制备和使用修饰的靶分子的方法。

    Apparatus and method based on cavity ring-down spectroscopy
    64.
    发明申请
    Apparatus and method based on cavity ring-down spectroscopy 审中-公开
    基于腔体衰减光谱的装置和方法

    公开(公告)号：US20060232779A1

    公开(公告)日：2006-10-19

    申请号：US10543568

    申请日：2004-01-08

    申请人： Andrew Shaw

    发明人： Andrew Shaw

    IPC分类号： G01N21/59

    CPC分类号： G01N21/39 ,  G01J3/42 ,  G01J2003/423

    摘要： This invention is generally concerned with sensing apparatus and methods, more particularly apparatus and methods for sensing techniques based upon cavity ring-down spectroscopy (CRDS). An evanescent wave cavity-based optical sensor is described. The sensor comprises an optical cavity formed by a pair of highly reflective surfaces (108, 110) such that light within said cavity makes a plurality of passes between said surfaces, an optical path between said surfaces including a reflection from a totally internally reflecting (112) surface, said reflection from said reflection from said surface generating an evanescent wave to providing a sensing function; a light source (102) to inject light into said cavity; and a detector (114) to detect a light level within said cavity; whereby absorption of said evanescent wave is detectable using said detector to provide said sensing function; wherein said light source comprises a continuous wave light source; and wherein said light source has a power and bandwidth sufficient to couple energy into at least two modes of oscillation of said cavity to overcome losses within the cavity and excite at least two modes of oscillation of said cavity.

    摘要翻译： 本发明一般涉及感测装置和方法，更具体地涉及用于基于空腔衰减光谱（CRDS）的感测技术的装置和方法。 描述了一种基于ev逝波腔的光学传感器。 传感器包括由一对高反射表面（108,110）形成的光腔，使得所述空腔内的光在所述表面之间形成多个通路，所述表面之间的光路包括来自全内反射的反射（112 ）表面，来自所述表面的所述反射的所述反射产生ev逝波，以提供感测功能; 用于将光注入所述空腔的光源（102）; 以及检测器（114），用于检测所述空腔内的光级; 由此使用所述检测器检测所述ev逝波的吸收以提供所述感测功能; 其中所述光源包括连续波光源; 并且其中所述光源具有足以将能量耦合到所述空腔的至少两个振荡模式中的功率和带宽，以克服腔内的损耗并激发所述空腔的至少两种振荡模式。

    Translation consistency checking for modified target instructions by comparing to original copy
    66.
    发明授权
    Translation consistency checking for modified target instructions by comparing to original copy 有权
    通过与原始副本进行比较，对修改后的目标指令进行翻译一致性检查

    公开(公告)号：US06594821B1

    公开(公告)日：2003-07-15

    申请号：US09539987

    申请日：2000-03-30

    申请人： John Banning ,  H. Peter Anvin ,  Robert Bedichek ,  Guillermo J. Rozas ,  Andrew Shaw ,  Linus Torvalds ,  Jason Wilson

    发明人： John Banning ,  H. Peter Anvin ,  Robert Bedichek ,  Guillermo J. Rozas ,  Andrew Shaw ,  Linus Torvalds ,  Jason Wilson

    IPC分类号： G06F9455

    CPC分类号： G06F9/3808 ,  G06F9/3812

    摘要： A method for maintaining consistency between translated host instructions and target instructions from which the host instructions have been translated including the steps of maintaining a copy of a target instruction for which a translated host instruction have been made, comparing the copy of the target instruction with a target instruction at a memory address at which the target instruction from which the copy was made was stored when translated, disabling the translated host instruction if the copy of the target instruction is not the same as the target instruction at the memory address, and executing the translated host instruction if the copy of the target instruction is the same as the target instruction at the memory address.

    摘要翻译： 一种用于保持转换的主机指令与已经被转换了主机指令的目标指令之间的一致性的方法，包括维护已经进行转换的主机指令的目标指令的副本的步骤，将目标指令的副本与 在翻译时存储复制的目标指令的存储器地址处的目标指令，如果目标指令的副本与存储器地址处的目标指令不相同，则禁用转换的主机指令，并执行 如果目标指令的副本与存储器地址上的目标指令相同，则转换主机指令。