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71 条记录 (耗时 0.047 秒)

    7-Heteroarylsulfonyl-tetrahydro-3-benzazepine derivatives as antipsychotic agents
    61.
    发明申请
    7-Heteroarylsulfonyl-tetrahydro-3-benzazepine derivatives as antipsychotic agents 审中-公开

    公开(公告)号：US20070093473A1

    公开(公告)日：2007-04-26

    申请号：US10571220

    申请日：2004-09-09

    申请人： David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Andrew Gribble ,  Andrew Lightfoot ,  Andrew Payne ,  Alexander Smith

    发明人： David Cooper ,  Ian Forbes ,  Vincenzo Garzya ,  Andrew Gribble ,  Andrew Lightfoot ,  Andrew Payne ,  Alexander Smith

    IPC分类号： A61K31/55 ,  C07D403/02 ,  C07D409/02

    CPC分类号： C04B35/632 ,  C07D401/12 ,  C07D409/12

    摘要： The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR3R4, —SO2NR3R4, —(CH2)pNR3R4, —(CH2)pNR3COR4, optionally substituted aryl ring, optionally substituted heteroaryl ring, a fused bicyclic heteroaromatic ring system or optionally substituted heterocyclyl ring; Ar1 represents optionally substituted heteroaryl ring; Ar2 represents optionally substituted aryl ring or optionally substituted heteroaryl ring; Z represents —(CH2)qX— wherein the —(CH2)q— group is attached to Ar2, or —X(CH2)q— wherein X is attached to Ar2, and wherein any of the —CH2— groups may be optionally substituted by one or more C1-6alkyl groups; X represents oxygen, —CH(OR5)—, —NR5— or —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups; R3 and R4 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; R5 represents hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 0, 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that when Ar1 is a pyridyl group, and Z is —CH2X— where X is attached to the Ar1 group, X is selected from —CH(OR5)—, —NR5— and —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups. The compounds of formula (I) are useful in therapy, in particular as antipsychotic agents.

    Universal clipboard
    62.
    发明申请
    Universal clipboard 有权
    通用剪贴板

    公开(公告)号：US20060175520A1

    公开(公告)日：2006-08-10

    申请号：US11048546

    申请日：2005-02-01

    申请人： David Cooper

    发明人： David Cooper

    IPC分类号： A47B97/04

    CPC分类号： B60N3/005 ,  A47B31/06 ,  A47B97/08 ,  B42F9/001

    摘要： The present invention discloses a portable, collapsible clipboard which may be mounted to a vehicle steering wheel by means of an elastic strap or removed and carried by means of a provided shoulder strap. The clipboard is comprised of two writing portions that are hingedly connected so that the clipboard can be folded in half or expanded to provide a larger writing surface. A latch is provided to keep the clipboard securely folded.

    摘要翻译： 本发明公开了一种便携式，可折叠的剪贴板，其可以通过弹性带安装到车辆方向盘，或者通过提供的肩带移除和携带。 剪贴板由铰接连接的两个书写部分组成，使得剪贴板可折叠成一半或扩展以提供较大的书写表面。 提供闩锁以保持剪贴板牢固地折叠。

    Haplotype partitioning
    63.
    发明申请
    Haplotype partitioning 审中-公开
    单倍型分区

    公开(公告)号：US20060121486A1

    公开(公告)日：2006-06-08

    申请号：US10539953

    申请日：2003-12-11

    申请人： David Cooper ,  Michael Krawczak ,  Jurgen Hedderich

    发明人： David Cooper ,  Michael Krawczak ,  Jurgen Hedderich

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： The invention relates to a method for identifying mutations and/or polymorphisms that are major determinants of a selected phenotype and is based on the identification of haplotypes and the partitioning thereof into groups that are major determinants for said phenotype.

    摘要翻译： 本发明涉及用于鉴定作为所选表型的主要决定因素的突变和/或多态性的方法，其基于单倍体的鉴定及其作为所述表型的主要决定因素的分组。

    Method for detecting growth hormone variations in humans, the variations and their uses
    64.
    发明申请
    Method for detecting growth hormone variations in humans, the variations and their uses 审中-公开
    检测人类生长激素变异的方法，变异及其用途

    公开(公告)号：US20050130150A1

    公开(公告)日：2005-06-16

    申请号：US10495234

    申请日：2002-11-12

    申请人： David Cooper ,  Ann Marie Procter ,  John Gregory ,  David Millar

    发明人： David Cooper ,  Ann Marie Procter ,  John Gregory ,  David Millar

    IPC分类号： G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6883 ,  G01N37/00 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The present invention relates to naturally-occuring growth hormone mutations; to a method for detecting them and their use in screening patients for growth hormone irregularities or for producing variant proteins suitable for treating such irregularities. In one aspect there is disclosed a detection method for detecting a variation in GH1 effective to act as an indicator of GH dysfunction in an individual, which detection method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence of the human GH1 gene from the individual; and (b) comparing the sequence obtained from the test sample with the standard sequence known to be that of the human GH1 gene, wherein a difference between the test sample sequence and the standard sequence indicates the presence of a variation (hereinafter “variant of GH1”) effective to act as an indicator of GH1 dysfunction characterised in that the test sample is obtained from an individual, either or both: exhibiting intra-uterine growth retardation (IUGR), defined as sufficient foetal height velocity diagnosed by standard methods known in the art; and/or small for gestational age (SGA), defined as insufficient (small) foetal body size (weight and/or length) for gestional age diagnosed by standard methods known in the art.

    摘要翻译： 本发明涉及天然存在的生长激素突变; 检测它们的方法及其在筛选患者生长激素不规则或用于产生适于治疗这种不规则的变体蛋白质的用途。 一方面，公开了一种检测方法，用于检测有效地作为个体的GH功能障碍的指标的GH1的变异，所述检测方法包括以下步骤：（a）获得包含人的核苷酸序列的测试样品 个体GH1基因; 和（b）将从测试样品获得的序列与已知为人类GH1基因的标准序列进行比较，其中测试样品序列与标准序列之间的差异表明存在变异（以下称为GH1的变体 “）有效地作为GH1功能障碍的指标，其特征在于，测试样品是从个体获得的，其中一种或两种：呈现子宫内生长迟缓（IUGR），定义为通过标准方法诊断的足够的胎儿高度速度 艺术; 和/或小于胎龄（SGA），定义为通过本领域已知的标准方法诊断的胎龄不足（小）胎儿体型（体重和/或长度）。

    Network link controller for dynamic designation of master nodes
    65.
    发明授权
    Network link controller for dynamic designation of master nodes 失效
    网络链路控制器用于动态指定主节点

    公开(公告)号：US5551066A

    公开(公告)日：1996-08-27

    申请号：US395206

    申请日：1995-02-27

    申请人： Robert A. Stillman ,  James A. Way ,  Jesse F. Cable, III ,  David Cooper ,  James Koskinen

    发明人： Robert A. Stillman ,  James A. Way ,  Jesse F. Cable, III ,  David Cooper ,  James Koskinen

    IPC分类号： H04L12/24 ,  H04B7/00 ,  H04J3/24

    CPC分类号： H04L41/16 ,  H04L41/0803

    摘要： A link controller for use in a node of a network includes a digital controller (102) that employs a knowledge-based control program (103). The device and method provide flexible master node designation, automatic installation, configuration and reconfiguration, and recognition and correction of network communication problems resulting from interference and other adverse conditions. The knowledge-based control program (103) employs an inference engine and a set of rules to dynamically optimize network configuration. Multipath is managed by locking on to reflected signals when a direct signal is unavailable. Operation is transparent to network users.

    摘要翻译： 用于网络节点的链路控制器包括采用基于知识的控制程序（103）的数字控制器（102）。 该装置和方法提供灵活的主节点指定，自动安装，配置和重新配置，以及由干扰和其他不利条件导致的网络通信问题的识别和校正。 基于知识的控制程序（103）采用推理引擎和一组规则来动态优化网络配置。 当直达信号不可用时，通过锁定到反射信号来管理多路径。 操作对网络用户透明。

    Window shade lock device
    69.
    发明授权
    Window shade lock device 失效
    窗帘锁装置

    公开(公告)号：US4890354A

    公开(公告)日：1990-01-02

    申请号：US239945

    申请日：1988-09-02

    申请人： David Cooper

    发明人： David Cooper

    IPC分类号： E05C17/62 ,  E06B9/80

    CPC分类号： E06B9/80 ,  E05D13/06 ,  E05Y2900/00 ,  E05Y2900/106 ,  E05Y2900/148 ,  Y10T16/35

    摘要： The window shade lock device includes a handle having a round or elongated hand grip end and a slide connector extending forwardly thereof. The slide connector is pivotally secured, preferably off center, to the preferably generally rectangular body of a slide bearing four spaced, axled, rotatable wheels, two on each of two opposite sides thereof. The wheels are adapted to ride in parallel spaced channels in a window shade side frame. The wheels extend beyond the side margins of the slide body. The slide body extends out of the frame into connection with the connector front end outside the frame. The handle is pivotally movable up and down between a locked and unlocked position. When in the locked position the slide connector front end biases the slide, specifically the wheels thereof, tightly against the frame to hold the lock in position. In the unlocked position the slide connector front end biases and spaces the slide from the frame for free movement therein. Locking of the handle to the frame also locks a window shade secured at its lower end to the handle and/or slide by a shade connector in the form of a flexible or rigid strut or the like. The device is compact, simple and efficient.

    摘要翻译： 窗帘锁定装置包括具有圆形或细长手柄端部的手柄以及向前延伸的滑动连接器。 滑动连接器优选地偏心地固定到滑动轴承的优选大体上矩形的主体上，该主体具有四个间隔开的，可旋转的旋转轮，两个在其两个相对侧中的每一个上。 车轮适于在窗帘侧框架中平行间隔的通道上行驶。 车轮延伸超出滑块主体的侧边。 滑动体从框架延伸出来，与框架外的连接器前端连接。 手柄可在锁定位置和解锁位置之间上下可枢转地移动。 当处于锁定位置时，滑动连接器前端将滑块特别是其轮子偏压在框架上以将锁定件保持在适当位置。 在解锁位置，滑动连接器前端偏置并将滑块与框架隔开，以便在其中自由移动。 将手柄锁定到框架上还将固定在其下端的窗帘遮住手柄和/或以柔性或刚性支柱等形式的遮光连接器滑动。 该设备结构紧凑，简单高效。