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公开(公告)号：US08167889B2
公开(公告)日：2012-05-01
申请号：US11771603
申请日：2007-06-29
CPC分类号： A61B17/8822 , A61F2002/4602 , A61F2002/4683 , A61K33/42
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译： 提供使用骨缺损填充的方法，例如矫形水泥，例如磷酸钙水泥等。 主题方法的一个特征是，与水泥的使用结合使用振动，例如在准备水泥时，在制备目标地点时，将水泥输送到目标地点和/或在运送之后 的水泥到目标地点。 还提供了用于实践主题方法的设备，系统和工具包。 主题方法，设备和系统可用于各种不同的应用。
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公开(公告)号：US20110290156A1
公开(公告)日：2011-12-01
申请号：US13191209
申请日：2011-07-26
CPC分类号： C04B28/04 , B01D2257/504 , C04B22/10 , C04B28/02 , C04B2103/0086 , C04B2111/00017 , C04B22/106
摘要： CO2-sequestering formed building materials are provided. The building materials of the invention include a composition comprising a carbonate/bicarbonate component. Additional aspects of the invention include methods of making and using the CO2-sequestering formed building material.
摘要翻译： 提供二氧化碳螯合形成的建筑材料。 本发明的建筑材料包括包含碳酸盐/碳酸氢盐组分的组合物。 本发明的另外的方面包括制备和使用形成二氧化碳螯合形成的建筑材料的方法。
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公开(公告)号：US07771684B2
公开(公告)日：2010-08-10
申请号：US12571398
申请日：2009-09-30
IPC分类号： C01B31/24
CPC分类号： C04B28/04 , B01D2257/504 , C04B22/10 , C04B28/02 , C04B2103/0086 , C04B2111/00017 , C04B22/106
摘要： CO2-sequestering formed building materials are provided. The building materials of the invention include a composition comprising a carbonate/bicarbonate component. Additional aspects of the invention include methods of making and using the CO2-sequestering formed building material.
摘要翻译： 提供二氧化碳螯合形成的建筑材料。 本发明的建筑材料包括包含碳酸盐/碳酸氢盐组分的组合物。 本发明的另外的方面包括制备和使用形成二氧化碳螯合形成的建筑材料的方法。
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公开(公告)号：US07735274B2
公开(公告)日：2010-06-15
申请号：US12126776
申请日：2008-05-23
申请人： Brent R. Constantz , Cecily Ryan , Laurence Clodic
发明人： Brent R. Constantz , Cecily Ryan , Laurence Clodic
CPC分类号： C04B28/04 , C04B14/26 , Y02W10/33 , Y02W10/37 , Y10T428/2982
摘要： Hydraulic cement compositions that include a carbonate compound composition, e.g., a salt-water derived carbonate compound composition containing crystalline and/or amorphous carbonate compounds, are provided. Also provided are methods of making and using the hydraulic cements, as well as settable compositions, such as concretes and mortars, prepared therefrom. The cements and compositions produced therefrom find use in a variety of applications, including use in a variety of building materials and building applications.
摘要翻译： 提供了包含碳酸盐化合物组合物的液压水泥组合物，例如含有结晶和/或无定形碳酸酯化合物的盐水衍生的碳酸盐化合物组合物。 还提供了制备和使用水硬性水泥的方法，以及由其制备的可固化组合物，例如混凝土和砂浆。 由此产生的水泥和组合物可用于各种应用，包括用于各种建筑材料和建筑应用中。
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公开(公告)号：US07658940B2
公开(公告)日：2010-02-09
申请号：US11694807
申请日：2007-03-30
申请人： Brent R. Constantz
发明人： Brent R. Constantz
CPC分类号： A61L27/365 , A61L27/12 , A61L27/3608 , A61L27/425
摘要： Aspects of the invention include methods for producing flowable compositions, e.g. pastes, that set into calcium phosphate containing products, where the products include autologous bone. Aspects of the invention further include compositions produced by the methods, as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
摘要翻译： 本发明的方面包括用于生产可流动组合物的方法，例如。 糊剂，其中含有磷酸钙的产品，其中产品包括自体骨。 本发明的方面还包括通过该方法制备的组合物，以及制备该组合物的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。
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公开(公告)号：US20090020044A1
公开(公告)日：2009-01-22
申请号：US12126776
申请日：2008-05-23
申请人： Brent R. Constantz , Cecily Ryan , Laurence Clodic
发明人： Brent R. Constantz , Cecily Ryan , Laurence Clodic
CPC分类号： C04B28/04 , C04B14/26 , Y02W10/33 , Y02W10/37 , Y10T428/2982
摘要： Hydraulic cement compositions that include a carbonate compound composition, e.g., a salt-water derived carbonate compound composition containing crystalline and/or amorphous carbonate compounds, are provided. Also provided are methods of making and using the hydraulic cements, as well as settable compositions, such as concretes and mortars, prepared therefrom. The cements and compositions produced therefrom find use in a variety of applications, including use in a variety of building materials and building applications.
摘要翻译： 提供了包含碳酸盐化合物组合物的液压水泥组合物，例如含有结晶和/或无定形碳酸酯化合物的盐水衍生的碳酸盐化合物组合物。 还提供了制备和使用水硬性水泥的方法以及由其制备的可固化组合物，例如混凝土和砂浆。 由此产生的水泥和组合物可用于各种应用，包括用于各种建筑材料和建筑应用中。
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公开(公告)号：US07252833B2
公开(公告)日：2007-08-07
申请号：US10717171
申请日：2003-11-18
申请人： Brent R. Constantz , David Delaney
发明人： Brent R. Constantz , David Delaney
CPC分类号： A61L24/02
摘要： Methods and compositions are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products that include an osteoclastogenic agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid and an osteoclastogenic agent, e.g., RANKL or a mimetic thereof, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
摘要翻译： 提供了用于生产可流动组合物的方法和组合物，例如。 糊剂，其设置为包含破骨细胞生成剂的磷酸钙产品。 在本发明方法中，将包含钙源和磷酸盐源的干燥反应物与凝固液和破骨细胞生成剂如RANKL或其模拟物组合，并将合并的反应物混合以产生可流动组合物。 还提供了组合物本身以及用于制备它们的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。
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公开(公告)号：US07252672B2
公开(公告)日：2007-08-07
申请号：US10797907
申请日：2004-03-09
CPC分类号： A61B17/8822 , A61F2002/4602 , A61F2002/4683 , A61K33/42
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译： 提供使用骨缺损填充的方法，例如矫形水泥，例如磷酸钙水泥等。 主题方法的一个特征是，与水泥的使用结合使用振动，例如在准备水泥时，在制备目标地点时，将水泥输送到目标地点和/或在运送之后 的水泥到目标地点。 还提供了用于实践主题方法的设备，系统和工具包。 主题方法，设备和系统可用于各种不同的应用。
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69.发明授权Catheter devices and methods for their use in the treatment of calcified vascular occlusions 有权导管装置及其用于治疗钙化血管闭塞的方法公开(公告)号：US06730063B2
公开(公告)日：2004-05-04
申请号：US09911529
申请日：2001-07-23
IPC分类号： A61M300
CPC分类号： A61B5/14539 , A61B17/22 , A61B2017/22084 , A61M29/02 , A61M2025/0004 , A61M2025/0034 , A61M2025/1052 , A61M2025/1093 , A61M2025/1095
摘要： Catheter devices and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter devices include at least a first, second and third lumen, where: (a) the first lumen is used for delivery of an acidic dissolution solution to the vascular site; (b) the second lumen is used for delivery of a buffer solution to the vascular site; and (c) the third lumen is used for removal of fluid from the vascular site. In many preferred embodiments, the first, second and third lumens are coaxial. In practicing the subject methods, the vascular site is flushed simultaneously with an acidic dissolution fluid and a buffer solution, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the acidic dissolution fluid and the remainder of the vascular site is not contacted with fluid having a pH that is lower than about 4. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter devices and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.
摘要翻译： 提供了用于增强通过血管闭塞占据的血管部位的流体流动的导管装置和方法。 主题导管装置包括至少第一，第二和第三腔，其中：（a）第一腔用于将酸性溶解溶液递送至血管部位; （b）第二管腔用于将缓冲溶液递送至血管部位; 和（c）第三腔用于从血管部位去除流体。 在许多优选实施例中，第一，第二和第三管腔是同轴的。 在实施本发明的方法中，血管部位与酸性溶解液和缓冲溶液同时冲洗，其中以如下方式进行冲洗，使得只有血管闭塞的表面与酸性溶解液接触，其余部分 血管部位不与pH低于约4的液体接触。以这种方式进行冲洗足以使液体流过血管部位以增强的时间，例如 增加或建立 主题导管装置和方法可用于治疗各种不同血管疾病，其特征在于存在钙化血管闭塞，包括外周和冠状动脉血管疾病。
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公开(公告)号：US06712798B2
公开(公告)日：2004-03-30
申请号：US10101544
申请日：2002-03-18
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61M2500
CPC分类号： A61M25/0032 , A61M25/10 , A61M2025/1052
摘要： Multilumen catheters are provided. The subject multilumen catheters include a proximal end and a distal end separated by a non-coaxial multilumen tube. The subject catheters are further characterized in that they include a multiport manifold at their proximal ends, where at least two of the ports of the multiport manifold may comprise luer valves. Also provided are systems for use in flushing a vascular site with fluid, usually at least two different fluids, where the subject systems are made up of two multilumen catheters according to the subject invention, where one of the catheters is inserted inside of the other. In addition, kits comprising various components of the subject systems, e.g., at least two different multilumen catheters, are provided. The subject multilumen catheters, systems and kits find use in a variety of different applications in which it is desired to flush a vascular site with at least one and preferably two different fluids, where particular applications of interest include the treatment of vascular lesions.
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